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Condition: Hyperactivity

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Total 310 results found since Jan 2013.

Brain-Computer Interface for Clinical Purposes: Cognitive Assessment and Rehabilitation.
Abstract Alongside the best-known applications of brain-computer interface (BCI) technology for restoring communication abilities and controlling external devices, we present the state of the art of BCI use for cognitive assessment and training purposes. We first describe some preliminary attempts to develop verbal-motor free BCI-based tests for evaluating specific or multiple cognitive domains in patients with Amyotrophic Lateral Sclerosis, disorders of consciousness, and other neurological diseases. Then we present the more heterogeneous and advanced field of BCI-based cognitive training, which has its roots in ...
Source: Biomed Res - September 16, 2017 Category: Research Authors: Carelli L, Solca F, Faini A, Meriggi P, Sangalli D, Cipresso P, Riva G, Ticozzi N, Ciammola A, Silani V, Poletti B Tags: Biomed Res Int Source Type: research

Diagnosis and Management of Patients with Paroxysmal Sympathetic Hyperactivity following Acute Brain Injuries Using a Consensus-Based Diagnostic Tool: A Single Institutional Case Series.
In conclusion, critical care clinicians should consider the possibility of PSH and can use PSH-AM as a useful diagnostic and guiding tool in the management of PSH. PMID: 28890524 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - September 12, 2017 Category: Research Authors: Godo S, Irino S, Nakagawa A, Kawazoe Y, Fujita M, Kudo D, Nomura R, Shimokawa H, Kushimoto S Tags: Tohoku J Exp Med Source Type: research

Investigating the Mechanisms of Methotrexate Neurotoxicity in Patients With Childhood Leukemia and Long-Term Survivors
Adverse neurological events are common (4-20%) during treatment for pediatric acute lymphoblastic leukaemia (ALL) and include seizures, stroke like syndrome and leukoencephalopathy. In addition, chronic neurotoxicity is emerging as a worrying late effect of treatment with long-term survivors experiencing decreased executive function, processing speed and memory function. Survivors are also at increased risk of experiencing learning difficulties, social withdrawal issues and inattention hyperactivity disorders.
Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2017 Category: Hematology Authors: Victoria Forster, Jane Carr-Wilkinson, Deborah Tweddle, Sirintra Nakjang, Sanaa Choufani, Rosanna Weksberg, Frederik van Delft Source Type: research

Rare genetic variants found to increase risk for Tourette syndrome
An international team led by researchers from UCLA and Massachusetts General Hospital has identified the first definitive genes associated with Tourette syndrome, giving scientists a long-sought foothold on the biology of the disease.The report in the June 21 issue of Neuron describes the discovery of rare mutations — either deletions or duplications of genetic material — in two neurodevelopmental genes, NRXN1 and CNTN6, in people with Tourette syndrome, a disorder characterized by multiple chronic, involuntary motor and vocal tics.“This is a first, key step in understanding the role of these genes in the disease pro...
Source: UCLA Newsroom: Health Sciences - June 21, 2017 Category: Universities & Medical Training Source Type: news

Secondary attention-deficit/hyperactivity disorder following perinatal and childhood stroke: impact on cognitive and academic outcomes.
Abstract This cross-sectional retrospective clinical research study examines a large group of children followed within a pediatric stroke program and a developmental attention-deficit/hyperactivity disorder (ADHD) clinic at the Hospital for Sick Children, between May 2004 and June 2016. All children with a history of stroke who participated in a neuropsychological assessment between the ages of 4 and 18 years were considered for inclusion. From a sample of 275 participants with a history of stroke, 36 children (13.1%) received a diagnosis of secondary ADHD. Children with secondary ADHD were younger at the time of...
Source: Child Neuropsychology - May 30, 2017 Category: Child Development Authors: Williams TS, Roberts SD, Coppens AM, Crosbie J, Dlamini N, Westmacott R Tags: Child Neuropsychol Source Type: research

Diabetes-induced abnormalities of mitochondrial function in rat brain cortex: the effect of n-3 fatty acid diet.
This study investigated the response of rat cortical mitochondria to streptozotocin-induced diabetes and the potential for fish oil emulsion (FOE) to modulate mitochondrial function. Diabetes-induced deregulation of the respiratory chain function as a result of diminished complex I activity (CI) and cytochrome c oxidase hyperactivity was associated with attenuation of antioxidant defense of isolated cortical mitochondria, monitored by SOD activity, the thiol content, the dityrosine and protein-lipid peroxidation adduct formation. A parallel reduction in phosphorylation of the energy marker AMPK has pointed out to disrupted...
Source: Molecular and Cellular Biochemistry - May 19, 2017 Category: Biochemistry Authors: Chomova M, Balazova M, Muchova J Tags: Mol Cell Biochem Source Type: research

Head injuries can alter hundreds of genes and lead to serious brain diseases, UCLA biologists report
Head injuries can harm hundreds of genes in the brain in a way that increases people ’s risk for a wide range of neurological and psychiatric disorders, UCLA life scientists report.The researchers identified for the first time master genes that they believe control hundreds of other genes which are linked to Alzheimer ’s disease, Parkinson’s disease, post-traumatic stress disorder, stroke, attention deficit hyperactivity disorder, autism, depression, schizophrenia and other disorders.Knowing what the master genes are could give scientists targets for new pharmaceuticals to treat brain diseases. Eventually, scientists...
Source: UCLA Newsroom: Health Sciences - March 6, 2017 Category: Universities & Medical Training Source Type: news

Cardiovascular Effects of Stimulant and Non-Stimulant Medication for Children and Adolescents with ADHD: A Systematic Review and Meta-Analysis of Trials of Methylphenidate, Amphetamines and Atomoxetine
ConclusionsStatistically significant pre –post increases of SBP, DBP and HR were associated with AMP and ATX treatment in children and adolescents with ADHD, while MPH treatment had a statistically significant effect only on SBP in these patients. These increases may be clinically significant for a significant minority of individuals tha t experience larger increases. Since increased BP and HR in general are considered risk factors for cardiovascular morbidity and mortality during adult life, paediatric patients using ADHD medication should be monitored closely and regularly for HR and BP.
Source: CNS Drugs - February 23, 2017 Category: Neurology Source Type: research

Transcranial Magnetic and Direct Current Stimulation in Children
AbstractPromising results in adult neurologic and psychiatric disorders are driving active research into transcranial brain stimulation techniques, particularly transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), in childhood and adolescent syndromes. TMS has realistic utility as an experimental tool tested in a range of pediatric neuropathologies such as perinatal stroke, depression, Tourette syndrome, and autism spectrum disorder (ASD). tDCS has also been tested as a treatment for a number of pediatric neurologic conditions, including ASD, attention-deficit/hyperactivity disorder, ...
Source: Current Neurology and Neuroscience Reports - February 21, 2017 Category: Neuroscience Source Type: research

Renal denervation for resistant hypertension.
CONCLUSIONS: In patients with resistant hypertension, there is low quality evidence that renal denervation does not change major cardiovascular events, and renal function. There was moderate quality evidence that it does not change blood pressure and and low quality evidence that it caused an increaseof bradycardia episodes. Future trials measuring patient-centred instead of surrogate outcomes, with longer follow-up periods, larger sample size and more standardized procedural methods are necessary to clarify the utility of this procedure in this population. PMID: 28220472 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 20, 2017 Category: Journals (General) Authors: Coppolino G, Pisano A, Rivoli L, Bolignano D Tags: Cochrane Database Syst Rev Source Type: research

Evaluations of Intravenous Administration of CD34+ Human Umbilical Cord Blood Cells in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy
This study suggests that the treatment protocol needs to be optimized for each pathological condition.Dev Neurosci
Source: Developmental Neuroscience - January 20, 2017 Category: Neuroscience Source Type: research

Evaluations of Intravenous Administration of CD34 < sup > + < /sup > Human Umbilical Cord Blood Cells in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy
This study suggests that the treatment protocol needs to be optimized for each pathological condition.Dev Neurosci
Source: Developmental Neuroscience - January 19, 2017 Category: Neuroscience Source Type: research

ADHD medications and cardiovascular adverse events in children and adolescents: cross ‐national comparison of risk communication in drug labeling
ConclusionsProduct labeling provides healthcare professionals and consumers with inconsistent messages regarding the potential causal relationship between stimulant use and specific cardiovascular risks in children and adolescents. Copyright © 2017 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - January 12, 2017 Category: Drugs & Pharmacology Authors: Jan Sieluk, Brittany Palasik, Susan dosReis, Peter Doshi Tags: Original Report Source Type: research

The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia
ConclusionHypertension can be induced by CIH in SD rats. The CIH-induced elevation of BP is at least partially mediated via the Nox4-induced ROS/RhoA/ROCK pathway.
Source: Sleep and Breathing - January 10, 2017 Category: Respiratory Medicine Source Type: research

The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.
CONCLUSION: Hypertension can be induced by CIH in SD rats. The CIH-induced elevation of BP is at least partially mediated via the Nox4-induced ROS/RhoA/ROCK pathway. PMID: 28078487 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - January 10, 2017 Category: Sleep Medicine Authors: Lu W, Kang J, Hu K, Tang S, Zhou X, Xu L, Li Y, Yu S Tags: Sleep Breath Source Type: research