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Total 633 results found since Jan 2013.
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies
Publication date: Available online 11 April 2018 Source:The Lancet Diabetes & Endocrinology Author(s): Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown Background In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying this superiority and the pathogenesis of resistant hypertension. Methods PATHWA...
Source: The Lancet Diabetes and Endocrinology - April 12, 2018 Category: Endocrinology Source Type: research
Jan Medical begins coop BrainPulse testing with the US Army
Jan Medical said today that it has launched a cooperative research and development deal with the US Army Medical Materiel Agency to evaluate its BrainPulse device.
Jan Medical’s BrainPulse device is designed to non-invasively capture novel physiological signals through a patient’s cardiac output, used to measure vascular and brain tissue conditions, the company said. The data can be used as an ‘aid to diagnoses’ for multiple indications, including concussion and stroke.
Initial testing as part of the R&D program was completed on March 9, with the first user feedback session conducted today, the Mountain View, ...
Source: Mass Device - April 10, 2018 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Neurological Research & Development Jan Medical Source Type: news
Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study
Publication date: Available online 9 April 2018 Source:The Lancet Respiratory Medicine Author(s): Gregor Warnecke, Dirk Van Raemdonck, Michael A Smith, Gilbert Massard, Jasleen Kukreja, Federico Rea, Gabriel Loor, Fabio De Robertis, Jayan Nagendran, Kumud K Dhital, Francisco Javier Moradiellos Díez, Christoph Knosalla, Christian A Bermudez, Steven Tsui, Kenneth McCurry, I-Wen Wang, Tobias Deuse, Guy Lesèche, Pascal Thomas, Igor Tudorache, Christian Kühn, Murat Avsar, Bettina Wiegmann, Wiebke Sommer, Arne Neyrinck, Marco Schiavon, Fiorella Calebrese, Nichola Santelmo, Anne Olland, Pierre-Emanuel Falcoz, Andre R Simon, A...
Source: The Lancet Respiratory Medicine - April 10, 2018 Category: Respiratory Medicine Source Type: research
Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical
AbstractThe first annual Stroke Translational Research Advancement Workshop (STRAW), entitled “Uncovering the Rosetta Stone: Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical” was held at the University of Kentucky on October 4–5, 2017. This workshop was organized by the Center for Advanced Translational Stroke Science. The workshop consisted of 2 days of a ctivities. These included three presentations establishing the areas of research in stroke therapeutics, discussing the routes for translation from bench to bedside, and identifying successes and failures in the field. On day 2, grant ...
Source: Translational Stroke Research - April 10, 2018 Category: Neurology Source Type: research
Brainomix raises $10m for AI stroke imaging tech
Brainomix said today that it raised nearly $10 million for the e-ASPECTS stroke imaging technology it’s developing using artificial intelligence.
The £7 million round was led by Parkwalk Advisors, joined by existing backers Chimera Partners and Oxford University Innovation Fund and the venture arm of pharma giant Boehringer Ingelheim.
Oxford, England-based Brainomix said its tech is designed to automate the evaluation of stroke patients using CT scan data and the Alberta Stroke Program Early CT Score method. The funds are earmarked for commercializing e-ASPECT, the company said.
“We welcome Boehringer Ingelhe...
Source: Mass Device - April 3, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Diagnostics Funding Roundup Imaging Neurological Boehringer Ingelheim Pharmaceuticals Brainomix Stroke Source Type: news
Neuroscience is the Next Oncology
by Michael D. Ehlers, MD, PhD
Dr. Ehlers is with Biogen in Cambridge, Massachusetts.
Innov Clin Neurosci. 2018;15(3–4):15–16
Funding: No funding was received for the preparation of this article.
Disclosures: Dr. Ehlers is an employee and shareholder at Biogen Inc. in Cambridge, Massachusetts.
Prominent and expensive failures in Alzheimer’s disease therapies have led to a contagious belief system in some parts of the biopharma industry that neuroscience is just too hard, too risky, and too uncertain. But, might this belief system itself be a residual bias of the past? Close inspection reveals all the signs of a coming...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Commentary Current Issue Source Type: research
AI firm Infervision scores $47M in funding
Chinese artificial intelligence (AI) software developer Infervision completed...Read more on AuntMinnie.comRelated Reading:
Infervision debuts AI stroke screening software
AI developer Infervision adds to coffers
Source: AuntMinnie.com Headlines - March 20, 2018 Category: Radiology Source Type: news
Dr. A.M. Barrett receives NIH funding to study hand function poststroke
(Kessler Foundation) Regaining hand function after stroke can be a significant factor in returning individuals to their homes, communities, and the workplace. Research indicates that intensive training can be beneficial, but may need to be delivered soon after stroke, during a critical period of heightened plasticity. This project will compare traditional rehabilitation methods with hand training using robotics and game-based virtual reality.
Source: EurekAlert! - Medicine and Health - March 15, 2018 Category: International Medicine & Public Health Source Type: news
6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (SMART-DATE): a randomised, open-label, non-inferiority trial
Publication date: Available online 12 March 2018 Source:The Lancet Author(s): Joo-Yong Hahn, Young Bin Song, Ju-Hyeon Oh, Deok-Kyu Cho, Jin Bae Lee, Joon-Hyung Doh, Sang-Hyun Kim, Jin-Ok Jeong, Jang-Ho Bae, Byung-Ok Kim, Jang Hyun Cho, Il-Woo Suh, Doo-il Kim, Hoon-Ki Park, Jong-Seon Park, Woong Gil Choi, Wang Soo Lee, Jihoon Kim, Ki Hong Choi, Taek Kyu Park, Joo Myung Lee, Jeong Hoon Yang, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon Background Current guidelines recommend dual antiplatelet therapy (DAPT) of aspirin plus a P2Y12 inhibitor for at least 12 months after implantation of drug-eluting stents (DES) in patients...
Source: The Lancet - March 13, 2018 Category: General Medicine Source Type: research
Effectiveness of a community-based educational programme in reducing the cumulative incidence and prevalence of human Taenia solium cysticercosis in Burkina Faso in 2011 –14 (EFECAB): a cluster-randomised controlled trial
This study is registered with ClinicalTrials.gov, number NCT0309339. Findings Two villages in the same randomisation block were excluded, resulting in a final sample size of 58 villages. Overall, the intervention tended towards a decrease in the cumulative incidence of active cysticercosis from baseline to after randomisation (adjusted cumulative incidence ratio 0·65, 95% Bayesian credible interval [95% CrI] 0·39–1·05) and a decrease in active cysticercosis prevalence from baseline to after randomisation (adjusted prevalence proportion ratio 0·84; 95% CrI 0·59–1·18). The intervention was shown to be effective in ...
Source: The Lancet Global Health - March 10, 2018 Category: International Medicine & Public Health Source Type: research
Improving the Health of Americans Through Prevention and Management of Diabetes and Heart Disease and Stroke
Funding to support state investments in implementing and evaluating evidence-based strategies to prevent and manage cardiovascular disease (CVD) and diabetes in high-burden populations/communities within each state and the District of Columbia, contributing to improved health outcomes.
Source: PHPartners.org - March 8, 2018 Category: International Medicine & Public Health Source Type: news
Innovative State and Local Public Health Strategies to Prevent and Manage Diabetes and Heart Disease and Stroke
Funding to support the design, testing, and evaluation of novel approaches to address evidence-based strategies aimed at reducing risks, complications, and barriers to prevention and control of diabetes and cardiovascular disease (CVD) in high-burden populations. Work will occur in state and local/city/county health departments with a population of 900,000 or more where significant reach may be achieved.
Source: PHPartners.org - March 5, 2018 Category: International Medicine & Public Health Source Type: news
Cardiovascular and renal burdens of prediabetes in the USA: analysis of data from serial cross-sectional surveys, 1988 –2014
Publication date: Available online 27 February 2018 Source:The Lancet Diabetes & Endocrinology Author(s): Mohammed K Ali, Kai McKeever Bullard, Sharon Saydah, Giuseppina Imperatore, Edward W Gregg Background There is controversy over the usefulness of prediabetes as a diagnostic label. Using data from US National Health and Nutrition Examination Surveys (NHANES) between 1988 and 2014, we examined the cardiovascular and renal burdens in adults with prediabetes over time and compared patterns with other glycaemic status groups. Methods We analysed cross-sectional survey data from non-pregnant adults aged 20 years an...
Source: The Lancet Diabetes and Endocrinology - February 28, 2018 Category: Endocrinology Source Type: research
Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study
Publication date: Available online 26 February 2018 Source:The Lancet Global Health Author(s): Mayowa O Owolabi, Fred Sarfo, Rufus Akinyemi, Mulugeta Gebregziabher, Onoja Akpa, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Lukman Owolabi, Bruce Ovbiagele Background Sub-Saharan Africa has the highest incidence, prevalence, and fatality from stroke globally. Yet, only little information about context-specific risk factors for prioritising interventions to reduce the stroke burden in sub-Saharan Africa is available. We aimed to identify and characterise the effect of the top modifiable risk factors for stroke in sub-Sahara...
Source: The Lancet Global Health - February 27, 2018 Category: International Medicine & Public Health Source Type: research
Long-running UAB study lands $20M grant
A long-running study based at UAB examining strokes on a racial and regional basis will be funded for another five years, thanks to a $20.4 million dollar grant.
The Reasons for Geographic and Racial Differences in stroke, or REGARDS, study will be funded through 2023 by a grant from the National Institutes of Health’s National Institutes of Neurological Disorders and Stroke. The study has received nearly $100 million in grant funding since it began in 2003
The study, which is based at UAB’s…
Source: bizjournals.com Health Care News Headlines - February 26, 2018 Category: Health Management Authors: Tyler Patchen Source Type: news
