Aedes –Chikungunya Virus Interaction: Key Role of Vector Midguts Microbiota and Its Saliva in the Host Infection

Conclusion and Perspectives Arbovirus infections, such as CHIKV, have been growing worldwide and are becoming a major public health problem, especially in immuno-compromised classes such as children and the elderly. CHIKV is dangerous since it can cause arthritis, fever and other impairments, making it necessary to seek new ways to counter the proliferation of this virus. Knowing the vector’s competence is fundamentally important, including an understanding of the vector virus interaction and the modulation of this interaction. Despite advances in the knowledge of mosquito competence in the transmission of CHIKV, little is known with respect to viral infection in the mosquito. However, it is important to highlight that the competence of the mosquito vector can be influenced by several characteristics, including the age of the mosquito, its nutritional status, stage of the gonotrophic cycle, environmental temperature conditions, salivary components and composition of its microbiota (Carrington et al., 2013; Bartholomay and Michel, 2018; Knecht et al., 2018). Thus, investigating the role of local mosquito populations, as well as kinetic and phenotypic characteristics of the different vectors for the transmission of pathogens, is very important in reducing the risk of possible disease outbreaks caused by many viruses, such as zika virus, dengue fever and yellow fever. In this regard, the mosquito microbiota is of fundamental importance to the viral infection of the mosqui...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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AbstractThe use of photobiomodulation therapy (PBMT) in the prevention of oral mucositis (OM) in paediatric care has increased. In this article, we report data of paediatric oncology/haematopoietic stem cell transplantation (HSCT) patients treated with PBMT to prevent chemotherapy-induced OM. A retrospective study was conducted at a Brazilian referral service. Prophylactic PBMT was used in children and adolescents ( ≤ 17 years) following the protocol: InGaAIP, 660 nm, 100 mW, 2 J, 3.33 W/cm2, and 20 s per point. Demographic data and OM severity scores were assessed. A regression model tested the association between OM w...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
AbstractPhotobiomodulation (PBM) has been used to modulate the inflammatory and immune responses, pain relief, and to promote wound healing. PBM is widely used in dental practice and its cellular effects should be investigated. The aim was to evaluate if PBM changes proteins cell death –related, such as caspase-6 and Bcl-2, in periodontal ligament cells. Eighteen mice were divided in three groups (n = 6), i.e., (I) control, (II) 3 J cm−2, and (III) 30 J cm−2. Low power infrared laser (830 nm) parameters were power at 10 mW, energy densities at 3 and 30 J cm−2 in continuous emission mode, exposure ti...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
A new analysis by U.S. News&World Report ranks three Kansas City-area counties among the healthiest communities in the United States.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Epithelial cell dysfunction has emerged as a central component of the pathophysiology of diffuse parenchymal diseases including idiopathic pulmonary fibrosis (IPF). Alveolar type 2 (AT2) cells represent a metabolically active lung cell population important for surfactant biosynthesis and alveolar homeostasis. AT2 cells and other distal lung epithelia, like all eukaryotic cells, contain an elegant quality control network to respond to intrinsic metabolic and biosynthetic challenges imparted by mutant protein conformers, dysfunctional subcellular organelles, and dysregulated telomeres. Failed AT2 quality control components (...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
CONCLUSIONS Neuroinflammation due to CTLA4h is mediated primarily by an infiltrative process with a distinct and striking dissociation between clinical symptoms and radiological findings in the majority of patients.FUNDING NIAID, NIH, Division of Intramural Research, NINDS, NIH, Division of Intramural Research, and the National Multiple Sclerosis Society–American Brain Foundation.TRIAL REGISTRATION ClinicalTrials.gov NCT00001355.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Trump claims Covid-19 only “really” affects people who have “other problems”;European stocks post worst fall in three months; UK cases pass 400,000;More than one in five Covid-19 deaths globally is in US. Follow the latest updatesUS nears 200,000 deaths‘Landmark moment’: 156 countries agree to vaccine allocation dealTaj Mahal reopens as coronavirus cases continue to rise in IndiaUK could see 200 deaths a day by November, warns chief medical officerUK coronavirus updates – live5.19amBSTAfter rescheduling her wedding three times this year, Nalan Altas was finally supposed to be getti...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news US news UK news Australia news Science Infectious diseases Source Type: news
New policy comes after serious quality control questions were raised about the data relied on by a study in the medical journalOne of the world ’s leading medical journals, the Lancet, has reformed its editorial policies following a shocking case of apparent research misconduct involving the study of hydroxychloroquine as a treatment for Covid-19.In May, the Lancet published a peer-reviewed study about the controversial drug hydroxychloroquine, which concluded Covid-19 patients who received the drug were dying at higher rates and experiencing more heart-related complications than other virus patients.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Medical research Infectious diseases Microbiology Health Source Type: news
A new analysis by U.S. News&World Report ranks four Greater Philadelphia suburbs among the healthiest communities in the United States.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
This study aims to elucidate nutrient dependent changes to the circadian transcriptome of whole flies. In particular, we aim to identify how dietary restriction influence circadian transcriptional output. Circadian analyses were performed to invesitigate diet-dependent changes in the number of circadian transcripts as well as their phases and circadian amplitude.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Drosophila melanogaster Source Type: research
Contributors : Dayong Liang ; Yan Wang ; Shaoshan Li ; Xiaodong Wang ; Yiping HuoSeries Type : Expression profiling by high throughput sequencingOrganism : Phaeocystis globosapurose:The large-scale reproduction of Phaeocystis globosa has caused serious damage to the marine ecosystem in the coastal waters of China. The outbreak of algae blooms depends on the competitive advantage of their heteromorphic life history: colonial formation is beneficial to resist zooplankton predation, and the single isolated cells can absorb nutrients rapidly. To better understand the different types of cells characteristics of P. globosa that ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Phaeocystis globosa Source Type: research
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