Network Medicine in the Age of Biomedical Big Data

Conclusion and Future Directions Above we reviewed a limited set of network medicine philosophies that seek to integrate biomedical big data to uncover meaningful biology. Network medicine approaches provide customized and optimized ways to leverage biomedical data. The choice of the appropriate network method is largely dictated by the underlying biological inquiry, hypotheses, study design, and available data. Although this review is not meant to be exhaustive, our intent was to give a essence of how biomedical data requires a nuanced approach when selecting network analyses and provide a resource for both network scientists and biologists to better understand the lexicon of network modeling of biomedical data. We believe that network medicine approaches will be vital in the future with the increasing emergence of diverse technologies, multi-omic data types, deeper levels of inquiry from tissues to cellular levels, platforms that include large amounts of publicly available biomedical data, and efforts in precision medicine, which aim to find the right drugs for the right patients at the right time. There is a growing realization that genomics is only a part of the story when it comes to cancer and other complex diseases. The field is working to augment genetic information (mutations, deletions, and other somatic genetic alterations) with other omics data, such as epigenomics (methylation, non-coding RNAs, histone modifications, chromatin structures), proteomics (in vitro ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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Conclusions: The Italian version of the SHI showed high values of reliability and validity scores. It is a good instrument to evaluate the impact of speech impairment in patients with oral and oropharyngeal cancer.Folia Phoniatr Logop
Source: Folia Phoniatrica et Logopaedica - Category: Speech-Language Pathology Source Type: research
Conclusions: Return of IRR in conjunction with cancer prevention counseling led to low levels of test-specific distress and uncertainty among carriers. No other adverse psychological outcomes were observed.Public Health Genomics
Source: Public Health Genomics - Category: Genetics & Stem Cells Source Type: research
CONCLUSIONS: Atypia remains the most significant contributor to the risk of upstaging papillary lesions to malignancy. Our research supports the practice of excising all atypical papillary lesions with selected excision of those without atypia. In our cohort, there was no association between race and risk of upstaging to malignacy. PMID: 30988233 [PubMed - as supplied by publisher]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
Authors: Zhang M, Deng W, Gong H, Li C, Wang Y, Liu X, Tao L, Zhou L Abstract Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of head and neck malignancies. Advanced LSCC has failed to demonstrate a satisfactory prognosis, despite the progresses in the diagnosis and treatment, and the optimal treatment modality continues to be debated. To evaluate the clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for patients with resected advanced LSCC, a retrospective analysis of 232 patients with LSCC who had undergone total laryngectomy and neck dissection between 2005 an...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Cheng Y, Fan Y, Liu X, Liu Y, Liu J, Wang D, Yu Y, Qin S, Liu W, Huang C, Zhang H, Liang J, Shi J, Sheng L, Yu H Abstract The majority of previous studies of lobaplatin in small cell lung cancer (SCLC) are small phase I-II studies. The present study aimed to verify the non-inferiority (in terms of efficacy) of lobaplatin plus etoposide (EL) vs. cisplatin plus etoposide (EP) in patients with previously untreated extensive-stage SCLC (ES-SCLC). This phase III non-inferiority randomized clinical trial enrolled patients at 17 sites between September 2010 and May 2013. Patients were randomized to EL (30 mg/m2 l...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, by performing a comprehensive bioinformatics analysis of DEGs, putative targets that could be used to elucidate the molecular mechanisms underlying NPC were identified. PMID: 30988824 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Zhao J, Liu P, Yu Y, Zhi J, Zheng X, Yu J, Gao M Abstract The most common genetic alteration identified in papillary thyroid cancer (PTC) encodes a valine to glutamic acid change at position 600 (V600E) in the BRAF proto-oncoprotein. The most accurate and reliable method for detecting this BRAF mutation has not yet been determined. In the present study, the sensitivity, specificity and feasibility of diagnostic methods for BRAF mutations were assessed. BRAF mutational analysis was performed by Sanger DNA sequencing, using the Cobas® 4800 BRAF V600 test and by immunohistochemistry (IHC). A total of 185 ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Zhai JM, An YH, Wang W, Fan YG, Yao GL Abstract Recently, interleukin (IL)-32 has been demonstrated to represent a novel biomarker for evaluating the prognosis of patients with gastric and lung cancer; however, its clinical significance in colon cancer remains unknown. In the present study, the IL-32 expression in 60 patients with colon cancer was examined with an immunohistochemistry assay. IL-32 expression was determined in 37 (61.67%) patients with colon cancer. Additionally, IL-32 was associated with tumor size and Dukes' stage. By using the Kaplan-Meier method, patients with positive IL-32 expression ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, the amino acid 1,199 of nestin is localized in the tail structure of the filament and polymerizes with other intermediate filament proteins. The present results suggest that missense variations of nestin affect pancreatic carcinogenesis in Japanese patients. PMID: 30988821 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Gao F, Li M, Xiang R, Zhou X, Zhu L, Zhai Y Abstract Expression of claudin-6 (CLDN6) in the tissues of gastric cancer patients and its association with clinical pathology and prognosis were investigated. A retrospective analysis was performed on 213 gastric cancer patients diagnosed and surgically treated in the Central Hospital of Zibo from January 2010 to January 2013. Cancer and normal adjacent tissues were obtained from the patients to detect the expression level of CLDN6 using reverse transcription-quantitative PCR (RT-qPCR). The association between the expression level of CLDN6 and the clinical and p...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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