Interleukin-7 improves the fitness of regulatory T cells for adoptive transfer

In conclusion, our data demonstrate the feasibility of expanding naïve Treg in the presence of IL-7 to generate a Treg product enriched in poorly differentiated CD45RA+ cells with enhanced survival capabilities.PMID:37671510 | DOI:10.1111/imm.13690

Source: Immunology - September 6, 2023 Category: Allergy & Immunology Authors: Ilaria Cosorich Jessica Filoni Carla Di Dedda Arianna Ferrari Tatiana Jofra Susanna Cesarano Chiara Bonini Lorenzo Piemonti Paolo Monti Source Type: research