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Nutrition: Flavonoids
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Total 274 results found since Jan 2013.
Eucalyptus camaldulensis efficiency for application against microbial infections
On account of the continuing increase in antimicrobial resistance among infectious agents which are mostly life-threatening, seeking novel and alternative therapeutic approaches seems essential. Eucalyptus camaldulensis, generally known as eucalyptus, contains various healing traits such as antimicrobial characteristics. These herbs generally grow alongside the rivers with both continuous and seasonal water. The antimicrobial applications of this herb, particularly against pandrug and multidrug resistant microorganisms mostly attributed to phenolic, polar terpene compounds and spathulenol. Major bioactive antimicrobial fra...
Source: Reviews in Medical Microbiology - January 1, 2021 Category: Microbiology Tags: BACTERIOLOGY Source Type: research
Development of a Fluorescent Assay to Search New Drugs Using Stable tdTomato-Leishmania, and the Selection of Galangin as a Candidate With Anti-Leishmanial Activity
Antimonials continue to be considered the first-line treatment for leishmaniases, but its use entails a wide range of side effects and serious reactions. The search of new drugs requires the development of methods more sensitive and faster than the conventional ones. We developed and validated a fluorescence assay based in the expression of tdTomato protein by Leishmania, and we applied this method to evaluate the activity in vitro of flavonoids and reference drugs. The pIR1SAT/tdTomato was constructed and integrated into the genome of Leishmania (Leishmania) amazonensis. Parasites were selected with nourseothricin (NTC). ...
Source: Frontiers in cellular and infection microbiology - June 4, 2021 Category: Microbiology Source Type: research
Effective antiviral medicinal plants and biological compounds against central nervous system infections: A mechanistic review.
CONCLUSION: Due to the increased resistance of microorganisms (bacteria, viruses and parasites) to antimicrobial therapies, alternative treatments, especially using plant sources and their bioactive constituents, appear to be more fruitful.
PMID: 31309894 [PubMed - as supplied by publisher]
Source: Current Drug Discovery Technologies - July 14, 2019 Category: Drugs & Pharmacology Authors: Malekmohammad K, Rafieian-Kopaei M, Sardari S, Sewell RDE Tags: Curr Drug Discov Technol Source Type: research
Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents
Planta Med DOI: 10.1055/a-1148-9000Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional medicine in endemic areas. Ethnopharmacological approaches seem to be helpful in selecting the most interesting plants for th...
Source: Planta Medica - April 22, 2020 Category: Drugs & Pharmacology Authors: Mamede, Lucia Ledoux, Allison Jansen, Olivia Fr édérich, Michel Tags: Reviews Source Type: research
Natural antioxidants as additional weapons in fight against malarial parasite
CONCLUSION: This study reviewed various literature sources related to natural products employed in antimalarial therapy directly or indirectly by countering/scavenging reactive oxygen species that were published between 2016 to till date. The literature survey made it possible to summarize the natural products used in the treatment of malaria, with emphasis on botanical extracts, as a single component, as well as in association with other botanical extracts. Natural antioxidants like polyphenols, flavonoids, alkaloids, having a broad range of biological effects against malaria. This review is pivoted around natural antioxi...
Source: Current Topics in Medicinal Chemistry - May 7, 2022 Category: Chemistry Authors: Sharma Arvind Virendra Chandrakant Sahu Ankur Kumar Pooja A Chawla Source Type: research
New strategies in the treatment of diseases caused by Acanthamoeba based on nanoparticles: a systematic review
CONCLUSION: This study showed that chlorhexidine and other plant metabolites loaded with silver and gold nanoparticles increase the anti-Acanthambae activity of these nanoparticles. However, green synthesized nanoparticles based on stabilization by plant gums, loaded with citrus fruits flavonoids hesperidin (HDN) and naringin (NRG), showed the best anti-Acanthambae effect. Nevertheless, further studies should be performed to determine their safety for human use.PMID:36372923 | DOI:10.2174/2772432818666221111155119
Source: Pharmacological Reviews - November 14, 2022 Category: Drugs & Pharmacology Authors: Pegah Shakib Hamed Kalani Muhammad Tahir Aleem Roghiyeh Faridnia Mustafa Zebardast Pour Kobra Moradpour Kourosh Cheraghipour Source Type: research
The Role of Flavanones as Scaffolds for the Development of New Treatments against Malaria and African and American Trypanosomiases
Conclusion: Flavanones, isolated and characterized from diverse plant parts, were reported to exhibit moderate to high activity against P. falciparum, T. cruzi, and T. brucei in in vitro studies. These potentially active flavanones can be used as scaffolds for the development of new antiparasitic agents. However, more studies on the cytotoxicity, pharmacokinetics, and mechanisms of action of potent flavanones should be performed.PMID:36582061 | DOI:10.2174/1389557523666221229122543
Source: Mini Reviews in Medicinal Chemistry - December 30, 2022 Category: Chemistry Authors: Pone Kamdem Boniface Elizabeth Igne Ferreira Fekam Boyom Fabrice Source Type: research
Capparis spinosa inhibits Leishmania major growth through nitric oxide production in vitro and arginase inhibition in silico
This study aimed to evaluate the effect of C. spinosa' extracts on Leishmania major promastigotes and amastigotes growth as well as on L-arginine metabolic pathways, especially the production of leishmanicidal molecules such as nitric oxide. Our results showed that C. spinosa' methanolic and aqueous extracts contained polyphenols and flavonoids at different concentrations. The methanolic extract of C. spinosa, compared to the aqueous extract, showed significantly higher amounts of total polyphenols (21.23 ± 1.08) mg GAE/g of dw (P < 0.05), as well as a higher antioxidant activity evaluated respectively by Reducing Powe...
Source: Experimental Parasitology - December 29, 2022 Category: Parasitology Authors: Dounia Darif Imane Nait Irahal Ikram Hammi Ayyoub Kihel Mohamed Reda Kachmar Myriam Riyad Fouzia Hmimid Khadija Akarid Source Type: research
The Role of Flavanones as Scaffolds for the Development of New Treatments against Malaria and African and American Trypanosomiases
Conclusion: Flavanones, isolated and characterized from diverse plant parts, were reported to exhibit moderate to high activity against P. falciparum, T. cruzi, and T. brucei in in vitro studies. These potentially active flavanones can be used as scaffolds for the development of new antiparasitic agents. However, more studies on the cytotoxicity, pharmacokinetics, and mechanisms of action of potent flavanones should be performed.PMID:36582061 | DOI:10.2174/1389557523666221229122543
Source: Mini Reviews in Medicinal Chemistry - December 30, 2022 Category: Chemistry Authors: Pone Kamdem Boniface Elizabeth Igne Ferreira Fekam Boyom Fabrice Source Type: research
Capparis spinosa inhibits Leishmania major growth through nitric oxide production in vitro and arginase inhibition in silico
This study aimed to evaluate the effect of C. spinosa' extracts on Leishmania major promastigotes and amastigotes growth as well as on L-arginine metabolic pathways, especially the production of leishmanicidal molecules such as nitric oxide. Our results showed that C. spinosa' methanolic and aqueous extracts contained polyphenols and flavonoids at different concentrations. The methanolic extract of C. spinosa, compared to the aqueous extract, showed significantly higher amounts of total polyphenols (21.23 ± 1.08) mg GAE/g of dw (P < 0.05), as well as a higher antioxidant activity evaluated respectively by Reducing Powe...
Source: Experimental Parasitology - December 29, 2022 Category: Parasitology Authors: Dounia Darif Imane Nait Irahal Ikram Hammi Ayyoub Kihel Mohamed Reda Kachmar Myriam Riyad Fouzia Hmimid Khadija Akarid Source Type: research
The Role of Flavanones as Scaffolds for the Development of New Treatments against Malaria and African and American Trypanosomiases
Conclusion: Flavanones, isolated and characterized from diverse plant parts, were reported to exhibit moderate to high activity against P. falciparum, T. cruzi, and T. brucei in in vitro studies. These potentially active flavanones can be used as scaffolds for the development of new antiparasitic agents. However, more studies on the cytotoxicity, pharmacokinetics, and mechanisms of action of potent flavanones should be performed.PMID:36582061 | DOI:10.2174/1389557523666221229122543
Source: Mini Reviews in Medicinal Chemistry - December 30, 2022 Category: Chemistry Authors: Pone Kamdem Boniface Elizabeth Igne Ferreira Fekam Boyom Fabrice Source Type: research
