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Condition: Diabetes Mellitus
Drug: Insulin

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Total 394 results found since Jan 2013.

Gender‐specific effects of oral hypoglycaemic agents on cancer risk in type 2 diabetes mellitus
ConclusionsOral insulin sensitizers, particularly thiazolidinedione, are associated with decreased malignancy risk in women with type 2 diabetes mellitus.
Source: Diabetes, Obesity and Metabolism - December 5, 2013 Category: Endocrinology Authors: G. E. C. Sun, B. J. Wells, K. Yip, R. Zimmerman, D. Raghavan, M. W. Kattan, S. R. Kashyap Tags: ORIGINAL ARTICLE Source Type: research

Metabolic Syndrome and Non-Cardiac Vascular Diseases: an Update from Human Studies.
Abstract The metabolic syndrome (MetS) is characterized by a cluster of risk factors including central obesity, hypertension, dyslipidemia and insulin resistance, The MetS is associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Several international organizations have defined MetS using different diagnostic criteria that produced discrepancies in the results of previous studies, thus leading to the latest Joint Interim Societies (JIS) MetS definition. Other risk factors than the diagnostic criteria that have been associated with MetS include lipid abnormalities, u...
Source: Current Pharmaceutical Design - December 5, 2013 Category: Drugs & Pharmacology Authors: Katsiki N, Athyros VG, Karagiannis A, Mikhailidis DP Tags: Curr Pharm Des Source Type: research

Relationship of obesity and insulin resistance with the cerebrovascular reactivity: a case control study
Conclusions: We found a diminished vasomotor reactivity in individuals with obesity which was not explained by the presence of insulin resistance.
Source: Cardiovascular Diabetology - January 3, 2014 Category: Cardiology Authors: Marcela Rodríguez-FloresCarlos Cantú-BritoEduardo García-GarcíaClaudia Cano-Nigenda Source Type: research

Impact of Diabetes Mellitus on Early and Midterm Outcomes After Transcatheter Aortic Valve Implantation (from a Multicenter Registry)
In conclusion, DM does not significantly affect rates of complications in patients who underwent TAVI. Insulin-treated DM, but not orally treated DM, is independently associated with death and myocardial infarction at midterm follow-up and should be included into future TAVI-dedicated scores.
Source: The American Journal of Cardiology - November 13, 2013 Category: Cardiology Authors: Federico Conrotto, Fabrizio D'Ascenzo, Francesca Giordana, Stefano Salizzoni, Corrado Tamburino, Giuseppe Tarantini, Patrizia Presbitero, Marco Barbanti, Valeria Gasparetto, Marco Mennuni, Massimo Napodano, Marco L. Rossi, Michele La Torre, Gaetana Ferrar Tags: Valvular Heart Disease Source Type: research

Diabetes Mellitus: Systemic And Oral Complications in 467 Patients From Cape-Fousp
Conclusion: Since most patients with diabetes have oral and systemic complications, the dentist must be able to identify and manage them.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 21, 2014 Category: ENT & OMF Authors: MARIA CAROLINA NUNES VILELA, CRISTINE AYAME IVANO, CÍNTIA DE PAULA MARTINS, KARIN SÁ FERNANDES, MARINA HELENA CURY GALLOTTINI, NATHALIE PEPE MEDEIROS DE REZENDE Tags: Online Only Articles Source Type: research

Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus.
CONCLUSIONS: Tight blood sugar control reduces the risk of developing microvascular diabetes complications. The evidence of benefit is mainly from studies in younger patients at early stages of the disease. Benefits need to be weighed against risks including severe hypoglycaemia, and patient training is an important aspect in practice. The effects of tight blood sugar control seem to become weaker once complications have been manifested. However, further research is needed on this issue. Furthermore, there is a lack of evidence from RCTs on the effects of tight blood sugar control in older patient populations or patients w...
Source: Cochrane Database of Systematic Reviews - February 14, 2014 Category: Journals (General) Authors: Fullerton B, Jeitler K, Seitz M, Horvath K, Berghold A, Siebenhofer A Tags: Cochrane Database Syst Rev Source Type: research

Modeling effects of SGLT‐2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes
ConclusionsOn the basis of simulation results, adding dapagliflozin to currently available treatment options is projected to further decrease the CV and microvascular complications associated with T2DM.
Source: Diabetes, Obesity and Metabolism - February 19, 2014 Category: Endocrinology Authors: J. Dziuba, P. Alperin, J. Racketa, U. Iloeje, D. Goswami, E. Hardy, I. Perlstein, H. L. Grossman, M. Cohen Tags: ORIGINAL ARTICLE Source Type: research

Unexpected inverse relationship between impaired glucose metabolism and lipoprotein-associated phospholipase A2 activity in patients with stable vascular disease.
CONCLUSION: In present study, we cannot confirm any additive risk of impaired glucose metabolism in terms of increased activity of Lp-PLA2. On the contrary, presence of inadequately controlled diabetes mellitus was independently associated with lower risk of elevated aLp-PLA2 . PMID: 24930071 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - June 11, 2014 Category: Internal Medicine Authors: Mayer O, Seidlerová J, Filipovský J, Timoracká K, Bruthans J, Vaněk J, Cerná L, Wohlfahrt P, Renata C, Trefil L Tags: Eur J Intern Med Source Type: research

Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting
Conclusion Within a short period of 3–4 weeks, CR led to substantial improvements in key risk factors such as lipid profile, blood pressure, and physical fitness for all patients, even if CKD was present.
Source: European Journal of Preventive Cardiology - August 18, 2014 Category: Cardiology Authors: Voller, H., Gitt, A., Jannowitz, C., Karoff, M., Karmann, B., Pittrow, D., Reibis, R., Hildemann, S. Tags: Original scientific papers Source Type: research

Evaluation of the relationship between serum apelin levels and vitamin D and mean platelet volume in diabetic patients.
CONCLUSION: We failed to show an association between vitamin D, apelin and MPV higher volumes of which may have a role in cardiovascular complications related to diabetes by increasing platelet activation. PMID: 25156130 [PubMed - as supplied by publisher]
Source: Annales d'Endocrinologie - August 22, 2014 Category: Endocrinology Authors: Kiskac M, Zorlu M, Cakirca M, Karatoprak C, Kesgin S, Büyükaydın B, Yavuz E, Ardic C, Camli AA, Cikrikcioglu MA Tags: Ann Endocrinol (Paris) Source Type: research

What is type 2 diabetes?
Type 2 diabetes mellitus (T2DM) is a common metabolic disorder characterized by chronic hyperglycemia. It is associated with reduced life expectancy owing to a greater risk of heart disease, stroke, peripheral neuropathy, renal disease, blindness and amputation. The best known predictors of increased diabetes risk are elevated fasting plasma glucose, abnormal glucose tolerance test, obesity and evidence of impaired insulin action. However, the mechanisms by which people with impaired fasting glucose and/or abnormal glucose tolerance ‘progress’ to overt T2DM are not completely understood.
Source: Medicine - October 21, 2014 Category: Internal Medicine Authors: Meera Shah, Adrian Vella Tags: Diabetes: basic facts Source Type: research

Glucose metabolism derangements in adults with the MELAS m.3243A>G mutation
In this study we used stable isotope infusion techniques to assess glucose metabolism in vivo and under physiological conditions in 5 diabetic and 11 non-diabetic adults with the m.3243A>G mutation and 10 healthy adult controls. Our results revealed increased glucose production due to increased gluconeogenesis in both diabetic and non-diabetic subjects with the m.3243A>G mutation. In addition, diabetic subjects demonstrated insulin resistance and relative insulin deficiency, resulting in an inability to increase glucose oxidation which can explain the development of DM in these subjects. Non-diabetic subjects...
Source: Mitochondrion - November 3, 2014 Category: Biochemistry Source Type: research

Macrovascular disease: pathogenesis and risk assessment
Type 2 diabetes mellitus is characterized by obesity and insulin resistance (IR). Macrovascular (cardiovascular) disease (CVD) encompasses myocardial infarction, stroke and peripheral artery disease. It is caused by atherosclerosis, a complex pathological process that is accelerated in people with diabetes and therefore accounts for a higher proportion of total mortality. Risk is modified by established factors including hypertension and dyslipidaemia (which are linked with underlying insulin resistance), and microalbuminuria/renal impairment.
Source: Medicine - November 21, 2014 Category: Internal Medicine Authors: Sandro Vella, John R. Petrie Tags: Macrovascular disease Source Type: research

Club 35 Poster session 1: Wednesday 3 December 2014, 09:00-16:00 * Location: Poster area
Left ventricle hypertrophy (LVH) is strongly associated with stroke and myocardial infarction in hypertensive patients. Hypertensive heart characterized by cardiomyocytes hypertrophy, fibroblasts proliferation, enlargement of interstitial collagen volume and their ratio disorders which result in dangerous complications. Renin-angiotensin-aldosterone system (RAAS) and insulin-like growth factor 1 (IGF-1) play significant role in development of myocardial fibrosis and LV remodelling in hypertensive patients. The purpose of the study is to evaluate relations between activity of RAAS and interstitial fibrosis markers and left ...
Source: European Heart Journal Cardiovascular Imaging - December 5, 2014 Category: Radiology Authors: Krestjyaninov, M., Gimaev, R., Razin, V., Halaph, H., Shameeva, O., Galli, E., Oger, E., Levery, M., Mabo, P., Donal, E., Rodriguez Munoz, D., Carbonell Sanroman, A., Moya Mur, J., Lazaro Rivera, C., Fernandez Santos, S., Rincon Diaz, L., Casas Rojo, E., Tags: Wednesday 13 December 2014 Source Type: research

Adiponectin, type 2 diabetes and cardiovascular risk
Conclusions In conclusion, increasing plasma adiponectin is associated with decreased risk of T2DM and subsequently reduced risk of CV events.
Source: European Journal of Preventive Cardiology - February 10, 2015 Category: Cardiology Authors: Lindberg, S., Jensen, J. S., Bjerre, M., Pedersen, S. H., Frystyk, J., Flyvbjerg, A., Galatius, S., Jeppesen, J., Mogelvang, R. Tags: Original scientific paper Source Type: research