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Condition: Cholesterol

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Total 572 results found since Jan 2013.

Assessment of Cholesterol-Derived Ionic Copolymers as Potential Vectors for Gene Delivery.
Abstract A library of cholesterol-derived ionic copolymers were synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization as 'smart' gene delivery vehicles holding diverse surface charges. Polyplex systems formed with anionic poly(methacrylic acid-co-cholesteryl methacrylate P(MAA-co-CMA) and cationic poly(dimethylamino ethyl methacrylate-co-cholesteryl methacrylate Q-P(DMAEMA-co-CMA) copolymer series were evaluated for their therapeutic efficiency. Cell viability assays, conducted on SHEP, HepG2, H460 and MRC5 cell lines, revealed that alterations in the copolymer composition (CMA mol...
Source: Biomacromolecules - October 14, 2013 Category: Biochemistry Authors: Sevimli S, Sagnella SM, Kavallaris M, Bulmus V, Davis TP Tags: Biomacromolecules Source Type: research

Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation.
In conclusion, it is suggested that FGF21 may be a potentially useful agent in the treatment of DCM. PMID: 29375676 [PubMed]
Source: Experimental and Therapeutic Medicine - January 30, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Aptamer-functionalized hybrid nanoparticle for the treatment of breast cancer.
CONCLUSION: This preliminary study concludes that aptamer-functionalized hybrid nanoparticles could be used to deliver P-gp targeted siRNA into the breast cancer cells to overcome chemoresistance. PMID: 28131717 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutics and Biopharmaceutics - January 24, 2017 Category: Drugs & Pharmacology Authors: Powell D, Chandra S, Dodson K, Shaheen F, Wilt K, Ireland S, Syed M, Dash S, Wiese T, Mandal T, Kundu A Tags: Eur J Pharm Biopharm Source Type: research

Abstract 5418: Tumor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and cell migration
Conclusions. Tumor-targeted nanoparticle delivery of HuR-RNAi in lung cancer cells selectively inhibited HuR and HuR-regulated oncoproteins resulting in diminished cell proliferation and cell migration in vitro. Acknowledgement. This study was funded by a grant (R01CA167516-01) from the National Cancer Institute. Citation Format: Ranganayaki Muralidharan, Anish Babu, Kanthesh Basalingappa, Anupama Munshi, Rajagopal Ramesh. Tumor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and cell migration. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Canc...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Muralidharan, R., Babu, A., Basalingappa, K., Munshi, A., Ramesh, R. Tags: Cancer Chemistry Source Type: research

Biodegradable lipid nanoparticles induce a prolonged RNA interference-mediated protein knockdown and show rapid hepatic clearance in mice and nonhuman primates
Publication date: 15 March 2017 Source:International Journal of Pharmaceutics, Volume 519, Issues 1–2 Author(s): Yuta Suzuki, Kenji Hyodo, Takuya Suzuki, Yohei Tanaka, Hiroshi Kikuchi, Hiroshi Ishihara Lipid nanoparticles based on ionizable lipids have been clinically validated as a means of delivery for RNA interference (RNAi) therapeutics. The ideal properties of RNAi carriers are efficient delivery of oligonucleotides into target cells and rapid elimination after the function is performed. Here, we report that degradable lipid nanoparticles are effective carriers of small interfering RNA (siRNA) and have a high thera...
Source: International Journal of Pharmaceutics - January 13, 2017 Category: Drugs & Pharmacology Source Type: research

Nucleic Acid Delivery System by the Combination of Lipid bubbles and Ultrasound.
CONCLUSION: Ultrasound technology is widely used in clinical settings not only for diagnosis but also for therapy. Ultrasonic devices are being actively developed. Computer-controlled ultrasound systems can provide precise exposure to the target site. The combination of precise ultrasound exposure and LBs might be useful for target site-specific nucleic acids delivery, and holds potential to be developed into a beneficial therapeutic and diagnostic system for various diseases. PMID: 30084324 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 7, 2018 Category: Drugs & Pharmacology Authors: Endo-Takahashi Y, Maruyama K, Negishi Y Tags: Curr Pharm Des Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia Patient-Oriented and Epidemiological Research
The objective of this research is to set the stage for the quantitative benchmarking of two anti-PCSK9 pharmacological modality classes, monoclonal antibodies (mAbs) and small interfering RNA (siRNA). To this end, we developed an integrative mathematical model of lipoprotein homeostasis describing the dynamic interplay between PCSK9, LDL-cholesterol (LDL-C), VLDL-cholesterol, HDL-cholesterol (HDL-C), apoB, lipoprotein a [Lp(a)], and triglycerides (TGs). We demonstrate that LDL-C decreased proportionally to PCSK9 reduction for both mAb and siRNA modalities. At marketed doses, however, treatment with mAbs resulted in an addi...
Source: The Journal of Lipid Research - August 31, 2019 Category: Lipidology Authors: Sokolov, V., Helmlinger, G., Nilsson, C., Zhudenkov, K., Skrtic, S., Hamren, B., Peskov, K., Hurt-Camejo, E., Jansson-Löfmark, R. Tags: Patient-Oriented and Epidemiological Research Source Type: research

Molecules, Vol. 24, Pages 3413: Design of Peptidomimetic Functionalized Cholesterol Based Lipid Nanoparticles for Efficient Delivery of Therapeutic Nucleic Acids
a Baigude Lipid nanoparticles (LNP) are the most potent carriers for the delivery of nucleic acid-based therapeutics. The first FDA approved a short interfering RNA (siRNA) drug that uses a cationic LNP system for the delivery of siRNA against human transthyretin (hTTR). However, preparation of such LNP involves tedious multi-step synthesis with relatively low yields. In the present study, we synthesized cationic peptidomimetic functionalized cholesterol (denote Chorn) in straightforward chemical approaches with high yield. When formulated with helper lipids, Chorn LNPs complexed with siRNA to form nanoparticles with a...
Source: Molecules - September 18, 2019 Category: Chemistry Authors: Ehexige Ehexige Tsogzolmaa Ganbold Xiang Yu Shuqin Han Huricha Baigude Tags: Article Source Type: research

New cholesterol drug shows promise
Conclusion Media headlines reporting on this phase I trial concentrated on the secondary outcome (that ALN-PCS reduced LDL cholesterol levels). However, these results will need to be confirmed during phase II and phase III clinical trials, which will involve more participants who would normally receive cholesterol-lowering treatment. While it is tempting to focus on the results of the cholesterol levels, phase I clinical trials are designed to test the safety of a new drug to make sure it is safe enough to test further. They also aim to determine what the highest tolerable dose is, so the appropriate one can be used in la...
Source: NHS News Feed - October 3, 2013 Category: Consumer Health News Tags: Heart/lungs Medical practice Medication Source Type: news

Promotion of human mesenchymal stem cell osteogenesis by PI3-kinase/Akt signaling, and the influence of caveolin-1/cholesterol homeostasis
Conclusions: PI3K/Akt signaling is a key pathway required for human MSC osteogenesis, and it is likely that localization of active Akt in non-caveolar and caveolar membrane rafts positively and negatively contributes to osteogenesis, respectively.
Source: Stem Cell Research and Therapy - December 1, 2015 Category: Stem Cells Authors: Natasha BakerJihee SohnRocky Tuan Source Type: research

PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages
ConclusionsThis study shows that in an inflammatory milieu, elevated levels of PCSK9 potently stimulate the expression of SRs (principally LOX-1) and ox-LDL uptake in macrophages, and thus contribute to the process of atherogenesis.
Source: Cardiovascular Research - March 29, 2018 Category: Cardiology Source Type: research

Nanoparticle-based "Two-pronged" approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux.
Abstract Reduction of lipoprotein uptake by macrophages and stimulation of cholesterol efflux are two essential steps required for atherosclerotic plaque regression. We used the optimized mannose-functionalized dendrimeric nanoparticle (mDNP)-based platform for macrophage-specific delivery of therapeutics to simultaneously deliver SR-A siRNA (to reduce LDL uptake) and LXR ligand (LXR-L, to stimulate cholesterol efflux) - a novel "Two-pronged" approach to facilitate plaque regression. mDNP-mediated delivery of SR-A siRNA led to a significant reduction in SR-A expression with a corresponding decrease in uptake of ox...
Source: Biomaterials - August 14, 2020 Category: Materials Science Authors: He H, Wang J, Yannie PJ, Korzun WJ, Yang H, Ghosh S Tags: Biomaterials Source Type: research

Investigation of water-insoluble hydrophobic polyethylenimines as RNAi vehicles in chronic myeloid leukemia therapy
J Biomed Mater Res A. 2021 May 8. doi: 10.1002/jbm.a.37214. Online ahead of print.ABSTRACTThe discovery of RNA interference (RNAi) more than two decades ago opened avenues for avant-garde cancer treatments that possess the ability to evade issues hampering current chemotherapeutic strategies, owing to its specific gene sequence-driven mechanism of action. A potent short interfering RNA (siRNA) delivery vehicle designed to overcome physiological barriers is imperative for successful RNAi therapy. For this purpose, this study explored the characteristics and therapeutic efficacy of low-molecular weight (MW) polyethylenimine ...
Source: Biomed Res - May 8, 2021 Category: Research Authors: Aysha S Ansari Remant K C Xiaoyan Jiang Hasan Uluda ǧ Source Type: research