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Drug: Insulin

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Total 51052 results found since Jan 2013.

Personalized intensification of insulin therapy in type 2 diabetes - does a basal-bolus regimen suit all patients?
Authors: Giugliano D, Sieradzki J, Stefanski A, Gentilella R Abstract Many patients with type 2 diabetes mellitus (T2DM) require insulin therapy. If basal insulin fails to achieve glycemic control, insulin intensification is one possible treatment intensification strategy. We summarized clinical data from randomized clinical trials designed to compare the efficacy and safety of basal-bolus and premixed insulin intensification regimens. We defined a between-group difference of ≥0.3% in end-of-study glycated hemoglobin (HbA1c) as clinically meaningful. A PubMed database search supplemented by author-identified pape...
Source: Current Medical Research and Opinion - April 30, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment of insulin resistance by acupuncture: a review of human and animal studies.
CONCLUSIONS: EA, used alone or in combination with other therapies, such as Chinese herbs or diet-exercise interventions, has the potential to be an effective treatment for insulin resistance. Additional controlled clinical studies of acupuncture are needed in subjects with diabetes mellitus, ischaemic heart disease, muscle atrophy, and fatty liver disease. PMID: 27256547 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - June 1, 2016 Category: Complementary Medicine Authors: Martinez B, Peplow PV Tags: Acupunct Med Source Type: research

Performance Analysis of Fuzzy-PID Controller for Blood Glucose Regulation in Type-1 Diabetic Patients
AbstractThis paper presents Fuzzy-PID (FPID) control scheme for a blood glucose control of type 1 diabetic subjects. A new metaheuristic Cuckoo Search Algorithm (CSA) is utilized to optimize the gains of FPID controller. CSA provides fast convergence and is capable of handling global optimization of continuous nonlinear systems. The proposed controller is an amalgamation of fuzzy logic and optimization which may provide an efficient solution for complex problems like blood glucose control. The task is to maintain normal glucose levels in the shortest possible time with minimum insulin dose. The glucose control is achieved ...
Source: Journal of Medical Systems - October 5, 2016 Category: Information Technology Source Type: research

Diabetes education of patients and their entourage: out-of-hospital national study (EDUCATED 2)
ConclusionsIn France, diabetic patients and their entourage are inadequately educated. Their education benefits most from care by a diabetologist.
Source: Acta Diabetologica - December 21, 2016 Category: Endocrinology Source Type: research

Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trial.
CONCLUSION: Metformin showed significant improvement in clinical outcomes but not in metabolic and endocrine outcomes in PCOS women; however, heterogeneity between studies was found to be moderate to high. PMID: 28058854 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - January 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Antidiabetic agents and cardiovascular outcomes in patients with heart diseases.
This article reviews evidence of benefits and risk of antidiabetic agents in cardiovascular (CV) outcomes, with a focus on medications approved by the FDA since 2008. Peer-reviewed articles were identified from MEDLINE and Current Content database (both 1966 to October 1, 2016) using the search terms insulin, metformin, rosiglitazone, pioglitazone, glyburide, glipizide, glimepiride, acarbose, miglitol, albiglutide, exenatide, liraglutide, lixisenatide, dulaglutide, pramlintide, meglitinide, alogliptin, linagliptin, saxagliptin, sitagliptin, canagliflozin, dapagliflozin, empagliflozin, colesevalam, bromocriptine, mortality,...
Source: Current Medical Research and Opinion - January 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of Probiotics on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Meta-Analysis of 12 Randomized Controlled Trials.
CONCLUSIONS This meta-analysis demonstrated that probiotics supplementation was associated with significant improvement in HbA1c and fasting insulin in type 2 diabetes patients. More randomized placebo-controlled trials with large sample sizes are warranted to confirm our conclusions. PMID: 28638006 [PubMed - in process]
Source: Medical Science Monitor - June 24, 2017 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNAs and metabolic disorders - where are we heading?
Authors: Sliwinska A, Kasinska MA, Drzewoski J Abstract MicroRNAs (miRNAs, miRs) are short, non-coding molecules engaged in normal functioning of eukaryotic cells, as negative regulators of gene expression. Since the first discovery of miRNA in the early 1990s, hundreds of different miRNAs and their targets have been identified. A growing number of studies have aimed to search for microRNAs which have a key role in the regulation of insulin signaling and metabolic homeostasis. Recent evidence indicates that dysregulation of miRNA expression is involved in the development of various diseases, including type 2 diabet...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Natural molecules for the therapy of hyperandrogenism and metabolic disorders in PCOS.
CONCLUSIONS: In this review will discuss the role of a number of natural associations between inositol and different substances in the treatment of hyperandrogenic symptoms in PCOS women. PMID: 28724177 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 22, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Can You Help Prevent These Insulin-Delivery Errors?
New consensus-based guidelines may inspire ideas to curb errors.   Insulin is considered a high-alert medication because it is often associated with significant patient harm when used in error.  “According to a 2014 survey of pharmacists and nurses conducted by the Institute for Safe Medication Practices (ISMP), IV insulin ranked first and subcutaneous insulin ranked ninth among nearly 40 drugs and drug classes identified as high-alert medications that concerned practitioners,” Susan F. Paparella, RN, MSN, vice president, ISMP, told MD+DI. “Yet of all the high-alert medications, subcutaneous insulin came in last ...
Source: MDDI - September 21, 2017 Category: Medical Devices Authors: Daphne Allen Tags: Medical Device Business Source Type: news

Reduction in Serum Triglyceride Levels in Diabetic Patients May Result in Decreased Insulin Dependence and Disease Regression.
CONCLUSIONS: A decrease in high triglyceride levels in "lipotoxic" diabetic patients may improve insulin intolerance and glucose homeostasis and reduce the need for insulin therapy. PMID: 29911757 [PubMed - in process]
Source: The Israel Medical Association Journal - June 19, 2018 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Comparison of metabolic outcomes in patients undergoing laparoscopic roux-en-Y gastric bypass versus sleeve gastrectomy - a systematic review and meta-analysis of randomised controlled trials.
CONCLUSION: Based on this meta-analysis, RYGB is more effective than SG in improving weight loss and short- and mid-term glycaemic and lipid metabolism control in patients with and without T2DM. Therefore, unless contraindicated, RYGB should be the first choice to treat patients with obesity and T2DM and/or dyslipidaemia. PMID: 30035801 [PubMed - in process]
Source: Swiss Medical Weekly - July 9, 2018 Category: General Medicine Authors: Hayoz C, Hermann T, Raptis DA, Brönnimann A, Peterli R, Zuber M Tags: Swiss Med Wkly Source Type: research

Significant effect of group education in patients with diabetes type 1.
CONCLUSIONS: These results strongly support the need for long-lasting structured education group courses for adult diabetic patients keen to change their habits in order to achieve self-management of the disease. PMID: 30112705 [PubMed - as supplied by publisher]
Source: Hormones - August 18, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Diabetes education and counselling in adult patients with diabetes (Update 2019).
Abstract Diabetes education and self-management play a critical role in diabetes care. Patient empowerment aims to actively influence the course of the disease by self-monitoring and subsequent treatment modification as well as the ability of patients to integrate diabetes into their daily life and to appropriately adapt it to their life style situation. Diabetes education has to be made accessible for all persons with the disease. In order to be able to provide a structured and validated education program, adequate personnel as well as space, organizational and financial prerequisites are required. Besides an i...
Source: Wiener Klinische Wochenschrift - April 11, 2019 Category: General Medicine Authors: Weitgasser R, Clodi M, Cvach S, Riedl M, Lechleitner M, Ludvik B Tags: Wien Klin Wochenschr Source Type: research

Data-Driven Blood Glucose Pattern Classification and Anomalies Detection: Machine-Learning Applications in Type 1 Diabetes
Conclusions: Despite the complexity of BG dynamics, there are many attempts to capture hypoglycemia and hyperglycemia incidences and the extent of an individual’s GV using different approaches. Recently, the advancement of diabetes technologies and continuous accumulation of self-collected health data have paved the way for popularity of machine learning in these tasks. According to the review, most of the identified studies used a theoretical threshold, which suffers from inter- and intrapatient variation. Therefore, future studies should consider the difference among patients and also track its temporal change over tim...
Source: Journal of Medical Internet Research - April 30, 2019 Category: General Medicine Authors: Ashenafi Zebene Woldaregay Eirik Årsand Taxiarchis Botsis David Albers Lena Mamykina Gunnar Hartvigsen Source Type: research