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Specialty: Urology & Nephrology
Condition: Hypertension

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Total 232 results found since Jan 2013.

Incidence of Cardiovascular Events after Nephrectomy - A Single Centre, Matched Pair Analysis between Donor and Tumour Nephrectomy in a Long Term Follow-Up
Conclusion: Decline of renal function after nephrectomy is the main risk factor for CVE. Close monitoring of renal function and new onset hypertension is warranted.Urol Int
Source: Urologia Internationalis - June 8, 2016 Category: Urology & Nephrology Source Type: research

Patient awareness and beliefs about the risk factors and comorbidities associated with chronic kidney disease – a mixed‐methods study
ConclusionParticipants had good understanding of some risk factors for CKD (hypertension and diabetes) but limited understanding of others. Awareness of comorbidities was also less than for other chronic conditions. Compared to diabetes and CVD, CKD was perceived to pose less of a threat to life. Patient education that addresses CKD risk factors, comorbidities and outcomes may increase awareness and foster better self‐management for people with CKD.
Source: Nephrology - May 31, 2016 Category: Urology & Nephrology Authors: Pamela A Lopez‐Vargas, Allison Tong, Martin Howell, Richard KS Phoon, Steven J Chadban, Yvonne Shen, Jonathan C Craig Tags: Original Article Source Type: research

Effects of Stenting for Atherosclerotic Renal Artery Stenosis on eGFR and Predictors of Clinical Events in the CORAL Trial.
CONCLUSIONS: Stenting did not influence eGFR in participants with atherosclerotic renal artery stenosis receiving renin-angiotensin system inhibition-based therapy. Predictors of clinical events were traditional risk factors for CKD and cardiovascular disease. PMID: 27225988 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 24, 2016 Category: Urology & Nephrology Authors: Tuttle KR, Dworkin LD, Henrich W, Greco BA, Steffes M, Tobe S, Shapiro JI, Jamerson K, Lyass A, Pencina K, Massaro JM, D'Agostino RB, Cutlip DE, Murphy TP, Cooper CJ Tags: Clin J Am Soc Nephrol Source Type: research

Nocturia indicates a poor health status and increases mortality in male patients with type 2 diabetes mellitus
Conclusions The presence of nocturia was associated with erectile dysfunction, systemic vascular events, higher mortality, and indicated poor health in male with type 2 diabetic mellitus.
Source: International Urology and Nephrology - May 6, 2016 Category: Urology & Nephrology Source Type: research

Climate Change and the Emergent Epidemic of CKD from Heat Stress in Rural Communities: The Case for Heat Stress Nephropathy.
Weiss I, Kanbay M, Wesseling C, Sánchez-Lozada LG, Johnson RJ Abstract Climate change has led to significant rise of 0.8°C-0.9°C in global mean temperature over the last century and has been linked with significant increases in the frequency and severity of heat waves (extreme heat events). Climate change has also been increasingly connected to detrimental human health. One of the consequences of climate-related extreme heat exposure is dehydration and volume loss, leading to acute mortality from exacerbations of pre-existing chronic disease, as well as from outright heat exhaustion and heat stroke. Recent stud...
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 4, 2016 Category: Urology & Nephrology Authors: Glaser J, Lemery J, Rajagopalan B, Diaz HF, García-Trabanino R, Taduri G, Madero M, Amarasinghe M, Abraham G, Anutrakulchai S, Jha V, Stenvinkel P, Roncal-Jimenez C, Lanaspa MA, Correa-Rotter R, Sheikh-Hamad D, Burdmann EA, Andres-Hernando A, Milagres T, Tags: Clin J Am Soc Nephrol Source Type: research

Age and Outcomes Associated with BP in Patients with Incident CKD.
CONCLUSIONS: In veterans with incident CKD, SBP showed different associations in older versus younger patients. The association of higher SBP with adverse outcomes was present but markedly reduced in older individuals, especially in those aged ≥80 years. Elevated DBP showed no consistent association with vascular outcomes in patients with incident CKD. PMID: 27103623 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 20, 2016 Category: Urology & Nephrology Authors: Kovesdy CP, Alrifai A, Gosmanova EO, Lu JL, Canada RB, Wall BM, Hung AM, Molnar MZ, Kalantar-Zadeh K Tags: Clin J Am Soc Nephrol Source Type: research

The Canadian experience using the expanded criteria donor classification for allocating deceased donor kidneys for transplantation
Conclusions The ECD classification identifies kidneys at increased risk for graft loss in Canadian patients. The performance of more granular measures of donor risk (e.g., Kidney Donor Risk Index) and its impact on organ allocation/utilization in Canadian patients requires further study.
Source: Canadian Journal of Kidney Health and Disease - March 23, 2016 Category: Urology & Nephrology Source Type: research

Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.
This systematic review and meta-analysis of 19 trials included 44,989 participants,  with 2496 major cardiovascular events were recorded during a mean 3·8 years of follow-up.  Patients in the more intensive blood pressure-lowering treatment group had mean blood pressure levels of 133/76 mm Hg, compared with 140/81 mm Hg in the less intensive treatment group. Intensive blood pressure-lowering treatment achieved RR reductions for major cardiovascular events (14% [95% CI 4-22]), myocardial infarction (13% [0-24]), stroke (22% [10-32]), albuminuria (10% [3-16]), and retinopathy progression (19% [0-34]). Howe...
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: General Nephrology Hypertension Internal Medicine for Nephrologists Source Type: research

Determinants of Mortality in Patients with Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention
In this study we included 293 consecutive patients with CKD who underwent PCI between 1st January 2007 and 30th September 2012. The primary outcome that we studied was all-cause mortality in a follow-up period of 12-69 months (mean 38.8 ± 21.7). Results: Age (p
Source: Cardiorenal Medicine - February 19, 2016 Category: Urology & Nephrology Source Type: research

Hypertension in late adolescence and cardiovascular mortality in midlife: a cohort study of 2.3 million 16- to 19-year-old examinees
Conclusions Established hypertension at a young age was independently associated with elevated stroke mortality in midlife. This finding warrants confirmatory large-scale long-term follow-up studies to address the distant effects of adolescent hypertension.
Source: Pediatric Nephrology - February 18, 2016 Category: Urology & Nephrology Source Type: research

Hypertension: Blood pressure lowering after lacunar stroke
Nature Reviews Nephrology 12, 126 (2016). doi:10.1038/nrneph.2016.11 Author: Jessica K. Edwards An analysis of >2,500 patients from the SPS3 randomized trial who experienced a lacunar stroke but maintained kidney function has found that intensive blood pressure (BP) lowering (
Source: Nature Reviews Nephrology - February 8, 2016 Category: Urology & Nephrology Authors: Jessica K. Edwards Tags: Research Highlight Source Type: research

Potential role of sodium glucose cotransporter 2 inhibitors in the treatment of hypertension
Purpose of review: The majority of patients with type 2 diabetes mellitus (T2DM) have hypertension requiring combination therapy. Sodium glucose cotransporter 2 (SGLT2) inhibitors are novel glucose-lowering drugs with shared and potentially unique beneficial effects on cardiovascular risk beyond glycemic control. This review focuses on the potential role of SGLT2 inhibitors in the treatment of hypertension associated with T2DM. Recent findings: SGLT2 inhibitors reduce office SBP by 3–5 mmHg and DBP by 2–3 mmHg across all class members. Corresponding clinically meaningful, significant blood pressure (BP) lowering e...
Source: Current Opinion in Nephrology and Hypertension - February 5, 2016 Category: Urology & Nephrology Tags: PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. Brown Source Type: research

Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway
The epithelial Na+ channel (ENaC) is decisive for sodium reabsorption by the aldosterone-sensitive distal nephron (ASDN) of the kidney. ENaC is regulated by the serum- and glucocorticoid-inducible kinase 1 (SGK1), a kinase genomically upregulated by several hormones including glucocorticoids and mineralocorticoids. SGK1 is activated by the serine/threonine kinase mammalian target of rapamycin (mTOR) isoform mTORC2. SGK1 knockout (sgk1–/– mice) impairs renal Na+ retention during salt depletion. The mTOR catalytic site inhibitor, PP242, but not mTORC1 inhibitor rapamycin, inhibits ENaC, decreases Na+ flux in isol...
Source: Nephrology Dialysis Transplantation - January 25, 2016 Category: Urology & Nephrology Authors: Lang, F., Pearce, D. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research

Modulation of stroke risk in chronic kidney disease
Stroke is the second most common cause of death and the leading cause of neurological disability worldwide, with huge economic costs and tragic human consequences. Both chronic kidney disease (CKD) and end-stage kidney disease are associated with a significantly increased risk of stroke. However, to date this has generated far less interest compared with the better-recognized links between cardiac and renal disease. Common risk factors for stroke, such as hypertension, hypercholesterolaemia, smoking and atrial fibrillation, are shared with the general population but are more prevalent in renal patients. In addition, factor...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Arnold, J., Sims, D., Ferro, C. J. Tags: CARDIOVASCULAR NEPHROLOGY Source Type: research

No increased risk of coronary heart disease for patients receiving androgen deprivation therapy for prostate cancer in Chinese/Taiwanese men
This study included 1278 patients with prostate cancer in the study group and 1278 subjects without prostate cancer in the comparison group. Each patient was individually tracked for a 3‐year period to identify those who had subsequently received a diagnosis of CHD. The results showed that the incidence rate of CHD during the 3‐year follow‐up period was 4.69 (95% CI: 2.99–5.48) per 100 person‐years and 2.67 (95% CI: 2.15–3.27) per 100 person‐years for the study and comparison cohort, respectively. The Cox proportional hazard regression showed that the hazard ratio for CHD during the 3‐year follow‐up perio...
Source: Andrology - December 29, 2015 Category: Urology & Nephrology Authors: L. H. Wang, C. K. Liu, C. H. Chen, L. T. Kao, H. C. Lin, C. Y. Huang Tags: Original Article Source Type: research