• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia
Conclusion: Using three different strategies to either prevent formation or enhance elimination of O2⋅_ during the post-asphyxial period, we saw both reduced leukocyte adherence and preserved BBB function with treatment. These findings suggest that agents which lower O2⋅_ in brain may be attractive new therapeutic interventions for the protection of the neonatal brain following asphyxia. Introduction Asphyxia is a relatively common source of neonatal brain damage (1), affecting ~2 in every 1,000 births (2). The hypoxic ischemia resulting from this oxygen deprivation can produ...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Social Vulnerability and Premature Cardiovascular Mortality Among US Counties, 2014 to 2018
CONCLUSIONS: In this analysis, US counties with more social vulnerabilities had higher premature CVD mortality, varied by demographic characteristics and rurality. Focused public health interventions should address the socioeconomic disparities faced by underserved communities to curb the growing burden of premature CVD.PMID:34662161 | DOI:10.1161/CIRCULATIONAHA.121.054516
Source: Circulation - October 18, 2021 Category: Cardiology Authors: Safi U Khan Zulqarnain Javed Ahmad N Lone Sourbha S Dani Zahir Amin Sadeer G Al-Kindi Salim S Virani Garima Sharma Ron Blankstein Michael J Blaha Miguel Cainzos-Achirica Khurram Nasir Source Type: research

Blood Cell-Bound C4d as a Marker of Complement Activation in Patients With the Antiphospholipid Syndrome
In conclusion the detection of complement activation products on circulating erythrocytes and platelets using a highly sensitive and specific assay further supports the view that APS is a complement-mediated disorder. Increased EC4d and PC4d percentages are associated with the active inflammatory disease in SLE. It is difficult to translate this finding to APS which is a non-acute inflammatory disorder. We failed to find an association with both the classification and non-classification criteria, including thrombocytopenia. However, we believe that this sensitive tool to evaluate complement activation may offer more inform...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Sex Differences in Sex Hormone Profiles and Prediction of Consciousness Recovery After Severe Traumatic Brain Injury
Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients. Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is increasing in incidence (1). Patients with acute severe TBI (sTBI) often develop severe disorders of consciousness, i.e., coma, minimally conscious state or vegetative state. Although many patients may regain consciousness during the 1-month post-TBI p...
Source: Frontiers in Endocrinology - April 25, 2019 Category: Endocrinology Source Type: research

Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Hands-Free Human-Computer Interface Based on Facial Myoelectric Pattern Recognition
Conclusion A facial movement-machine interface was developed in this study in order to help users with limited hand function manipulate electronic devices. Facial movements were detected using four EMG sensors, and five movement patterns were classified using myoelectric pattern recognition algorithms. The results from 10 able-bodied subjects show that facial movements can be detected and classified at high accuracies. The pattern-based continuous mapping between facial movements and cursor actions achieved high performance in both a typing task and a drawing task. Ethics Statement This study was approved by the Committ...
Source: Frontiers in Neurology - April 29, 2019 Category: Neurology Source Type: research

Dimensions of Poststroke Depression and Neuropsychological Deficits in Older Adults
Stroke is the leading cause of both serious and long-term disability and the fifth leading cause of death in the United States.1,2 Poststroke depression (PSD) afflicts approximately one-fourth of stroke survivors and increases the likelihood of persistent disability.3 –6 Prompt identification and treatment of PSD can improve affective symptoms and stroke related disability.7,8
Source: The American Journal of Geriatric Psychiatry - January 24, 2020 Category: Geriatrics Authors: Dora Kanellopoulos, Victoria Wilkins, Jimmy Avari, Lauren Oberlin, Lindsay Arader, Merete Chaplin, Samprit Banerjee, George S. Alexopoulos Tags: Regular Research Article Source Type: research

Risk Stratification and Management of Extracranial Carotid Artery Disease
Stroke is the fifth leading cause of death in the United States and is a leading cause of disability. Extracranial internal carotid artery stenosis is a major cause of ischemic stroke, as it is estimated to cause 8% to 15% of ischemic strokes. It is critical to improve our strategies for stroke prevention and treatment in order to reduce the burden of this disease. Herein, we review approaches for the diagnosis and risk stratification of carotid artery disease as well as interventional strategies for the prevention and treatment of strokes caused by carotid artery disease.
Source: Cardiology Clinics - October 20, 2021 Category: Cardiology Authors: Anna K. Krawisz, Brett J. Carroll, Eric A. Secemsky Source Type: research

Predicting Transcarotid Artery Revascularization adverse outcomes by Imaging Characteristics
Approximately 20-30% of ischemic strokes are caused by internal carotid artery stenosis. Stroke is the leading cause of disability and the second leading cause of death in the United States. Second generation Trans Carotid Arterial Revascularization (TCAR) stenting, using the ENROUTE flow reversal technology to prevent embolic stroke during the stenting process, has demonstrated stroke and death outcomes equivalent to CEA with reduced cranial nerve injury. However, at present, it is not known whether imaging characteristics obtained pre-operatively can predict outcomes of TCAR procedures.
Source: Annals of Vascular Surgery - June 14, 2022 Category: Surgery Authors: Elizabeth Blears, Sefali Patel, Mark Doyle, Nicholas Lombardi, Satish Muluk Tags: Clinical Research Source Type: research

Lessons Learned from Managing Antithrombotic Therapy in Children Supported with Pediatric Ventricular Assist Devices
Stroke, thromboembolism, and bleeding are the most recognized complications associated with pediatric ventricular assist devices (VADs) and the leading cause of death and disability on VAD support. Recently, newer antithrombotic strategies like bivalirudin have emerged that appear to be associated with a reduction in the neurologic event rates, especially for smaller pediatric-specific VADs like the Berlin Heart and PediMag/CentriMag systems where the risk of stroke is the highest. While contemporary antithrombotic therapies have likely contributed to lowering adverse event rates, we speculate that clotting and bleeding ad...
Source: ASAIO Journal - November 1, 2022 Category: Medical Devices Tags: Review Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19