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Condition: Glaucoma

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Total 129 results found since Jan 2013.

Say Yes to Yoga
By Stacy SimonThe ancient Indian practice of yoga combines meditation, breathing, and precise postures and poses to make a connection with thoughts, body, and spirit. People who practice yoga claim it leads to a state of physical health, relaxation, happiness, peace, and tranquility.Some evidence shows that yoga can lower stress, increase strength, and lessen lower back pain, while providing exercise. And according to a report from the National Institutes of Health, there is also some evidence to suggest yoga may be helpful when used alongside conventional medical treatment to help relieve some of the symptoms linked to ca...
Source: American Cancer Society :: News and Features - September 1, 2016 Category: Cancer & Oncology Tags: Complementary and Alternative Methods Source Type: news

Macular ganglion cell layer abnormalities in Spectral Domain (SD) –OCT outside glaucomatous neuropathy
ConclusionsGCL abnormalities are not specifics for chronic glaucoma, we can find them in maculopathies, central nervous system pathologies and optic neuropathies.
Source: Acta Ophthalmologica - September 13, 2016 Category: Opthalmology Authors: M. Mendes, H. El Chehab, V. Bouteleux, E. Agard, A. Russo, C. Dot Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research

Abnormal neurovascular coupling during status epilepticus migrainosus in Sturge-Weber syndrome
Sturge-Weber syndrome is a rare, sporadic, neurocutaneous disorder classically characterized by a facial nevus in the trigeminal distribution (port wine stain), leptomeningeal angiomatosis, and glaucoma, although intracranial changes can be present without cutaneous involvement.1 Seizures occur in up to 75% of individuals, are often associated with headache, and stroke-like episodes causing prolonged neurologic deficits are also described.1,2
Source: Neurology - January 8, 2017 Category: Neurology Authors: Sethi, M., Kowalczyk, M. A., Dalic, L. J., Archer, J. S., Jackson, G. D. Tags: Migraine, Status epilepticus, Functional neuroimaging, PET in epilepsy, SPECT in epilepsy CLINICAL/SCIENTIFIC NOTES Source Type: research

Ten-year results of pallidal stimulation for cricopharyngeal dystonia with spasmodic dysphonia
Sturge-Weber syndrome is a rare, sporadic, neurocutaneous disorder classically characterized by a facial nevus in the trigeminal distribution (port wine stain), leptomeningeal angiomatosis, and glaucoma, although intracranial changes can be present without cutaneous involvement.1 Seizures occur in up to 75% of individuals, are often associated with headache, and stroke-like episodes causing prolonged neurologic deficits are also described.1,2
Source: Neurology - January 8, 2017 Category: Neurology Authors: Horisawa, S., Ochiai, T., Goto, S., Nakajima, T., Kawamata, T., Taira, T. Tags: Dystonia, Surgery/Stimulation CLINICAL/SCIENTIFIC NOTES Source Type: research

Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors
AbstractRecent studies identified Rho-kinase enzymes (ROCK-I and ROCK-II) as important targets that are involved in a variety of diseases. Synthetic Rho-kinase inhibitors have emerged as potential therapeutic agents to treat disorders such as hypertension, stroke, cancer, diabetes, glaucoma, etc. Our study is the first to screen the total ethanol extract of the medicinal mushroomGanoderma lingzhi with thirty-five compounds for Rho-kinase inhibitory activity. Moreover, a molecular binding experiment was designed to investigate the binding affinity of the compounds at the active sites of Rho-kinase enzymes. The structure –...
Source: Journal of Natural Medicines - January 9, 2017 Category: Drugs & Pharmacology Source Type: research

Annual incidences of visual impairment during 10-year period in Mie prefecture, Japan
ConclusionsThe results indicate that in Japan, the rates of the major causes of visual impairment altered in the most recent 10-year period reflecting the recent changes in the social background and advances in ocular and systemic treatment.
Source: Japanese Journal of Ophthalmology - April 26, 2017 Category: Opthalmology Source Type: research

Analysis of Sturge –Weber syndrome: A retrospective study of multiple associated variables
Conclusions There are multiple clinical manifestations of Sturge–Weber syndrome. Being familiar with all of them is vitally important for diagnosing and for monitoring and treating the condition correctly, which will improve the quality of life of these patients.
Source: Neurologia - May 30, 2017 Category: Neurology Source Type: research

Mystery of Retinal Vein Occlusion: Vasoactivity of the Vein and Possible Involvement of Endothelin-1.
Abstract Retinal vein occlusion (RVO) is a common vascular disease of retina; however, the pathomechanism leading to RVO is not yet clear. In general, increasing age, hypertension, arteriosclerosis, diabetes mellitus, dyslipidemia, cardiovascular disorder, and cerebral stroke are systemic risk factors of RVO. However, RVO often occur in the unilateral eye and sometimes develop in young subjects who have no arteriosclerosis. In addition, RVO show different variations on the degrees of severity; some RVO are resolved without any treatment and others develop vision-threatening complications such as macular edema, com...
Source: Biomed Res - September 15, 2017 Category: Research Authors: Kida T Tags: Biomed Res Int Source Type: research

Molecules, Vol. 22, Pages 1766: Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents
iaozhen Jiao Ping Xie Inhibitors of Rho kinase (ROCK) have potential therapeutic applicability in a wide range of diseases, such as hypertension, stroke, asthma and glaucoma. In a previous article, we described the lead discovery of DL0805, a new ROCK I inhibitor, showing potent inhibitory activity (IC50 6.7 μM). Herein, we present the lead optimization of compound DL0805, resulting in the discovery of 24- and 39-fold more-active analogues 4a (IC50 0.27 μM) and 4b (IC50 0.17 μM), among other active analogues. Moreover, ex-vivo studies demonstrated that 4a and 4b exhibited comparable vasorelaxant activity to the ap...
Source: Molecules - October 19, 2017 Category: Chemistry Authors: Yangyang Yao Renze Li Xiaoyu Liu Feilong Yang Ying Yang Xiaoyu Li Xiang Shi Tianyi Yuan Lianhua Fang Guanhua Du Xiaozhen Jiao Ping Xie Tags: Article Source Type: research

Ocular Manifestations of Obstructive Sleep Apnea
Conclusions:Hypoxia induced by nightly cessation of breathing increases patients' risk of coronary artery disease, heart failure, stroke, and other conditions. As with many maladies detrimental to vascular health, obstructive sleep apnea affects the eye and ocular adnexa. This paper summarizes the current evidence implicating OSA in these ocular maladies and highlights their proposed mechanisms. The authors describe ocular pathology which sleep specialists may encounter. We encourage more aggressive attention to ocular symptoms in patients with sleep apnea to prevent vision-threatening complications. Further research shoul...
Source: Journal of Clinical Sleep Medicine : JCSM - November 14, 2017 Category: Sleep Medicine Source Type: research

IDx Closer to Nod for Diabetic Retinopathy Diagnostic
Privately held IDx is developing an artificial intelligence-based system that could help with the diagnosis diabetic retinopathy – a disease that leads to blindness if undetected. The company met its endpoints in a pivotal trial of the IDx-DR system. The trial involved 900 diabetes patients at 10 sites. The study was designed to evaluate the diagnostic accuracy of the technology in detecting moderate to severe diabetic retinopathy, including macular edema. The results of the pivotal trial met the study hypotheses that were developed in consultation with FDA and demonstrated the IDx-DR system exceeded these performance go...
Source: MDDI - February 23, 2018 Category: Medical Devices Authors: Omar Ford Tags: Digital Health Medical Device Business Source Type: news

Sturge Weber syndrome: A rare clinical presentation with bilateral port wine stain and leptomenigeal angiomatosis
Introduction: Sturge-Weber syndrome (SWS) is a neurocutaneous syndrome that has a heterogeneous spectrum of manifestations, characterized by facial port-wine stain (PWS) within the trigeminal nerve distribution, ipsilateral leptomeningeal angiomatosis, glaucoma, seizures, stroke-like episodes, hemiparesis, and mental retardation. The diagnosis is based on clinical presentation and cranial imaging features. Treatment is a challenge and multidisciplinary approach is required to control ophthalmic, neurologic and dermatologic manifestations.
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

A Review on the Extraction of Quantitative Retinal Microvascular Image Feature.
Authors: Kipli K, Hoque ME, Lim LT, Mahmood MH, Sahari SK, Sapawi R, Rajaee N, Joseph A Abstract Digital image processing is one of the most widely used computer vision technologies in biomedical engineering. In the present modern ophthalmological practice, biomarkers analysis through digital fundus image processing analysis greatly contributes to vision science. This further facilitates developments in medical imaging, enabling this robust technology to attain extensive scopes in biomedical engineering platform. Various diagnostic techniques are used to analyze retinal microvasculature image to enable geometric fe...
Source: Computational and Mathematical Methods in Medicine - August 3, 2018 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A3 Adenosine Receptor Antagonists and Partial Agonists (U.S. Patent Application Number 13/056,997)
Disclosed are A3 adenosine receptor antagonists and/or partial agonists of formula (I): wherein R1 to R5 are as described herein, as well as pharmaceutical compositions thereof and methods of use thereof. The antagonists or partial agonists find use in treating a number of diseases including cancer, glaucoma, inflammatory diseases, asthma, stroke, myocardial infarction, allergic reactions, rhinitis, poison ivy induced responses, urticaria, scleroderma, arthritis, brain arteriole diameter constriction, bronchoconstriction, and myocardial ischemia, as well as in preventing cardiac ischemia. Also disclosed are radiolabeled co...
Source: NIDDK Research Resources - August 16, 2018 Category: Endocrinology Source Type: research

Link Between Air Pollution and Intraocular Pressure
Ambient air pollution is currently a significant environmental risk to health. Black carbon (BC) is a component of atmospheric particulate matter that has a diameter of less than 2.5 μm. Because of this small size, these particles tend to stay in the air longer and are prone to be inhaled. Long-term exposure to BC has been associated with health hazards, such as adverse birth outcomes, respiratory disease, diabetes, atherosclerosis, stroke, and decline in cognitive function. Oc ular diseases, such as dry eye, have also been found to be associated with air pollution. However, whether ambient air pollution is associated wit...
Source: JAMA Ophthalmology - February 1, 2019 Category: Opthalmology Source Type: research