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Specialty: Cardiology
Condition: Patent Foramen Ovale

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Total 614 results found since Jan 2013.

ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden
CONCLUSION: ADAMTS-13 activity is inversely correlated with the number of vascular risk factors across different stroke etiologies. Further study is warranted to establish ADAMTS-13 as a mediator of cerebrovascular risk.PMID:36703637 | PMC:PMC9871749 | DOI:10.3389/fneur.2022.1045478
Source: Atherosclerosis - January 27, 2023 Category: Cardiology Authors: Gerrit M Grosse Andrei Leotescu Jan-Thorben Sieweke Sonja Schneppenheim Ulrich Budde Nora L Ziegler Saskia Biber Maria M Gabriel Johanna Ernst Ramona Schuppner Ralf Lichtinghagen Udo Bavendiek Julian Widder Karin Weissenborn Source Type: research

Patent Foramen Ovale, Subclinical Cerebrovascular Disease, and Ischemic Stroke in a Population-Based Cohort
ConclusionsIn this community-based cohort, PFO was not associated with an increased risk of clinical stroke or subclinical cerebrovascular disease.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 24, 2013 Category: Cardiology Source Type: research

Implanted endocardial lead characteristics and risk of stroke or transient ischemic attack
Conclusions Most physical characteristics of contemporary leads do not impact rate of stroke/TIA among patients receiving implantable devices. The presence of a PFO is a major risk factor for stroke/TIA in patients with endovascular leads.
Source: Journal of Interventional Cardiac Electrophysiology - September 25, 2014 Category: Cardiology Source Type: research

Device Closure of Patent Foramen Ovale After Stroke Pooled Analysis of Completed Randomized Trials
ConclusionsAmong patients with PFO and cryptogenic stroke, closure reduced recurrent stroke and had a statistically significant effect on the composite of stroke, transient ischemic attack, and death in adjusted but not unadjusted analyses.
Source: Journal of the American College of Cardiology - February 23, 2016 Category: Cardiology Source Type: research

Young Paradoxical Stroke Treated Successfully with Mechanical Thrombectomy Using Solitaire and Transcatheter Closure of Patent Foramen Oval.
We report the case of a 27-year-old woman with a massive cerebral infarction but no evidence for any atherosclerosis, who received an urgent mechanical thrombectomy with a Solitaire device. In order to ascertain the etiology of stroke, transcranialDoppler (TCD) and transesophageal echocardiograph (TEE) were conducted. TCD showed severe right-to-left shunting (shower effect) after Valsalva maneuver and bubble test and TEE identified a PFO. Therefore, the patient had suffered a paradoxical stroke associated with PFO. After two weeks of the stroke onset, transcatheter PFO closure with Cardio-O-Fix occluder was also performed ...
Source: International Heart Journal - October 3, 2017 Category: Cardiology Tags: Int Heart J Source Type: research

Patent foramen ovale closure vs. medical therapy for cryptogenic stroke: a meta-analysis of randomized controlled trials
ConclusionIn selected patients with cryptogenic stroke, PFO closure is superior to medical therapy for the prevention of further stroke: this is particularly true for patients with moderate-to-large shunts. Guidelines should be updated to reflect this.
Source: European Heart Journal - March 24, 2018 Category: Cardiology Source Type: research

Patent foramen ovale closure reduces recurrent stroke risk in cryptogenic stroke: A systematic review and meta-analysis of randomized controlled trials.
CONCLUSION: PFO device closure in appropriately selected patients with moderate to severe right-to-left shunt and/or atrial septal aneurysm shows benefit with respect to recurrent strokes, particularly in younger patients. Further studies are essential to evaluate the impact of higher incidence of atrial fibrillation seen with the PFO closure device on long-term mortality and stroke rates. PMID: 29983901 [PubMed]
Source: World Journal of Cardiology - June 26, 2018 Category: Cardiology Authors: Anantha-Narayanan M, Anugula D, Das G Tags: World J Cardiol Source Type: research

Surgical vs. drug therapy in patients with patent foramen ovale and cryptogenic stroke.
CONCLUSION: Compared with drug therapy, PFO closure reduced the risk of recurrent stroke among patients with a risk score of ≥2 and reduced the incidence of serious bleeding without increasing the risk of new-onset atrial fibrillation or atrial flutter. PMID: 32394019 [PubMed - as supplied by publisher]
Source: Herz - May 14, 2020 Category: Cardiology Tags: Herz Source Type: research

Long-term risk of recurrent cerebrovascular events after patent foramen ovale closure: Results from a real-world stroke cohort
CONCLUSION: In this long-term follow-up-study of patients with a cerebral ischaemic event who had received PFO-closure with different devices, rates of recurrent stroke/TIA were low and largely related to large artery atherosclerosis and small vessel disease. Thorough vascular risk factor control seems crucial for secondary stroke prevention in patients treated for PFO-related stroke.PMID:37658692 | DOI:10.1177/23969873231197564
Source: Atherosclerosis - September 2, 2023 Category: Cardiology Authors: Markus Kneihsl Susanna Horner Isra Hatab Nora Sch öngrundner Diether Kramer Gabor Toth-Gayor Gernot Grangl Gerit W ünsch Simon Fandler-H öfler Melanie Haidegger Natalie Berger Sai Veeranki Urs Fischer Christian Enzinger Thomas Gattringer Source Type: research

Stroke or Transient Ischemic Attack in Patients with Transvenous Pacemaker or Defibrillator and Echocardiographically Detected Patent Foramen Ovale.
CONCLUSIONS: In patients with endocardial leads, the presence of a PFO on routine echocardiography is associated with a substantially increased risk of embolic stroke/TIA. This finding suggests a role of screening for PFOs in patients who require CIEDs, if detected, PFO closure, anticoagulation, or non-vascular lead placement may be considered. PMID: 23946264 [PubMed - as supplied by publisher]
Source: Circulation - August 14, 2013 Category: Cardiology Authors: Desimone CV, Friedman PA, Noheria A, Patel NA, Desimone DC, Bdeir S, Aakre CA, Vaidya VR, Slusser JP, Hodge DO, Ackerman MJ, Rabinstein AA, Asirvatham SJ Tags: Circulation Source Type: research

Patent foramen ovale closure or medical therapy for cryptogenic ischemic stroke: an updated meta-analysis of randomized controlled trials
ConclusionsPFO-C after cryptogenic ischemic stroke is safe and effective to reduce the risk of recurrent stroke and recurrent stroke  + TIA, albeit with an increased risk for NOAF.
Source: Clinical Research in Cardiology - March 2, 2018 Category: Cardiology Source Type: research

Implications of detection of foramen ovale patent after cryptogenic ischemic stroke
ConclusionPFO ’s (size and complexity) and patients’ characteristics influenced clinical decision when PFO was detected on TEE. The risk for recurrent stroke was not increased in patients who did not undergo PFO closure; although two patients waiting for PFO closure had recurrent stroke, demonstrating its imp ortance.
Source: Journal of Echocardiography - July 14, 2018 Category: Cardiology Source Type: research

Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated meta-analysis of randomized trials.
CONCLUSION: In certain groups of patients presenting with stroke, PFOC is beneficial in preventing future stroke compared to medical therapy. PMID: 31110604 [PubMed]
Source: World Journal of Cardiology - April 25, 2019 Category: Cardiology Authors: Dahal K, Yousuf A, Watti H, Liang B, Sharma S, Rijal J, Katikaneni P, Modi K, Tandon N, Azrin M, Lee J Tags: World J Cardiol Source Type: research