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Total 1700 results found since Jan 2013.

Clinical Use Of Biologics For Asthma Treatment By Allergy Specialists: A Questionnaire Survey.
CONCLUSION: This represents the largest survey of allergy specialists, about real-world use of asthma biologics. It appears there has been reasonably good dissemination and application of current guidelines among allergists based on prescribing patterns. However, there responses demonstrate the need for the continued modification of asthma guidelines that incorporate novel biologics and other pathway-specific agents into step therapy. As clinical phenotypes and predictive biomarkers develop, allergy specialists will be better prepared to practice precision medicine that optimizes use of asthma biologics. PMID: 3262901...
Source: Annals of Allergy, Asthma and Immunology - July 2, 2020 Category: Allergy & Immunology Authors: Kuruvilla M, Ariue B, Oppenheimer JJ, Singh U, Bernstein JA Tags: Ann Allergy Asthma Immunol Source Type: research

Disappearance of severe oral allergy syndrome following omalizumab treatment.
Authors: Asero R Abstract Summary: The first case of disappearance of apple-induced oral allergy syndrome in a birch pollen-allergic patient following omalizumab treatment is reported. This observation in a case of type 2 food allergy suggests that omalizumab is potentially an effective preventive treatment for patients with severe, type 1 food allergies. PMID: 28497679 [PubMed - in process]
Source: European Annals of Allergy and Clinical Immunology - May 13, 2017 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Chronic sinusitis pathophysiology: The role of allergy.
CONCLUSION: Treatments of this disease include agents directed at allergic mediators such as leukotriene modifiers and corticosteroids, although this doesnot necessarily signify that an IgE-dependent mechanism can be ascribed. However, more recently, omalizumab has shown promise, including in patientswithout obvious aeroallergen sensitization. Although many aspects of the role of allergy in CHES remain a mystery, the mechanisms that are being elucidatedallow for improved understanding of this disease, which ultimately will lead to better treatments for our patients who live daily with this disease. PMID: 23601202 [Pub...
Source: American Journal of Rhinology and Allergy - April 18, 2013 Category: ENT & OMF Authors: Kennedy JL, Borish L Tags: Am J Rhinol Allergy Source Type: research

Omalizumab as monotherapy for food allergy
Purpose of review To familiarize the reader with the most recent insights in the use of Omalizumab (monoclonal anti-immunoglobulin E) monotherapy in the treatment of patients with severe food allergy. Recent findings The current data from early stage clinical trials show that Omalizumab may be safe and effective by itself in providing desensitization to one or several foods without requiring allergen exposure. Summary In the near future, advances in knowledge will guide the adoption and implementation of any new therapy for food allergy and allow the development of a personalized treatment tailored on the...
Source: Current Opinion in Allergy and Clinical Immunology - April 30, 2021 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Cow's milk allergy
Purpose of review To highlight the most recent insights on cow's milk allergy (CMA), its treatment, and management. Recent findings CMA is one of the most common food allergies among children. Burdened by the risk for fatal reaction, CMA may imply also a severe impairment of health-related quality of life at individual and family level as well as well as individual and societal costs. The updated Diagnosis and Rationale for Action against Cow's Milk Allergy series is going to provide a series of manuscripts that will offer a comprehensive state-of-the-art specifically on CMA, including international evidence-bas...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Secondary prevention of latex allergy
Purpose of review The present review addresses the secondary prevention in healthcare worker, healthcare setting, and in patients outside the healthcare setting. Recent findings There is sufficient knowledge of the broad aetiology of latex allergy for secondary preventive programmes to be widely adopted. Currently, avoidance of latex-containing surgical products is mandatory in the care of sensitized patients. They should also have a list of occult sources of natural rubber latex exposure and cross-reacting fruits. During all health-care procedures latex allergic patients should be treated in a ‘latex-free’ ...
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: SKIN ALLERGY: Edited by Eustachio Nettis Source Type: research

Individually dosed omalizumab: an effective treatment for severe peanut allergy
Conclusions and Clinical RelevanceIndividually dosed omalizumab, monitored by CD‐sens, is an effective and safe treatment for severe peanut allergy. The ratio of IgE‐ab to storage protein Ara h 2/IgE as well as CD‐sens to peanut may predict the need of a higher omalizumab dose. Clinical trials numbers: EudraCT; 2012‐005625‐78, ClinicalTrials. gov; NCT02402231This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - November 23, 2016 Category: Allergy & Immunology Authors: J Brandstr öm, M Vetander, G Lilja, S. G O Johansson, A‐C Sundqvist, F Kalm, C Nilsson, A Nopp Tags: Original Article ‐Clinical Allergy Source Type: research

Omalizumab facilitates rapid oral desensitization for peanut allergy
Peanut oral immunotherapy is a promising approach to peanut allergy, but reactions are frequent, and some patients cannot be desensitized. The anti-IgE medication omalizumab (Xolair; Genentech, South San Francisco, Calif) might allow more rapid peanut updosing and decrease reactions.
Source: Journal of Allergy and Clinical Immunology - September 5, 2016 Category: Allergy & Immunology Authors: Andrew J. MacGinnitie, Rima Rachid, Hana Gragg, Sara V. Little, Paul Lakin, Antonella Cianferoni, Jennifer Heimall, Melanie Makhija, Rachel Robison, R. Sharon Chinthrajah, John Lee, Jennifer Lebovidge, Tina Dominguez, Courtney Rooney, Megan Ott Lewis, Jen Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: research

How to actively treat food allergy
Purpose of review In the last years, food allergy treatment is moving away from food avoidance to interventional treatments. We review here the recent developments on immunotherapy with food allergens. Recent findings Oral immunotherapy remains the best studied form of food immunotherapy. In 2017, further evidence has been added to its efficacy. Its mechanisms of action are under scrutiny. To reduce its side effects, studies have been dedicated to the simultaneous use of biologics, in particular omalizumab. Among the other forms of food immunotherapy that are being developed, the epicutaneous application of food aller...
Source: Current Opinion in Allergy and Clinical Immunology - April 26, 2018 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

Position document IgE-mediated allergy to egg protein.
Abstract Egg is the food that most often causes allergy in young Spanish children, with an incidence of 2.4-2.6% in the first 2 years of life. The prevalence of sensitisation and allergy to egg is greater in children with allergy to cow's milk and in those suffering atopic dermatitis. The protein component from egg white is the cause of the allergic response in child. The major allergens in egg white are ovomucoid and ovalbumin. Most of the allergic reactions affect the skin, followed by gastrointestinal and respiratory systems. Egg allergy is one of the most common causes of severe anaphylaxis. The diagnosis of e...
Source: Allergologia et Immunopathologia - July 2, 2013 Category: Allergy & Immunology Authors: Martorell A, Alonso E, Boné J, Echeverría L, López MC, Martín F, Nevot S, Plaza AM, Food allergy committee of SEICAP Tags: Allergol Immunopathol (Madr) Source Type: research

A potential breakthrough for peanut allergy treatment
Peanut allergies are among the most rapidly growing food allergies in the United States. Millions of children are currently living with the condition, with new cases being diagnosed daily. (A recent study shows the number of reported peanut allergies tripled in just over a decade.) And because allergic reactions to peanuts tend to be the most severe—80 to 95 percent of all food allergy deaths are peanut or tree nut related—the trend is a serious cause for concern. But a small pilot study published by the Journal of Allergy and Clinical Immunology, may offer hope for the hundred of thousands of families living with the ...
Source: Thrive, Children's Hospital Boston - November 4, 2013 Category: Pediatrics Authors: Tripp Underwood Tags: All posts Food allergies Kids' safety Milk allergies Parenting clinical trial food allergy Dale Umetsu Lynda Schneider peanut allergies Rima Rachid Source Type: news

Combining Anti-IgE Monoclonal Antibodies and Oral Immunotherapy for the Treatment of Food Allergy
AbstractImmunoglobulin E (IgE)-mediated food allergy is a real public health problem worldwide. The prevalence of food allergy is particularly high in children. Patients with food allergy experience high morbidity with a change in quality of life due to the risk of severe anaphylaxis. Current treatment options are poor. Allergen avoidance is widely recommended but exposes patients to accidental ingestion. Oral immunotherapy is also used in patients with food allergies to the most common allergens. Oral immunotherapy consists of a daily administration of small, gradually increasing amounts of allergens to induce desensitisa...
Source: Clinical Reviews in Allergy and Immunology - September 22, 2021 Category: Allergy & Immunology Source Type: research

Oral immunotherapy and potential treatment.
Authors: Sato S, Yanagida N, Ebisawa M Abstract The standardized therapeutic approach for food allergy is based on avoidance of allergens in foods. Oral immunotherapy (OIT) is a significant focus of food allergy research and appears to be effective in inducing desensitization. However, most patients receiving OIT have mild to moderate symptoms during the therapy, and it has not been clearly established whether OIT is effective in inducing permanent tolerance. Recently, novel therapeutic approaches for food allergy, or sublingual immunotherapy and epicutaneous immunotherapy using an anti-IgE monoclonal antibody (oma...
Source: Chemical Immunology and Allergy - May 31, 2015 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research