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Total 503 results found since Jan 2013.

Inhibitory effects of curcumin on sequel of infections and their signaling pathways: a review
This study reviewed the inhibitory effects of curcumin on infections. Based on these studies, the plant drug of curcumin is a therapeutic effective agent for the advancement of treatment against the types of pathogens including bacteria, viruses, parasites, and fungi. Nevertheless, it seems that be essential for more researches, especially about parasites and fungi that have been performed fewer studies about the effect of curcumin on them. Curcumin exerts its effects on sequel of infections and their agents via influence on signaling pathways, cell cycle, drug synergism, inducing apoptosis and inhibition of virulence factors.
Source: Reviews in Medical Microbiology - March 30, 2019 Category: Microbiology Tags: ANTIBIOTICS Source Type: research

IJERPH, Vol. 15, Pages 1037: Clinical Efficacy Associated with Enhanced Antioxidant Enzyme Activities of Silver Nanoparticles Biosynthesized Using Moringa oleifera Leaf Extract, Against Cutaneous Leishmaniasis in a Murine Model of Leishmania major
In conclusion, treatment with silver nanoparticles biosynthesized using Moringa oleifera extract has higher and faster clinical efficacy than standard pentavalent antimonial treatment, probably by boosting the endogenous antioxidant activity.
Source: International Journal of Environmental Research and Public Health - May 22, 2018 Category: Environmental Health Authors: Manal El-khadragy Ebtesam M. Alolayan Dina M. Metwally Mohamed F. Serag El-Din Sara S. Alobud Nour I. Alsultan Sarah S. Alsaif Manal A. Awad Ahmed E. Abdel Moneim Tags: Article Source Type: research

Aedes –Chikungunya Virus Interaction: Key Role of Vector Midguts Microbiota and Its Saliva in the Host Infection
Conclusion and Perspectives Arbovirus infections, such as CHIKV, have been growing worldwide and are becoming a major public health problem, especially in immuno-compromised classes such as children and the elderly. CHIKV is dangerous since it can cause arthritis, fever and other impairments, making it necessary to seek new ways to counter the proliferation of this virus. Knowing the vector’s competence is fundamentally important, including an understanding of the vector virus interaction and the modulation of this interaction. Despite advances in the knowledge of mosquito competence in the transmission of CHIKV, l...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Auranofin, an Anti-rheumatic Gold Drug, Aggravates the Radiation-Induced Acute Intestinal Injury in Mice
Conclusion In this study, we found that a non-toxic dose of auranofin significantly aggravated the severity of the radiation-induced intestinal injury. This suggests that auranofin treatment can be an independent factor that influences the risk of intestinal complications after pelvic or abdominal radiotherapy. Ethics Statement All the protocols used in this study were approved by the Institutional Animal Care and Use Committee of the Korean Institute of Radiological and Medical Sciences (IACUC permit number: KIRAMS217-0007). Author Contributions H-JL, JS, and Y-BL designed the experiments. EL and JK conducted the exp...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

The photodynamic action of pheophorbide a induces cell death through oxidative stress in Leishmania amazonensis
Publication date: Available online 11 August 2017 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): Nathielle Miranda, Hélito Volpato, Jean Henrique da Silva Rodrigues, Wilker Caetano, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Celso Vataru Nakamura Leishmaniasis is a disease caused by hemoflagellate protozoa, affecting millions of people worldwide. The difficulties of treating patients with this parasitosis include the limited efficacy and many side effects of the currently available drugs. Therefore, the search for new compounds with leishmanicidal action is necessary. Photodynamic therapy has...
Source: Journal of Photochemistry and Photobiology B: Biology - August 11, 2017 Category: Speech-Language Pathology Source Type: research

In vivo and in vitro anti-schistosomiasis effect of garlic (Allium sativum): a systematic review
CONCLUSION: Effective anti-schistosomal responses of garlic in studies show that the active compounds of garlic can be used as a complement with chemical drugs or as an alternative for them, and this is needed to optimize the consumption of these active compounds for medicinal uses.PMID:35227185 | DOI:10.2174/1570163819666220228154752
Source: Current Drug Discovery Technologies - March 1, 2022 Category: Drugs & Pharmacology Authors: Pegah Shakib Hamed Kalani Ali Safar Maken Ali Mustafa Zebardastpour Kobra Moradpour Jeffery Ho Vahideh Heydari Nazarabad Kourosh Cheraghipour Source Type: research

Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets
Conclusion Our modeling of the modulation of the tick regulome in response to A. phagocytophilum infection provided new insights into the mechanisms that target specific functions in different tick tissues. These results supported the use of network analysis for the study of regulome response to infection. Although general mechanisms affected by A. phagocytophilum infection may be conserved even between tick and human cells (de la Fuente et al., 2016b), the effect of vector-pathogen co-evolution on pathogen isolates adaptation to grow in tick cells (Alberdi et al., 2015) may result in differences between isolates in the m...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

Application of Machine Learning in Microbiology
Conclusion Microorganisms are involved in many life activities, and affect their surrounding environment and other organisms. Microorganisms play important roles in human heath, crop growth, livestock farming, environmental management, industrial chemical production and food production. In the 19th century, people first observed microbes using microscopes and began to study them. However, the development of high-throughput sequencing technology has led to generation of large amounts of microbial related data. As a result, machine-learning methods are now being applied to microbiological research. Here, we discuss the curr...
Source: Frontiers in Microbiology - April 17, 2019 Category: Microbiology Source Type: research

Biogenic silver nanoparticles (AgNp-Bio) reduce Toxoplasma gondii infection and proliferation in HeLa cells, and induce autophagy and death of tachyzoites by apoptosis-like mechanism
Acta Trop. 2021 Jul 28:106070. doi: 10.1016/j.actatropica.2021.106070. Online ahead of print.ABSTRACTToxoplasma gondii is a protozoan parasite that can cause severe and debilitating diseases, especially in immunocompromised individuals. The available treatment is based on drugs that have low efficacy, high toxicity, several adverse effects, and need long periods of treatment. Thus, the search for therapeutic alternatives is urgently needed. Biogenic silver nanoparticles (AgNp-Bio) have been associated with several biological effects, as antiproliferative, pro-apoptotic, antioxidant, antiviral, antifungal, and antiprotozoal...
Source: Acta Tropica - July 31, 2021 Category: Infectious Diseases Authors: Raquel Arruda da Silva Sanfelice Bruna Taciane da Silva Bortoleti Fernanda Tomiotto-Pellissier Taylon Felipe Silva Larissa Rodrigues Bosqui Gerson Nakazato Pablo Menegon Castilho Luiz Daniel de Barros Jo ão Luis Garcia Danielle Lazarin-Bid óia Ivete Con Source Type: research