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Design and Implementation of a National Program to Monitor the Prevalence of SARS-CoV-2 IgG Antibodies in England Using Self-Testing: The REACT-2 Study
Am J Public Health. 2023 Sep 21:e1-e9. doi: 10.2105/AJPH.2023.307381. Online ahead of print.ABSTRACTData System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28...
Source: Am J Public Health - September 21, 2023 Category: International Medicine & Public Health Authors: Helen Ward Christina Atchison Matthew Whitaker Bethan Davies Deborah Ashby Ara Darzi Marc Chadeau-Hyam Steven Riley Christl A Donnelly Wendy Barclay Graham S Cooke Paul Elliott Source Type: research
Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
ConclusionSensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus.PMID:37733239 | DOI:10.2807/1560-7917.ES.2023.28.38.2200938
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Tom áš Kliegr Ji řà Jarkovský Helena Ji Å™incová Jaroslav Kucha Å™ Tom áš Karel David Chud án Stanislav Voj ÃÅ™ Michal Zav Å™el Ond Å™ej Å anca Ruth Tachezy Source Type: research
Surveillance of SARS-CoV-2 infection based on self-administered swabs, Denmark, May to July 2022: evaluation of a pilot study
ConclusionParticipants successfully performed self-swabs and answered symptom questionnaires. Also, WGS analysis of samples was possible. The system can support surveillance of respiratory pathogens and also holds potential as a diagnostic tool, easing access to test for at-risk groups, while also reducing the burden on healthcare system resources.PMID:37733236 | DOI:10.2807/1560-7917.ES.2023.28.38.2200907
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Kamille Fogh Tine Graakj ær Larsen Cyril Jean-Marie Martel Frederik Trier M øller Lasse Skafte Vestergaard Ramona Trebbien Anne-Marie Vangsted Tyra Grove Krause Source Type: research
Design and Implementation of a National Program to Monitor the Prevalence of SARS-CoV-2 IgG Antibodies in England Using Self-Testing: The REACT-2 Study
Am J Public Health. 2023 Sep 21:e1-e9. doi: 10.2105/AJPH.2023.307381. Online ahead of print.ABSTRACTData System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28...
Source: American Journal of Public Health - September 21, 2023 Category: International Medicine & Public Health Authors: Helen Ward Christina Atchison Matthew Whitaker Bethan Davies Deborah Ashby Ara Darzi Marc Chadeau-Hyam Steven Riley Christl A Donnelly Wendy Barclay Graham S Cooke Paul Elliott Source Type: research
Recent Advances in Metagenomic Approaches, Applications, and Challenge
Curr Microbiol. 2023 Sep 21;80(11):347. doi: 10.1007/s00284-023-03451-5.ABSTRACTAdvances in metagenomics analysis with the advent of next-generation sequencing have extended our knowledge of microbial communities as compared to conventional techniques providing advanced approach to identify novel and uncultivable microorganisms based on their genetic information derived from a particular environment. Shotgun metagenomics involves investigating the DNA of the entire community without the requirement of PCR amplification. It provides access to study all genes present in the sample. On the other hand, amplicon sequencing targ...
Source: Current Microbiology - September 21, 2023 Category: Microbiology Authors: Niguse K Lema Mesfin T Gemeda Adugna A Woldesemayat Source Type: research
Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Virus Research - September 21, 2023 Category: Virology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2
Conclusion: For Swedish patients on active cancer treatment, high self-assessed COVID-19-related anxiety or strict adherence to self-isolation guidelines were not associated with a lower risk of COVID-19. Patients with HM were less likely to develop serological antibody response after COVID-19 and were more likely to require advanced hospital care, but expressed less COVID-19-related anxiety than patients with SM.PMID:37729083 | DOI:10.1080/0284186X.2023.2257873
Source: Acta Oncologica - September 20, 2023 Category: Cancer & Oncology Authors: Beatrice Ginman Simon Pahnke Eva Freyhult Tove Hoffman Linda Kolstad Bengt R önnberg Åke Lundkvist Kerstin Hamberg Levedahl Gunilla Enblad Ingrid Glimelius Source Type: research
Efficient trapping and destruction of SARS-CoV-2 using PECO-assisted Molekule air purifiers in the laboratory and real-world settings
Ecotoxicol Environ Saf. 2023 Sep 18;264:115487. doi: 10.1016/j.ecoenv.2023.115487. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted human-to-human via aerosols and air-borne droplets. Therefore, capturing and destroying viruses from indoor premises are essential to reduce the probability of human exposure and virus transmission. While the heating, ventilation, and air conditioning (HVAC) systems help in reducing the indoor viral load, a targeted approach is required to effectively remove SARS-CoV-2 from indoor air to address human exposure concerns. The present study...
Source: Ecotoxicology and Environmental Safety - September 20, 2023 Category: Environmental Health Authors: Arpan Acharya Kerri Surbaugh Michellie Thurman Chatura Wickramaratne Philip Myers Rajat Mittal Kabita Pandey Elizabeth Klug Sarah J Stein Ashley R Ravnholdt Vicki L Herrera Danielle N Rivera Paul Williams Joshua L Santarpia Ajeet Kaushik Jaspreet S Dhau S Source Type: research
Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2
Conclusion: For Swedish patients on active cancer treatment, high self-assessed COVID-19-related anxiety or strict adherence to self-isolation guidelines were not associated with a lower risk of COVID-19. Patients with HM were less likely to develop serological antibody response after COVID-19 and were more likely to require advanced hospital care, but expressed less COVID-19-related anxiety than patients with SM.PMID:37729083 | DOI:10.1080/0284186X.2023.2257873
Source: Acta Oncologica - September 20, 2023 Category: Cancer & Oncology Authors: Beatrice Ginman Simon Pahnke Eva Freyhult Tove Hoffman Linda Kolstad Bengt R önnberg Åke Lundkvist Kerstin Hamberg Levedahl Gunilla Enblad Ingrid Glimelius Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
The Pathogenesis of COVID-19-Related Taste Disorder and Treatments
J Dent Res. 2023 Sep 20:220345231182926. doi: 10.1177/00220345231182926. Online ahead of print.ABSTRACTCOVID-19, mainly manifested as acute respiratory distress syndrome, has afflicted millions of people worldwide since 2019. Taste dysfunction is a common early-stage symptom of COVID-19 infection that burdens patients for weeks or even permanently in some cases. Owing to its subjectivity and complexity, the mechanism of taste disorder is poorly studied. Previous studies have reported that the COVID-19 entry receptors are highly expressed in taste buds, thereby intensifying the cytocidal effect. Taste receptor cells are vul...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: J Wang R Liu H Ma W Zhang Source Type: research
Patient-reported reactogenicity and safety of COVID-19 vaccinations vs. comparator vaccinations: a comparative observational cohort study
CONCLUSION: The rate of adverse reactions after established vaccinations was roughly comparable to previous studies. Two weeks after vaccination, participants in the SARS-CoV-2 vaccination group reported more local and systemic local reactions than participants in the comparator group. In the further course, however, there were no higher odds of medical consultations in either of the two groups. Thus, altogether, we assume comparable safety.TRIAL REGISTRATION: DRKS-ID DRKS00025881 and DRKS-ID DRKS00025373.PMID:37726711 | DOI:10.1186/s12916-023-03064-6
Source: Herpes - September 19, 2023 Category: Infectious Diseases Authors: Felix Werner Nikoletta Zeschick Thomas K ühlein Philipp Steininger Klaus Überla Isabelle Kaiser Maria Sebasti ão Susann Hueber Lisette Warkentin Source Type: research
Clinical Utility of Sero-Immunological Responses Against SARS-CoV-2 Nucleocapsid Protein During Subsequent Prevalence of Wild-Type, Delta Variant, and Omicron Variant
In conclusion, nucleocapsid antibody provides instructive clues about the immunogenicity of nucleocapsid proteins by different seroconversion rates and titers according to the severity of infection, host immune status, and different variants of concern.PMID:37724496 | DOI:10.3346/jkms.2023.38.e292
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Beomki Lee Jae-Hoon Ko Jin Yang Baek Haein Kim Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Kyong Ran Peck Eun-Suk Kang Source Type: research
