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Condition: Reflex Sympathetic Dystrophy

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Total 132 results found since Jan 2013.

Mineralocorticoid and angiotensin II type 1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarction.
This article is protected by copyright. All rights reserved. PMID: 24951624 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 20, 2014 Category: Physiology Authors: Huang BS, Chen A, Ahmad M, Wang HW, Leenen FH Tags: J Physiol Source Type: research

The system with zwitterionic lactose-based surfactant for complexation and delivery of small interfering ribonucleic acid—A structural and spectroscopic study
This article presents results of a study on the structural effects associated with siRNA complexation by a surfactant comprising a lactose group (N-(3-propanesulfone)-N-dodecyl-amino-beta-D-lactose hydrochloride, LA12). The double stranded siRNA oligomer (21 base pairs) used in this study is responsible for silencing a gene that can be important in the therapy of myotonic dystrophy type 1. The obtained siRNA/LA12 lipoplexes were studied using the methods of small angle scattering of synchrotron radiation, circular dichroism spectroscopy, Fourier transform infrared spectroscopy, and electrophoretic mobility tests. ...
Source: Applied Physics Letters - May 24, 2016 Category: Physics Authors: Michalina Skupin, Krzysztof Sobczak, Ryszard Zieliński and Maciej Kozak Source Type: research

Effectiveness of cationic liposome‐mediated local delivery of myostatin‐targeting small interfering RNA in vivo
This study evaluated the effectiveness of local administration of cationic liposome‐delivered myostatin‐targeting siRNA. Myostatin (Mst)‐siRNA and scrambled (scr)‐siRNA‐lipoplexes were injected into the masseter muscles of wild type and dystrophin‐deficient mdx mice, which model Duchenne muscular dystrophy. One week after injection, the masseter muscles were dissected for histometric analyses. To evaluate changes in masseter muscle activity, masseter electromyographic (EMG) measurements were performed. One week after local administration of Mst‐siRNA‐lipoplexes, masseter muscles and myofibrils were signific...
Source: Development, Growth and Differentiation - February 1, 2014 Category: Research Authors: Hiroyo Mori, Nobuhiko Kawai, Nao Kinouchi, Natsuko Hichijo, Tatsuhiro Ishida, Emi Kawakami, Sumihare Noji, Eiji Tanaka Tags: Original Article Source Type: research

The role of P2X7 receptor in PC12 cells after exposure to oxygen-glucose deprivation.
In this study, the effects of P2X7 on the viability or [Ca(2+)]i in PC12 cells after exposure to oxygen-glucose deprivation (OGD) were investigated. The results showed that the viability of PC12 cells was decreased under the condition of OGD. BzATP, a P2X7 agonist, decreased the viability, while P2X7 antagonist oxATP or P2X7 siRNA reversed the viability of PC12 cells under the condition of OGD. The expression levels of P2X7 mRNA and protein in PC12 cells were up-regulated under the condition of OGD or BzATP treatment. The expression levels of P2X7 mRNA and protein were significantly decreased in OGD PC12 cells, which were ...
Source: Autonomic Neuroscience - March 30, 2014 Category: Neuroscience Authors: Fan B, Liu S, Xu C, Liu J, Kong F, Li G, Zhang C, Gao Y, Xu H, Yu S, Zheng C, Peng L, Song M, Wu B, Lv Q, Zou L, Ying M, Zhang X, Liang S Tags: Auton Neurosci Source Type: research

Microglial P2X7 receptor in the hypothalamic paraventricular nuclei contributes to sympathoexcitatory responses in acute myocardial infarction rat
Publication date: 5 February 2015 Source:Neuroscience Letters, Volume 587 Author(s): Dongshu Du , Meiyan Jiang , Min Liu , Jin Wang , Chunmei Xia , Ruijuan Guan , Linlin Shen , Yonghua Ji , Danian Zhu Several pieces of evidence indicate that the microglial P2X7 receptor (P2X7R) regulate cardiovascular activities. We explored the possible roles of microglial P2X7R in the PVN mediated sympathoexcitatory responses in acute myocardial infarction (AMI) rat. Sprague–Dawley rats underwent coronary artery ligation to induce AMI. The rats received intraperitoneal administration of the P2X7R antagonist Brilliant Blue-G (BBG, 25 ...
Source: Neuroscience Letters - December 29, 2014 Category: Neuroscience Source Type: research

Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II – induced hypothalamic reactive oxygen species and hypertension
Publication date: 4 August 2016 Source:Neuroscience, Volume 329 Author(s): Hong-Wei Wang, Bing S. Huang, Roselyn A. White, Aidong Chen, Monir Ahmad, Frans H.H. Leenen Activation of angiotensinergic pathways by central aldosterone (Aldo)-mineralocorticoid receptor (MR) pathway plays a critical role in angiotensin II (Ang II)-induced hypertension. The subfornical organ (SFO) contains both MR and angiotensin II type 1 receptors (AT1R) and can relay the signals of circulating Ang II to downstream nuclei such as the paraventricular nucleus (PVN), supraoptic nucleus (SON) and rostral ventrolateral medulla (RVLM). In Wist...
Source: Neuroscience - May 20, 2016 Category: Neuroscience Source Type: research

P2X7 receptor regulates sympathoexcitatory response in myocardial infarction rats via NF- κB and MAPK pathways.
P2X7 receptor regulates sympathoexcitatory response in myocardial infarction rats via NF-κB and MAPK pathways. Am J Transl Res. 2017;9(11):4954-4962 Authors: Wu Q, Xu H, Hao L, Ma G, Sun J, Song X, Ding F, Wang N Abstract Previous studies have provided evidence for the regulatory effect of P2X7 receptor (P2X7R) on cardiovascular activities. Our study focused on exploring the function and fundamental mechanism of microglial P2X7R in controlling sympathoexcitatory response using rats with acute myocardial infarction (AMI). Coronary artery ligation was used in rats to cause AMI. And before that, rats wer...
Source: American Journal of Translational Research - December 10, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat.
Abstract Malignant ventricular arrhythmias (VAs) following myocardial infarction (MI) is a lethal complication resulting from sympathetic nerve hyperactivity. Numerous evidence have shown that inflammation within the paraventricular nucleus (PVN) participates in sympathetic hyperactivity. Our aim was to explore the role of Macrophage-inducible C-type lectin (Mincle) within the PVN in augmenting sympathetic activity following MI,and whether NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome/IL-1β axis is involved in this activity. MI was induced by coronary artery ligation. Mincle expression l...
Source: J Cell Mol Med - October 24, 2018 Category: Molecular Biology Authors: Wang Y, Yin J, Wang C, Hu H, Li X, Xue M, Liu J, Cheng W, Wang Y, Li Y, Shi Y, Tan J, Li X, Liu F, Liu Q, Yan S Tags: J Cell Mol Med Source Type: research

Myotube formation is affected by adipogenic lineage cells in a cell-to-cell contact-independent manner.
Abstract Intramuscular adipose tissue (IMAT) formation is observed in some pathological conditions such as Duchenne muscular dystrophy (DMD) and sarcopenia. Several studies have suggested that IMAT formation is not only negatively correlated with skeletal muscle mass but also causes decreased muscle contraction in sarcopenia. In the present study, we examined whether adipocytes affect myogenesis. For this purpose, skeletal muscle progenitor cells were transfected with siRNA of PPARγ (siPPARγ) in an attempt to inhibit adipogenesis. Myosin heavy chain (MHC)-positive myotube formation was promoted in cells transfec...
Source: Experimental Cell Research - April 8, 2014 Category: Cytology Authors: Takegahara Y, Yamanouchi K, Nakamura K, Nakano SI, Nishihara M Tags: Exp Cell Res Source Type: research

ERK1/2 MAPK Signaling in Hypothalamic Paraventricular Nucleus Contributes to Sympathetic Excitation in Rats with Heart Failure after Myocardial Infarction.
Abstract Brain mitogen-activated protein kinase (MAPK) signaling pathways are activated in heart failure (HF) induced by myocardial infarction and contribute to augmented sympathetic nerve activity. We tested whether silencing brain extracellular signal-regulated kinases 1 and 2 (ERK1/2, also known as p44/42 MAPK) in the hypothalamic paraventricular nucleus (PVN), a forebrain source of presympathetic neurons, would reduce the upregulation of sympatho-excitatory mediators in the PVN and the augmented sympathetic nerve activity in rats with HF. Sprague-Dawley rats underwent left anterior descending coronary artery l...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 22, 2016 Category: Physiology Authors: Yu Y, Wei SG, Zhang ZH, Weiss RM, Felder RB Tags: Am J Physiol Heart Circ Physiol Source Type: research

ERK1/2 MAPK signaling in hypothalamic paraventricular nucleus contributes to sympathetic excitation in rats with heart failure after myocardial infarction
Brain MAPK signaling pathways are activated in heart failure (HF) induced by myocardial infarction and contribute to augmented sympathetic nerve activity. We tested whether decreasing ERK1/2 (also known as p44/42 MAPK) signaling in the hypothalamic paraventricular nucleus (PVN), a forebrain source of presympathetic neurons, would reduce the upregulation of sympathoexcitatory mediators in the PVN and augmented sympathetic nerve activity in rats with HF. Sprague-Dawley rats underwent left anterior descending coronary artery ligation to induce HF, with left ventricular dysfunction confirmed by echocardiography. One week after...
Source: AJP: Heart and Circulatory Physiology - March 15, 2016 Category: Cardiology Authors: Yu, Y., Wei, S.-G., Zhang, Z.-H., Weiss, R. M., Felder, R. B. Tags: CARDIOVASCULAR NEUROHORMONAL REGULATION Source Type: research

Maladaptative autophagy impairs adipose function in Congenital Generalized Lipodystrophy due to cavin-1 deficiency.
CONCLUSIONS: This study showed that cavin-1 deficiency resulted in maladaptative autophagy which contributed to insulin resistance and altered adipocyte differentiation. These new pathophysiological mechanisms could open new therapeutic perspectives for adipose tissue diseases including CGL4. PMID: 27144934 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - May 3, 2016 Category: Endocrinology Authors: Salle-Teyssières L, Auclair M, Terro F, Nemani M, Elsayed SM, Elsobky E, Lathrop M, Délépine M, Lascols O, Capeau J, Magré J, Vigouroux C Tags: J Clin Endocrinol Metab Source Type: research

Gγ7 proteins contribute to coupling of nociceptin/orphanin FQ peptide (NOP) opioid receptors and voltage-gated Ca2+ channels in rat stellate ganglion neurons
Publication date: 3 August 2016 Source:Neuroscience Letters, Volume 627 Author(s): Saifeldin Mahmoud, Mohamed Farrag, Victor Ruiz-Velasco The nociceptin/orphanin FQ peptide (NOP) opioid receptors regulate neurotransmitter release via inhibition of voltage-gated Ca2+ channels (CaV2.2) in sympathetic and sensory neurons. Stimulation of NOP receptors by its endogenous agonist, nociception (Noc), leads to membrane-delimited, voltage-dependent (VD) block of CaV2.2 channel currents mediated by Gβγ protein subunits. Previously we reported that the pertussis toxin-sensitive Gαi1 and Gβ2/β4 isoforms mediate the functional...
Source: Neuroscience Letters - June 6, 2016 Category: Neuroscience Source Type: research

Regulating gene expression towards solving ocular surface diseases
SummaryTreatment of genetic eye disease poses significant medical and surgical challenges. We used a bioluminescent corneal reporter gene mouse model to assess efficacy and potency of a number of gene therapy approaches for corneal dystrophy. Various modalities were assessed for delivery of short interfering RNA (siRNA) targeting one of five mutant alleles present in the corneal bioluminescent mouse model enabling assessment of topical, subconjunctival and intrastromal delivery. Potent and sustained in vivo gene silencing >50% for up to 7 days was observed. This siRNA therapy only provides a transient silencing of the ...
Source: Acta Ophthalmologica - September 13, 2016 Category: Opthalmology Authors: T. Moore, S. Atkinson, E. Maurizi, D. Schiroli, L. Mairs, K. Christie, I. McLean, E. Allen, D.L. Pedrioli, J. Moore, A. Nesbit Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research

Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function.
CONCLUSIONS: The corneal endothelium in PPCD3 is characterized by morphologic, anatomic, and molecular features that are more consistent with an epithelial-like rather than an endothelial-like phenotype. Although these characteristics have been well documented, we demonstrate for the first time that susceptibility to UV-induced apoptosis and cell barrier function are significantly altered in the setting of reduced ZEB1. The significance of an altered cellular response to apoptotic stimuli and increased cell barrier function in the pathobiology of PPCD remains to be fully elucidated. PMID: 29046608 [PubMed - in process]
Source: Molecular Vision - October 20, 2017 Category: Molecular Biology Tags: Mol Vis Source Type: research