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Condition: von Willebrand Disease

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Total 292 results found since Jan 2013.

Factors defining occurrence of ischemic and hemorrhagic strokes during continuous flow left ventricular assist device support
ConclusionsIn addition to LVAD-related thrombogenicity, the subsequent need for anticoagulation, and an acquired von Willebrand syndrome, several clinical factors, such as deviation from the anticoagulation regimen, hypertension, COPD, device infections, and aortic cross clamping, appear to have an influence on the extremely high rate of postoperative ischemic and hemorrhagic strokes.
Source: General Thoracic and Cardiovascular Surgery - August 20, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease
In conclusion, both in acute and chronic cerebrovascular disease patients, ADAMTS13 levels were significantly decreased, with the lowest ADAMTS13 levels found in acute str oke patients. This difference was even more distinct when the ratio of VWF:ADAMTS13 was considered. These results demonstrate the potentially important involvement of the VWF/ADAMTS13 axis in ischemic stroke.
Source: PLoS One - June 7, 2017 Category: Biomedical Science Authors: Frederik Denorme Source Type: research

Hypercoagulability and Migraine
BackgroundA growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro‐emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AimOur objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated es...
Source: Headache: The Journal of Head and Face Pain - February 8, 2017 Category: Neurology Authors: Gretchen E. Tietjen, Stuart A. Collins Tags: Headache Currents Source Type: research

Hypercoagulability and Migraine.
Abstract BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including tho...
Source: Headache - February 8, 2017 Category: Neurology Authors: Tietjen GE, Collins SA Tags: Headache Source Type: research

Recurrent posterior strokes in inflammatory bowel disease patients.
Conclusion. The association between IBD and posterior strokes is a novel finding. Factor VIII elevation may serve as a biomarker of a peristroke hypercoagulable state in patients with IBD. PMID: 25784930 [PubMed]
Source: Gastroenterology Research and Practice - March 19, 2015 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Delayed treatment with ADAMTS13 ameliorates cerebaral ischemic injury without hemorrhagic complication.
We examined whether ADAMTS13 has a longer therapeutic time window in ischemic stroke than tPA in mice subjected to middle cerebral artery occlusion (MCAO). ADAMTS13 (0.1mg/kg) or tPA (10mg/kg) was administered i.v., immediately after reperfusion of after 2-h or 4-h MCAO for comparison of the therapeutic time windows in ischemic stroke. Infarct volume, hemorrhagic volume, plasma high-mobility group box1 (HMGB1) levels and cerebral blood flow were measured 24h after MCAO. Both ADAMTS13 and tPA improved the infarct volume without hemorrhagic complications in 2-h MCAO mice. On the other hand, ADAMTS13 reduced the infarct volum...
Source: Brain Research - August 5, 2015 Category: Neurology Authors: Nakano T, Irie K, Hayakawa K, Sano K, Nakamura Y, Tanaka M, Yamashita Y, Satho T, Fujioka M, Muroi C, Matsuo K, Ishikura H, Futagami K, Mishima K Tags: Brain Res Source Type: research

Von Willebrand factor and ADAMTS13 plasma in older patients with high CHA2DS2-VASc Score with and without atrial fibrillation.
CONCLUSIONS: For elderly patients with a high incidence rate of stroke and thrombosis, we should pay more attention to the thrombotic events, and atrial fibrillation can be used as one of the risk factors involved and improving the risk scoring system of stroke. PMID: 29164570 [PubMed - in process]
Source: Pharmacological Reviews - November 1, 2017 Category: Drugs & Pharmacology Authors: Zhang F, Yang XC, Jia XW, Tang XH, Wang Z, Wang ZQ Tags: Eur Rev Med Pharmacol Sci Source Type: research

Reduced prevalence of arterial thrombosis in von Willebrand disease
ConclusionsThis is the first study showing that VWD patients have a reduced prevalence of arterial thrombosis and provides important insights into the role of VWF in the pathogenesis of arterial thrombosis.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - March 18, 2013 Category: Hematology Authors: Y V. Sanders, J Eikenboom, E M. Wee, J G. Bom, M H. Cnossen, M E.L. Degenaar‐Dujardin, K Fijnvandraat, P W. Kamphuisen, B A.P. Laros‐ Gorkom, K Meijer, E P. Mauser‐Bunschoten, F W.G. Leebeek, Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Valproic acid ameliorates ischemic brain injury in hyperglycemic rats with permanent middle cerebral occlusion.
In this study, we investigate the effects of VPA on permanent ischemic stroke with hyperglycemia. Hyperglycemia was induced by streptozotocin (STZ) injection 3 days before. Test animals received a single injection of VPA immediately after induction of ischemia. Control animals received occlusion and physiological saline injection, or STZ, occlusion, and saline. Magnetic resonance imaging of cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) was performed 60min after ischemia. Infarct volume, neurological deficits, rotarod test performance, and immunohistological markers were assessed 3 days after ischemia. ...
Source: Brain Research - February 23, 2015 Category: Neurology Authors: Suda S, Ueda M, Nito C, Nishiyama Y, Okubo S, Abe A, Aoki J, Suzuki K, Sakamoto Y, Kimura K Tags: Brain Res Source Type: research

C-reactive protein, von Willebrand factor and carotid artery intima-media thickness correlate with CHA2DS2-VASc in patients with acute atrial fibrillation.
Conclusions The tested parameters allow with moderate sensitivity and specificity to predict the presence of indications for chronic oral antithrombotic prophylaxis in patients with acute onset of AF. Determining the real ability of predicting the stroke requires an adequate assessment in a prospective long-term observation. PMID: 26463558 [PubMed - as supplied by publisher]
Source: Polskie Archiwum Medycyny Wewnetrznej - October 17, 2015 Category: Internal Medicine Tags: Pol Arch Med Wewn Source Type: research

Ischemic strokes in congenital bleeding disorders: comparison with myocardial infarction and other acute coronary syndromes.
CONCLUSIONS: The significance of these findings is discussed in view of the discrepancies observed between Ischemic stroke and Myocardial infarction. PMID: 27305946 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - June 18, 2016 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi.
Conclusions -We provide evidence that NAC is an effective and safe alternative to currently available antithrombotic agents to restore vessel patency after arterial occlusion. PMID: 28487393 [PubMed - as supplied by publisher]
Source: Circulation - May 9, 2017 Category: Cardiology Authors: Martinez de Lizarrondo S, Gakuba C, Herbig BA, Repessé Y, Ali C, Denis CV, Lenting P, Touzé E, Diamond SL, Vivien D, Gauberti M Tags: Circulation Source Type: research

Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury
Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressive stroke can still develop despite successful recanalization, a process termed “reperfusion injury.” Mounting experimental evidence suggests that platelets and T cells contribute to cerebral ischemia/reperfusion injury, and ischemic stroke is increasingly considered a thrombo-inflammatory disease. The inte...
Source: Frontiers in Immunology - October 31, 2019 Category: Allergy & Immunology Source Type: research

Von Willebrand Factor and the Risk of Dementia: A Population-Based Study (P1.092)
Conclusions: Higher levels of Von Willebrand factor are associated with an increased risk of dementia, including Alzheimer’s disease, possibly due to direct prothrombotic effects or secondary to endothelial injury.Disclosure: Dr. Wolters has nothing to disclose. Dr. Boender has nothing to disclose. Dr. Hofman has nothing to disclose. Dr. De Maat has nothing to disclose. Dr. Koudstaal has nothing to disclose. Dr. Leebeek has received research support from Baxter and CSL Behring. Dr. Ikram has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Wolters, F., Boender, J., Hofman, A., De Maat, M., Koudstaal, P., Leebeek, F., Ikram, M. Tags: Epidemiology of Aging and Dementias Source Type: research

Recurrent ischemic strokes as the initial presentation of thrombotic thrombocytopenic purpura with normal platelets: a case report. (P1.296)
Conclusions:Recurrent strokes in multiple vascular territories should prompt suspicion of hypercoagulable, cardioembolic, or vasculitis/opathy. TTP can be a cause of hypercoagulability in patients with cryptogenic stroke even without major hematologic abnormalities. TTP is treatable with plasma exchange and immunosuppression. Thus, one must consider TTP even in the absence of hematologic abnormalities, especially in a young patient with no stroke risk factors and otherwise negative stroke work-up.Disclosure: Dr. Horton has nothing to disclose. Dr. Doyle has nothing to disclose. Dr. Powell has received research support from...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Horton, L., Doyle, A., Powell, C., Gebreyohanns, M. Tags: Cerebrovascular Disease Case Reports I Source Type: research