• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Homocysteine, Ischemic Stroke, and Coronary Heart Disease in Hypertensive Patients: A Population-Based, Prospective Cohort Study Clinical Sciences
Conclusions— Hyperhomocysteinemia in Chinese hypertensive patients is significantly associated with IS risk but not coronary heart disease susceptibility, and folic acid supplementation can efficiently reduce tHcy levels.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Han, L., Wu, Q., Wang, C., Hao, Y., Zhao, J., Zhang, L., Fan, R., Liu, Y., Li, R., Chen, Z., Zhang, T., Chen, S., Ma, J., Liu, S., Peng, X., Duan, S. Tags: Myocardial cardiomyopathy disease, Valvular heart disease, Clinical Studies, Acute Cerebral Hemorrhage, Cerebral Venous Thrombosis Clinical Sciences Source Type: research

Incident Cancer in a Cohort of 3,247 Cancer Diagnosis Free Ischemic Stroke Patients
Conclusions: The annual rate of age-adjusted cancer incidence was higher among ischemic stroke patients compared with those in the general population. The odds of mortality were three folds higher among stroke survivors who developed incident cancer.Cerebrovasc Dis 2015;39:262-268
Source: Cerebrovascular Diseases - April 7, 2015 Category: Neurology Source Type: research

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map.
Conclusion: Reduced salt intake, omega-3 LC-PUFA use, and folate supplementation could reduce risk for some cardiovascular outcomes in adults. Combined calcium plus vitamin D might increase risk for stroke. Primary Funding Source: None. PMID: 31284304 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 8, 2019 Category: Internal Medicine Authors: Khan SU, Khan MU, Riaz H, Valavoor S, Zhao D, Vaughan L, Okunrintemi V, Riaz IB, Khan MS, Kaluski E, Murad MH, Blaha MJ, Guallar E, Michos ED Tags: Ann Intern Med Source Type: research

The effect of folic acid in patients with cardiovascular disease: A systematic review and meta-analysis
Conclusion: This meta-analysis suggested that folic acid supplementation significantly reduced the risk of stroke in patients with CVD.
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials Epidemiology
Conclusions Our meta-analysis indicated a 10% lower risk of stroke and a 4% lower risk of overall CVD with folic acid supplementation. A greater benefit for CVD was observed among participants with lower plasma folate levels and without preexisting CVD and in studies with larger decreases in homocysteine levels. Folic acid supplementation had no significant effect on risk of coronary heart disease.
Source: JAHA:Journal of the American Heart Association - August 14, 2016 Category: Cardiology Authors: Li, Y., Huang, T., Zheng, Y., Muka, T., Troup, J., Hu, F. B. Tags: Cardiovascular Disease, Diet and Nutrition Epidemiology Source Type: research

Health maintenance in women.
Abstract The health maintenance examination is an opportunity to focus on disease prevention and health promotion. The patient history should include screening for tobacco use, alcohol misuse, intimate partner violence, and depression. Premenopausal women should receive preconception counseling and contraception as needed, and all women planning or capable of pregnancy should take 400 to 800 mcg of folic acid per day. High-risk sexually active women should be counseled on reducing the risk of sexually transmitted infections, and screened for chlamydia, gonorrhea, and syphilis. All women should be screened for huma...
Source: American Family Physician - January 1, 2013 Category: Primary Care Authors: Riley M, Dobson M, Jones E, Kirst N Tags: Am Fam Physician Source Type: research

Depression in the Elderly: A Common Condition That's Often Overlooked
When Suzette Santos, RN, a behavioral health nurse with the Visiting Nurse Service of New York (VNSNY), was assigned to the case of Grace*, an 89-year-old resident of Nassau County on Long Island, she had some idea what to expect. Suzette had cared for Grace a year earlier, as the elderly woman struggled to cope with depression brought on by the recent loss of her husband and lifelong partner. When Suzette reconnected with her patient this time, she could immediately see that Grace's depression had gotten worse. "She had lost a lot of weight -- about 20 pounds," Suzette recalls. "She had no interest in cooking or eating, ...
Source: Healthy Living - The Huffington Post - December 23, 2015 Category: Consumer Health News Source Type: news

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study
Conclusion: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062 Received: 14 April 2017 Revised: 13 November 2017 Accepted: 15 November 2017 Published: 15 December 2017 Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu Supplemental Material is ava...
Source: EHP Research - December 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prediction Model for the Efficacy of Folic Acid Therapy on Hyperhomocysteinaemia based on genetic risk score methods.
Abstract No risk assessment tools for the efficacy of folic acid treatment for hyperhomocysteinaemia (HHcy) have been developed. We aimed to use two common genetic risk score (GRS) methods to construct prediction models for the efficacy of folic acid therapy on HHcy, and the best gene-environment prediction model was screened out. A prospective cohort study enrolling 638 HHcy patients was performed. We used logistic regression model to estimate the associations of two GRS methods with the efficacy. Performances were compared using area under the receiver operating characteristic curve (AUC). The simple count genet...
Source: The British Journal of Nutrition - April 1, 2019 Category: Nutrition Authors: Du B, Zhang C, Yue L, Ren B, Zhao Q, Li D, He Y, Zhang W Tags: Br J Nutr Source Type: research

A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency
Conclusion: We identified a novel non-sense mutation in MTHFR gene in a single Egyptian family with severe MTHFR deficiency. The present investigation is clinically important, as it adds to the growing list of MTHFR mutations, which might help in genetic counseling of families of affected children and proper genotype-phenotype correlation. Background Severe 5,10-Methylenetetrahydrofolate reductase (MTHFR; OMIM 236250) deficiency is a rare inborn error of metabolism and inherited in an autosomal recessive fashion. It is a very common disorder of folate metabolism and is clinically characterized with low plasma methion...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research