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Mechanisms of Allergic Disease ‐ Environmental and genetic determinants for the development of allergy
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - March 13, 2015 Category: Allergy & Immunology Authors: Dianne E Campbell, Robert J. Boyle, Catherine A Thornton, Susan L. Prescott Tags: Invited Review Source Type: research

HLA-G5 and G7 Isoforms in Pregnant Women.
Abstract Human leukocyte antigen-G which is an immune tolerance effecter molecule has an important role in the maintenance of fetus during pregnancy. Abortion is one of the complications of pregnancy period.  In this research, we have studied levels of HLA-G 5, HLA-G7 isoforms in the abortion-threatened pregnant women in comparison with controls. In a case-control study, 101 abortion-threatened women and 101 healthy pregnant women (healthy controls) with age range 21-32 years were studied. Gene expression of HLA-5 and HLA-7 isoforms was analyzed by real-time polymerase chain reaction after mRNA extraction and cDN...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 18, 2015 Category: Allergy & Immunology Authors: Abediankenari S, Farzad F, Rahmani Z, Hashemi-Soteh MB Tags: Iran J Allergy Asthma Immunol Source Type: research

Maternofetal transfer of antibodies and the influence of maternal atopic status on the neonate.
CONCLUSIONS: Maternal IgE cannot be transferred to the child in utero. Maternal atopic status has no significant effect on neonatal immune responses. PMID: 25785752 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - March 1, 2015 Category: ENT & OMF Authors: Yu Z, Chen J, Zhang Q, Yin X, Wang Y, Fu J, Zou L, Kong W Tags: Am J Rhinol Allergy Source Type: research

Mechanisms of allergic disease – environmental and genetic determinants for the development of allergy
Summary Allergic disease can be viewed as an early manifestation of immune dysregulation. Environmental exposures including maternal inflammation, diet, nutrient balance, microbial colonization and toxin exposures can directly and indirectly influence immune programming in both pregnancy and the postnatal period. The intrauterine microclimate is critical for maternal and fetal immunological tolerance to sustain viable pregnancy, but appears susceptible to environmental conditions. Targeting aspects of the modern environment that promote aberrant patterns of immune response is logical for interventions aimed at primary prev...
Source: Clinical and Experimental Allergy - April 16, 2015 Category: Allergy & Immunology Authors: D. E. Campbell, R. J. Boyle, C. A. Thornton, S. L. Prescott Tags: State of the Art Reviews on Mechanisms of Allergic Disease Source Type: research

Risk factors identified for gestational eczema
HOUSTON– New-onset eczema during pregnancy is a common phenomenon with several newly identified risk factors. This disease entity deserves a proper name: gestational eczema, Dr. Wilfried J.J. Karmaus asserted at the annual meeting of the American Academy of Allergy, Asthma, and Immunology. In...
Source: Skin and Allergy News - April 18, 2015 Category: Dermatology Tags: FPN News FPN Allergy & Immunology FPN Women's Health OBGYN News OBGYN Complications OBGYN Obstetrics SAN Clinical News SAN News Source Type: news

Overcoming recurrent spontaneous abortions in women suffering from IgG subclass deficiency: high efficiency of low dose intravenous immunoglobulins treatment.
CONCLUSIONS: Low dose immunoglobulin infusion is the only effective way to reach successful pregnancy, despite previous habitual abortions in patients suffering from IgG subclass deficiency without autoimmunity and/or coagulation disorders, likely restoring idiotype-antiidiotype network; showing evidence of IgG subclasses deficiency (mostly IgG1 and IgG3) may help identify patients who can benefit from iv. immunoglobulin treatment. PMID: 25951147 [PubMed - in process]
Source: European Annals of Allergy and Clinical Immunology - June 4, 2015 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Vaccine therapy update for pregnant, immunocompromised, and chronic diseases patients.
Authors: De Sanctis JB, Garmendia JV Abstract The use of vaccines in pregnant, immunocompromised or chronic diseases patients has been widely discussed in the literature recently. Vaccines continue to be a safe and effective method to induce or recall immune response to several infective agents or even induce an effective response in chronically infected patients. The general presumption of adverse events, lack of response and unwanted tolerance seem to be responsible for the decreased vaccination rate in these patients. In the present review, the use of rational vaccination schemes, new patents of use, along as ne...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 4, 2015 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Relationship between in utero C-reactive protein levels and asthma in at-risk children.
CONCLUSION: Prenatal CRP levels are associated with asthma by year 3 and wheezing in year 3 within a high-risk, urban, mostly Mexican, cohort. Maternal systemic inflammation might reflect a prenatal environment that could increase offspring susceptibility to develop wheezing and asthma young in life. PMID: 26272280 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - August 11, 2015 Category: Allergy & Immunology Authors: Lapin B, Ownby D, Turyk M, Piorkowski J, Freels S, Chavez N, Wagner-Cassanova C, Hernandez E, Pelzel D, Vergara C, Persky V Tags: Ann Allergy Asthma Immunol Source Type: research

In-utero exposures and the evolving epidemiology of paediatric allergy
Purpose of review: Emerging evidence suggests that the rising prevalence of early-onset ‘noncommunicable’ diseases, such as paediatric atopy, is related to modern environmental changes, the effects of which appear to commence in utero or even preconception. Here, we review how recent publications have contributed further to our understanding of the influence of in-utero exposures on the predisposition to immune dysregulation, with a particular focus on the evolving epidemiology of paediatric allergy. Recent findings: New evidence suggests that inter-individual variations in immune function development are principally d...
Source: Current Opinion in Allergy and Clinical Immunology - August 29, 2015 Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research

Prenatal Particulate Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study.
CONCLUSIONS: Prenatal exposure to both indoor PM₂.₅ and ETS may increase susceptibility to LRTIs. This effect can be modified by polymorphisms in reactive oxygen species-related genes. PMID: 26333704 [PubMed]
Source: Allergy, Asthma and Immunology Research - September 6, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?
CONCLUSIONS: It is indicated that maternal folic acid supplementation during early pregnancy may increase the risk of wheeze in early childhood and that the TT genotype of MTHFR C677T polymorphism impairing folic acid metabolism would be at high risk of asthma development. These results might provide additional information for recommendations regarding forced folate consumption or folic acid supplements during pregnancy based on its well-established benefits for the prevention of congenital malformations. However, currently available evidence is of low quality which is needed to further elucidate. PMID: 26333700 [PubMed]
Source: Allergy, Asthma and Immunology Research - September 6, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Effects of maternal geohelminth infections on allergy in early childhood
Maternal geohelminth infections during pregnancy may protect against allergy development in childhood.
Source: Journal of Allergy and Clinical Immunology - September 19, 2015 Category: Allergy & Immunology Authors: Philip J. Cooper, Martha E. Chico, Leila D. Amorim, Carlos Sandoval, Maritza Vaca, Agostino Strina, Ana Clara Campos, Laura C. Rodrigues, Mauricio L. Barreto, David P. Strachan Source Type: research

Maternal exposure to GOS/Inulin mixture prevents food allergies and promotes tolerance in offspring in mice
ConclusionThe treatment of pregnant and lactating mice with non‐digestible GOS/Inulin prebiotics promotes a long‐term protective effect against food allergies in the offspring.This article is protected by copyright. All rights reserved.
Source: Allergy - October 1, 2015 Category: Allergy & Immunology Authors: Grégory Bouchaud, Laure Castan, Julie Chesné, Faouzi Braza, Philippe Aubert, Michel Neunlist, Antoine Magnan, Marie Bodinier Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Prevalence, Severity, and Treatment of Recurrent Wheezing During the First Year of Life: A Cross-Sectional Study of 12,405 Latin American Infants.
CONCLUSIONS: RW affects 1.6 out of 10 infants during the first year of life, with a high prevalence of severe episodes, frequent visits to the Emergency Department, and frequent admissions for wheezing. Besides the elevated prescription of asthma medications, there is an excessive use of antibiotics and paracetamol in infants with RW and also in the whole sample, which is mainly related to common colds. PMID: 26540498 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 7, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Successful use of 20% subcutaneous immunoglobulin in pregnant women with primary immune deficiency.
PMID: 26707772 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - January 1, 2016 Category: Allergy & Immunology Authors: Duff C, Krishnaswamy G, Ghably J Tags: Ann Allergy Asthma Immunol Source Type: research