• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

How Good is Photoscreening For Young Children ’ s Vision Problems?
This study showed that not only was smartphone photoscreening feasible, but was quite good at screening for potential vision problems. Smartphone photoscreening has the advantages of being more ubiquitously available and thus children in almost any location can be screened. A study of photoscreening using a handheld digital photoscreener in primary care offices validated the technology showing an overall referral rate of 10% to an ophthalmologist with suspected astigmatism, anisometropia and strabismus being the most common reasons. The overall positive predictive rate was 0.60. “…[O]ver 60% of children referre...
Source: PediatricEducation.org - January 4, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Automatic Grading of Retinal Blood Vessel in Deep Retinal Image Diagnosis
AbstractAutomatic grading of retinal blood vessels from fundus image can be a useful tool for diagnosis, planning and treatment of eye. Automatic diagnosis of retinal images for early detection of glaucoma, stroke, and blindness is emerging in intelligent health care system. The method primarily depends on various abnormal signs, such as area of hard exudates, area of blood vessels, bifurcation points, texture, and entropies. The development of an automated screening system based on vessel width, tortuosity, and vessel branching are also used for grading. However, the automated method that directly can come to a decision b...
Source: Journal of Medical Systems - August 31, 2020 Category: Information Technology Source Type: research

Arterial Occlusions to the Eye: From Retinal Emboli to Ocular Ischemic Syndrome
The objective of this review article is to provide the general ophthalmologists with information on how to recognize the symptoms and to best manage these patients. The management is to investigate for the cause of the transient monocular visual loss and to apply secondary prevention to address atherosclerotic risk factors to prevent further ischemic events like a stroke.
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

CD4+ T-Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy
Retinal ischemic events as a result of occlusion of the ocular vasculature share similar causes of central nervous system stroke and are among the most common cause of acute and irreversible vision loss in elderly patients. Currently, there is no established treatment, and the condition often leaves patients with seriously impaired vision or blindness. The immune system, particularly T-cell –mediated responses, is thought to be intricately involved, but the exact roles remain elusive. We found that acute ischemia-reperfusion injury to the retina induced a prolonged phase of retinal ganglion cell loss that continued to p...
Source: American Journal of Pathology - May 6, 2020 Category: Pathology Authors: Thi Hong Khanh Vu, Huihui Chen, Li Pan, Kin-Sang Cho, Djoeke Doesburg, Eric F. Thee, Nan Wu, Elisa Arlotti, Martine J. Jager, Dong Feng Chen Tags: Regular article Source Type: research

CD4+ T Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy
Retinal ischemic events as a result of occlusion of the ocular vasculature share similar etiologies of central nervous system (CNS) stroke and are among the most common cause of acute and irreversible vision loss in elderly patients. Currently, there is no established treatment, and the condition often leaves patients with seriously impaired vision or blindness. The immune system, particularly T cell-mediated responses, is thought to be intricately involved, but their exact roles remain elusive.
Source: American Journal of Pathology - May 6, 2020 Category: Pathology Authors: Thi Hong Khanh Vu, Huihui Chen, Li Pan, Kin-Sang Cho, Djoeke Doesburg, Eric F. Thee, Nan Wu, Elisa Arlotti, Martine J. Jager, Dong Feng Chen Tags: Regular Article Source Type: research

CD4+ T Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy.
Abstract Retinal ischemic events as a result of occlusion of the ocular vasculature share similar etiologies of central nervous system (CNS) stroke and are among the most common cause of acute and irreversible vision loss in elderly patients. Currently, there is no established treatment, and the condition often leaves patients with seriously impaired vision or blindness. The immune system, particularly T cell-mediated responses, is thought to be intricately involved, but their exact roles remain elusive. Here we showed that acute ischemia/reperfusion injury to the retina induced a prolonged phase of retinal gangli...
Source: The American Journal of Pathology - May 6, 2020 Category: Pathology Authors: Khanh Vu TH, Chen H, Pan L, Cho KS, Doesburg D, Thee EF, Wu N, Arlotti E, Jager MJ, Chen DF Tags: Am J Pathol Source Type: research

Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues
Ischemic retinopathies represent a major cause of visual impairment and blindness. They include diabetic retinopathy (DR), acute glaucoma, retinopathy of prematurity (ROP), and central (or branch) retinal artery occlusion (CRAO). These conditions share in common a period of ischemia or reduced blood supply to the retinal tissue that eventually leads to neuronal degeneration. Similarly, acute brain injury from ischemia or trauma leads to neurodegeneration and can have devastating consequences in patients with stroke or traumatic brain injury (TBI). In all of these conditions, current treatment strategies are limited by thei...
Source: Frontiers in Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Source Type: research

Atrial Fibrillation: An Underestimated Cause of Ischemic Monocular Visual Loss?
Introduction: Atrial fibrillation (AF) is a major cause of ischemic stroke and Transient Ischemic Attack (TIA) and investigation for paroxysmal AF is recommended following an embolic brain event. In contrast, retinal ischemic monocular blindness is traditionally considered most linked to carotid artery disease (CAS) and investigating for AF is less vigilant. We aimed to determine the prevalence of AF in patients with ischemic monocular blindness. Methods: Consecutive records of all patients presenting to a daily TIA clinic with transient or permanent ischemic monocular blindness were reviewed, January 2014-October 2016.
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Angeliki Zarkali, Suk Fun Cheng, Agnes Dados, Robert Simister, Arvind Chandratheva Source Type: research

A 23-Year-Old Woman with Sudden-Onset Blindness of the Right Eye
A 23-year-woman was presented for sudden-onset monocular blindness. Branch retinal artery occlusion in the right eye and multiple brain embolism were detected. Trousseau syndrome due to bilateral ovarian cancer was diagnosed; no embolic events were observed after anticoagulant therapy and surgical resection.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Yosuke Takeuchi, Keiichi Nakahara, Makoto Nakajima, Yasuteru Inoue, Riyo Matsumura, Munekage Yamaguchi, Hidetaka Katabuchi, Yukio Ando Tags: Case Report Source Type: research

Mitochondrial Disorder: Maternally Inherited Diabetes and Deafness.
Authors: Tsang SH, Aycinena ARP, Sharma T Abstract Patients with maternally inherited diabetes and deafness (MIDD) have insulin-dependent diabetes with relatively low BMI; usually the onset of the diabetes is during the third or fourth decade of life and it is associated with progressive neurosensory deafness. The fundus shows circumferentially oriented but discontinuous patches of RPE and choriocapillaris (CC) atrophy around the macula, within the arcades (Figs. 31.1 and 31.2). Sometimes even hyperpigmentation can be seen, also around the optic nerve, or pattern-like dystrophy may occur. Vision is usually good, ab...
Source: Advances in Experimental Medicine and Biology - December 25, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

MEK/ERK/1/2 sensitive vascular changes coincide with retinal functional deficit, following transient ophthalmic artery occlusion.
In conclusion, this is the first study to show a beneficial in vivo effect of U0126 on vascular contractility following ischemia in the ophthalmic artery. Coupled with the knowledge obtained from cerebral vasculature, these results point towards a novel therapeutic approach following ischemia-related injuries to the eye. PMID: 30439349 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - November 12, 2018 Category: Opthalmology Authors: Blixt FW, Haanes KA, Ohlsson L, Sörensen KD, Fedulov V, Warfvinge K, Edvinsson L Tags: Exp Eye Res Source Type: research

Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature.
Conclusions- This study establishes mice with late endothelial cell-specific loss of Tspan12 as a model to study pathological consequences of BRB impairment in an otherwise intact vasculature. PMID: 30354230 [PubMed - in process]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 26, 2018 Category: Cardiology Authors: Zhang C, Lai MB, Pedler MG, Johnson V, Adams RH, Petrash JM, Chen Z, Junge HJ Tags: Arterioscler Thromb Vasc Biol Source Type: research

Bile acids and their effects on diabetes
AbstractDiabetes is a widespread, rapidly increasing metabolic disease that is driven by hyperglycemia. Early glycemic control is of primary importance to avoid vascular complications including development of retinal disorders leading to blindness, end-stage renal disease, and accelerated atherosclerosis with a higher risk of myocardial infarction, stroke and limb amputations. Even after hyperglycemia has been brought under control, “metabolic memory,” a cluster of irreversible metabolic changes that allow diabetes to progress, may persist depending on the duration of hyperglycemia. Manipulation of bile acid (BA) recep...
Source: Frontiers of Medicine - October 10, 2018 Category: General Medicine Source Type: research

Transient monocular blindness: Vascular causes and differential diagnoses.
Authors: Bidot S, Biotti D Abstract Transient monocular blindness is an acute episode of ischemic origin in which one eye has profound visual loss, followed by full recovery within one hour. Transient monocular blindness most often occurs in the setting of retinal ischemia secondary to carotid embolism, but other mechanisms have been reported, including thrombosis (most often in the setting of giant cell arteritis), hemodynamic disorders (secondary to severe carotid stenosis) or vasospasm. Transient monocular blindness is considered a transient ischemic attack originating in the carotid arteries and must benefit fr...
Source: Journal Francais d Ophtalmologie - May 20, 2018 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

Transient monocular blindness: Vascular causes and differential diagnoses.
Authors: Bidot S, Biotti D Abstract Transient monocular blindness is an acute episode of ischemic origin in which one eye has profound visual loss, followed by full recovery within one hour. Transient monocular blindness most often occurs in the setting of retinal ischemia secondary to carotid embolism, but other mechanisms have been reported, including thrombosis (most often in the setting of giant cell arteritis), hemodynamic disorders (secondary to severe carotid stenosis), or vasospasm. Transient monocular blindness is considered a transient ischemic attack originating in the carotid arteries, and must be manag...
Source: Journal Francais d Ophtalmologie - April 22, 2018 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

Pages: 1  2  3