Fast Intracortical Sensory-Motor Integration: A Window Into the Pathophysiology of Parkinson ’s Disease

This study underscores the importance of chronic stimulation in the modulation of sensorimotor integration and proprioception. The authors considered two possible mechanisms underlying SAI modulation by STN DBS. High-frequency DBS of the STN might normalize synchronization between basal ganglia structures, which might restore the ability of thalamocortical relay cells to respond to depolarizing inputs involved in sensorimotor integration (Brown et al., 2001; Rubin and Terman, 2004). Alternatively, STN DBS might have a direct effect on cortical structures through antidromic stimulation of the cortico-subthalamic pathway. In addition, the delayed effect of STN DBS on SAI may reflect long-term plastic changes in the sensorimotor cortex (Udupa et al., 2016). Whatever the underlying mechanisms may be, the modulatory effects of STN-DBS on SAI corroborate a sensorimotor integrative function of the STN as suggested by animal studies. Many STN neurons in the monkey (Wichmann et al., 1994) and patients with PD (Hutchison et al., 1998; Rodriguez-Oroz et al., 2001; Theodosopoulos et al., 2003) respond to cutaneous stimuli and passive movements. Alteration of sensory properties of the STN has been observed in animal models of PD. Peripheral sensory stimulation by hind paw pinch led to a greater increase in STN activity in dopamine-depleted rats than controls, suggesting altered STN sensitivity to afferent sensory inputs in the parkinsonian state (Magill et al., 2001). Is SAI Abnormal in...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research

Related Links:

AIM: To investigate the function and progression of non-suicidal self-injury (NSSI) and its relationship with suicide attempts. METHOD: Qualitative in-depth interviews were conducted with 15 adolescents psychiatrically hospitalized following a suic...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
INTRODUCTION: Suicide belongs to the leading causes of maternal perinatal mortality and suicidal ideation is one of the strongest predictors for suicide attempt and completion and thus represents an opportunity for early intervention prior to self and infa...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: The association between air pollution exposure and emotional and behavioural problems in children is unclear. We aimed to assess prenatal and postnatal exposure to several air pollutants and child's depressive and anxiety symptoms, and aggressi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Growing economic inequality across the family and school contexts that adolescents inhabit may have significant consequences for their psychological well-being. Yet little research has assessed the mental health repercussions of economic inequities or whet...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Objective: To investigate the trajectory of sleep deficiency after concussion and examine its role as a predictor of postconcussive symptoms (PCS) over 3 weeks and at 3 months post-concussion. Design: This was a prospective pilot study of 29 ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
In developing their policy on paediatric medical assistance in dying (MAID), DeMichelis, Shaul and Rapoport decide to treat euthanasia and physician-assisted suicide as ethically and practically equivalent to other end-of-life interventions, particularly p...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Poor dual-task gait (walking while performing a cognitively demanding task) has been linked to progression to dementia in older adults with mild cognitive impairment (MCI). However, many of these findings come from research environments; gait p...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
The purpose of this study was to determine changes in balance, postural sway, and quality of life after 6 wk of simulated horseback riding in adults diagnosed with Parkinson's disease. Eight older adults completed two 60-min riding sessions weekly for 6 wk...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
INTRODUCTION: Multiple rehabilitation therapies have been reported to be effective for poststroke balance impairment. However, the comparative effectiveness of these rehabilitation therapies is still unclear. Therefore, the aim of this study is to summaris...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
BACKGROUND: The epidemiology of suicide within the elderly is unique to each cultural setting. In most countries, despite the higher rate of suicide attempts among adolescents and young people, the rate of suicide deaths in the elderly is higher than other...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
More News: Alzheimer's | Ambien | Ativan | Back Pain | Brain | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Cerebellum | Chronic Pain | Databases & Libraries | Deep Brain Stimulation | Dementia | Denmark Health | Depression | Dialysis | Diazepam | Dystonia | Gastroenterology | Genetics | Germany Health | Grants | Heart | Huntington's Disease | Italy Health | Lorazepam | Netherlands Health | Neurology | Neuroscience | Neurosurgery | Niemann-Pick Disease | Orthopaedics | Pain | Pain Management | Parkinson's Disease | Progressive Supranuclear Palsy | Psychiatry | Restless Legs Syndrome | Sleep Disorders | Sleep Medicine | Stroke | Study | Valium