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Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Oversleeping: The Effects and Health Risks of Sleeping Too Much
This article originally appeared on the Amerisleep blog. Rosie Osmun is the Creative Content Manager at Amerisleep, a progressive memory foam mattress brand focused on eco-friendly sleep solutions. Rosie writes more posts on the Amerisleep blog about the science of sleep, eco-friendly living, leading a healthy lifestyle and more. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - January 29, 2016 Category: Consumer Health News Source Type: news

Relationship Between Bone Mass And Muscle Weakness In Chronic Neurological Diseases (P3.036)
Conclusions: This study demonstrates greater commitment tendency to bone density in regions with weakness, compared to those without it, this could be related to disuse. This series had insufficient vitamin D. The neurologist should consider bone mass evaluation in patients with chronic muscle weakness.Disclosure: Dr. Gutierrez has nothing to disclose. Dr. Rodriguez has nothing to disclose. Dr. Garcea has nothing to disclose. Dr. Rey has nothing to disclose. Dr. Lepera has nothing to disclose. Dr. Monica has nothing to disclose. Dr. Monica has nothing to disclose. Dr. Eduardo has nothing to disclose. Dr. Berenice has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gutierrez, M., Rodriguez, G. E., Garcea, D., Rey, R., Lepera, S., Monica, E., Monica, D., Eduardo, K., Berenice, S. Tags: General Neurology II Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Evidence for the Importance of Vitamin D Status in Neurologic Conditions
Opinion statement Vitamin D status has been proposed as relevant to many neurological disorders. Data suggest that vitamin D may be important for the development of the nervous system, and it also plays a role in neuroimmunology and neuroprotection. Lower levels of circulating 25-hydroxyvitamin D have been linked with increased risk of multiple sclerosis (MS) and Alzheimer’s disease (AD). While people with amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and stroke have lower vitamin D levels than those without the diseases, it is unclear if this is because hypovitaminosis D contributes to disea...
Source: Current Treatment Options in Neurology - November 4, 2015 Category: Neurology Source Type: research

Vitamin d intake and its protective role in multiple sclerosis: the checkmate to survivin?
Vitamin D has long been speculated to reduce the risk of multiple sclerosis (MS). However, its role in development and modulating the course of MS has yet to be clarified. To date, there is no scientific evidence for the use of vitamin D as monotherapy for MS in clinical practice and perplexities still exist on potential disadvantages of Vitamin D intake. We hypothesize that vitamin D may be effective against MS inhibiting survivin gene expression and thereby affecting the development and progression of the disease. However, decreased levels of survivin may lead to worse outcomes during the acute phase of cardiovascular co...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2016 Category: Drugs & Pharmacology Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

What Causes Facial Nerve Palsy?
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - June 3, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Sunshine and multiple sclerosis
In 1960, Donald Acheson1 made the seminal observation that the global distribution of multiple sclerosis (MS) may be related to available hours of sunshine; this observation was met with disbelief at the time. However, over the subsequent more than 50 years, it has become clear that he may well be right. The effect of sunlight exposure and subsequent vitamin D production (generated by photolysis of 7-dehydrocholesterol in the skin by ultraviolet radiation (UVR)) on the onset and progression of MS has become a significant research focus particularly over the last 10 years, with large-scale clinical trials of vitam...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 2, 2013 Category: Neurosurgery Authors: Taylor, B. V. Tags: Immunology (including allergy), Multiple sclerosis, Stroke Editorial commentaries Source Type: research

Vitamin D and neurology.
Abstract Vitamin D deficiency is associated with a higher risk of multiple sclerosis and also with a higher relapse rate as well as a higher number of MRI lesions. Elders with vitamin D deficiency have worse cognitive performance. Vitamin D deficiency is a risk factor for developing Alzheimer's disease. Ischemic stroke are more frequent and more severe in patients with low vitamin D levels. Carotid atherosclerosis is more frequent and more severe in patients with vitamin D deficiency. Vitamin D deficiency is associated with a higher risk and worse prognosis of Parkinson's disease. In the different neurological dis...
Source: Presse Medicale - September 18, 2013 Category: Journals (General) Authors: Thouvenot E, Camu W Tags: Presse Med Source Type: research

Vitamin D Is A Prognostic Factor Of Amyotrophic Lateral Sclerosis And Confers Protection To Motoneurons In Vitro (P4.084)
CONCLUSIONS:Our findings suggest that vitamin D as a reliable prognostic factor of ALS and support a neuroprotective function of vitamin D on MNs in vitro.Study Supported by:Disclosure: Dr. William has received personal compensation for activities with Novartis, Merck & Co. Inc., Sanofi-Aventis Pharmaceuticals Inc., Biogen Idec, and Actelion. Dr. Tremblier has nothing to disclose. Dr. Plassot has nothing to disclose. Dr. Alphandery has nothing to disclose. Dr. Salsac has nothing to disclose. Dr. Pageot has nothing to disclose. Dr. Juntas-Morales has nothing to disclose. Dr. Scamps has nothing to disclose. Dr. Daures ha...
Source: Neurology - April 9, 2014 Category: Neurology Authors: William, C., Tremblier, B., Plassot, C., Alphandery, S., Salsac, C., Pageot, N., Juntas-Morales, R., Scamps, F., Daures, J. P., Raoul, C. Tags: ALS: Trials and Biomarkers Source Type: research

Hyperhomocysteinemia and neurologic disorders: a review.
This article provides a review of the current literature on the possible roles of eHcy relevant to various neurologic disorders. PMID: 25324876 [PubMed]
Source: Journal of Clinical Neurology - December 2, 2014 Category: Neurology Tags: J Clin Neurol Source Type: research

Bone Morphogenetic Proteins: Inhibitors of Myelination in Development and Disease.
Abstract Myelin, the lipid membrane that surrounds axons, is critical for the propagation of nervous impulses and axonal maintenance. The destruction of myelin or lack of myelin formation due to disease or injury causes severe motor and cognitive disability. Regeneration of myelin is theoretically possible but rarely happens. Myelin is synthesized as the plasma membrane of the oligodendrocyte in the central nervous system. During development, myelin and oligodendrocytes are generated from oligodendrocyte progenitors through a process modulated by extrinsic growth factors signaling to cell-intrinsic proteins. Among...
Source: Vitamins and Hormones - August 20, 2015 Category: Endocrinology Authors: Grinspan JB Tags: Vitam Horm Source Type: research

What Genetics are Associated with Multiple Sclerosis?
Discussion Multiple sclerosis (MS) is “a chronic degenerative, often episodic disease of the central nervous system marked by patchy destruction of the myelin that surrounds and insulates nerve fibers, usually appearing in young adulthood and manifested by one or more mild to severe neural and muscular impairments, as spastic weakness in one or more limbs, local sensory losses, bladder dysfunction, or visual disturbances.” It is a chronic disease and therefore symptoms must occur more than once. The first episode is called an acute demyelinating attack. Fifteen to forty-five percent of children with their first...
Source: PediatricEducation.org - April 4, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

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