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Influence of LH and high-density lipoprotein cholesterol (HDL-C) on metformin response in women with polycystic ovary syndrome
Conclusion In weight-matched PCOS subjects, laboratory markers might predict the metformin response. Higher levels of basal LH and lower levels of HDL-C are correlated with a positive response to metformin treatment in PCOS subjects.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - October 12, 2014 Category: OBGYN Source Type: research
Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome.
Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437
Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov
We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research
17β-Estradiol and Natural Progesterone for Menopausal Hormone Therapy: REPLENISH Phase 3 Study Design of a Combination Capsule and Evidence Review
Several formulations of hormone therapy (HT) containing estrogens and progestins have been approved by the United States Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of menopausal symptoms. The primary indication for HT is the relief of moderate to severe vasomotor symptoms (VMS) [1]. The most effective treatment for hot flushes is HT consisting of estrogens with or without progestogens [2]. However, publication of data showing possible harm in women of a mean age of 63 that were treated for more than 5 years with conjugated equine estrogens (CEE) and medroxyprogesterone acetate ...
Source: Maturitas - March 10, 2015 Category: Primary Care Authors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick, James H. Pickar, David F. Archer Tags: Review Source Type: research
Expression of the Streptococcus pneumoniae yoeB Chromosomal toxin gene causes Cell Death in the model plant Arabidopsis thaliana
Conclusions:
Expression of the YoeB toxin from Streptococcus pneumoniae is lethal in Arabidopsis. We believe this is the first report of a toxin from a bacterial toxin-antitoxin system functioning in plants. The results presented here mark an important milestone towards the development of a cell ablation based bio-containment strategy, which may be useful for functional studies and for the control of spread of transgenic plants.
Source: BMC Biotechnology - April 12, 2015 Category: Biotechnology Authors: Fauziah BakarChew YeoJennifer Harikrishna Source Type: research
Interventions for hirsutism (excluding laser and photoepilation therapy alone).
CONCLUSIONS: Treatments may need to incorporate pharmacological therapies, cosmetic procedures, and psychological support. For mild hirsutism there is evidence of limited quality that OCPs are effective. Flutamide 250 mg twice daily and spironolactone 100 mg daily appeared to be effective and safe, albeit the evidence was low to very low quality. Finasteride 5 mg daily showed inconsistent results in different comparisons, therefore no firm conclusions can be made. As the side effects of antiandrogens and finasteride are well known, these should be accounted for in any clinical decision-making. There was low quality evidenc...
Source: Cochrane Database of Systematic Reviews - April 28, 2015 Category: Journals (General) Authors: van Zuuren EJ, Fedorowicz Z, Carter B, Pandis N Tags: Cochrane Database Syst Rev Source Type: research
The CYP17 MspA1 Polymorphism and the Gender Dysphoria
ConclusionOur data confirm a sex‐dependent allele distribution of the CYP17 MspA1 polymorphism in the transsexual population, FtM > MtF, suggestive of a hypothetical A2 involvement in transsexualism since the allele frequencies in the general population seem to be clearly related to geographic origin and ethnic background, but not sex. Fernández R, Cortés‐Cortés J, Esteva I, Gómez‐Gil E, Almaraz MC, Lema E, Rumbo T, Haro‐Mora J‐J, Roda E, Guillamón A, and Pásaro E. The CYP17 MspA1 polymorphism and gender dysphoria. J Sex Med **;**:**–**.
Source: The Journal of Sexual Medicine - April 29, 2015 Category: Sexual Medicine Authors: Rosa Fernández, Joselyn Cortés‐Cortés, Isabel Esteva, Esther Gómez‐Gil, Mari Cruz Almaraz, Estefanía Lema, Teresa Rumbo, Juan‐Jesús Haro‐Mora, Ester Roda, Antonio Guillamón, Eduardo Pásaro Tags: Brief Communication Source Type: research
Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells
Publication date: 5 September 2015 Source:Molecular and Cellular Endocrinology, Volume 412 Author(s): Hsun-Ming Chang, Jung-Chien Cheng, He-Feng Huang, Feng-Tao Shi, Peter C.K. Leung Activins are homo- or heterodimers of inhibin β subunits that play important roles in the reproductive system. Our previous work has shown that activins A (βAβA), B (βBβB) and AB (βAβB) induce aromatase/estradiol, but suppress StAR/progesterone production in human granulosa-lutein cells. However, the underlying molecular determinants of these effects have not been examined. In this continuing study, we used immortalized human gra...
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
Pre- and postnatal bisphenol A treatment does not alter the number of tyrosine hydroxylase-positive cells in the anteroventral periventricular nucleus (AVPV) of weanling male and female rats.
Abstract
Exposure to Bisphenol A (BPA) may interfere with brain sexual differentiation. Altered numbers of tyrosine hydroxylase (TH) cells in the rodent anteroventral periventricular nucleus (AVPV) after developmental BPA treatment have been reported; however, definitive conclusions are lacking. The current study incorporated many of the guidelines suggested for endocrine disrupter research. Specifically, ethinyl estradiol (EE2) served as a reference estrogen, exogenous environmental estrogen exposure was controlled, BPA was administered orally, and subjects consumed a low phytoestrogen diet. Here, on gestational ...
Source: Brain Research - July 20, 2015 Category: Neurology Authors: Ferguson SA, Paule MG, He Z Tags: Brain Res Source Type: research
Serum progesterone levels greater than 20 ng/dl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates
Conclusion
P4 levels >20 ng/ml on the day of transfer (during frozen single euploid embryo transfer cycles) were associated with decreased OPR/LBR.
Source: Journal of Assisted Reproduction and Genetics - August 4, 2015 Category: Reproduction Medicine Source Type: research
Action of methyl-, propyl- and butylparaben on GPR30 gene and protein expression, cAMP levels and activation of ERK1/2 and PI3K/Akt signaling pathways in MCF-7 breast cancer cells and MCF-10A non-transformed breast epithelial cells.
Abstract
In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells. Cells were exposed to methyl-, propyl- or butylparaben at a concentration of 20nM; 17-β-estradiol (10nM) was used as a positive control. 17β-estradiol and all tested parabens increased GPR30 gene and protein expression in MCF-7 and MCF-10A cells. No parabens affected cAMP levels in either cell line, with the exception of propylparaben in MCF-10A cells. 17β-estradiol, propylparaben, and butylparaben increased phosphory...
Source: Toxicology Letters - August 4, 2015 Category: Toxicology Authors: Wróbel AM, Gregoraszczuk EŁ Tags: Toxicol Lett Source Type: research
Endocrine control of canine mammary neoplasms: serum reproductive hormone levels and tissue expression of steroid hormone, prolactin and growth hormone receptors
Conclusions:
Herein, it has been confirmed that transformation towards malignant neoplasms is associated with significant reduction of gene expression of particular hormone receptors. Only PRLR in malignant tumors seems to be influenced by circulating PRL levels. In dogs, CDH-1 can be used as a prognostic factor; its expression, however, in benign tumors is influenced by cycle stage.
Source: BMC Veterinary Research - September 15, 2015 Category: Veterinary Research Authors: Michèle SpoerriFranco GuscettiSonja HartnackAlois BoosChristine OeiOrsolya BaloghRenata NowaczykErika MichelIris ReichlerMariusz Kowalewski Source Type: research
Ovarian steroids regulate gene expression in the dorsal raphe of old female macaques.
Abstract
With extended life spans in modern humans, menopause has become a significant risk factor for depression, anxiety, loss of cognitive functions, weight gain, metabolic disease, osteoporosis, cardiovascular disease, and neurodegenerative diseases. Clinical studies have found beneficial neural effects of ovarian steroid hormone therapy (HT) during the menopausal transition and data are emerging that it can be continued long term. To further understand molecular underpinnings of the clinical studies, we used quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) to examine gene expression in t...
Source: Neurobiology of Aging - December 24, 2015 Category: Geriatrics Authors: Bethea CL, Kohama SG, Reddy AP, Urbanski HF Tags: Neurobiol Aging Source Type: research
Oral Nicotine Alters Uterine Histo-Morphology but Does Not Disrupt the Estrous Cycle in Female Rats
Conclusions:
These preclinical studies suggest that nicotine intake results in structural changes in uterine tissues without disrupting estrous cyclicity or estradiol hormone levels. Though oral nicotine may not be totally risk-free, continuing research on this mode of nicotine administration is worthwhile to determine optimal dosing and duration of consumption for its potential use as an NRT.
Source: Nicotine and Tobacco Research - April 8, 2016 Category: Addiction Authors: Halder, S., Trauth, S., Pearce, A. R. Tags: Original Investigation Source Type: research
Volume expanders for the prevention of ovarian hyperstimulation syndrome.
CONCLUSIONS: Evidence suggests that the plasma expanders assessed in this review (human albumin, HES and mannitol) reduce rates of moderate and severe OHSS in women at high risk. Adverse events appear to be uncommon, but were too poorly reported to reach any firm conclusions, and there were no data on live birth. However, there was evidence that human albumin reduces pregnancy rates. While there was no evidence that HES, or mannitol had any influence on pregnancy rates, the evidence of effectiveness was based on very few trials which need to be confirmed in additional, larger randomised controlled trials (RCTs) before they...
Source: Cochrane Database of Systematic Reviews - August 30, 2016 Category: Journals (General) Authors: Youssef MA, Mourad S Tags: Cochrane Database Syst Rev Source Type: research
Estrogen receptor α and β are involved in the activation of lordosis behavior in estradiol-primed rats.
Abstract
The present study was designed to assess the participation of estrogen receptors alpha (ERα) and beta (ERβ) in the short-term facilitation of lordosis behavior in ovariectomized (ovx), estradiol (E2) primed rats. In experiment 1, dose response curves for PPT and DPN (ERα and ERβ agonists, respectively) facilitation of lordosis behavior (lordosis quotient and lordosis score) were established by infusing these agonists into the right lateral ventricle (icv) in female rats injected 40h previously with 5μg of E2 benzoate. PPT doses of 0.08 and 0.4ng produced high lordosis quotients starting at 30min and ...
Source: Hormones and Behavior - August 31, 2016 Category: Endocrinology Authors: Domínguez-Ordóñez R, García-Juárez M, Lima-Hernández FJ, Gómora-Arrati P, Blaustein JD, Etgen AM, González-Flores O Tags: Horm Behav Source Type: research
