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High insulin levels linked to increased asthma risk in children
High insulin levels during childhood may increase risk of asthma, according to research to be presented at the American Academy of Allergy Asthma and Immunology Annual Meeting.Endocrinology Advisor
Source: Society for Endocrinology - March 20, 2020 Category: Endocrinology Source Type: news

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses
In conclusion, our study indicated that 3 weeks antibiotic administration induced elevated expression of many cytokines in mouse colon, suggesting that there might be a direct interaction between antibiotics and host tissue. Furthermore, different antibiotics used can lead to different effects on mouse models. Broad spectrum antibiotic enrofloxacin had a stronger effect on the cytokines response in the colon. Vancomycin can induce significant changes in composition and metabolic profiling of gut microbiota. Compared to enrofloxacin and vancomycin, polymixin B sulfate had a weakest effect. The differences observed in compos...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

New Trends in Migraine Pharmacology: Targeting Calcitonin Gene –Related Peptide (CGRP) With Monoclonal Antibodies
Conclusion Migraine is a disabling and debilitating neurovascular painful condition representing more than 90% of cases of recurrent headache and toward which the tendency can be inherited (MacGregor, 2017). Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol have proven strong, level A, evidence for migraine prevention (American Academy of Neurology and American Headache Society, 2015). However, all the classic oral preventative treatments including tricyclic antidepressants, beta blockers, 5-HT2 antagonists ergots and anti-epileptic drugs were not developed for migraine and provide 50% ...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

Long-Term Exposure to Transportation Noise in Relation to Development of Obesity —a Cohort Study
Conclusion: Our results link transportation noise exposure to development of obesity and suggest that combined exposure from different sources may be particularly harmful. https://doi.org/10.1289/EHP1910 Received: 17 March 2017 Revised: 5 October 2017 Accepted: 9 October 2017 Published: 20 November 2017 Address correspondence to A. Pyko, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Telephone: 46(0) 852487561. Email: Andrei.pyko@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP1910). The authors declare they have no actual or potential competing fina...
Source: EHP Research - November 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

8 Things You Need To Know About Your Body's Energy Levels
By Hallie Levine Your energy makeover starts now It’s no wonder so many of us struggle with energy issues. We go, go, go from morning to night, running on little but grit and caffeine. But it doesn’t have to be that way! “The reality is, you can get a real boost by making a few simple changes,” says Nada Milosavljevic, MD, director of the integrative health program at Massachusetts General Hospital. That’s why we put together this complete guide to all-day energy: It’s packed with proven strategies that will keep you powered up as you plow through your to-do list. You’ll also learn...
Source: Healthy Living - The Huffington Post - May 4, 2017 Category: Consumer Health News Source Type: news

Despite Health Risks, Many Argue GMOs Could Help Solve Food Security
By Mbom SixtusYAOUNDE, Cameroon, Dec 23 2015 (IPS)Cameroon is on the path to introduce genetically modified organisms (GMO’s). This would be overseen by the Cameroon Academy of Sciences, in collaboration with the National Biosafety Committee, if the Cameroon Cotton Corporation successfully implements a three-year test cultivation of cotton. The introduction of GMOs is seen by many as a measure to improve Cameroon’s agricultural yields and guarantee food security, despite health risks.“Genetically modified organisms will help Cameroon solve many problems which researchers of the Ministry of Agriculture and Rural Devel...
Source: IPS Inter Press Service - Health - December 23, 2015 Category: Global & Universal Authors: Mbom Sixtus Tags: Africa Development & Aid Environment Featured Food & Agriculture Headlines Health TerraViva United Nations Better World Cameroon Cameroon Academy of Sciences Cameroon Christian University Institute Cameroon Cotton Corporation Camer Source Type: news