Prognostic implications of high-sensitivity cardiac troponin T assay in a real-world population with non-ST-elevation acute coronary syndrome
Conclusions Our investigation on a real-world NSTE-ACS population showed good prognostic performance of hsTnT in the risk stratification of the hard endpoint, but did not demonstrate the improved prognostic ability of hsTnT over contemporary cTn. Neither troponin assay predicted the recurrence of UA, suggesting the acute rise of cardiac troponin as a marker of severity, but not the occurrence of future coronary instability. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - June 20, 2018 Category: Cardiology Source Type: research

Ventricular tachycardia-inducibility predicts arrhythmic events in post-myocardial infarction patients with low ejection fraction. A systematic review and meta-analysis
Conclusions Inducibility of ventricular arrhythmias at EPS is a strong predictor of the arrhythmic endpoint in post-MI patients with impaired EF, particularly when VT-inducibility is tested. EPS could help selecting the patients who can mostly benefit from ICD therapy. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - June 14, 2018 Category: Cardiology Source Type: research

Nationwide real-world database of 20,462 patients enrolled in the Japanese Acute Myocardial Infarction Registry (JAMIR): Impact of emergency coronary intervention in a super-aging population
Conclusions The large JAMIR database, with 24% of AMI patients aged ≥80 years, could provide useful information about medical care in an aging society. The reasonable in-hospital outcomes observed may justify consideration of PCI for patients with AMI aged ≥80 years. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - June 14, 2018 Category: Cardiology Source Type: research

The simple method for predicting metabolic equivalents using heart rate in patients with cardiovascular disease
Publication date: June 2018 Source:IJC Heart & Vasculature, Volume 19 Author(s): Shuhei Yamamoto, Takaaki Ishida, Kayoko Misawa, Masayoshi Ohira, Fumie Yajima, Satoko Higuchi, Saeko Yamasaki, Yasuo Yoshimura (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 30, 2018 Category: Cardiology Source Type: research

Can cystatin C-based estimated glomerular filtration rate help to guide individualized risk factor modification programs?
Publication date: Available online 25 May 2018 Source:IJC Heart & Vasculature Author(s): Dominik Linz, Mathias Hohl, Dobromir Dobrev (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 26, 2018 Category: Cardiology Source Type: research

Impact of out-stent plaque characteristics on vascular response after second generation drug-eluting stent implantation: iMAP-intravascular ultrasound and angioscopic study
Conclusions Impact of out-stent plaque characteristics on vascular response was different among the three types of G2-DES. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 26, 2018 Category: Cardiology Source Type: research

Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension
Conclusion BPA therapy reduced the pulmonary arterial pressure in patients with CTEPH and was associated with an improvement in the ECG findings related to RVH. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 26, 2018 Category: Cardiology Source Type: research

Clinical and electrocardiographic characteristics for prediction of new-onset atrial fibrillation in asymptomatic patients with atrial premature complexes
Conclusion Higher APCs burden, higher fastest APCs running HR and lower minimal HR were associated with new-onset AF in asymptomatic patients with APCs in the long-term follow up. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 18, 2018 Category: Cardiology Source Type: research

Cardiovascular disease and brain health: Focus on white matter hyperintensities
Publication date: June 2018 Source:IJC Heart & Vasculature, Volume 19 Author(s): Francesco Moroni, Enrico Ammirati, Maria A. Rocca, Massimo Filippi, Marco Magnoni, Paolo G. Camici Diseases affecting the brain contribute to a substantial proportion of morbidity and mortality in the general population. Conditions such as stroke, dementia and cognitive impairment have a prominent impact on global public health. Despite the heterogeneous clinical manifestations of these conditions and their diverse prognostic implications, current evidence supports a role for cardiovascular disease as a common pathophysiological groun...
Source: IJC Heart and Vasculature - May 15, 2018 Category: Cardiology Source Type: research

Association of frequent premature ventricular complex & gt;10% and stroke-like symptoms without a prior diagnosis of stroke or transient ischemic attack
Conclusion High PVCs burdens (>10%) were associated with and stroke-like symptoms without a prior diagnosis of stroke or transient ischemic attack in the long-term follow up, suggesting more intensive medical therapy with close clinical follow-up will be required. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 11, 2018 Category: Cardiology Source Type: research

Prognostic value of proximal left coronary artery flow velocity detected by transthoracic Doppler echocardiography
Conclusions An increased CFV in the proximal LCA was associated with cardiac death, incremental to the clinical and basic echocardiographic parameters. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 8, 2018 Category: Cardiology Source Type: research

Changes in coronary atherosclerosis, composition, and fractional flow reserve evaluated by coronary computed tomography angiography in patients with type 2 diabetes
Conclusions In Japanese patients with diabetes and intermediate coronary artery stenosis, alogliptin could not improve FFRCT or reduce atheroma volume, whereas the plaque composition changed. A progression of atheroma volume was associated with a reduction in FFRCT. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 5, 2018 Category: Cardiology Source Type: research

Effect of cardiac rehabilitation on the renal function in chronic kidney disease - Analysis using serum cystatin-C based glomerular filtration rate
Conclusions In CVD patients, a novel CR program significantly improved the exercise capacity. Further, CR was shown to have a favorable effect on the renal function when it was estimated by the eGFRcys. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 5, 2018 Category: Cardiology Source Type: research

The sternal wire code; Solving the problem of missing coronary artery bypass graft records during cardiac catheterization
Conclusions About 1 in 6 patients with previous CABG, who require emergency coronary angiography, undergo this procedure without graft-notes and would benefit from the sternal wire code which appears clinically acceptable and accurate. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 5, 2018 Category: Cardiology Source Type: research

Junior medical student performed focused cardiac ultrasound after brief training to detect significant valvular heart disease
Conclusions Teaching junior medical students to perform and interpret FOCUS was feasible after brief training and better than PE in detecting significant valvular lesions. Further studies are warranted to determine the utility of incorporating this new technology into mainstream medical training. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 5, 2018 Category: Cardiology Source Type: research

Low-frequency and low-intensity ultrasound increases cardiac parasympathetic neural activity and decreases clinic hypertension in elderly hypertensive subjects with type 2 diabetes
Conclusions The ultrasound treatment increases the cardiac parasympathetic neural activity and decreases the differences between SBP at home and at a clinic visit in elderly hypertensive subjects with type 2 diabetes. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - May 5, 2018 Category: Cardiology Source Type: research

The long-term efficacy of concomitant maze IV surgery in patients with atrial fibrillation
Conclusion CMIV in the present cohort provided limited long-term success in obtaining SR. SAF, longer AF duration, and postoperative ATA were associated with late AF recurrence. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - April 13, 2018 Category: Cardiology Source Type: research

Building medical knowledge from real world registries: The case of heart failure
Publication date: Available online 10 April 2018 Source:IJC Heart & Vasculature Author(s): Alberto Aimo, Chiara Seghieri, Sabina Nuti, Michele Emdin (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - April 10, 2018 Category: Cardiology Source Type: research

Left ventricular scar and the acute hemodynamic effects of multivein and multipolar pacing in cardiac resynchronization
Conclusions Multisite pacing with MPP and MVP shows no AHR benefit in all-comers compared to optimized BestBiV pacing. There was a minority of patients with significant scar volume in relation to the LV site that exhibited a small AHR improvement with MPP. (Study identifier NCT01883141) (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - April 10, 2018 Category: Cardiology Source Type: research

Changes in contractility determine coronary haemodynamics in dyssynchronous left ventricular heart failure, not vice versa
Conclusions Acutely increasing coronary flow with adenosine in patients with systolic heart failure does not increase contractility. Changes in coronary flow with biventricular pacing are likely to be a consequence of enhanced cardiac contractility from resynchronization and not vice versa. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - April 4, 2018 Category: Cardiology Source Type: research

Association between the ratio of anti-angiogenic isoform of VEGF-A to total VEGF-A and adverse clinical outcomes in patients after acute myocardial infarction
Conclusion The assessment of VEGF-A165b combined with VEGF-A may be a valuable screening tool for predicting MACCEs in clinical practice. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - March 23, 2018 Category: Cardiology Source Type: research

Atherosclerosis as an inflammatory disease: Doubts? No more
Publication date: June 2018 Source:IJC Heart & Vasculature, Volume 19 Author(s): Mauro Vaccarezza, Cristina Balla, Paola Rizzo (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - March 21, 2018 Category: Cardiology Source Type: research

Angiotensin, transforming growth factor β and aortic dilatation in Marfan syndrome: Of mice and humans
Publication date: March 2018 Source:IJC Heart & Vasculature, Volume 18 Author(s): Christopher Yu, Richmond W. Jeremy Marfan syndrome is consequent upon mutations in FBN1, which encodes the extracellular matrix microfibrillar protein fibrillin-1. The phenotype is characterised by development of thoracic aortic aneurysm. Current understanding of the pathogenesis of aneurysms in Marfan syndrome focuses upon abnormal vascular smooth muscle cell signalling through the transforming growth factor beta (TGFβ) pathway. Angiotensin II (Ang II) can directly induce aortic dilatation and also influence TGFβ synthesis...
Source: IJC Heart and Vasculature - March 13, 2018 Category: Cardiology Source Type: research

“Will she live a long happy life?” Parents' concerns for their children with Fontan circulation
Conclusions Fear of death and the psychological well-being of their children were the main parental concerns. It highlights the need to clearly communicate information on outcomes to families, and the need for family-focused psychological interventions to improve the psychosocial functioning of both parents and young people. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - March 10, 2018 Category: Cardiology Source Type: research

High risk electrocardiographic markers in Brugada syndrome
Publication date: March 2018 Source:IJC Heart & Vasculature, Volume 18 Author(s): Dimitrios Asvestas, Gary Tse, Adrian Baranchuk, George Bazoukis, Tong Liu, Athanasios Saplaouras, Panagiotis Korantzopoulos, Christina Goga, Michael Efremidis, Antonios Sideris, Konstantinos P. Letsas Several clinical, electrocardiographic (ECG) and electrophysiological markers have been proposed to provide optimal risk stratification in patients with Brugada syndrome (BrS). Of the different markers, only a spontaneous type 1 ECG pattern has clearly shown a sufficiently high predictive value. This review article highlights specific E...
Source: IJC Heart and Vasculature - March 9, 2018 Category: Cardiology Source Type: research

Reverse remodeling in Dilated Cardiomyopathy: Insights and future perspectives
Publication date: March 2018 Source:IJC Heart & Vasculature, Volume 18 Author(s): M. Merlo, T. Caiffa, M. Gobbo, L. Adamo, G. Sinagra Dilated Cardiomyopathy (DCM) has been classically considered a progressive disease of the heart muscle that inexorably progresses towards refractory heart failure, ventricular arrhythmias and heart transplant. However, the prognosis of DCM has significantly improved in the past few years, mostly as the result of successful therapy-induced reverse remodeling. Reverse remodeling is a complex process that involves not only the left ventricle, but also many other cardiac structures and ...
Source: IJC Heart and Vasculature - March 9, 2018 Category: Cardiology Source Type: research

Utilisation of real-world data from heart failure registries in OECD countries - A systematic review
Conclusion Since 2000 there has been an upward trend in the number of published observational studies on heart failure registries in OECD countries with increasingly diverse outcomes and advanced statistical methods to improve their validity and reliability. This indicates that the utilisation of real-world data has experienced a significant upsurge in complementing the findings of clinical trials for improved research of heart failure treatments. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - March 9, 2018 Category: Cardiology Source Type: research

Influence of observer experience on cardiac magnetic resonance strain measurements using feature tracking and conventional tagging
Conclusions Reliability and accuracy of FT based strain analysis, more than tagging based strain analysis, is dependent on reader experience. CMR strain experience or dedicated training in strain evaluation is necessary for FT to deliver accurate strain data, comparable to that of CMR tagging. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - March 6, 2018 Category: Cardiology Source Type: research

Targeting inflammatory citokines to prevent constriction in tuberculous pericarditis and beyond?
Publication date: Available online 5 March 2018 Source:IJC Heart & Vasculature Author(s): Massimo Imazio (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - March 5, 2018 Category: Cardiology Source Type: research

Reduced heart rate response after premature ventricular contraction depending on severity of atrial fibrillation symptoms – Analysis on heart rate turbulence in atrial fibrillation patients
Conclusions The usual heart rate acceleration after premature ventricular contraction is significantly diminished in pts with milder AF symptoms as compared to pts with severe AF symptoms. The mechanism of association between this diminished response and symptoms should be further investigated. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - February 27, 2018 Category: Cardiology Source Type: research

Invasive physiological indices to determine the functional significance of coronary stenosis
Publication date: March 2018 Source:IJC Heart & Vasculature, Volume 18 Author(s): Firas R. AL-Obaidi, William F. Fearon, Andy S.C. Yong Physiological measurements are now commonly used to assess coronary lesions in the cardiac catheterisation laboratory, and this practice is evidence-based and supported by clinical guidelines. Fractional flow reserve is currently the gold standard method to determine whether coronary lesions are functionally significant, and is used to guide revascularization. There are however several other physiological measurements that have been proposed as alternatives to the fractional flow ...
Source: IJC Heart and Vasculature - February 23, 2018 Category: Cardiology Source Type: research

Therapeutic potential of cycling high-intensity interval training in patients with peripheral artery disease: A pilot study
Publication date: March 2018 Source:IJC Heart & Vasculature, Volume 18 Author(s): Yoshitaka Iso, Hiroshi Suzuki, Etsushi Kyuno, Atsuo Maeda, Fumiyoshi Tsunoda, Ryo Miyazawa, Hitoshi Kowaita, Hitomi Kitai, Tetsuya Takahashi, Takeyuki Sambe (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - February 22, 2018 Category: Cardiology Source Type: research

Age modifies the risk of atrial fibrillation among athletes: A systematic literature review and meta-analysis
Conclusion Athletes have an increased risk of AF compared to the general population. Age appears to modify the risk of AF in athletes. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - February 18, 2018 Category: Cardiology Source Type: research

Mobilization of progenitor cells and assessment of vessel healing after second generation drug-eluting stenting by optical coherence tomography
Conclusions Mobilization of progenitor cells was suppressed, and differentiation of mononuclear cells into endothelial-like cells was inhibited, in association with increased number of uncovered stent struts, even after second generation drug-eluting stenting. These data suggest that new approaches are necessary to enhance stent healing. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - February 18, 2018 Category: Cardiology Source Type: research

Reporting of coronary artery calcification on chest CT studies in breast cancer patients at high risk of cancer therapy related cardiac events
Conclusions CAC was commonly detected on chest CT studies in this observational study of breast cancer patients at high risk of cardiac oncology events. The presence of CAC was often not reported clinically but reporting rates have increased over time. Recent SCCT/STR guidelines recommend reporting the presence of CAC on routine chest CT scans in recognition of the importance of CAC as a predictor of cardiovascular events. Reporting of CAC on chest CTs may help to further risk stratify breast cancer patients and improve cardiovascular outcomes in this vulnerable population. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - February 18, 2018 Category: Cardiology Source Type: research

Exercise self-efficacy in adults with congenital heart disease
Conclusion In this study we show that many adults with CHD have low ESE. Age is an important predictor of low ESE and should, therefore, be considered in counselling patients with CHD. In addition, muscle endurance training may improve ESE, and thus enhance the potential for being physically active in this population. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - February 18, 2018 Category: Cardiology Source Type: research

Evolving management and improving outcomes of pregnancy-associated spontaneous coronary artery dissection (P-SCAD): a systematic review
Conclusion This systematic review of temporal changes in presentation, management and outcomes of P-SCAD represents the widest range of variables analysed in the largest cohort of P-SCAD patients to date. In the setting of earlier coronary angiography and increasingly conservative management, maternal and foetal survival rates continue to improve. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - January 3, 2018 Category: Cardiology Source Type: research

Sudden cardiac arrest during marathon training in a young adult with short QT syndrome
Publication date: Available online 22 November 2017 Source:IJC Heart & Vasculature Author(s): Daisuke Wakatsuki, Yoshitaka Iso, Hiroshi Mase, Masaaki Kurata, Etsushi Kyuno, Hisa Shimojima, Taku Asano, Takeyuki Sambe, Hiroshi Suzuki (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - December 15, 2017 Category: Cardiology Source Type: research

Serum adiponectin and TNF α concentrations are closely associated with epicardial adipose tissue fatty acid profiles in patients undergoing cardiovascular surgery
Conclusions These results suggest that there is a close relationship between epicardial FA profiles and serum levels of adiponectin and TNFα. Dietary therapy to target FA profiles may be helpful to modulate inflammation. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - December 15, 2017 Category: Cardiology Source Type: research

Haptoglobin 2-2 genotype is associated with presence and progression of MRI depicted atherosclerotic intraplaque hemorrhage
Conclusions Patients with the Hp2-2 genotype had a significantly higher prevalence of carotid baseline IPH, which progressed over a two year follow up period. Detection of pre-symptomatic vascular disease using haptoglobin genotyping may allow for better risk stratification of populations at risk of stroke and in need of more targeted imaging investigations. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - December 15, 2017 Category: Cardiology Source Type: research

The interaction of QRS duration with cardiac magnetic resonance derived scar and mechanical dyssynchrony in systolic heart failure: Implications for cardiac resynchronization therapy
Conclusions 25% of patients with systolic heart failure and a NQRS (<130ms) have CMR derived mechanical dyssynchrony. Our findings suggest MD in this group may be secondary to myocardial scar rather than electrical dyssynchrony and therefore not amenable to correction by CRT. This may give insight into non-response and potential harm from CRT in this group. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - December 15, 2017 Category: Cardiology Source Type: research

The circular RNA MICRA for risk stratification after myocardial infarction
Conclusion We report that the circRNA MICRA improves risk classification after MI, supporting the added value of this novel biomarker in future prognostication strategies. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - November 11, 2017 Category: Cardiology Source Type: research

Pulmonary artery dysfunction in chronic thromboembolic pulmonary hypertension
Conclusions These results indicated that the pulmonary artery dysfunction exists in patients with CTEPH, which may be involved in the pathogenesis and progression of CTEPH. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - November 10, 2017 Category: Cardiology Source Type: research

Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study
Conclusion Monitoring the early effect of adjunctive immunotherapy in plasma or saliva is a possibility in pericarditis. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - November 4, 2017 Category: Cardiology Source Type: research

Cardiac rehabilitation in patients with cardiovascular disease leads various hemodynamic parameters obtained using simple non-invasive tests to their appropriate levels
In conclusion, CR may lead various hemodynamic parameters obtained using simple non-invasive tests to their appropriate levels. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - October 12, 2017 Category: Cardiology Source Type: research

Left atrial deformation: Useful index for early detection of cardiac damage in chronic mitral regurgitation
Publication date: December 2017 Source:IJC Heart & Vasculature, Volume 17 Author(s): M. Cameli, E. Incampo, S. Mondillo In chronic mitral regurgitation (MR) left atrium is one of the first cardiac structures that is involved in remodeling and ultrastructural changes for a progressive volume overload. Severe left atrial (LA) dilation on echocardiography and new onset of atrial fibrillation in asymptomatic patients with preserved Left Ventricular (LV) function, appeared as a Class IIb recommendation for consideration for surgical mitral valve repair in the actual guidelines. However, before atrial dilatation and dys...
Source: IJC Heart and Vasculature - October 3, 2017 Category: Cardiology Source Type: research

Incidence of cancers in patients with atherosclerotic cardiovascular diseases
Conclusions A presence of atherosclerotic CVD itself may have a potential risk for cancer developments. Trial registration ClinicalTrials.gov. number, NCT03005834 (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - September 14, 2017 Category: Cardiology Source Type: research

Contrast microsphere enhancement of the tricuspid regurgitant spectral Doppler signal - Is it still necessary with contemporary scanners?
Conclusion In the era of contemporary scanners, CE improved the ability to detect and measure TRV, except in those with clear unenhanced TR spectral Doppler signals or greater than mild tricuspid regurgitation. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - September 4, 2017 Category: Cardiology Source Type: research

Low-frequency and low-intensity ultrasound irradiation to the forearm improves an index of arterial stiffness in subjects with type 2 diabetes and hypertension
Conclusions The low-frequency and low-intensity ultrasound irradiation to the forearm for 10min might be useful as a preventive application for arterial stiffness in subjects with type 2 diabetes and hypertension. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - August 11, 2017 Category: Cardiology Source Type: research

Associations of increased arterial stiffness with left ventricular ejection performance and right ventricular systolic pressure in mitral regurgitation before and after surgery: Wave intensity analysis
Conclusions In the MR group before surgery, increased arterial stiffness suppresses compensatory enhancement of W1, and increases RVSP. Prolonged (Q-W1)st has the potential for predicting low EF after surgery. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - July 13, 2017 Category: Cardiology Source Type: research