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Specialty: Neuroscience
Condition: Pain

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Total 180 results found since Jan 2013.

MMP ‐9 in translation: from molecule to brain physiology, pathology, and therapy
This article is part of the 60th Anniversary special issue. MMP‐9, through cleavage of specific target proteins, plays a major role in synaptic plasticity and neuroinflammation, and by those virtues contributes to brain physiology and a host of neurological and psychiatric disorders. This article is part of the 60th Anniversary special issue.
Source: Journal of Neurochemistry - March 20, 2016 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Bench to Bedside Source Type: research

Motor Cortex Neurostimulation Technologies for Chronic Post-stroke Pain: Implications of Tissue Damage on Stimulation Currents
Anthony T. O ’Brien, Rivadavio Amorim, R. Jarrett Rushmore, Uri Eden, Linda Afifi, Laura Dipietro, Timothy Wagner, Antoni Valero-Cabré
Source: Frontiers in Human Neuroscience - November 9, 2016 Category: Neuroscience Source Type: research

Intravascular lymphoma mimicking vasculitis
This report documents the presence of intravascular lymphoma diagnosed on a brain biopsy in a 60-year-old man. He initially presented 6months before brain biopsy with chest pain and hypotension, warranting coronary artery bypass graft surgery. Four months later, he presented with signs attributed to a stroke (diaphoresis, slumped over in a chair and left hand weakness). He subsequently developed a sudden onset wide-based gait, left leg numbness, word finding difficulties and worsening confusion. A MRI study showed multiple infarcts in the brain, including cerebellum. Invasive angiogram suggested vasculitis. He was started ...
Source: Journal of Clinical Neuroscience - November 10, 2016 Category: Neuroscience Source Type: research

The effects of ultrasound-guided corticosteroid injection for the treatment of hemiplegic shoulder pain on depression and anxiety in patients with chronic stroke
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Source: International Journal of Neuroscience - January 25, 2017 Category: Neuroscience Authors: Min Cheol Chang Source Type: research

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do not ...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research

The effects of ultrasound-guided corticosteroid injection for the treatment of hemiplegic shoulder pain on depression and anxiety in patients with chronic stroke
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Source: International Journal of Neuroscience - January 25, 2017 Category: Neuroscience Authors: Min Cheol Chang Source Type: research

The role of regulatory T cells in nervous system pathologies
Regulatory T (Treg) cells are a special subpopulation of immunosuppressive T cells that are essential for sustaining immune homeostasis. They maintain self‐tolerance, inhibit autoimmunity, and act as critical negative regulators of inflammation in various pathological states including autoimmunity, injury, and degeneration of the nervous system. Treg cells are known to convey both beneficial and detrimental influences in certain disease contexts, and accumulating research suggests that their action may be altered in a range of peripheral and central nervous system pathologies. In this review, we discuss emerging evidence...
Source: Journal of Neuroscience Research - May 10, 2017 Category: Neuroscience Authors: Samuel S. Duffy, Brooke A. Keating, Chamini J. Perera, Gila Moalem ‐Taylor Tags: REVIEW Source Type: research

Cannabinoids for Treatment of MS Symptoms: State of the Evidence
AbstractPurpose of ReviewCannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible d...
Source: Current Neurology and Neuroscience Reports - June 19, 2018 Category: Neuroscience Source Type: research

Quality of life among children who had undergone ventriculoperitoneal shunt surgery
Conclusion: Children who underwent VP shunt face various health-related problems in different domains and low QOL. Although cognitive domain was the most affected, multiple surgeries had the most significant impact on QOL. Appropriately focused interventions and holistic management are essential to improve the QOL of children undergoing VP shunt.
Source: Journal of Pediatric Neurosciences - July 5, 2018 Category: Neuroscience Authors: Priyanka Prakash Manju Dhandapani Sandhya Ghai Neena V Singh Sivashanmugam Dhandapani Source Type: research

Noninvasive neuromodulation for rehabilitation of sensorimotor function and reduction of chronic pain
ConclusionFurther efforts are warranted to adapt neuromodulation/neurostimulation protocols per patient owing to neuroplastic changes that favor vs. hinder improvement of function. A sole solution for all cases is not suggested. An individualized approach relying on biomarkers and clinical outcomes should ease the implementation in clinical practice of noninvasive neuromodulation as an innovative therapeutic option to speed-up recovery towards gains beyond those already reached, thus to further improve the quality of life.
Source: Neurophysiologie Clinique - August 1, 2018 Category: Neuroscience Source Type: research

Neuroscience and Greek mythology.
This article highlights the major reflections of ancient Greek mythology in modern neuroscience. An analysis of ancient Greek texts and medical literature using the MeSH term mythology was performed to identify mythological references pertaining to neuroscience. The findings are discussed in relation to etymology, early conceptualization of the nervous system structure and function, incipient characterization of neuropsychiatric disease, and philosophical stance to the practice of medicine in ancient Greece. The search identified numerous observations in clinical neurology (e.g., stroke, epilepsy, cognitive and movement di...
Source: Journal of the History of the Neurosciences - October 18, 2018 Category: Neuroscience Tags: J Hist Neurosci Source Type: research

Fast Intracortical Sensory-Motor Integration: A Window Into the Pathophysiology of Parkinson ’s Disease
Conclusion and Outlook In this review, we have discussed the possible contributions of the fast-afferent somatosensory pathway, the intracortical integrative component and the fast-efferent corticomotor pathway to alterations of SAI in PD. We concluded that PD-related changes in SAI are most likely caused at the cortical level, where sensory input is rapidly integrated into a motor output. This makes SAI a useful tool to probe how PD impacts on the sensorimotor integration processing at the cortical level. Studies performed on PD patients have shown variable results, ranging from reduced to normal or even enhanced SAI fi...
Source: Frontiers in Human Neuroscience - April 7, 2019 Category: Neuroscience Source Type: research

Transcranial Direct Current Stimulation Use in Warfighting: Benefits, Risks, and Future Prospects
Conclusion The aim of this paper was to examine whether military tDCS use can be efficacious and ethical in military settings. Our assessment is that tDCS offers a number of cognitive, motor, and perceptual enhancement opportunities which could provide value in military situations like training and operations. There is potential scope for use in a number of key areas that directly affect practical battlefield advantage and survivability, such as deceptive capabilities, risk-taking, threat detection, perception, and physiological improvement. Additionally, tDCS has the potential to improve command and control decision maki...
Source: Frontiers in Human Neuroscience - April 17, 2019 Category: Neuroscience Source Type: research

Muscle Synergies During Repetitive Stoop Lifting With a Bioelectrically-Controlled Lumbar Support Exoskeleton
Conclusions Our current study aims to examine the effects of a lumbar support exoskeleton from the perspective of muscle coordination with muscle synergy analysis. For our experimental protocol, we assumed a fixed spatial set of muscle synergy weights, but variable recruitment (timing coefficients) for each condition. Chvatal and Ting (2012) provided evidence in their results and cited a multitude of studies that strongly support the assumption that modifications in human walking can be attributed to variances in the recruitment of spatially-fixed muscle synergies. Our results indicate that muscle coordination patterns a...
Source: Frontiers in Human Neuroscience - April 29, 2019 Category: Neuroscience Source Type: research

Establishment of optimal two-point discrimination test method and consideration of reproducibility
Publication date: Available online 30 September 2019Source: Neuroscience LettersAuthor(s): Hirotake Yokota, Naofumi Otsuru, Rie Kikuchi, Rinako Suzuki, Sho Kojima, Kei Saito, Shota Miyaguchi, Yasuto Inukai, Hideaki OnishiAbstractTwo-point discrimination (TPD) has been widely used as a parameter for the examination of higher-order perceptual functions in the field of rehabilitation. Previous research has shown that the threshold of TPD increases with aging or pathological conditions such as stroke or chronic pain. It has also been reported that the threshold can be decreased by continuous tactile or electrical stimulation. ...
Source: Neuroscience Letters - October 1, 2019 Category: Neuroscience Source Type: research