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Condition: Dementia
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Total 225 results found since Jan 2013.

Progressive Cognitive Deficits in a Mouse Model of Recurrent Photothrombotic Stroke Brief Reports
Conclusions— Our results show progressive cognitive deficits in a mouse model of recurrent photothrombotic stroke. The presented model resembles the clinical features of human multi-infarct dementia and enables the investigation of its pathophysiological mechanisms and the evaluation of treatment strategies.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Schmidt, A., Diederich, K., Strecker, J.-K., Geng, B., Hoppen, M., Duning, T., Schabitz, W.-R., Minnerup, J. Tags: Behavioral Changes and Stroke Brief Reports Source Type: research

Cognitive performance after stroke – The Framingham Heart Study
ConclusionsClinical stroke is associated with subsequent poorer performance in multiple cognitive domains. This association cannot be entirely explained by the individual's cognitive function prior to stroke or by concomitant vascular risk factor levels.
Source: International Journal of Stroke - April 1, 2014 Category: Neurology Authors: Galit Weinstein, Sarah R. Preis, Alexa S. Beiser, Rhoda Au, Margaret Kelly‐Hayes, Carlos S. Kase, Philip A. Wolf, Sudha Seshadri Tags: Research Source Type: research

Executive function, but not memory, associates with incident coronary heart disease and stroke
Conclusion: Lower executive function, but not memory, is associated with higher risk of coronary heart disease and stroke. Lower executive function, as an independent risk indicator, might better reflect brain vascular pathologies.
Source: Neurology - August 31, 2015 Category: Neurology Authors: Rostamian, S., van Buchem, M. A., Westendorp, R. G. J., Jukema, J. W., Mooijaart, S. P., Sabayan, B., de Craen, A. J. M. Tags: All Cerebrovascular disease/Stroke, Cardiac, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Montreal Cognitive Assessment 5-Minute Protocol Is a Brief, Valid, Reliable, and Feasible Cognitive Screen for Telephone Administration Clinical Sciences
Conclusions— The MoCA 5-minute protocol is a free, valid, and reliable cognitive screen for stroke and transient ischemic attack. It is brief and highly feasible for telephone administration.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Wong, A., Nyenhuis, D., Black, S. E., Law, L. S. N., Lo, E. S. K., Kwan, P. W. L., Au, L., Chan, A. Y. Y., Wong, L. K. S., Nasreddine, Z., Mok, V. Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Texture Features of Magnetic Resonance Images: an Early Marker of Post-stroke Cognitive Impairment
AbstractStroke is frequently associated with delayed, long-term cognitive impairment (CI) and dementia. Recent research has focused on identifying early predictive markers of CI occurrence. We carried out a texture analysis of magnetic resonance (MR) images to identify predictive markers of CI occurrence based on a combination of preclinical and clinical data. Seventy-two-hour post-stroke T1W MR images of 160 consecutive patients were examined, including 75 patients with confirmed CI at the 6-month post-stroke neuropsychological examination. Texture features were measured in the hippocampus and entorhinal cortex and compar...
Source: Translational Stroke Research - October 31, 2019 Category: Neurology Source Type: research

The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (I9-4B)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Treating Dementia in an Age of Mixed Disease Data Blitz Presentations Source Type: research

Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach
AbstractDue to the reactive medical approach applied to disease management, stroke has reached an epidemic scale worldwide. In 2019, the global stroke prevalence was 101.5 million people, wherefrom 77.2 million (about 76%) suffered from ischemic stroke; 20.7 and 8.4 million suffered from intracerebral and subarachnoid haemorrhage, respectively. Globally in the year 2019 — 3.3, 2.9 and 0.4 million individuals died of ischemic stroke, intracerebral and subarachnoid haemorrhage, respectively. During the last three decades, the absolute number of cases increased substantially. The current prevalence of stroke is 110 million ...
Source: EPMA Journal - November 17, 2022 Category: International Medicine & Public Health Source Type: research

IgA natural antibodies are produced following T-cell independent B-cell activation following stroke.
Abstract Up to 30% of stroke patients experience cognitive decline within one year of their stroke. There are currently no FDA-approved drugs that can prevent post-stroke cognitive decline, in part due to a poor understanding of the mechanisms involved. We have previously demonstrated that a B-lymphocyte response to stroke, marked by IgA+ cells, can cause delayed cognitive dysfunction in mice and that a similar adaptive immune response occurs in the brains of some human stroke patients that suffer from vascular dementia. The stimuli which trigger B-lymphocyte activation following stroke, and their target antigens,...
Source: Brain, Behavior, and Immunity - September 17, 2020 Category: Neurology Authors: Zbesko JC, Frye JB, Becktel DA, Gerardo DK, Stokes J, Calderon K, Nguyen TV, Bhattacharya D, Doyle KP Tags: Brain Behav Immun Source Type: research

Ipsilateral hippocampal atrophy is associated with long‐term memory dysfunction after ischemic stroke in young adults
Abstract Memory impairment after stroke in young adults is poorly understood. In elderly stroke survivors memory impairments and the concomitant loss of hippocampal volume are usually explained by coexisting neurodegenerative disease (e.g., amyloid pathology) in interaction with stroke. However, neurodegenerative disease, such as amyloid pathology, is generally absent at young age. Accumulating evidence suggests that infarction itself may cause secondary neurodegeneration in remote areas. Therefore, we investigated the relation between long‐term memory performance and hippocampal volume in young patients with first‐eve...
Source: Human Brain Mapping - March 1, 2015 Category: Neurology Authors: Pauline Schaapsmeerders, Inge W.M. van Uden, Anil M. Tuladhar, Noortje A.M. Maaijwee, Ewoud J. van Dijk, Loes C.A. Rutten‐Jacobs, Renate M. Arntz, Hennie C. Schoonderwaldt, Lucille D.A. Dorresteijn, Frank‐Erik de Leeuw, Roy P.C. Kessels Tags: Research Article Source Type: research

Prediction of post-stroke cognitive impairment using brain FDG PET: deep learning-based approach
CONCLUSION: The DL-based cognitive signature using FDG PET was successfully transferred to an independent stroke cohort. It is suggested that DL-based cognitive evaluation using FDG PET could be utilized as an objective biomarker for cognitive dysfunction in patients with cerebrovascular diseases.PMID:34599654 | DOI:10.1007/s00259-021-05556-0
Source: Molecular Medicine - October 2, 2021 Category: Molecular Biology Authors: Reeree Lee Hongyoon Choi Kwang-Yeol Park Jeong-Min Kim Ju Won Seok Source Type: research

Brain volume loss precedes cognitive decline in the first year after ischaemic stroke
Conclusions Brain volume loss precedes cognitive decline in the first year after ischaemic stroke. Tracking brain volume after stroke is important because brain volume is predictive of cognitive decline and atrophy is a hallmark of dementia.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: Werden, E., Cumming, T., Bird, L., Khlif, M., Brodtmann, A. Tags: Abstracts Source Type: research

IJERPH, Vol. 18, Pages 6500: Free Fatty Acids Are Associated with the Cognitive Functions in Stroke Survivors
ta Szczuko Ischemic stroke is a leading cause of motor impairment and psychosocial disability. Although free fatty acids (FFA) have been proven to affect the risk of stroke and potentially dementia, the evidence of their impact on cognitive functions in stroke patients is lacking. We aimed to establish such potential relationships. Seventy-two ischemic stroke patients were prospectively analysed. Their cognitive functions were assessed seven days post-stroke and six months later as follow-up (n = 41). Seven days post-stroke analysis of serum FFAs levels showed direct correlations between Cognitive Verbal Learning Test ...
Source: International Journal of Environmental Research and Public Health - June 16, 2021 Category: Environmental Health Authors: Dariusz Kotl ęga Barbara Peda Joanna Palma Agnieszka Zembro ń-Łacny Monika Go łąb-Janowska Marta Masztalewicz Przemys ław Nowacki Ma łgorzata Szczuko Tags: Article Source Type: research

Inherited and Uncommon Causes of Stroke
This article is a practical guide to identifying uncommon causes of stroke and offers guidance for evaluation and management, even when large controlled trials are lacking in these rarer forms of stroke. Recent Findings: Fabry disease causes early-onset stroke, particularly of the vertebrobasilar system; enzyme replacement therapy should be considered in affected patients. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), often misdiagnosed as multiple sclerosis, causes migraines, early-onset lacunar strokes, and dementia. Moyamoya disease can cause either ischemic or he...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2017 Category: Neurology Tags: Review Articles Source Type: research

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model.
Abstract Vascular dementia ranks as the second leading cause of dementia in the United States. However, its underlying pathophysiological mechanism is not fully understood and no effective treatment is available. The purpose of the current study was to evaluate long-term cognitive deficits induced by transient middle cerebral artery occlusion (tMCAO) in rats and to investigate the underlying mechanism. Sprague-Dawley rats were subjected to tMCAO or sham surgery. Behavior tests for locomotor activity and cognitive function were conducted at 7 or 30 days after stroke. Hippocampal long term potentiation (LTP) and inv...
Source: Neurobiology of Disease - July 8, 2013 Category: Neurology Authors: Li W, Huang R, Shetty RA, Thangthaeng N, Liu R, Chen Z, Sumien N, Rutledge M, Dillon GH, Yuan F, Forster MJ, Simpkins JW, Yang SH Tags: Neurobiol Dis Source Type: research

Preventing post-stroke dementia. The MARCH Trial. Protocol and statistical analysis plan of a randomized clinical trial testing the safety and efficacy of Maraviroc in post-stroke cognitive impairment
CONCLUSIONS: The results of this work could lead to a novel, readily available, therapeutic avenue to reduce PSCI, and possibly other pathologies. This study will test safety and effectiveness of Maraviroc in limiting cognitive deterioration and/or post stroke cognitive impairment in patients with cerebral small vessel disease.SCHEDULE: First-patient first-visit was May 2021. Recruitment to complete in 2023, follow-up to complete in 2024.PMID:36082248 | PMC:PMC9446318 | DOI:10.1177/23969873221098857
Source: Atherosclerosis - September 9, 2022 Category: Cardiology Authors: Einor Ben Assayag Jeremy Molad Estelle Seyman Ofer Rotschild Ehud Zeltzer Udi Sadeh-Gonik Noa Bregman Aviva Alpernas Yahel Segal Dafna Ben Bashat Talya Nathan Muhamad Hawwari Oren Tene Hen Hallevi Source Type: research