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Risk of intracranial hemorrhage associated with autosomal dominant polycystic kidney disease in patients with end stage renal disease
Conclusions: ADPKD is a significant risk factor for ICH among patients on maintenance dialysis. Our Medicare primary cohort was older than in previous studies of intracranial aneurysm rupture among ADPKD patients. There are also limitations inherent to using the USRDS database.
Source: BioMed Central - February 26, 2014 Category: Journals (General) Authors: David J YooLawrence AgodoaChristina M YuanKevin C AbbottRobert Nee Source Type: research

Age may explain the association of an early dialysis initiation with poor survival
Conclusion: History of ischemic heart disease, serum albumin and dialysis start before 2005 were risk factors for mortality in ESRD patients. Older age is usually associated with early dialysis initiation, so age adjustment is needed to perform studies aimed to calculate the effect of eGFR at dialysis initiation on survival.
Source: QJM - October 24, 2014 Category: Internal Medicine Authors: Soler, M. J., Montero, N., Pascual, M. J., Barrios, C., Marquez, E., Orfila, M. A., Cao, H., Arcos, E., Collado, S., Comas, J., Pascual, J. Tags: Original papers Source Type: research

The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients
Conclusion GLS≥-15% provided additional prognostic information that allowed for the early identification of high-risk PD patients.
Source: IJC Heart and Vasculature - November 13, 2014 Category: Cardiology Source Type: research

Outcomes of Open Repair of Mycotic Descending Thoracic and Thoracoabdominal Aortic Aneurysms
Conclusions Open repair of mycotic descending thoracic and thoracoabdominal aortic aneurysms remains the gold standard of therapy. Aggressive intraoperative debridement with in situ prosthetic reconstruction permits a high rate of success in this very high risk cohort of patients. Lifelong antibiotic suppression therapy may prevent late prosthetic graft infection.
Source: The Annals of Thoracic Surgery - August 14, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Outcomes of Open Repair of Mycotic Descending Thoracic and Thoracoabdominal Aortic Aneurysms.
CONCLUSIONS: Open repair of mycotic descending thoracic and thoracoabdominal aortic aneurysms remains the gold standard of therapy. Aggressive intraoperative debridement with in situ prosthetic reconstruction permits a high rate of success in this very high risk cohort of patients. Lifelong antibiotic suppression therapy may prevent late prosthetic graft infection. PMID: 26277557 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - August 13, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Lau C, Gaudino M, de Biasi AR, Munjal M, Girardi LN Tags: Ann Thorac Surg Source Type: research

The “Sapienza University Mortality and Morbidity Event Rate (SUMMER) Study in Diabetes”: Study Protocol
Discussion The “SUMMER study in diabetes” is aimed at identifying new molecular promoters of mortality and major vascular events in patients with T2DM. Most likely, these novel pathogenic factors will be instrumental for unraveling new pathways underlying such dramatic events. In addition, they will also be used as additional markers to increase the performance of already existing risk-scoring models in predicting the above mentioned outcomes in T2DM, as well as in setting up new preventive and treatment strategies, possibly tailored to specific pathogenic backgrounds.
Source: Nutrition, Metabolism and Cardiovascular Diseases - October 9, 2015 Category: Nutrition Source Type: research

Safety of warfarin therapy in chronic hemodialysis patients: a prospective cohort study
Conclusion The results of this study suggested that warfarin use by HD patients might not be harmful in chronic state, while the safety for the initiation of warfarin therapy in HD patients remained to be determined.
Source: Clinical and Experimental Nephrology - December 1, 2015 Category: Urology & Nephrology Source Type: research

Effectiveness of family involvement in newly diagnosed type 2 diabetes patients: a follow-up study
In recent years, the global prevalence of diabetes has increased significantly. The number of Chinese patients with type 2 diabetes mellitus (T2DM) ranks first in the world. Diabetes ranks in the third place among chronic non-communicable diseases according to the morbidity, disability and mortality as well as the degree of harm to human health, and it has brought a heavy burden on healthcare [1–3]. The family is an important place for people to influence lifestyle intervention of family members to participate may improve health and reduce disease relapse rate, increase well-being of the family, help improve diabetes, hy...
Source: Patient Education and Counseling - December 30, 2015 Category: Global & Universal Authors: Mai Shi, Mei-Yan Xu, Zhao-Lan Liu, Xue-Ying Duan, Yan-Bo Zhu, Hui-Mei Shi, Bo Jiang, Xiao-Mei Zhang, Xiao-Han Yu Source Type: research

Long-term effects following 4 years of randomized treatment with atorvastatin in patients with type 2 diabetes mellitus on hemodialysis
The 4D (Die Deutsche Diabetes Dialyse) Study was a randomized, double-blind trial comparing 4 years of treatment with atorvastatin to placebo in 1255 hemodialysis patients with type 2 diabetes. The primary end point of cardiovascular events (cardiac death, myocardial infarction, and stroke) was non-significantly reduced by 8%. However, long-term effects remained uncertain. Therefore, surviving patients were invited to a follow-up survey done by questionnaire. Post-trial statin therapy was at nephrologist discretion, and outcomes were centrally adjudicated and analyzed by intention to treat and time to first event in the or...
Source: Kidney International - February 17, 2016 Category: Urology & Nephrology Authors: Vera Krane, Kay-Renke Schmidt, Lena J. Gutjahr-Lengsfeld, Johannes F.E. Mann, Winfried März, Florian Swoboda, Christoph Wanner, 4D Study Investigators (the German Diabetes and Dialysis Study Investigators) Tags: Clinical Trial Source Type: research

Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus.
Authors: Kautzky-Willer A, Harreiter J, Pacini G Abstract T2DM is more frequently diagnosed at lower age and body-mass-index in men, however the most prominent risk factor, which is obesity, is more common in women. Generally, large sex-ratio differences across countries are observed. Diversities in biology, culture, lifestyle, environment and socioeconomic status impact differences between males and females in predisposition, development and clinical presentation. Genetic effects and epigenetic mechanisms, nutritional factors and sedentary lifestyle affect risk and complications differently in both sexes. Furtherm...
Source: Endocrine Reviews - May 11, 2016 Category: Endocrinology Tags: Endocr Rev Source Type: research

Glycemic Control for Patients With Type 2 Diabetes Mellitus: Our Evolving Faith in the Face of Evidence Original Articles
Conclusions— Discordance exists between the research evidence and academic and clinical policy statements about the value of tight glycemic control to reduce micro- and macrovascular complications. This discordance may distort priorities in the research and practice agendas designed to improve the lives of patients with type 2 diabetes mellitus.
Source: Circulation: Cardiovascular Quality and Outcomes - September 19, 2016 Category: Cardiology Authors: Rodriguez-Gutierrez, R., Montori, V. M. Tags: Complications, Meta Analysis, Quality and Outcomes, Statements and Guidelines Original Articles Source Type: research

Lipoprotein(a) concentrations, apolipoprotein(a) isoforms and clinical endpoints in haemodialysis patients with type 2 diabetes mellitus: results from the 4D Study
Conclusions High Lp(a) concentrations and LMW apo(a) isoforms are risk predictors for all-cause mortality and death due to infection in haemodialysis patients with diabetes mellitus. These associations are modified by age.
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Kollerits, B., Drechsler, C., Krane, V., Lamina, C., März, W., Dieplinger, H., Ritz, E., Wanner, C., Kronenberg, F., for the German Diabetes and Dialysis Study Investigators Tags: Chronic Kidney Disease Source Type: research

HDL Cholesterol Efflux Does Not Predict Cardiovascular Risk in Hemodialysis Patients
In conclusion, HDL cholesterol efflux capacity is not a prognostic cardiovascular risk marker in this cohort of patients with diabetes on hemodialysis.
Source: Journal of the American Society of Nephrology : JASN - February 27, 2017 Category: Urology & Nephrology Authors: Kopecky, C., Ebtehaj, S., Genser, B., Drechsler, C., Krane, V., Antlanger, M., Kovarik, J. J., Kaltenecker, C. C., Parvizi, M., Wanner, C., Weichhart, T., Säemann, M. D., Tietge, U. J. F. Tags: Brief Communications Source Type: research

Soluble Urokinase Plasminogen Activator Receptor and Outcomes in Patients with Diabetes on Hemodialysis.
CONCLUSIONS: The association of soluble urokinase plasminogen activator receptor levels with outcomes persists in patients on hemodialysis. Additional study is warranted to characterize the underlying pathways of that association, which may yield opportunities to develop new therapeutic strategies. PMID: 28495863 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 11, 2017 Category: Urology & Nephrology Authors: Drechsler C, Hayek SS, Wei C, Sever S, Genser B, Krane V, Meinitzer A, März W, Wanner C, Reiser J Tags: Clin J Am Soc Nephrol Source Type: research

Reoperation for Coronary Artery Bypass Grafting Surgery: Outcomes and Considerations for Expanding Interventional Procedures
Conclusions Redo CABG can be performed safely with low early and late morbidity and mortality. Important predictors of long-term mortality such as age, diabetes, renal disease, and peripheral vascular disease were identified and should guide the treatment strategy chosen for this challenging group of patients.
Source: The Annals of Thoracic Surgery - May 18, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

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