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Condition: Osteoporosis
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Total 249 results found since Jan 2013.

Chronic obstructive pulmonary disease.
Abstract The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes pr...
Source: The Indian Journal of Medical Research - February 1, 2013 Category: Biomedical Science Authors: Vijayan VK Tags: Indian J Med Res Source Type: research

C-reactive protein and fracture risk: European Prospective Investigation into Cancer Norfolk Study
Conclusion: A U-shaped association was observed between CRP and fracture risk. The increased risk of fracture observed at lower end of CRP compared to intermediate levels require further exploration, confirmation in other populations, and investigation into potential biological mechanisms.Highlights:
Source: Bone - July 17, 2013 Category: Orthopaedics Authors: Sara Ahmadi-Abhari, Robert N. Luben, Nicholas J. Wareham, Kay-Tee Khaw Tags: Original Articles Source Type: research

Lack of parental warmth, abuse in childhood linked to multiple health risks in adulthood
This study was also supported by the MacArthur Research Network on Socioeconomic Status and Health through grants from the John D. and Catherine T. MacArthur Foundation, and by grant T32-MH19925 and the Cousins Center for Psychoneuroimmunology at the UCLA.   The UCLA Cousins Center for Psychoneuroimmunology encompasses an interdisciplinary network of scientists working to advance the understanding of psychoneuroimmunology by linking basic and clinical research programs and by translating findings into clinical practice. The center is affiliated with the Semel Institute for Neuroscience and Human Behavior and the David...
Source: UCLA Newsroom: Health Sciences - October 1, 2013 Category: Universities & Medical Training Source Type: news

Effects of calcium intake on the cardiovascular system in postmenopausal women
We present a review of the current literature which provides a balanced summary of the possible beneficial and adverse effects of calcium intake in postmenopausal women on cardiovascular parameters. Taking into account the modest effect of calcium supplementation in reducing fracture rates, a reassessment of the role, benefits and adverse effects of calcium supplements should be conducted in postmenopausal women.
Source: Atherosclerosis - October 14, 2013 Category: Cardiology Authors: D. Challoumas, C. Cobbold, G. Dimitrakakis Tags: Reviews Source Type: research

Insomnia as a risk factor for ill health: results from the large population‐based prospective HUNT Study in Norway
Summary Insomnia co‐occurs with many health problems, but less is known about the prospective associations. The aim of the current study was to investigate if insomnia predicts cumulative incidence of mental and physical conditions. Prospective population‐based data from the two last Nord‐Trøndelag Health Studies (HUNT2 in 1995–97 and HUNT3 in 2006–08), comprising 24 715 people in the working population, were used to study insomnia as a risk factor for incidence of physical and mental conditions. Insomnia was defined according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM...
Source: Journal of Sleep Research - October 1, 2013 Category: Neurology Authors: Børge Sivertsen, Tea Lallukka, Paula Salo, Ståle Pallesen, Mari Hysing, Steinar Krokstad, Simon Øverland Tags: Regular Research Paper Source Type: research

Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)
Conclusions Among RA patients, there is a high prevalence of comorbidities and their risk factors. In this multinational sample, variability among countries was wide, not only in prevalence but also in compliance with recommendations for preventing and managing these comorbidities. Systematic measurement of vital signs and laboratory testing detects otherwise unrecognised comorbid conditions.
Source: Annals of the Rheumatic Diseases - December 4, 2013 Category: Rheumatology Authors: Dougados, M., Soubrier, M., Antunez, A., Balint, P., Balsa, A., Buch, M. H., Casado, G., Detert, J., El-zorkany, B., Emery, P., Hajjaj-Hassouni, N., Harigai, M., Luo, S.-F., Kurucz, R., Maciel, G., Mola, E. M., Montecucco, C. M., McInnes, I., Radner, H., Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoporosis, Rheumatoid arthritis, Epidemiology, Calcium and bone Clinical and epidemiological research Source Type: research

Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities
A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated. Although the human genome has 19 ALDH genes, one ALDH emerges as a particularly important enzyme in a variety of human pathologies. This ALDH, ALDH2, is located in the mitochondrial matrix with much known about its role in ethanol metabolism. Less known is a new body of research to be discussed in this review, suggesting that ALDH2 dysfunction may contribute to a variety of h...
Source: Physiological Reviews - January 1, 2014 Category: Physiology Authors: Chen, C.-H., Ferreira, J. C. B., Gross, E. R., Mochly-Rosen, D. Tags: Articles Source Type: research

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
Abstract A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated. Although the human genome has 19 ALDH genes, one ALDH emerges as a particularly important enzyme in a variety of human pathologies. This ALDH, ALDH2, is located in the mitochondrial matrix with much known about its role in ethanol metabolism. Less known is a new body of research to be discussed in this review, suggesting that ALDH2 dysfunction may contribute...
Source: Physiological Reviews - January 1, 2014 Category: Physiology Authors: Chen CH, Ferreira JC, Gross ER, Mochly-Rosen D Tags: Physiol Rev Source Type: research

Falls and comorbidity: The pathway to fractures.
CONCLUSIONS: The results suggest that the overall reduction in fractures can be explained by reduction in falls related comorbidity. PMID: 24434943 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - January 16, 2014 Category: Global & Universal Authors: Jørgensen TS, Hansen AH, Sahlberg M, Gislason GH, Torp-Pedersen C, Andersson C, Holm E Tags: Scand J Public Health Source Type: research

The association between self-reported history of physical diseases and psychological distress in a community-dwelling Japanese population: the Ohsaki Cohort 2006 Study
Conclusions: Subjects with a history of physical disease were significantly and positively associated with psychological distress, and social support did not modify this association for most physical diseases. Even after patients have left hospital following treatment for physical disease, they require continuous monitoring for psychological distress by doctors and paramedics.
Source: The European Journal of Public Health - January 24, 2014 Category: Journals (General) Authors: Nakaya, N., Kogure, M., Saito-Nakaya, K., Tomata, Y., Sone, T., Kakizaki, M., Tsuji, I. Tags: Mental health Source Type: research

Agreement between self-reported and general practitioner-reported chronic conditions among multimorbid patients in primary care - results of the MultiCare cohort study
Conclusions: For multimorbidity research, the knowledge of diseases with high disagreement levels between the patients' perceived illnesses and their physicians' reports is important. The analysis shows that different patient characteristics have an impact on the agreement. Findings from this study should be included in the development of clinical guidelines for multimorbidity aiming to optimize health care. Further research is needed to identify more reasons for disagreement and their consequences in health care.Trial registration: ISRCTN89818205.
Source: BMC Family Practice - March 1, 2014 Category: Primary Care Authors: Heike HansenIngmar SchäferGerhard SchönSteffi Riedel-HellerJochen GensichenSiegfried WeyererJuliana PetersenHans-Helmut KönigHorst BickelAngela FuchsSusanne HöfelsBirgitt WieseKarl WegscheiderHendrik van den BusscheMartin Scherer Source Type: research

Clinical prediction rules in practice: review of clinical guidelines and survey of GPs.
CONCLUSION: GPs use CPRs to guide management but also to comply with local policy requirements. Future research could focus on which clinical areas clinicians would most benefit from CPRs and promoting the use of robust, externally validated CPRs. PMID: 24686888 [PubMed - in process]
Source: The British Journal of General Practice - April 1, 2014 Category: Primary Care Authors: Plüddemann A, Wallace E, Bankhead C, Keogh C, Van der Windt D, Lasserson D, Galvin R, Moschetti I, Kearley K, O'Brien K, Sanders S, Mallett S, Malanda U, Thompson M, Fahey T, Stevens R Tags: Br J Gen Pract Source Type: research

Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan.
Conclusion: People diagnosed with OSA are at increased risk for subsequent osteoporosis. PMID: 24735427 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - April 15, 2014 Category: Endocrinology Authors: Chen YL, Weng SF, Shen YC, Chou CW, Yang CY, Wang JJ, Tien KJ Tags: J Clin Endocrinol Metab Source Type: research

Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men.
CONCLUSIONS: Vitamin D alone is unlikely to prevent fractures in the doses and formulations tested so far in older people. Supplements of vitamin D and calcium may prevent hip or any type of fracture. There was a small but significant increase in gastrointestinal symptoms and renal disease associated with vitamin D and calcium. This review found that there was no increased risk of death from taking calcium and vitamin D. PMID: 24729336 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - April 14, 2014 Category: Journals (General) Authors: Avenell A, Mak JC, O'Connell D Tags: Cochrane Database Syst Rev Source Type: research

Cohort Profile: The Namwon Study and the Dong-gu Study
These two cohorts were designed to examine the increasing burden of chronic diseases among Korean populations. The studies investigated determinants for stroke, osteoporosis, dementia and cancer among middle-aged and elderly Korean populations. The Namwon Study baseline survey was performed between 2004 and 2007 (n = 10 667), and followed up 4 years later (n = 8157, follow-up rate = 76.5%). The baseline survey of the Dong-gu Study was administered over 2007–2010 (n = 9260), and will be followed up between 2014 and 2015. Questionnaires included assessment of cognitive function, psychiatric health and lifestyle factors...
Source: International Journal of Epidemiology - April 23, 2014 Category: Epidemiology Authors: Kweon, S.-S., Shin, M.-H., Jeong, S.-K., Nam, H.-S., Lee, Y.-H., Park, K.-S., Ryu, S.-Y., Choi, S.-W., Kim, B.-H., Rhee, J.-A., Zheng, W., Choi, J.-S. Tags: Cohort Profiles Source Type: research