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Nutrition: Antidoxidants
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In silico Analysis of SOD1 Aggregation Inhibition Modes of Tertiary Amine Pyrazolone and Pyrano Coumarin Ferulate as ALS drug candidates
Phys. Chem. Chem. Phys., 2023, Accepted Manuscript DOI: 10.1039/D3CP03978A, PaperAziza Rahman, Bondeepa Saikia, Anupaul Baruah Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, the familial form (fALS) of which is often cognated to mutations in the antioxidant enzyme Cu/Zn superoxide dismutase 1 (SOD1) leading... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - September 23, 2023 Category: Chemistry Authors: Aziza Rahman Source Type: research
Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Cell Mol Immunol. 2023 Sep 22. doi: 10.1038/s41423-023-01084-z. Online ahead of print.ABSTRACTInhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However, the agonists of inhibitory immune receptors remain largely unknown, representing untapped sources of treatments for autoimmune diseases. Here, we show that V-set and transmembrane domain-containing 1 (VSTM1) is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1 (Gal1) is essential for maintaining neutrophil viability mediated by downregulated reactive...
Source: Cellular and Molecular Immunology - September 22, 2023 Category: Molecular Biology Authors: Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C Tsokos Minghong Jiang Xuan Zhang Source Type: research
Effects of < em > Aeriscardovia aeriphila < /em > on growth performance, antioxidant functions, immune responses, and gut microbiota in broiler chickens
In conclusion, oral administration of A. aeriphila could improve the growth performance, serum antioxidant capacity, immune modulation, and gut health of broilers. Our findings may provide important information for the application of A. aeriphila in poultry production.PMID:37735944 | DOI:10.1631/jzus.B2200621
Source: J Zhejiang Univ Sci ... - September 22, 2023 Category: Science Authors: Muhammad Zahid Farooq Xinkai Wang Xianghua Yan Source Type: research
Comparison of Effectiveness of Moringa Oleifera Leaves Extract Gel (2%) with Retino A (0.1%) Cream for Treatment of Oral Leukoplakia: Double Blinded Randomized Control Trial
CONCLUSION: This study showed that M. oleifera mucoadhesive gel (2%) is an effective and safe treatment option for oral leukoplakia patients. It demonstrated a significant reduction in lesion size compared to Retino-A cream (0.1%) after 3 months of therapy, without any reported adverse effects. However, long-term follow-up studies are needed to evaluate its long-term effectiveness. The potent antioxidant property of M. oleifera makes it a promising candidate for further studies with concentration variations and in other potentially malignant oral disorders, such as lichen planus and OSMF. The development of chemotherapeuti...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Sulem Ansari Shivayogi Charantimath Anabelle Fernandes Jayraj B Malik Prashanth Panta Source Type: research
Toxicity of bisphenol A (BPA) and its analogues BPF and BPS on the free-floating macrophyte Salvinia biloba
Chemosphere. 2023 Sep 19:140235. doi: 10.1016/j.chemosphere.2023.140235. Online ahead of print.ABSTRACTEvidence linking the toxicity of bisphenol A (BPA) to environmental and public-health issues has led to restrictions on its use. This compound has been gradually replaced with analogues proposed as a safer alternative, normally bisphenol F (BPF) and bisphenol S (BPS), but these substitutes are structurally almost identical to BPA, suggesting they may pose similar risks. The effects of BPA and these analogues were compared for antioxidant activity, lipid peroxidation, free-radical generation, photosynthetic pigments, and c...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Jaqueline da Silva Santos Montcharles da Silva Pontes Matheus Bispo de Souza Simone Yasuda Fernandes Ricardo Antunes de Azevedo Gilberto Jos é de Arruda Etenaldo Felipe Santiago Source Type: research
Effects of Dietary Valine Chelated Zinc Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Intestine Health in Weaned Piglets
In conclusion, the present research showed that supplementation of ZnVal improves growth performance by increasing antioxidant capacity and immunity and regulating intestinal morphology and the optimal inclusion level of ZnVal was 65~80 mg/kg.PMID:37730969 | DOI:10.1007/s12011-023-03870-2
Source: Biological Trace Element Research - September 21, 2023 Category: Biology Authors: Tuan Zhang Nan Zhang Shuyu Peng Yawei Zhang Huakai Wang Shiyu Huang Min Zhu Yongxi Ma Source Type: research
The performance of hypochlorous acid modified Ag nanoparticle-based assay in the determination of total antioxidant capacity of Boswellia Serrata and Aronia
In this study, the SNPAC method was developed by using hypochlorous (ClO-) at pH 9.3. Polyvinylpyrrolidone (PVP) was used as a stabilizer. The existence of HOCl enables to formation stronger and more stable yellow emission which gives sensitivity. As a result, lower LOD and LOQ values were achieved by the AgNP-HOCl method. The obtaining lower values was attributed to the reoxidation of silver atoms with ClO- ions in the presence of PVP. The newly modified method was applied to the total antioxidant capacity (TAC) measurement of Boswellia Serrata, Aronia Melanocarpa tea, and juice. The results were compared with the results...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Z ülal Eryaman Julide Hizal Mesut Y ılmazoğlu U ğur Daban Hande Mert Nergiz Kanmaz Source Type: research
Toxicity of bisphenol A (BPA) and its analogues BPF and BPS on the free-floating macrophyte Salvinia biloba
Chemosphere. 2023 Sep 19:140235. doi: 10.1016/j.chemosphere.2023.140235. Online ahead of print.ABSTRACTEvidence linking the toxicity of bisphenol A (BPA) to environmental and public-health issues has led to restrictions on its use. This compound has been gradually replaced with analogues proposed as a safer alternative, normally bisphenol F (BPF) and bisphenol S (BPS), but these substitutes are structurally almost identical to BPA, suggesting they may pose similar risks. The effects of BPA and these analogues were compared for antioxidant activity, lipid peroxidation, free-radical generation, photosynthetic pigments, and c...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Jaqueline da Silva Santos Montcharles da Silva Pontes Matheus Bispo de Souza Simone Yasuda Fernandes Ricardo Antunes de Azevedo Gilberto Jos é de Arruda Etenaldo Felipe Santiago Source Type: research
Phenyl glycosides from < em > Bacopa monnieri < /em > with their antioxidant and anti-inflammatory activities
This study described the isolation and identification of one new, bacomoside D3 (1), and seven known phenyl glycosides (2 - 8). The structures of isolates were established by analysis of their spectroscopic data or hydrolysis followed by HPLC analysis together with a comparison to those reported in the literature. These compounds were evaluated for antioxidant and anti-inflammatory activities. Among them, compounds 4 and 5 exhibited strong DPPH radical scavenging activity with IC50 values of 9.77 ± 0.08 and 3.50 ± 0.04 µM, respectively. Compounds 2 and 5 significantly inhibited TNF-α production in LPS-stimulated RAW264...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Thi Phuong Anh Dinh Le Thi Thuy Nguyen Thi Thuy My Van Thong Nguyen Le Huyen Tram Tuan Anh Nguyen Dao Huy Toan Thu Huong Tran Thu Ha Tran Thanh Bui Van Nguyen Van Bach Source Type: research
Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors: analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies
CONCLUSIONS: The results indicate that local oxidative stress may be associated with increased probability of ANA formation in a sex-specific manner.PMID:37732061 | PMC:PMC10507751 | DOI:10.5114/aoms/139313
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Pawe ł Krzemień S ławomir Kasperczyk Maciej Banach Aleksandra Kasperczyk Micha ł Dobrakowski Tomasz Tomasik Adam Windak Miros ław Mastej Alberico Catapano Kausik K Ray Dimitri P Mikhailidis Peter P Toth George Howard Gregory Y H Lip Maciej Tomaszewsk Source Type: research
Involvement of PI3K/Akt/ β-catenin signaling in schisandrin B-mitigated bone deterioration in an experimental rat model of estrogen deficiency
CONCLUSIONS: SchB exerted anti-osteoporotic activity in OVX-operated rats by accelerating the phosphorylation of PI3K and Akt, subsequently upregulating the expression of β-catenin.PMID:37732059 | PMC:PMC10507775 | DOI:10.5114/aoms.2020.92873
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Yimin Liang Wei Li Xiang Li Jun Nan Source Type: research
< em > Equisetum arvense < /em > L aqueous extract: a novel chemotherapeutic supplement for treatment of human colon carcinoma
CONCLUSIONS: The cell viability of Equisetum arvense L was very low against human colorectal carcinoma cell lines without any cytotoxicity towards the normal (HUVEC) cell line. The best anti-human colorectal carcinoma properties of Equisetum arvense L against the above cell lines were observed in the case of the HT 29 cell line.PMID:37732051 | PMC:PMC10507773 | DOI:10.5114/aoms/138146
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Lei Wang Luojun Zhang Guangtao Zheng Haiping Luo Attalla F El-Kott Ayman E El-Kenawy Source Type: research
The protective effect of apigenin against inorganic arsenic salt-induced toxicity in PC12 cells
In conclusion, the obtained results of the present study have clinical significance and indicate that apigenin is a promising candidate for shielding the nervous system from toxic effects caused by arsenic. These findings require further investigation using in vivo experimental models.PMID:37730986 | DOI:10.1007/s11356-023-29884-w
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Rafa Almeer Nouf M Alyami Source Type: research
Alpinetin: anti-human gastric cancer potential and urease inhibition activity < em > in vitro < /em >
CONCLUSIONS: It seems that the anti-human gastric carcinoma effect of the investigated molecule is due to its antioxidant effects.PMID:37732032 | PMC:PMC10507754 | DOI:10.5114/aoms/138832
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Hui Zhang Qian Jiang Guojin Gong Mingzhen Li Saad H Alotaibi Source Type: research
Novel green synthesis of silver nanoparticles mediated by < em > Curcumae kwangsiensis < /em > for anti-lung cancer activities: a preclinical trial study
CONCLUSIONS: After confirming the above results in the clinical trial research, this formulation can be administered to treat human lung cancers in humans.PMID:37732031 | PMC:PMC10507782 | DOI:10.5114/aoms/134059
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Zhihong Liu Zhuohong Zhang Xiaomei Du Ying Liu Abdullah Alarfaj Abdurahman Hirad Siddique Akber Ansari Zhiguo Zhang Source Type: research
