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Condition: Atrial Septal Defect

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Total 129 results found since Jan 2013.

Ischemic Stroke in Children and Young Adults With Congenital Heart Disease Congenital Heart Disease
Conclusions The risk of developing ischemic stroke was almost 11 times higher in young patients with CHD than in the general population, although absolute risk is low. Cardiovascular comorbidities were strongly associated with the development of ischemic stroke in young CHD patients.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Mandalenakis, Z., Rosengren, A., Lappas, G., Eriksson, P., Hansson, P.-O., Dellborg, M. Tags: Epidemiology, Congenital Heart Disease, Ischemic Stroke Source Type: research

Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study
CONCLUSIONS: Certain embolic sources and uncommon causes may be etiologically important causes of ischemic stroke in young adults. However, the contribution of conventional vascular risk factors and lifestyle-related risk factors is not negligible with advancing age, even in young adults.PMID:35830430 | DOI:10.1371/journal.pone.0268481
Source: Atherosclerosis - July 13, 2022 Category: Cardiology Authors: Yuichiro Ohya Ryu Matsuo Noriko Sato Fumi Irie Kuniyuki Nakamura Yoshinobu Wakisaka Tetsuro Ago Masahiro Kamouchi Takanari Kitazono Investigators for Fukuoka Stroke Registry Source Type: research

Toward a better understanding of PFO and stroke risk
A patent foramen ovale (PFO) is a remnant of the fetal circulation and may be found in approximately 25% of adults.1 Multiple case-control studies have demonstrated an association between PFO and cryptogenic ischemic stroke, particularly in younger patients.2 The mechanism for the association is presumed to be venous thromboembolism through the PFO and into the cerebral circulation (i.e., paradoxical embolization).3 Randomized studies of percutaneous PFO closure devices for secondary stroke prevention have been in progress for years with slow enrollment because of off-label use of atrial septal defect closure devices.4,5 T...
Source: Neurology - August 12, 2013 Category: Neurology Authors: Messe, S. R., Kernan, W. N. Tags: Stroke in young adults, Stroke prevention, Prognosis, Embolism EDITORIALS Source Type: research

Percutaneous atrial shunt closure and the risk of recurrent ischemic stroke: A register-based, nationwide cohort study
Patent foramen ovale may cause paradoxical emboli1. Cryptogenic ischemic cerebrovascular events (stroke or transient ischemic attack) (CVE) accounts for about 25% of ischemic strokes.2,3 Transcatheter closure of atrial shunts, including atrial septal defects (ASD) and patent foramen ovale (PFO), was introduced in 1996.4-6 Initially,randomized studies failed7-9 but more recent randomized studies have shown superiority of interventional treatment, with 68 % reduction of recurrent stroke after transcatheter closure of PFO compared with medical treatment in patients with cryptogenic CVE.
Source: Journal of Stroke and Cerebrovascular Diseases - March 23, 2023 Category: Neurology Authors: Alexia Karagianni, Zacharias Mandalenakis, Savvas Papadopoulos, Mikael Dellborg, Peter Eriksson Source Type: research

Gore Takes on Abbott with New PFO Stroke Indication
W.L. Gore & Associates has received FDA approval to expand the indication of the Gore Cardioform Septal Occluder to reduce the risk of recurrent ischemic stroke in patients. The device treats patients through the closure of patent foramen ovale (PFO). Cardioform’s previous indication was for the closure of atrial septal defects that are up to 17mm in size. Gore’s Structural Heart Leader, Jake Goble said Cardioform has the potential to redefine stroke prevention. Goble began working for Gore in 2007. It was around that time the company began to explore the possibility of having the Cardioform focus on stroke prevent...
Source: MDDI - April 3, 2018 Category: Medical Devices Authors: Omar Ford Tags: Cardiovascular Source Type: news

Airplane stroke syndrome
We describe the patient, stroke, and flight characteristics. Over the study period, 131 million passengers arrived at Melbourne airport. Our centre admitted 5727 stroke patients, of whom 42 (0.73%) had flight-related strokes. Flight-related stroke patients were younger (median age 65 versus 73, p<0.001), had similar stroke severity, and received intravenous thrombolysis more often than non-flight-related stroke patients. Seven patients had flight-related intracerebral haemorrhage. The aetiology of the ischaemic strokes was cardioembolic in 14/35 (40%), including seven patients with confirmed PFO, one with atrial sep...
Source: Journal of Clinical Neuroscience - February 20, 2016 Category: Neuroscience Source Type: research

ESOC 2017 Roundup: Gore touts lowered ischemic stroke, new brain infarcts in PFO Occluder test
W.L. Gore & Associates yesterday released results from the Reduce study of its Cardioform Septal Occluder devices used to close patent foramen ovale, touting a reduction in recurrent ischemic strokes and new brain infarcts. The Gore Cardioform Septal Occluder is designed to be inserted via catheter and is currently cleared by the FDA for closure of atrial septal defects. “It is of the utmost importance to us to be transparent and share clinical data as quickly as possible. We completed our two-year primary endpoint follow-up with patients in March and have worked diligently to release these important data to the ...
Source: Mass Device - May 17, 2017 Category: Medical Devices Authors: Fink Densford Tags: Cardiac Implants Cardiovascular Catheters Clinical Trials Stryker W.L. Gore & Associates Source Type: news

Does Atrial Septal Defect Increase the Risk of Stroke Following Total Hip and Knee Arthroplasty?
CONCLUSIONS: Patients with ASD undergoing THA and TKA are predisposed to stroke in the postoperative period. Orthopaedic surgeons indicating patients for surgery and internists performing preoperative medical clearance should be aware of these risks and discuss them prior to surgery. The efficacy of pharmacological and surgical measures to reduce postoperative stroke within this patient population should be topics of future investigation. PMID: 29310146 [PubMed - as supplied by publisher]
Source: Surgical Technology International - January 9, 2018 Category: Surgery Tags: Surg Technol Int Source Type: research

Atrial fibrillation and stroke in adult patients with atrial septal defect and the long-term effect of closure
Conclusions Patients with ASD had a higher risk of first-time AF after closure than the comparison cohort. There was no effect of closure on the use of AF-related medicine in patients with prevalent AF.
Source: Heart - April 9, 2015 Category: Cardiology Authors: Nyboe, C., Olsen, M. S., Nielsen-Kudsk, J. E., Hjortdal, V. E. Tags: Congenital heart disease in adult patients, Congenital heart disease, Drugs: cardiovascular system, Epidemiology Source Type: research

Ischemic Stroke Occurring During Intercourse in Young Women on Oral Contraceptives
We present 2 cases of young women taking oral contraceptives, each presenting with an ischemic stroke. Transthoracic echocardiography revealed a patent foramen ovale in one patient and an atrial septal defect in the other. The most likely cause of stroke in both patients is embolic. Despite conflicting evidence, young patients presenting with ischemic stroke and found to have a patent foramen ovale or atrial septal defect should be considered for possible device-based closure.
Source: The American Journal of Cardiology - May 19, 2014 Category: Cardiology Authors: P. Elliott Miller, Lorrel Brown, Paras Khandheria, Jon R. Resar Tags: Case Report Source Type: research

Closing patent foramen ovale in cryptogenic stroke: The underscored importance of other interatrial shunt variants.
Abstract Recent trials and metanalysis even not fully conclusive and still debated, at least suggested that mechanical device-based closure of patent foramen ovale (PFO) is more effective than medical therapy in prevent recurrence of stroke. In a proportion ranging from 20% to nearly 40% of patients in literature, PFO is associated to atrial septal aneurysm (ASA): ASA is a well-known entity often associated with additional fenestration. Additionally small atrial septal defects ("Flat ASD") can present with signs of paradoxical embolism and cannot be easily detected by transthoracic echocardiography or even by tran...
Source: World Journal of Cardiology - June 26, 2015 Category: Cardiology Authors: Rigatelli G, Rigatelli A Tags: World J Cardiol Source Type: research

Atrial Septal Defect and the Risk of Ischemic Stroke in the Perioperative Period of Noncardiac Surgery
Stroke is a serious complication of non-cardiac surgery. Congenital defects of the interatrial septum may be a potent risk factor for perioperative stroke. The aim of the present study was to determine the association between atrial septal defect (ASD) or patent foramen ovale (PFO) and in-hospital perioperative ischemic stroke after non-cardiac surgery in a large nationwide cohort of patients hospitalized in the United States. Patients undergoing noncardiac surgery between 2004 and 2014 were identified using the Healthcare Cost and Utilization Project's National Inpatient Sample.
Source: The American Journal of Cardiology - July 14, 2019 Category: Cardiology Authors: Nathaniel R. Smilowitz, Varun Subashchandran, Jeffrey S. Berger Source Type: research

Simultaneous onset of myocardial infarction and ischemic stroke in a patient with atrial fibrillation: Multiple territory injury revealed on angiography and magnetic resonance
An 84-year-old man with a history of hypertension and paroxysmal atrial fibrillation (AF) who received no anticoagulant drugs experienced acute chest pain and transient loss of consciousness. He was transferred to our emergency room. His initial electrocardiogram showed sinus rhythm with ST-segment elevation in the I, aVL, and V1–V6 leads. His blood pressure was 158/92mmHg and his pulse was regular at 70beats per minute. A chest radiograph showed increased heart size and pulmonary vascular congestion. His troponin T level was elevated (more than 0.1ng/mL). He was diagnosed with ST-elevation myocardial infarction (MI) and...
Source: International Journal of Cardiology - February 4, 2014 Category: Cardiology Authors: Osamu Hashimoto, Kozo Sato, Yohei Numasawa, Joji Hosokawa, Masahiro Endo Tags: Online Letters to the Editor Source Type: research

Orthodeoxia-platypnea syndrome and stroke: Overlapping pathophysiology
Orthodeoxia-platypnea syndrome (OPS) is a rare cause of dyspnea and hypoxemia induced by upright positioning due to orthostatic conditions [1]. Right-to-left interatrial shunt due to an atrial septal defect or patent foramen ovale (PFO) is the most common cause of this syndrome [2]. Although PFO has been implicated as a potential cause of paradoxical embolism and cerebral embolism in cryptogenic stroke [3], OPS due to PFO has rarely been described presenting as stroke [2,4,5].
Source: Journal of the Neurological Sciences - June 24, 2015 Category: Neurology Authors: Célia Machado, Ricardo Pereira, José Amorim, Carlos Galvão, João Pinho, Carla Ferreira, João Rocha Tags: Letter to the Editor Source Type: research