Aedes –Chikungunya Virus Interaction: Key Role of Vector Midguts Microbiota and Its Saliva in the Host Infection

Conclusion and Perspectives Arbovirus infections, such as CHIKV, have been growing worldwide and are becoming a major public health problem, especially in immuno-compromised classes such as children and the elderly. CHIKV is dangerous since it can cause arthritis, fever and other impairments, making it necessary to seek new ways to counter the proliferation of this virus. Knowing the vector’s competence is fundamentally important, including an understanding of the vector virus interaction and the modulation of this interaction. Despite advances in the knowledge of mosquito competence in the transmission of CHIKV, little is known with respect to viral infection in the mosquito. However, it is important to highlight that the competence of the mosquito vector can be influenced by several characteristics, including the age of the mosquito, its nutritional status, stage of the gonotrophic cycle, environmental temperature conditions, salivary components and composition of its microbiota (Carrington et al., 2013; Bartholomay and Michel, 2018; Knecht et al., 2018). Thus, investigating the role of local mosquito populations, as well as kinetic and phenotypic characteristics of the different vectors for the transmission of pathogens, is very important in reducing the risk of possible disease outbreaks caused by many viruses, such as zika virus, dengue fever and yellow fever. In this regard, the mosquito microbiota is of fundamental importance to the viral infection of the mosqui...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Abstract It is of great importance to detect chlorotetracycline (CTC) in a highly sensitive and specific way because of its wide distribution in aquaculture and animal husbandry. Herein, we propose a novel ratiometric fluorescence strategy to assay CTC by using bovine serum albumin stabilized gold nanoclusters (BSA-AuNCs). The BSA-AuNCs consisting of 25 gold atoms (Au25NCs) display a red emission at 640 nm (λex = 370 nm). In the presence of CTC, a new blue emission at 425 nm is emerged and its intensity dramatically increases with the addition of more the analyte; meanwhile the red emission at 640...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
ConclusionsPhysical and psychological functioning, pain, fatigue and appetite loss had prognostic significance above and beyond clinical predictors in CRC. Routine monitoring of these PROs may allow earlier detection and amelioration of problems, which may improve quality of life and perhaps extend survival. More research is needed to determine prognostic value of PROs in early-stage CRC, and prognostic significance of changes in PRO scores.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionsSelf-rated health of the general US adult population in 2017 was similar to 2002, but after adjusting for health problems, scores were slightly higher in 2017.  Sociodemographic shifts in age and education explain some of the differences in scores, and by removing health and sociodemographic factors, we found the VAS reveals self-rated health is slightly better in 2017 than 2002.
Source: Quality of Life Research - Category: Health Management Source Type: research
Research has shown that the experience of Childhood Sexual Abuse (CSA) can increase the rates of physical and emotional sequela, including depression, anxiety, PTSD, and physical pain. However, little is known about the healing journeys for those women who...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: The meniscus is vital for load bearing, knee stabilization, and shock absorption, making a meniscal tear a well-recognized sport-related injury in children and young adults. An inverse relationship between the quality and value of orthopaedic c...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Over the last 10 years, the rate of adolescents ages 15 to 19 committing suicide in the United States increased drastically, with an overall rate of 6.7 suicides per 100  000 per year in 2007 and a rate of 11.8 per 100 000 per year in 2017.1 The rat...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: We aim to test the effectiveness of the EmpaTeach intervention to prevent physical violence from teachers to students in Nyarugusu Refugee Camp, Tanzania. EmpaTeach is a 10-week, 14-session, classroom management and cognitive-behavioural therap...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: High school athletes with lower extremity sports injuries (LESIs) frequently present to the emergency department in the United States. Previous epidemiological studies have presented rates and mechanisms of LESIs in these athletes. No studies, ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
OBJECTIVE: We conducted a scoping review of the literature to assess the prevalence of hospital policies regarding emergency contraception (EC) and the frequency that U.S. emergency departments (EDs) provide EC to sexual assault survivors. STUDY DESIGN: We...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This study was carried out at Biocor Instituto, Anesthesiology, Nova Lima, MG, Brazil.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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