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Condition: Dementia

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Total 4555 results found since Jan 2013.

Predictors of mortality and disability in stroke-associated pneumonia
AbstractWhilst stroke-associated pneumonia (SAP) is common and associated with poor outcomes, less is known about the determinants of these adverse clinical outcomes in SAP. To identify the factors that influence mortality and morbidity in SAP. Data for patients with SAP (n = 854) were extracted from a regional Hospital Stroke Register in Norfolk, UK (2003–2015). SAP was defined as pneumonia occurring within 7 days of admission by the treating clinicians. Mutlivariable regression models were constructed to assess factors influencing survival and the level of di sability at discharge using modified Rankin Scale [mRS]...
Source: Acta Neurologica Belgica - April 28, 2019 Category: Neurology Source Type: research

Preventing dementia by preventing stroke: The Berlin Manifesto
This article summarizes the evidence for translation into action.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 18, 2019 Category: Geriatrics Source Type: research

Subjective Memory Complaints and Sensitivity of the Subjective Memory Complaint Questionnaire in Post-Stroke Dementia Patients
Conclusions: The SMCQ may be a valid measure of cognitive function among patients with stroke, is sensitive for post-stroke dementia, and may assume a complementary role for assessing patients with stroke.Dement Geriatr Cogn Disord
Source: Dementia and Geriatric Cognitive Disorders - August 11, 2020 Category: Geriatrics Source Type: research

IJERPH, Vol. 17, Pages 7203: The Prevalence of Cognitive Impairment on Admission to Nursing Home among Residents with and without Stroke: A Cross –Sectional Survey of Nursing Homes in Ireland
IJERPH, Vol. 17, Pages 7203: The Prevalence of Cognitive Impairment on Admission to Nursing Home among Residents with and without Stroke: A Cross–Sectional Survey of Nursing Homes in Ireland International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17197203 Authors: Nora-Ann Donnelly Eithne Sexton Niamh A. Merriman Kathleen E. Bennett David J Williams Frances Horgan Paddy Gillespie Anne Hickey Maev-Ann Wren Post–stroke cognitive impairment (PSCI) is a common consequence of stroke. Epidemiological evidence indicates that, with an ageing population, stroke an...
Source: International Journal of Environmental Research and Public Health - September 30, 2020 Category: Environmental Health Authors: Nora-Ann Donnelly Eithne Sexton Niamh A. Merriman Kathleen E. Bennett David J Williams Frances Horgan Paddy Gillespie Anne Hickey Maev-Ann Wren Tags: Article Source Type: research

IJERPH, Vol. 18, Pages 6500: Free Fatty Acids Are Associated with the Cognitive Functions in Stroke Survivors
ta Szczuko Ischemic stroke is a leading cause of motor impairment and psychosocial disability. Although free fatty acids (FFA) have been proven to affect the risk of stroke and potentially dementia, the evidence of their impact on cognitive functions in stroke patients is lacking. We aimed to establish such potential relationships. Seventy-two ischemic stroke patients were prospectively analysed. Their cognitive functions were assessed seven days post-stroke and six months later as follow-up (n = 41). Seven days post-stroke analysis of serum FFAs levels showed direct correlations between Cognitive Verbal Learning Test ...
Source: International Journal of Environmental Research and Public Health - June 16, 2021 Category: Environmental Health Authors: Dariusz Kotl ęga Barbara Peda Joanna Palma Agnieszka Zembro ń-Łacny Monika Go łąb-Janowska Marta Masztalewicz Przemys ław Nowacki Ma łgorzata Szczuko Tags: Article Source Type: research

Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke
Circ Res. 2022 Apr 15;130(8):1167-1186. doi: 10.1161/CIRCRESAHA.121.319994. Epub 2022 Apr 14.ABSTRACTInflammation and immune mechanisms are crucially involved in the pathophysiology of the development, acute damage cascades, and chronic course after ischemic stroke. Atherosclerosis is an inflammatory disease, and, in addition to classical risk factors, maladaptive immune mechanisms lead to an increased risk of stroke. Accordingly, individuals with signs of inflammation or corresponding biomarkers have an increased risk of stroke. Anti-inflammatory drugs, such as IL (interleukin)-1β blockers, methotrexate, or colchicine, r...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Matthias Endres Maria A Moro Christian H Nolte Claudia Dames Marion S Buckwalter Andreas Meisel Source Type: research

EXERTION: a pilot trial on the effect of aerobic, smartwatch-controlled exercise on stroke recovery: effects on motor function, structural repair, cognition, mental well-being, and the immune system
This study investigates the effect of smartwatch-controlled aerobic exercise on functional recovery, cognition, emotional well-being, the immune system, and neuronal network reorganization in stroke patients. Trial registration ClinicalTrials.gov NCT Number: NCT05690165. First posted19 January 2023. Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05690165.PMID:37170385 | DOI:10.1186/s42466-023-00244-w
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Frederike A Straeten Stephanie van Zyl Bastian Maus Jochen Bauer Heiner Raum Catharina C Gross Sabine Bruchmann Nils C Landmeyer Cornelius Faber Jens Minnerup Antje Schmidt-Pogoda Source Type: research

Association of Stroke with the Receptor-Binding Profiles of Antipsychotics—A Case-Crossover Study
Conclusions: Our findings suggest an association between stroke risk and high M1 muscarinic and α2 adrenergic affinity. The clinical implication is to start antipsychotics treatment at low dosages and to closely monitor the side effects in the initial treatment, particularly for individuals with older age and the presence of dementia.
Source: Biological Psychiatry - August 9, 2012 Category: Psychiatry Authors: Chi-Shin Wu, Sheng-Chang Wang, Susan Shur-Fen Gau, Hui-Ju Tsai, Yu-Cheng Cheng Tags: Archival Reports Source Type: research

Enlarged perivascular spaces and cerebral small vessel disease
ConclusionsEnlarged perivascular spaces are associated with age, lacunar stroke subtype and white matter lesions and should be considered as another magnetic resonance imaging marker of cerebral small vessel disease. Further evaluation of enlarged perivascular spaces in studies of ageing, stroke, and dementia is needed to determine their pathophysiological importance.
Source: International Journal of Stroke - May 22, 2013 Category: Neurology Authors: Gillian M. Potter, Fergus N. Doubal, Caroline A. Jackson, Francesca M. Chappell, Cathie L. Sudlow, Martin S. Dennis, Joanna M. Wardlaw Tags: Research Source Type: research

The panoply of field-dependent behavior in 1436 stroke patients. The mirror neuron system uncoupled and the consequences of loss of personal autonomy.
Abstract Evaluation of the multifaceted nature of frontal network syndromes is uniquely challenging and rarely tested in the acute/sub-acute stroke period. Field-dependent behavior such as imitation behavior, utilization behavior, and environmental dependency syndrome, as a component of altered environmental autonomy, may be a reliable bedside test. This research focused on the frequency of field-dependent behavior in stroke, the subtypes and relation to frontal lobe lesion location and stroke etiology. A validated frontal network score incorporating a 10-point imitation behavior scale was applied to alert patient...
Source: Neurocase - September 2, 2013 Category: Neurology Authors: Hoffmann M Tags: Neurocase Source Type: research

The exact science of stroke thrombolysis and the quiet art of patient selection
The science of metric-based patient stratification for intravenous thrombolysis, revolutionized by the landmark National Institute of Neurological Disorders and Stroke trial, has transformed acute ischaemic stroke therapy. Recanalization of an occluded artery produces tissue reperfusion that unequivocally improves outcome and function in patients with acute ischaemic stroke. Recanalization can be achieved mainly through intravenous thrombolysis, but other methods such as intra-arterial thrombolysis or mechanical thrombectomy can also be employed. Strict guidelines preclude many patients from being treated by intravenous th...
Source: Brain - December 11, 2013 Category: Neurology Authors: Balami, J. S., Hadley, G., Sutherland, B. A., Karbalai, H., Buchan, A. M. Tags: Review Article Source Type: research

Cortical Photothrombotic Infarcts Impair the Recall of Previously Acquired Memories but Spare the Formation of New Ones Basic Sciences
Conclusions— Photothrombotic cortical infarcts impair the recall of memories acquired before stroke, whereas the formation of new memories remains unimpaired. The observed deficits in the water maze are not confounded by disturbed motor functions. Overall, experimental photothrombotic strokes are well suited for the investigation of specific cognitive impairments after stroke.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Diederich, K., Schmidt, A., Strecker, J.-K., Schabitz, W.-R., Schilling, M., Minnerup, J. Tags: Animal models of human disease Basic Sciences Source Type: research