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Obesity Increases Risk of Ischemic Stroke in Young Adults Brief Reports
Conclusions— These results indicate that obesity is a risk factor for young onset ischemic stroke and suggest that this association may be partially mediated through hypertension, diabetes mellitus, or other variables associated with these conditions.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Mitchell, A. B., Cole, J. W., McArdle, P. F., Cheng, Y.-C., Ryan, K. A., Sparks, M. J., Mitchell, B. D., Kittner, S. J. Tags: Risk Factors for Stroke Brief Reports Source Type: research

Diabetes Mellitus: A Risk Factor for Ischemic Stroke in a Large Biracial Population Clinical Sciences
Conclusions— Those with diabetes mellitus remain at greatly increased risk for stroke at all ages, especially <65 years, regardless of race. The rates and risk ratios for 1999 and 2005, although similar to those previously reported for the mid-1990s, take on increased significance, given the epidemic of diabetes mellitus and metabolic syndrome throughout the US and the world.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Khoury, J. C., Kleindorfer, D., Alwell, K., Moomaw, C. J., Woo, D., Adeoye, O., Flaherty, M. L., Khatri, P., Ferioli, S., Broderick, J. P., Kissela, B. M. Tags: Other diabetes, Acute Cerebral Infarction, Risk Factors for Stroke Clinical Sciences Source Type: research

Delays in Presentation Time Under the COVID-19 Epidemic in Patients With Transient Ischemic Attack and Mild Stroke: A Retrospective Study of Three Hospitals in a Japanese Prefecture
Conclusions: The COVID-19 epidemic might increase the ODT of patients with TIA/mild stroke.
Source: Frontiers in Neurology - October 27, 2021 Category: Neurology Source Type: research

The “know your numbers” program in Atahualpa — A pilot study aimed to reduce cardiovascular diseases and stroke burden in rural communities of developing countries
The burden of cardiovascular diseases and stroke is steadily increasing in many low- and middle-income countries, to the point that these conditions have been considered as the new epidemics of the developing world . The World Health Organization has set a global goal of reducing deaths from non-communicable diseases (including stroke and ischemic heart disease) by 25% by 2025 . It seems that people living in rural communities are most vulnerable to these “new epidemics”. There, a process of epidemiologic transition is aggravated by poor access to medical care and by income issues that preclude people to afford the cos...
Source: International Journal of Cardiology - May 6, 2013 Category: Cardiology Authors: Oscar H. Del Brutto, Martha Montalván, Daniel Tettamanti, Ernesto Peñaherrera, Rocío Santibáñez, Freddy Pow-Chon-Long, Victor J. Del Brutto Tags: Letters to the Editor Source Type: research

Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea.
Authors: Franklin KA, Lindberg E Abstract The prevalence of obstructive sleep apnea (OSA) defined at an apnea-hypopnea index (AHI) ≥5 was a mean of 22% (range, 9-37%) in men and 17% (range, 4-50%) in women in eleven published epidemiological studies published between 1993 and 2013. OSA with excessive daytime sleepiness occurred in 6% (range, 3-18%) of men and in 4% (range, 1-17%) of women. The prevalence increased with time and OSA was reported in 37% of men and in 50% of women in studies from 2008 and 2013 respectively. OSA is more prevalent in men than in women and increases with age and obesity. Smoking and al...
Source: Journal of Thoracic Disease - September 20, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Fast Heartburn Relief Without Deadly Drugs
Since gastroesophageal reflux disease (GERD) was first identified in the early 1930s, the number of people experiencing heartburn has increased substantially. In fact, one study shows that in just 10 years, the number of people experiencing:1 Any GERD symptoms increased by 30% Symptoms at least once a week increased by 47% Severe GERD increased by 24% While these numbers are concerning, I’ll admit they’re not surprising considering the typical American diet. Our nutrition-less, grain-based diet of carbohydrates and starches has wrecked our health and made our bodies behave in ways nature never intended. This has led ...
Source: Al Sears, MD Natural Remedies - August 28, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Heart Health Natural Cures Nutrition Source Type: news

Influence of dietary patterns on the risk of acute myocardial infarction in China population: the INTERHEART China study.
CONCLUSIONS: Unhealthy dietary intake can increase the AMI risk. Improving intake of vegetables, fruits and tofu have the potential to partially prevent the rising epidemic of cardiovascular disease in China. PMID: 23422108 [PubMed - in process]
Source: Chinese Medical Journal - February 1, 2013 Category: Journals (General) Authors: Guo J, Li W, Wang Y, Chen T, Teo K, Liu LS, Yusuf S, INTERHEART China study investigators Tags: Chin Med J (Engl) Source Type: research

Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease.
Abstract There is a global epidemic of obesity, metabolic syndrome, and diabetes mellitus. Insulin resistance (IR) is etiologic for both metabolic syndrome and diabetes mellitus. IR induces a broad range of toxic systemic effects, including dyslipidemia, hypertension, hyperglycemia, increased production of advanced glycosylation end products, increased inflammatory tone, as well as a prothrombotic and pro-oxidative state. Patients with IR are highly vulnerable to the development of accelerated atherosclerosis as well its clinical sequelae, including coronary artery disease and myocardial infarction, carotid artery...
Source: Current Vascular Pharmacology - April 25, 2013 Category: Drugs & Pharmacology Authors: Toth PP Tags: Curr Vasc Pharmacol Source Type: research

Population-based study of cardiovascular health in Atahualpa, a rural village of coastal Ecuador
The American Heart Association (AHA) recently defined the metrics needed to categorize cardiovascular health (CVH), to implement strategies directed to reduce vascular deaths among US populations . The same could be applied to developing countries, where stroke and cardiovascular diseases will be the next health epidemics due to changes in lifestyle and increased life expectancy . Indeed, the rate of vascular deaths in Latin America is higher than in the developed world; this excess mortality fraction could be related to modifiable factors, including: inadequate access to medical care, increasing obesity and diabetes melli...
Source: International Journal of Cardiology - February 13, 2013 Category: Cardiology Authors: Oscar H. Del Brutto, Milton Santamaría, Elio Ochoa, Ernesto Peñaherrera, Rocío Santibáñez, Freddy Pow-Chon-Long, Mauricio Zambrano, Victor J. Del Brutto Tags: Letters to the Editor Source Type: research

Relationship between body mass index and left atrial appendage thrombus in nonvalvular atrial fibrillation
Abstract Atrial fibrillation and obesity are two major growing epidemics in the United States and globally. Obese people are at the increased risk of developing atrial fibrillation. The contribution of obesity as an independent risk factor for stroke in the setting of atrial fibrillation remains unclear. We tested the hypothesis that non-valvular atrial fibrillation (NVAF) patients with increased body mass index (BMI) would be at increased risk for the development of left atrial appendage thrombus (LAAT). Consecutive, anticoagulation naïve patients with NVAF referred for a transesophageal echocardiogram (TEE) bet...
Source: Journal of Thrombosis and Thrombolysis - August 18, 2015 Category: Hematology Source Type: research

Prevalence, incidence and concomitant co-morbidities of type 2 diabetes mellitus in South Western Germany - a retrospective cohort and case control study in claims data of a large statutory health insurance
Conclusions: T2DM is common and increasing in South Western Germany. In particular a quarter of the population in higher ages was afflicted by T2DM. Interestingly a region-specific pattern was observed as well as an increase in numbers during earlier years in life. Our data underline the need for diabetes awareness programmes including early diagnosis measures as well as structured and timely health surveys for major diseases such as T2DM and its concomitant co-morbidities.
Source: BMC Public Health - September 3, 2015 Category: Consumer Health News Authors: Michael BoehmeGisela BuecheleJulia Frankenhauser-MannussJana MuellerDietlinde LumpBernhard BoehmDietrich Rothenbacher Source Type: research

Glycaemic, Blood Pressure and Low Density Lipoprotein Cholesterol Control in Adult Patients with Diabetes in Singapore: A Review of Singapore Literature Over Two Decades.
CONCLUSION: Mirroring global patterns, the glycaemic, BP and LDL-C control in adult diabetic patients in Singapore do not appear to be treated to target in the majority of patients. PMID: 29177366 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - October 1, 2017 Category: General Medicine Authors: Poh Z, Venkataraman K, Toh SE, Low LL Tags: Ann Acad Med Singapore Source Type: research

Characterisation of bone and joint infections due to Group B Streptococcus serotype III sequence type 283
This study adds to growing evidence of a distinct clinical presentation associated with ST283 GBS, involving predominantly healthier patients without significant comorbidities, and with distinct clinical manifestations with regard to bone and joint disease.
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 18, 2018 Category: Microbiology Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Prevalence of micro and macro vascular complications and their risk factors in type 2 diabetes in Saudi Arabian population: an analysis from SHIS
CONCLUSIONS: The high prevalence of microvascular and macrovascular complications in diabetic patients poses a serious threat to public health in Saudi Arabia. A multisectoral approach needs to be undertaken to properly control and modify common risk factors at the community level.PMID:34227065 | DOI:10.26355/eurrev_202106_26137
Source: Pharmacological Reviews - July 6, 2021 Category: Drugs & Pharmacology Authors: M S Ahmad T Alslamah S M Alannaz R A Shaik R K Ahmad M Yusuf M Khan A Ghimire Source Type: research

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