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Activin-A in the regulation of immunity in health and disease.
Abstract The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially identified as an inducer of follicle-stimulating hormone secretion. Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and two typ...
Source: Journal of Autoimmunity - August 11, 2019 Category: Allergy & Immunology Authors: Morianos I, Papadopoulou G, Semitekolou M, Xanthou G Tags: J Autoimmun Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review
The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review Qiancheng Deng1, Yangyang Luo1,2, Christopher Chang3, Haijing Wu1, Yan Ding4* and Rong Xiao1* 1Hunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China 2Department of Dermatology, Hunan Children's Hospital, Changsha, China 3Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, United States 4Department of Dermatology, Hainan Provincial Dermatology Disease Hospital, Haikou, China A...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

Innate Lymphoid Cells in Helminth Infections —Obligatory or Accessory?
Conclusion ILC2s are clearly an inherent feature of the immune response to helminth infection, and in all probability their evolution has been driven by the threat of parasites. While in experimental model systems they are not always found to be essential, they are often center stage, particularly in the early phases of infection of each helminth system so far analyzed. They also form an important conceptual and mechanistic link with the allergic response that will allow us to understand in more detail the genesis and control of allergic disorders. In this respect, a much fuller analysis of ILC biology and function in the...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis
Conclusion Via a HPLC system and a BATMAN-TCM platform, for the first time we performed detailed HPLC fingerprint analysis and network pharmacology studies of QP ointment. By in-depth animal and molecular analysis, we identified a number of chronic dermatitis-associated Th1/2 cytokines, itch mediators, and cellular signaling pathways in the skin, DRG and serum for QP to treat the inflammation and chronic itch associated with ACD. Our data clearly suggested, upon stimulation, cytokines and itch-related mediators are released from the skin and neuronal tissues, and QP could effectively work on both the skin and sensory neur...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells
This study was provided by the Canadian Institutes of Health Research and the Manitoba Health Research Council. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Sprent J, Kishimoto H. The thymus and central tolerance. Philos Trans R Soc Lond B Biol Sci. (2001) 356:609–16. doi: 10.1098/rstb.2001.0846 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Sakaguchi S, Wing K, Miyara M. Regulatory T cells - a brief history and perspective...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Resolution of milk-protein allergy after hematopoietic stem cell transplant in a patient with ipex syndrome
We present a patient with IPEX syndrome whose milk protein allergy resolved after receiving a stem cell transplant for his primary immunodeficiency.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Brooks, A. Helgeson, F. Lobo Tags: M310 Source Type: research

Enhanced Therapeutic Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase 3 in a Murine Atopic Dermatitis ‐Like Skin Inflammation Model
Allergy,Volume 0, Issue ja, -Not available-.
Source: Allergy - August 24, 2018 Category: Allergy & Immunology Authors: Shyam Kishor Sah , Gaurav Agrahari , Cuong Thach Nguyen , Yeon ‐Soo Kim , Kyung‐Sun Kang , Tae‐Yoon Kim Source Type: research

AhR mediates an anti ‐inflammatory feedback mechanism in human Langerhans cells involving FcεRI and IDO
ConclusionsOur study shows that AhR activation by FICZ reduces FcεRI and upregulates IDO expression in LC. This AhR‐mediated anti‐inflammatory feedback mechanism may dampen the allergen‐induced inflammation in AD.
Source: Allergy - May 10, 2017 Category: Allergy & Immunology Authors: S. Koch, T. J. Stroisch, J. Vorac, N. Herrmann, N. Leib, S. Schnautz, H. Kirins, I. F örster, H. Weighardt, T. Bieber Tags: ORIGINAL ARTICLE Source Type: research

AhR mediates an anti ‐inflammatory feed‐back mechanism in human Langerhans cells involving FcεRI and IDO
ConclusionsOur study shows that AhR activation by FICZ reduces FcεRI and up‐regulates IDO expression in LC. This AhR‐mediated anti‐inflammatory feedback mechanism may dampen the allergen‐induced inflammation in AD.This article is protected by copyright. All rights reserved.
Source: Allergy - April 4, 2017 Category: Allergy & Immunology Authors: Susanne Koch, Tim J. Stroisch, Julia Vorac, Nadine Herrmann, Nicole Leib, Sylvia Schnautz, Helene Kirins, Irmgard F örster, Heike Weighardt, Thomas Bieber Tags: Original Article: Experimental Allergy and Immunology Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

A challenging undertaking: Stem cell transplantation for immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare, life-threatening systemic autoimmune disorder caused by mutations in the forkhead box P3 (FOXP3) gene, which is required for the development and function of regulatory T cells and prevention of autoimmunity.1 Although most patients present in infancy with a clinical triad of intractable diarrhea, insulin-dependent diabetes, and eczematous dermatitis, some patients present with severe food allergies, other autoimmune manifestations, or both.
Source: Journal of Allergy and Clinical Immunology - November 7, 2015 Category: Allergy & Immunology Authors: Zeynep Yesim Kucuk, Jack J. Bleesing, Rebecca Marsh, Kejian Zhang, Stella Davies, Alexandra H. Filipovich Tags: Letter to the Editor Source Type: research

Signal transduction and chemotaxis in mast cells.
Abstract Mast cells play crucial roles in both innate and adaptive arms of the immune system. Along with basophils, mast cells are essential effector cells for allergic inflammation that causes asthma, allergic rhinitis, food allergy and atopic dermatitis. Mast cells are usually increased in inflammatory sites of allergy and, upon activation, release various chemical, lipid, peptide and protein mediators of allergic reactions. Since antigen/immunoglobulin E (IgE)-mediated activation of these cells is a central event to trigger allergic reactions, innumerable studies have been conducted on how these cells are activ...
Source: European Journal of Pharmacology - May 1, 2015 Category: Drugs & Pharmacology Authors: Draber P, Halova I, Polakovicova I, Kawakami T Tags: Eur J Pharmacol Source Type: research

Gut immune reconstitution in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome after hematopoietic stem cell transplantation
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is an inherited syndrome of early-onset systemic autoimmunity and the prototype of immune dysregulatory disorders. It is caused by mutations of forkhead box p3 (FOXP3) gene (Xp11.23), encoding a key transcription factor for natural regulatory T (nTreg) cells.1 Treg cell dysfunction leads to severe multi-organ autoimmune phenomena including enteropathy, dermatitis, endocrinopathy, and other organ-specific diseases.2 Patients often present early in infancy and, without treatment, usually die in the first years of life.
Source: Journal of Allergy and Clinical Immunology - October 25, 2014 Category: Allergy & Immunology Authors: Eleonora Gambineri, Sara Ciullini Mannurita, Helen Robertson, Marina Vignoli, Beate Haugk, Paolo Lionetti, Sophie Hambleton, Dawn Barge, Andrew R. Gennery, Mary Slatter, Zohreh Nademi, Terence J. Flood, Anthony Jackson, Mario Abinun, Andrew J. Cant Tags: Letter to the Editor Source Type: research

Cutaneous manifestations in patients with Wiskott-Aldrich syndrome submitted to haematopoietic stem cell transplantation
Conclusions Cutaneous manifestations in patients with WAS are frequent, especially those similar to the eczema found in AD.
Source: Archives of Disease in Childhood - March 11, 2013 Category: Pediatrics Authors: Loyola Presa, J. G., de Carvalho, V. O., Morrisey, L. R., Bonfim, C. M., Abagge, K. T., Vasselai, A., Marinoni, L. P. Tags: Immunology (including allergy), Dermatology, Artificial and donated transplantation Original article Source Type: research