• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Towards the implementation of optimal cardiac magnetic resonance risk stratification in PAH
Chest. 2023 Jul 30:S0012-3692(23)01066-8. doi: 10.1016/j.chest.2023.07.028. Online ahead of print.ABSTRACTBACKGROUND: The 2022 European pulmonary hypertension (PH) guidelines incorporate cardiac magnetic resonance (CMR) imaging metrics in the risk stratification of pulmonary arterial hypertension (PAH) patients. Thresholds to identify patients at estimated 1-year mortality risks of <5%, 5-20% and >20% are introduced. However, these cut-off values are mostly single center based and require external validation.RESEARCH QUESTIONS: What are the discriminative prognostic properties of the current cardiac magnetic resonanc...
Source: Chest - August 1, 2023 Category: Respiratory Medicine Authors: L R Celant J N Wessels J T Marcus L J Meijboom H J Bogaard F S de Man A Vonk Noordegraaf Source Type: research

Factors Associated With the Development of Tinnitus and With the Degree of Annoyance Caused by Newly Developed Tinnitus
Objectives: Tinnitus is highly prevalent, but only a few risk factors for developing tinnitus are known and little is known about factors associated with the degree of annoyance of new-onset tinnitus. Longitudinal analysis can reveal risk factors associated with the development of tinnitus and might lead to targeted prevention. The aim of this study is twofold. (1) To identify risk factors that are longitudinally associated with the odds of developing tinnitus 5 years later. (2) To identify factors that are cross-sectionally associated with tinnitus annoyance in adults with new-onset tinnitus. Methods: Baseline,...
Source: Ear and Hearing - October 28, 2022 Category: Audiology Tags: Research Article Source Type: research

Longitudinal bidirectional associations between internalizing mental disorders and cardiometabolic disorders in the general adult population
ConclusionsOur findings indicate that INTs increase the risk of both the presence and the onset of CMs in the short term, while CMs may increase the likelihood of the first onset of INTs in the longer term. Further research is needed to better understand the mechanisms underlying the observed associations.
Source: Social Psychiatry and Psychiatric Epidemiology - January 5, 2021 Category: Psychiatry Source Type: research

Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis
AbstractBACKGROUNDPolycystic ovary syndrome (PCOS) is associated with cardiometabolic disease, but recent systematic reviews and meta-analyses of longitudinal studies that quantify these associations are lacking.OBJECTIVE AND RATIONALEIs PCOS a risk factor for cardiometabolic disease?SEARCH METHODSWe searched from inception to September 2019 in MEDLINE and EMBASE using controlled terms (e.g. MESH) and text words for PCOS and cardiometabolic outcomes, including cardiovascular disease (CVD), stroke, myocardial infarction, hypertension (HT), type 2 diabetes (T2D), metabolic syndrome and dyslipidaemia. Cohort studies and case ...
Source: Human Reproduction Update - September 30, 2020 Category: OBGYN Source Type: research

Smoking Does Not Alter Treatment Effect of Intravenous Thrombolysis in Mild to Moderate Acute Ischemic Stroke —A Dutch String-of-Pearls Institute (PSI) Stroke Study
Conclusions: In patients with mild to moderate AIS admitted within 12 h of symptom onset, smoking did not modify treatment effect of thrombolysis.
Source: Frontiers in Neurology - July 30, 2020 Category: Neurology Source Type: research

ICDs Have Come a Long Way in 40 Years
Michel Mirowski and his colleagues gave the field of implantable cardioverter-defibrillators (ICDs) a pretty good start, but what's more impressive is how far the technology has advanced since that first human ICD implant in February 1980. In the past 40 years we've seen ICDs become dramatically smaller, longer lasting, more capable, more personalized, subcutaneous (non-transvenous), and even MRI-firendly. And that's not to mention the advanced data connectivity and monitoring capabilities that the latest technologies offer. So without further ado, let's take a look at the current ICD landscape and the companie...
Source: MDDI - February 4, 2020 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Source Type: news

Opportunistic screening versus usual care for diagnosing atrial fibrillation in general practice: a cluster randomised controlled trial.
CONCLUSION: Opportunistic screening with a single-lead ECG at the discretion of the GP did not result in a higher yield of newly detected cases of AF in patients aged ≥65 years in the community than usual care. For higher participation rates in future studies, more rigorous screening methods are needed. PMID: 31988084 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - January 26, 2020 Category: Primary Care Authors: Kaasenbrood F, Hollander M, de Bruijn SH, Dolmans CP, Tieleman RG, Hoes AW, Rutten FH Tags: Br J Gen Pract Source Type: research

Effect of sildenafil on maternal hemodynamics in pregnancies complicated by severe early-onset fetal growth restriction: planned subgroup analysis from a multicenter randomized placebo-controlled double-blind trial.
CONCLUSIONS: Sildenafil in a dose of 25 mg three times daily increases HR, reduces BP and reduces arterial stiffness in pregnancies complicated by FGR. These changes are modest, consistent with the anticipated vasodilatory effect and their clinical impact on the mother and baby, in both the short- and long-term, remains uncertain. This article is protected by copyright. All rights reserved. PMID: 31432556 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - August 19, 2019 Category: Radiology Authors: Khalil A, Sharp A, Cornforth C, Jackson R, Mousa H, Stock S, Harrold J, Turner MA, Kenny LC, Baker PN, Johnstone ED, von Dadelszen P, Magee L, Papageorghiou AT, Alfirevic Z Tags: Ultrasound Obstet Gynecol Source Type: research

Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease
Conclusion: Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the intracranial carotid artery is most frequently affected. Intracranial arterial calcifications might be associated with imaging markers of SVD and are highly correlated with WMHs, lacunes, and CMBs. Quantification of calcification on CT provides additional information on the pathophysiology of SVD. Intracranial arterial calcification could act as a potential marker of SVD. Introduction Atherosclerosis is a systemic vascular process that is considered a major cause of cerebrovascular and cardiovascular di...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Prevalence and vascular risk factors of basal ganglia calcifications in patients at risk for cerebrovascular disease
Conclusions In this study with patients suspected of acute ischemic stroke, basal ganglia calcifications were common and significantly associated with older age and lower BMI.
Source: Journal of Neuroradiology - April 27, 2019 Category: Radiology Source Type: research

Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Periodontal Disease Is Associated With Increased Risk of Hypertension: A Cross-Sectional Study
Conclusion: Periodontal disease is significantly and positively correlated with increased risk of hypertension in Chinese population, and exact mechanisms of this association should be explored in future. Introduction Periodontal disease is a complex polymicrobial inflammation, including gingivitis and periodontitis. According to the 2015 Global Burden of Disease (GBD) study, the prevalence of severe chronic periodontitis in 2015 has reached 616 million (Kassebaum et al., 2017). In China, the periodontal disease standardized DALYs rate has risen from 24.7 in 1990 to 25.7 in 2013 according to the data from 2013 GBD ...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Repeated Changes to the Gravitational Field Negatively Affect the Serum Concentration of Select Growth Factors and Cytokines
This study was carried out in accordance with the recommendations of the ethical committee of the Ruhr-Universität Bochum with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the ethical committee of the Ruhr-Universität Bochum (Register-Number 5158–14). Author Contributions US, FS, LG, and AK performed the experiments. US and TR analyzed the data, created the figures, and drafted the manuscript. TW, FS, and NB designed the study. All authors revised the manuscript and approved its fina...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Pages: 1  2