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Total 6033 results found since Jan 2013.
In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
This article aims to establish the protocols and demonstrate a few examples of in vitro oxygen imaging of BAP devices using EPROI. All pO2 measurements were performed using a recently introduced 720 MHz/25 mT preclinical oxygen imager instrument, JIVA-25™. We began by performing pO2 calibration of the biomaterials used in BAPs at 25 mT magnetic field since no such data exist. We compared the EPROI pO2 measurement with a single-point probe for a few selected materials. We also performed trityl OX071 toxicity studies with fibroblasts, as well as insulin-producing cells (beta TC6, MIN6, and human islet cells). Finally, we p...
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Mrignayani Kotecha Longhai Wang Safa Hameed Navin Viswakarma Minglin Ma Cherie Stabler Corinne A Hoesli Boris Epel Source Type: research
Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers
CONCLUSIONS: Physicians appear to consider the recipient characteristics that inform expected post-transplant survival score when deciding whether to accept a marginal kidney for a given recipient.PMID:37729938 | DOI:10.2215/CJN.0000000000000302
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 20, 2023 Category: Urology & Nephrology Authors: Juan M Gonzalez Sepulveda Sanjay Mehrotra Jui-Chen Yang Karolina J Schantz Yolanda Becker Richard Formica Daniela P Ladner Dixon Kaufman John Friedewald Source Type: research
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nrf2: Therapeutic target of islet function protection in diabetes and islet transplantation
Biomed Pharmacother. 2023 Sep 11;167:115463. doi: 10.1016/j.biopha.2023.115463. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor 2 (Nrf2) has been reported as a major intracellular regulator of antioxidant stress, notably in islet β cells with low antioxidant enzyme content. Nrf2 is capable of regulating antioxidant function, while it can also regulate insulin secretion, proliferation, and differentiation of β cells, ER stress, as well as mitochondrial function. Thus, Nrf2 pharmacological activators have been employed in the laboratory for the treatment of diabetic mice. Islet cells are exposed to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Butian Wei Xin Zhang Jiwei Qian Zhe Tang Bo Zhang Source Type: research
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research
Endothelial Progenitor Cells in Autoimmune Disorders
The objective of this review was to describe EPCs, their properties and their involvement in several autoimmune diseases.PMID:37676423 | DOI:10.1007/s12015-023-10617-y
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Guillaume Feugray S ébastien Miranda V éronique Le Cam Duchez J érémy Bellien Paul Billoir Source Type: research
Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research
Proteome analysis, bioinformatic prediction and experimental evidence revealed immune response down-regulation function for serum-starved human fibroblasts
CONCLUSION: Under serum starvation-induced metabolic stress, both PBMCs and fibroblasts produced molecules like heat shock proteins and amyloid-beta, which can have pathogenic roles in auto-inflammatory diseases such as rheumatoid arthritis, type 1 diabetes mellitus, systemic lupus erythematosus, aging, and cancer. However, starved fibroblasts showed immunosuppressive activity in an in vitro model of allogeneic transplantation, suggesting their potential to modify such adverse reactions by down-regulating the immune system.PMID:37674821 | PMC:PMC10477462 | DOI:10.1016/j.heliyon.2023.e19238
Source: Cancer Control - September 7, 2023 Category: Cancer & Oncology Authors: Negar Jafari Reza Gheitasi Hamid Reza Khorasani Monireh Golpour Maryam Mehri Kosar Nayeri Roghayeh Pourbagher Mobina Mostafazadeh Behnam Kalali Amrollah Mostafazadeh Source Type: research
A specific plasma amino acid profile in the Insulin2 < sup > Q104del < /sup > Kuma mice at the diabetic state and reversal from hyperglycemia
Biochem Biophys Res Commun. 2023 Aug 30;679:58-65. doi: 10.1016/j.bbrc.2023.08.064. Online ahead of print.ABSTRACTThe metabolites in the plasma serve as potential biomarkers of disease. We previously established an early-onset diabetes mouse model, Ins2+/Q104del Kuma mice, under a severe immune-deficient (Rag-2/Jak3 double-deficient in BALB/c) background. Here, we revealed the differences in plasma amino acid profiles between Kuma and the wild-type mice. We observed an early reduction in glucogenic and ketogenic amino acids, a late increase in branched-chain amino acids (BCAAs) and succinyl CoA-related amino acids, and a t...
Source: Biochemical and Biophysical Research communications - September 6, 2023 Category: Biochemistry Authors: Naoya Hiyoshi Takayuki Enomoto Fumiya Uefune Yusuke Kato Yumeng Wu Kimi Araki Daisuke Sakano Nobuaki Shiraki Shoen Kume Source Type: research
Interleukin-7 improves the fitness of regulatory T cells for adoptive transfer
In conclusion, our data demonstrate the feasibility of expanding naïve Treg in the presence of IL-7 to generate a Treg product enriched in poorly differentiated CD45RA+ cells with enhanced survival capabilities.PMID:37671510 | DOI:10.1111/imm.13690
Source: Immunology - September 6, 2023 Category: Allergy & Immunology Authors: Ilaria Cosorich Jessica Filoni Carla Di Dedda Arianna Ferrari Tatiana Jofra Susanna Cesarano Chiara Bonini Lorenzo Piemonti Paolo Monti Source Type: research
Interventions for fatigue in people with kidney failure requiring dialysis
CONCLUSIONS: Exercise, aromatherapy, massage and acupressure may improve fatigue compared to placebo, standard care or no intervention. Pharmacological and other non-pharmacological interventions had uncertain effects on fatigue or fatigue-related outcomes in people receiving dialysis. Future adequately powered, high-quality studies are likely to change the estimated effects of interventions for fatigue and fatigue-related outcomes in people receiving dialysis.PMID:37651553 | DOI:10.1002/14651858.CD013074.pub2
Source: Cochrane Database of Systematic Reviews - August 31, 2023 Category: General Medicine Authors: Patrizia Natale Angela Ju Giovanni Fm Strippoli Jonathan C Craig Valeria M Saglimbene Mark L Unruh Giovanni Stallone Allison Jaure Source Type: research
Beta-cell death and dysfunction drives hyperglycaemia in organ donors
CONCLUSIONS: In pancreas donors, hyperglycaemia requiring IT is strongly associated with beta-cell death. This provides an explanation for the relationship of donor IT with post-transplant beta-cell dysfunction in transplant recipients.PMID:37646197 | DOI:10.1111/dom.15248
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Iestyn M Shapey Angela Summers James O'Sullivan Catherine Fullwood Neil A Hanley John Casey Shareen Forbes Miranda Rosenthal Paul R V Johnson Pratik Choudhary James Bushnell James A M Shaw Daniel Neiman Ruth Shemer Benjamin Glaser Yuval Dor Titus Augustin Source Type: research
