Predictors of mortality and disability in stroke-associated pneumonia

AbstractWhilst stroke-associated pneumonia (SAP) is common and associated with poor outcomes, less is known about the determinants of these adverse clinical outcomes in SAP. To identify the factors that influence mortality and morbidity in SAP. Data for patients with SAP (n = 854) were extracted from a regional Hospital Stroke Register in Norfolk, UK (2003–2015). SAP was defined as pneumonia occurring within 7 days of admission by the treating clinicians. Mutlivariable regression models were constructed to assess factors influencing survival and the level of di sability at discharge using modified Rankin Scale [mRS]. Mean (SD) age was 83.0 (8.7) years and ischaemic stroke occurred in 727 (85.0%). Mortality was 19.0% at 30 days and 44.0% at 6 months. Stroke severity assessment using National Institutes of Health Stroke Scale was not recorded in the data s et although Oxfordshire Community Stroke Project was Classification. In the multivariable analyses, 30-day mortality was independently associated with age (OR 1.04, 95% CI 1.01–1.07,p = 0.01), haemorrhagic stroke (2.27, 1.07–4.78,p = 0.03) and pre-stroke disability (mRS 4–5 v 0–1: 6.45, 3.12–13.35,p <  0.001). 6-month mortality was independently associated with age (<  0.001), pre-stroke disability (p <  0.001) and certain comorbidities, including the following: dementia (6.53, 4.73–9.03,p <  0.001), lung cancer (2.07, 1.14–3.77,p = 0.017) and previous transient isc...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research