New Trends in Migraine Pharmacology: Targeting Calcitonin Gene –Related Peptide (CGRP) With Monoclonal Antibodies

This study aims at investigating the still poorly clear pathogenesis of migraine and the potential role of anti-CGRP mAbs in the scenario of prophylaxis of migraine. Introduction: Migraine Clinic Migraine consists in unilateral headache accompanied by a cluster of other sensory, autonomic and cognitive symptoms and it has been identified by the global burden of disease (GBD) study 2016 as the sixth most prevalent disorder and one of the main causes of disability all over the world, often occuring in working age and in young adult and middle-aged women (Collaborators, 2018). Hence, migraine represents a very serious social issue in terms of years of life lived with disability (YLDs) and the most important cause of YLDs within 15 to 49 years of age (see Steiner et al., 2018). The burden of such disease has not been identified until recently because: migraine is not a cause of permanent disability or death; headache occasionally occurs in general population (Collaborators, 2018). Although a definite pathogenesis for migraine is not known, the extracranial circulation is involved (Drummond and Lance, 1983). The clinical course of migraine is articulated in different following or concomitant stages: premonitory, aura, headache, and postdrome (similar to the premonitory phase) (Goadsby et al., 2017a). The premonitory phase includes irritability, food craving, stiff neck and can occur from 2 to 72 h prior to the attack and continues over the other phases. According to the de...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news UK news US news Australia news Science Infectious diseases Source Type: news
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Source: Texto e Contexto - Enfermagem - Category: International Medicine & Public Health Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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