Filtered By:
Condition: Rheumatoid Arthritis

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 292 results found since Jan 2013.

Effect of CD95 on inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.
CONCLUSION: Stimulation of CD95 could promote RA-FLS proliferation and inflammation, and activation of the PI3K/Akt signaling pathway might be the possible mechanism. PMID: 25084560 [PubMed - as supplied by publisher]
Source: Cellular Immunology - July 21, 2014 Category: Allergy & Immunology Authors: Li X, Zhang Z, Peng A, He M, Xu J, Shen S, Zhuang J, Huang X Tags: Cell Immunol Source Type: research

The Discoidin Domain Receptor 2/Annexin A2/Matrix Metalloproteinase 13 Loop Promotes Joint Destruction in Arthritis Through Promoting Migration and Invasion of Fibroblast‐like Synoviocytes
ConclusionAnnexin A2 is a key molecule in the DDR‐2/annexin A2/MMP‐13 loop, the activation of which contributes to joint destruction in RA, mainly through promoting invasion of FLS. Annexin A2 might therefore become a novel clinical target for RA treatment.
Source: Arthritis and Rheumatism - August 26, 2014 Category: Rheumatology Authors: Wei Zhao, Cun Zhang, Man Shi, Jian Zhang, Meng Li, Xiaochang Xue, Zhao Zhang, Zhen Shu, Jinyu Zhu, Nan Mu, Weina Li, Qiang Hao, Zhijun Wang, Li Gong, Wei Zhang, Yingqi Zhang Tags: Rheumatoid Arthritis Source Type: research

Inhibition of transient receptor potential melastatin 7 (TRPM7) channel induces RA FLSs apoptosis through endoplasmic reticulum (ER) stress
In this study, using a combination of Western blotting, RT-PCR, and nuclear morphology analysis, we investigated the influence and potential function of TRPM7 channels on the apoptosis induced by thapsigargin in RA FLSs. Chemical inhibitors (Gd3+ and 2-APB) and specific siRNA for TRPM7 were used to study the role of TRPM7 in RA FLSs apoptosis. The expression of TRPM7 was significantly potentiated in RA FLSs. Co-incubation of RA FLSs with Gd3+, 2-APB, or TRPM7-siRNA increased cell apoptosis. Furthermore, we found that suppression of TRPM7 channels also increased the expression CHOP and calpain and decreased the expression c...
Source: Clinical Rheumatology - October 10, 2014 Category: Rheumatology Source Type: research

Redox‐Mediated Angiogenesis in the Hypoxic Joint of Inflammatory Arthritis
ConclusionWe demonstrated that hypoxia activates NOX‐2 protein expression, and NOX‐2–induced oxidative stress may be an initiating factor in driving angiogenesis.
Source: Arthritis and Rheumatism - November 25, 2014 Category: Rheumatology Authors: Monika Biniecka, Mary Connolly, Wei Gao, Chin T. Ng, Emese Balogh, Martina Gogarty, Lelani Santos, Evelyn Murphy, David Brayden, Douglas J. Veale, Ursula Fearon Tags: Rheumatoid Arthritis Source Type: research

A disintegrin and metalloprotease-10 is correlated with disease activity and mediates monocyte migration and adhesion in rheumatoid arthritis.
We examined the secretion of ADAM-10 in biological fluids from patients with rheumatoid arthritis (RA) and the role it plays in monocyte migration. ADAM-10 levels were measured using enzyme-linked immunosorbent assays and immunofluorescence. To examine the role of ADAM-10 in RA synovial fluids (SFs), we studied THP-1 and monocyte chemotaxis. To determine whether ADAM-10 plays a role in cell proliferation in the RA synovium, we assayed the proliferation of ADAM-10 small interfering RNA (siRNA)-transfected RA fibroblast-like synoviocytes (FLSs). The ADAM-10 level in RA serum was significantly higher than that in normal serum...
Source: Translational Research : the journal of laboratory and clinical medicine - February 28, 2015 Category: Laboratory Medicine Authors: Isozaki T, Ishii S, Nishimi S, Nishimi A, Oguro N, Seki S, Miura Y, Miwa Y, Oh K, Toyoshima Y, Nakamura M, Inagaki K, Kasama T Tags: Transl Res Source Type: research

Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4+ T Helper Cells
Conclusions: Inhibiting Gβγ to produce these shifts in cytokine mRNA production might be beneficial for patients with autoimmune diseases such as rheumatoid arthritis (RA), Crohn’s disease (CD), psoriasis, multiple sclerosis (MS), and Hashimoto’s thyroiditis (HT), in which both IFN-γ and IL-17A are elevated. Published on None
Source: Journal of Molecular Signaling - August 21, 2015 Category: Molecular Biology Source Type: research

Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis
In this study, we have investigated the role of histone deacetylase (HDAC) enzymes in RA synovial fibroblasts (RASFs), a key cellular mediator of cartilage and bone destruction and determined effects of HDAC1 inhibition on both RASF phenotype in vitro, and joint inflammation and damage in the collagen-induced arthritis (CIA) model. Expression of HDACs 1–11 messenger ribonucleic acid (mRNA) was compared between RASFs and osteoarthritic synovial fibroblast (OASFs) using quantitative polymerase chain reaction. HDAC1 expression in RASFs was inhibited using small interfering RNA (siRNA) technology to assess effects on inv...
Source: Human Molecular Genetics - September 10, 2015 Category: Genetics & Stem Cells Authors: Hawtree, S., Muthana, M., Wilkinson, J. M., Akil, M., Wilson, A. G. Tags: ORIGINAL ARTICLES Source Type: research

GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness.
CONCLUSION: GREM1 is highly expressed in RA joints, and functions as a regulator of survival, proliferation, migration, and invasion of RA-FLS. PMID: 26834210 [PubMed - as supplied by publisher]
Source: J Rheumatol - February 1, 2016 Category: Rheumatology Authors: Han EJ, Yoo SA, Kim GM, Hwang D, Cho CS, You S, Kim WU Tags: J Rheumatol Source Type: research

PGK1, a glucose metabolism enzyme, may play an important role in rheumatoid arthritis
Conclusions PGK1, a glycolytic enzyme catalyzing the conversion of 3-phosphoglycerate into 2-phosphoglycerate, has increased expression in synovial tissues and blood of RA, which may be involved in pro-inflammation and synovial hyperplasia of the disease.
Source: Inflammation Research - June 23, 2016 Category: Research Source Type: research

CD147 induces up-regulation of vascular endothelial growth factor in U937-derived foam cells through PI3K/AKT pathway.
Abstract Intraplaque angiogenesis has been recognized as an important risk factor for the rupture of advanced atherosclerotic plaques in recent years. CD147, also called Extracellular Matrix Metalloproteinase Inducer, has been found the ability to promote angiogenesis in many pathological conditions such as cancer diseases and rheumatoid arthritis via the up-regulation of vascular endothelial growth factor (VEGF), a critical mediator of angiogenesis. We investigated whether CD147 would also induce the up-regulation of VEGF in the foam cells formation process and explored the probable signaling pathway. The results...
Source: Archives of Biochemistry and Biophysics - September 8, 2016 Category: Biochemistry Authors: Zong J, Li Y, Du D, Liu Y, Yin Y Tags: Arch Biochem Biophys Source Type: research

Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis
Conclusions Macrophage response to MTX is polarisation-dependent and determined by the TS-p53 axis. CCL20 and LIF constitute novel macrophage markers for MTX responsiveness in vitro.
Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Municio, C., Soler Palacios, B., Estrada-Capetillo, L., Benguria, A., Dopazo, A., Garcia-Lorenzo, E., Fernandez-Arroyo, S., Joven, J., Miranda-Carus, M. E., Gonzalez-Alvaro, I., Puig-Kröger, A. Tags: Immunology (including allergy), Inflammation, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis.
Abstract To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA). FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA). An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression. The standard of protein was measured by Western blot or immunofluorescence. The excretion and genetic expression of inflammatory factors were, respectively, estimated by enz...
Source: J Cell Mol Med - November 16, 2016 Category: Molecular Biology Authors: Chen D, Zeng S, Huang M, Xu H, Liang L, Yang X Tags: J Cell Mol Med Source Type: research

Roles of 1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > and Vitamin D Receptor in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus by Regulating the Activation of CD4 < sup > + < /sup > T Cells and the PKC δ/ERK Signaling Pathway
Conclusion:Our study provide evidence that 1,25(OH)2D3 and VDR could inhibit the activation of CD4+ T cells and suppress the immune response of SLE and RA through inhibiting PKC δ/ERK pathway and promoting DNA methylation of CD11a, CD70 and CD40L.Cell Physiol Biochem 2016;40:743-756
Source: Cellular Physiology and Biochemistry - December 2, 2016 Category: Cytology Source Type: research

Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone
This study suggests FGF11 as a novel factor driving pathological bone resorption in osteolytic disease and as a potential target for the development of new anti-resorptive therapeutic agents.
Source: Calcified Tissue International - January 17, 2017 Category: Orthopaedics Source Type: research

Inhibition of 6 ‐phosphofructo‐2‐kinase suppresses fibroblast‐like synoviocytes‐ mediated synovial inflammation and joint destruction in rheumatoid arthritis
Conclusion And ImplicationsElevated PFKFB3 expression might contribute to synovial inflammation and aggressive behaviors of RA FLSs, suggesting a novel strategy of targeting PFKFB3 to prevent synovial inflammation and joint destruction in RA.
Source: British Journal of Pharmacology - February 27, 2017 Category: Drugs & Pharmacology Authors: Yaoyao Zou, Shan Zeng, Mingcheng Huang, Qian Qiu, Youjun Xiao, Maohua Shi, Zhongping Zhan, Liuqin Liang, Xiuyan Yang, Hanshi Xu Tags: RESEARCH PAPER Source Type: research