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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

A severe, relapsing case of myelin oligodendrocyte glycoprotein IgG-associated CNS inflammation
A 55-year-old man presented in October 2004 with general unease, vomiting, and gait disturbance. Initially diagnosed with an inner ear infection, the patient's symptoms did not improve and he was evaluated further. MRI revealed a cerebellar lesion, which led to the suspicion of a posterior circulation stroke, and he was started on antiplatelet drugs. However, an angiogram suggested no vascular pathology. In March 2011, he had another episode of ataxia and MRI showed a right brainstem lesion. Cryptogenic stroke was reconsidered. In March 2013, the patient developed paraparesis with urinary and bowel symptoms. MRI revealed m...
Source: Neurology Clinical Practice - February 12, 2018 Category: Neurology Authors: Saviour, M., Hamid, S., Moore, P., Mutch, K., Bhojak, M., Duddy, M., Jacob, A. Tags: All Demyelinating disease (CNS), Devic's syndrome, Optic neuritis; see Neuro-ophthalmology/Optic Nerve, Transverse myelitis Case Source Type: research

Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders.
Authors: Tae WS, Ham BJ, Pyun SB, Kang SH, Kim BJ Abstract Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter. The signal contrast in DTI is generated by differences in the Brownian motion of the water molecules in brain tissue. Postprocessed DTI scalars can be used to evaluate changes in the brain tissue caused by disease, disease progression, and treatment responses, which has led to an enormous amount of interest in DTI in clinical research. This review article provides insights into DTI scalars and the biological background of DTI as a relative...
Source: Journal of Clinical Neurology - March 7, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Everything you always wanted to know about sex and Neurology: neurological disability and sexuality
Conclusions Disability proved to be the main variable related to the presence of sexual dysfunction. Patients with ALS had the worst rates of sexual dysfunction. Patients with MS were similar to the control group. As for the PD group, no patient had normal sexuality. Finally, in stroke patients, the presence of comorbidities and their treatment may have negatively influenced sexuality. These findings showed that patients with chronic neurological diseases have sexual dysfunction and underscore the need for neurologists to know and address this problem.RESUMO Las enfermedades neurol ógicas crónicas generan discapacidad af...
Source: Arquivos de Neuro-Psiquiatria - July 26, 2018 Category: Neurology Source Type: research

More Research Is Needed on Lifestyle Behaviors That Influence Progression of Parkinson's Disease
This article highlights some of these challenges in the design of lifestyle studies in PD, and suggests a more coordinated international effort is required, including ongoing longitudinal observational studies. In combination with pharmaceutical treatments, healthy lifestyle behaviors may slow the progression of PD, empower patients, and reduce disease burden. For optimal care of people with PD, it is important to close this gap in current knowledge and discover whether such associations exist. Introduction Parkinson's disease (PD) is an age-related complex progressive neurodegenerative disorder, with key p...
Source: Frontiers in Neurology - April 29, 2019 Category: Neurology Source Type: research

Efficiency and Patient-Reported Outcome Measures From Clinic to Home: The Human Empowerment Aging and Disability Program for Digital-Health Rehabilitation
Discussion: Our results suggest that a tele-health-based approach is both feasible and efficient in providing rehabilitation care to CNDs from clinic to home. Increasing and maintaining participation as well as autonomy in daily routine are promising findings that open up scenarios for the continuity of care at home through DH-care for CNDs.
Source: Frontiers in Neurology - November 18, 2019 Category: Neurology Source Type: research

Neurological Disorders Associated With COVID-19 Hospital Admissions: Experience of a Single Tertiary Healthcare Center
Conclusion: Although the exact prevalence and etiology remain unclear, new onset of neurological disorders, in addition to anosmia, is non-sporadic during the acute COVID-19-infection. Longitudinal follow-up of these patients is required to determine the clinical and functional outcome, treatment response and long-term effects of the SARS-CoV-2 infection.
Source: Frontiers in Neurology - February 19, 2021 Category: Neurology Source Type: research

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases
Transcranial Magnetic Stimulation (TMS) has widespread use in research and clinical application. For psychiatric applications, such as depression or OCD, repetitive TMS protocols (rTMS) are an established and globally applied treatment option. While promising, rTMS is not yet as common in treating neurological diseases, except for neurorehabilitation after (motor) stroke and neuropathic pain treatment. This may soon change. New clinical studies testing the potential of rTMS in various other neurological conditions appear at a rapid pace. This can prove challenging for both practitioners and clinical researchers. Although m...
Source: Frontiers in Neurology - May 20, 2022 Category: Neurology Source Type: research

Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study
This study aims to clarify the role of BoNT-A in the context of non-stroke spasticity (NSS). We enrolled 86 patients affected by multiple sclerosis, spinal cord injury, and traumatic brain injury with clinical indication to perform BoNT-A treatment. Subjects were evaluated before injection and after 1, 3, and 6 months. At every visit, spasticity severity using the modified Ashworth scale, pain using the numeric rating scale, QoL using the Euro Qol Group EQ-5D-5L, and the perceived treatment effect using the Global Assessment of Efficacy scale were recorded. In our population BoNT-A demonstrated to have a significant effect...
Source: Frontiers in Neurology - April 6, 2023 Category: Neurology Source Type: research

Validity, reliability and minimal detectable change of Mini-BESTest Turkish version in neurological disorders
ConclusionsMini-BESTestTR showed significant correlations with other balance assessment measures, and concurrent and convergent validity of Mini-BESTestTR was demonstrated when administered to a sample of patients with chronic stroke, Parkinson ’s disease and multiple sclerosis.
Source: Acta Neurologica Belgica - June 16, 2023 Category: Neurology Source Type: research

Multiple sclerosis lesions that impair memory map to a connected memory circuit
ConclusionsLesion locations associated with memory dysfunction in MS map onto a specific brain circuit centered on the hippocampus. Lesion damage to this circuit fully mediated associations between lesion volume and memory. A circuit-based approach to mapping MS symptoms based on lesions visible on standard structural imaging may prove useful for localization and prognosis of higher order deficits in MS.
Source: Journal of Neurology - August 2, 2023 Category: Neurology Source Type: research

How not to read an EEG: Introductory statements
Misdiagnosis is a major public health issue. However, it is impossible to eliminate diagnostic error from the treatment decision-making process.1 Neurologic conditions, such as stroke, multiple sclerosis, and epilepsy, are at risk for missed, delayed, and wrong diagnoses.2 For patients with seizures, up to 30% referred to epilepsy monitoring units are ultimately discovered to have an alternate diagnosis.3,4 A significant number of patients identified with psychogenic nonepileptic events have had at least one EEG that was misinterpreted as abnormal.4 Seizure-related histories are sometimes nebulous and incomplete. Therefore...
Source: Neurology - December 24, 2012 Category: Neurology Authors: Tatum, W. O. Tags: All Epilepsy/Seizures, EEG HOW NOT TO READ AN EEG Source Type: research

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While pain is neither uncommon nor novel, the concept of central pain (CP) has only recently become a prominent concern in the medical literature. CP results from lesions to the central nervous system caused by conditions such as stroke, multiple sclerosis, epilepsy, Parkinson's disease, and brain and spinal cord injuries. With the incidence of disability from these conditions increasing dramatically worldwide, it is no surprise that the diagnosis and treatment of CP are of growing interest in the fields of pain management, neurology, neurosurgery, and anesthesiology. However, inconsistent and contradictory reporting has e...
Source: Journal of the Neurological Sciences - January 14, 2013 Category: Neurology Authors: Aimee L. Alphonso, Jack W. Tsao Tags: Book Reviews Source Type: research

GRK2 and group I mGluR mediate inflammation‐induced sensitization to excitotoxic neurodegeneration
Abstract Objectives:The concept of inflammation‐induced sensitization is emerging in the field of perinatal brain injury, stroke, Alzheimer disease and multiple sclerosis. However, mechanisms underpinning this process remain unidentified. Methods:We combined in vivo systemic lipopolysaccharide (LPS) or Interleukin‐1β (IL‐1β) induced sensitization of neonatal and adult rodent cortical neurons to excitotoxic neurodegeneration with in vitroIL‐1β sensitization of human and rodent neurons to excitotoxic neurodegeneration. Within these inflammation‐induced sensitization models we assessed metabotropic glutamatergic ...
Source: Annals of Neurology - February 11, 2013 Category: Neurology Authors: Vincent Degos, Stéphane Peineau, Cora Nijboer, Angela M. Kaindl, Stéphanie Sigaut, Géraldine Favrais, Frank Plaisant, Natacha Teissier, Elodie Gouadon, Alain Lombet, Elie Saliba, Graham L. Collingridge, Mervyn Maze, Ferdinando Nicoletti, Cobi Heijnen, Tags: Research Article Source Type: research

Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies
This study demonstrates that NVU regulation can be investigated using OHCs. We observed in this model system an increase in vascularization and a down-regulation of TJ proteins, similar to the vascular changes described in a chronic focus of epileptic patients, and in rodent models of epilepsy or inflammation. We observed that Zonula occludens-1 (ZO-1) protein disappeared after seizures associated with neuronal damage. In these conditions, the angiopoeitin-1 system was down-regulated, and the application of r-angiopoeitin-1 allowed TJ re-assembly. This article demonstrates that organotypic culture is a useful model to deci...
Source: Cerebrospinal Fluid Research - February 7, 2013 Category: Neurology Authors: Mélanie Morin-BrureauFrédéric De BockMireille Lerner-Natoli Source Type: research