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Condition: Ischemic Stroke
Therapy: Thrombolytic Therapy

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Total 959 results found since Jan 2013.

Perspectives in neonatal and childhood arterial ischemic stroke.
Authors: Fluss J, Dinomais M, Kossotoroff M, Vuillerot C, Darteyre S, Chabrier S Abstract INTRODUCTION: Over the last decade considerable advances have been made in the identification, understanding and management of pediatric arterial ischemic stroke. Such increasing knowledge has also brought new perspectives and interrogations in the current acute and rehabilitative care of these patients. AREAS COVERED: In developed countries, focal cerebral arteriopathy is one of the most common causes of arterial ischemic stroke in childhood and imaging features are well characterized. However, there are ongoing debates regar...
Source: Expert Review of Neurotherapeutics - October 1, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Thrombolysis for stroke in Ireland: increasing access and maintaining safety in a challenging environment
ConclusionStroke thrombolysis is being effectively and safely provided in acute stroke services in Ireland despite regular involvement of non-specialist staff. There is still potential to improve thrombolysis rate.
Source: Irish Journal of Medical Science - July 17, 2017 Category: General Medicine Source Type: research

Early and One-Year Outcomes of Acute Stroke in the Industrial Region of Poland During the Decade 2006 –2015: The Silesian Stroke Registry
Conclusions: In a large population of industrial province, we showed recent, positive trends in AS admissions, treatment and 1-year outcomes. Development of stroke unit networks and increase in thrombolytic treatment were at least in part responsible for survival improvement and reduction of recurrence of AS. However, case-fatality and stroke recurrence remain high compared to those of other developed countries.Neuroepidemiology 2018;50:183 –194
Source: Neuroepidemiology - March 27, 2018 Category: Epidemiology Source Type: research

Pentraxin-3 in Thrombolytic Therapy for Acute Ischemic Stroke: No Relation with Curative Effect and Prognosis.
CONCLUSIONS PTX3 is not suitable to serve as an indicator of thrombolytic efficacy and had no association with long-term prognosis in stroke patients receiving thrombolytic therapy. PMID: 29949524 [PubMed - in process]
Source: Medical Science Monitor - June 29, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Fibrinolysis: Strategies to enhance the treatment of acute ischemic stroke.
This article is protected by copyright. All rights reserved. PMID: 29953716 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 28, 2018 Category: Hematology Authors: Henderson SJ, Weitz JI, Kim PY Tags: J Thromb Haemost Source Type: research

A Successful Quality Improvement Project for Detection and Management of Acute Stroke in Hospitalized Patients
CONCLUSION: The new IHS protocol has led to a marked increase in cases identified, rapid evaluation, and high utilization rate of acute stroke therapies.
Source: Journal of Neuroscience Nursing - July 30, 2020 Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research

Clinical efficacy and imaging evaluation of recombinant tissue plasminogen activator thrombolytic therapy in patients with wake up stroke: A randomized controlled trial
This study will be a single-blinded, randomized controlled trial with 2 parallel groups. It will be conducted at North China University of science and technology affiliated hospital. Discussion: There is no consistent conclusion about the pathogenesis of wake up stroke. Wake up stroke is more likely to manifest as small vessel disease. The incidence of wake up stroke patients is relatively high, and the effectiveness and safety of intravenous thrombolysis under the guidance of multimode imaging therapy in wake up stroke need to be further explored by prospective, large-scale studies. Trial registration: ClinicalTrial...
Source: Medicine - September 4, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke.
Conclusions: Our findings suggest that immune invasion of the neurovascular unit represents a previously unrecognized mechanism underlying tPA-mediated brain hemorrhage, which can be overcome by precise immune modulation during thrombolytic therapy. PMID: 33070717 [PubMed - as supplied by publisher]
Source: Circulation Research - October 19, 2020 Category: Cardiology Authors: Shi K, Zou M, Jia DM, Shi S, Yang X, Liu Q, Dong J, Sheth KN, Wang X, Shi FD Tags: Circ Res Source Type: research

RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke
Abstract Objective:Hemorrhagic transformation (HT) is a major complication of ischemic stroke that worsens outcomes and increases mortality. Disruption of the blood brain barrier is a central feature to HT pathogenesis, and leukocytes may contribute to this process. We sought to determine whether ischemic strokes that develop HT have differences in RNA expression in blood within 3 hours of stroke onset prior to treatment with thrombolytic therapy. Methods:Stroke patient blood samples were obtained prior to treatment with thrombolysis, and leukocyte RNA assessed by microarray analysis. Strokes that developed HT (n=11) were ...
Source: Annals of Neurology - March 7, 2013 Category: Neurology Authors: Glen C Jickling, Bradley P Ander, Boryana Stamova, Xinhua Zhan, Dazhi Liu, Lena Rothstein BSc, Piero Verro, Jane Khoury, Edward C Jauch, Arthur Pancioli, Joseph P Broderick, Frank R Sharp Tags: Research Article Source Type: research

Measuring Quality Improvement in Acute Ischemic Stroke Care: Interrupted Time Series Analysis of Door-to-Needle Time
Background: In patients with acute ischemic stroke, early treatment with recombinant tissue plasminogen activator (rtPA) improves functional outcome by effectively reducing disability and dependency. Timely thrombolysis, within 1 h, is a vital aspect of acute stroke treatment, and is reflected in the widely used performance indicator ‘door-to-needle time' (DNT). DNT measures the time from the moment the patient enters the emergency department until he/she receives intravenous rtPA. The purpose of the study was to measure quality improvement from the first implementation of thrombolysis in stroke patients in a university ...
Source: Cerebrovascular Diseases Extra - November 7, 2014 Category: Neurology Source Type: research

National data on stroke outcomes in Thailand
In conclusion, the prevalence and outcomes of stroke in Thailand were comparable with other countries. The era of thrombolytic therapy has just begun in Thailand.
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

An Executable Graphical Model for In Silico Prototyping of Processes for Acute Stroke Care (P1.019)
CONCLUSIONS: In silico care process prototyping permits evaluation of proposed innovations in simulated settings. 1. Grotta JC. tPA for stroke: important progress in achieving faster treatment. JAMA. 2014 Apr 23-30;311(16):1615-7. 2. Ford AL et al. Reducing door-to-needle times using Toyota's lean manufacturing principles and value stream analysis. Stroke. 2012 Dec;43(12):3395-8. 3. Meretoja A et al. Reducing in-hospital delay to 20 minutes in stroke thrombolysis. Neurology. 2012 Jul 24;79(4):306-13. Study Supported by:Genentech, Inc.Disclosure: Dr. Norris has received personal compensation for activities with Genentech. D...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Norris, D., Levy, D. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research

Multidisciplinary In Situ Mock Stroke Codes Improve Thrombolytic Delivery by Decreasing Door To Needle Times in a Comprehensive Stroke Center. (P6.086)
Conclusions: Door to needle time is reduced as a result of MSCs. MSCs should be routinely performed at CSCs to improve door to needle time and patient outcomes.Disclosure: Dr. Burshtein has nothing to disclose. Dr. Kapoor has nothing to disclose. Dr. Sorrentino has nothing to disclose. Dr. Michael has nothing to disclose. Dr. Carrazco has nothing to disclose. Dr. Wright has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Burshtein, R., Kapoor, A., Sorrentino, C., Michael, C., Carrazco, C., Wright, P. Tags: Cerebrovascular Disease and Interventional Neurology: Patient Safety and Quality Source Type: research

Recognition of Stroke by EMS is Associated with Improvement in Emergency Department Quality Measures.
CONCLUSION: Recognition of stroke by EMS providers was independently associated with faster door-to-physician time, faster door-to-CT time, and greater odds of receiving thrombolysis. Quality initiatives to improve EMS recognition of stroke have the potential to improve hospital-based quality of stroke care. PMID: 27246289 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - June 3, 2016 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Drip-and-Ship Thrombolytic Therapy Supported by the Telestroke System for Acute Ischemic Stroke Patients Living in Medically Under-served Areas.
Authors: Kageji T, Obata F, Oka H, Kanematsu Y, Tabata R, Tani K, Bando H, Nagahiro S Abstract There are a few stroke specialists in medically under-served areas in Japan. Consequently, in remote area patients may not receive thrombolysis with intravenous recombinant tissue plasminogen activator (iv rt-PA), the standard treatment for acute ischemic stroke. Using a mobile telestroke support system (TSS) that accesses the internet via a smart phone, we implemented iv rt-PA infusion therapy under a drip-and-ship protocol to treat the stroke patients in medically under-served areas. The physicians at the Tokushima Pref...
Source: Neurologia Medico-Chirurgica - June 25, 2016 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research