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Condition: Liver Disease
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Total 328 results found since Jan 2013.
Amelioration of Non-alcoholic Fatty Liver Disease by Hepatic Stimulator Substance via Preservation of Carnitine Palmitoyl Transferase-1 Activity.
In conclusion, HSS reduces lipotoxicity to mitochondria most likely via preservation of CPT-1.
PMID: 26108664 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - June 24, 2015 Category: Cytology Authors: Xiao W, Ren M, Zhang C, Li S, An W Tags: Am J Physiol Cell Physiol Source Type: research
Hepatic TLR4 Signaling in Obese NAFLD.
CONCLUSION: TLR4 expression is up-regulated in a large cohort of NASH patients, when compared to those with NAFL, and this occurs within the setting of increased LPS and fatty acids.
PMID: 26113297 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - June 25, 2015 Category: Gastroenterology Authors: Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
Long non-coding RNAs era in liver cancer.
Authors: Guerrieri F
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignancies leading to high mortality rates in the general population and the sixth most common cancer worldwide. HCC is characterized by deregulation of multiple genes and signalling pathways. These genetic effects can involve both protein coding genes as well as non-coding RNA genes. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nt, constituting a subpopulation of ncRNAs. Their biological effects are not well understood compared to small non-coding RNA (microRNAs), but they have been recently recognized to exe...
Source: World Journal of Hepatology - August 12, 2015 Category: Gastroenterology Tags: World J Hepatol Source Type: research
Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity
In conclusion, HSS reduces lipotoxicity to mitochondria most likely via preservation of CPT-1.
Source: AJP: Cell Physiology - August 15, 2015 Category: Cytology Authors: Xiao, W., Ren, M., Zhang, C., Li, S., An, W. Tags: ARTICLES Source Type: research
Molecules, Vol. 20, Pages 17944-17975: Therapeutic Oligonucleotides Targeting Liver Disease: TTR Amyloidosis
The liver has become an increasingly interesting target for oligonucleotide therapy. Mutations of the gene encoding transthyretin (TTR), expressed in vast amounts by the liver, result in a complex degenerative disease, termed familial amyloid polyneuropathy (FAP). Misfolded variants of TTR are linked to the establishment of extracellular protein deposition in various tissues, including the heart and the peripheral nervous system. Recent progress in the chemistry and formulation of antisense (ASO) and small interfering RNA (siRNA) designed for a knockdown of TTR mRNA in the liver has allowed to address the issue of gene-spe...
Source: Molecules - September 30, 2015 Category: Chemistry Authors: Christoph NiemietzGursimran ChandhokHartmut Schmidt Tags: Review Source Type: research
Post-transcriptional HAMP Regulation by PA Is Mediated via HuR Gene Regulation
In conclusion, lipids mediate post-transcriptional regulation of HAMP throughPKC- and HuR-dependent mechanisms.
Source: Journal of Biological Chemistry - October 2, 2015 Category: Chemistry Authors: Lu, S., Mott, J. L., Harrison-Findik, D. D. Tags: Metabolism Source Type: research
Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via AMPK- mTOR pathway.
Abstract
Autophagy plays an important role in liver triglyceride (TG) metabolism. Inhibition of autophagy could reduce the clearance of TG in the liver. Hydrogen sulfide (H2S) is a potent stimulator of autophagic flux. Recent studies showed H2S is protective against Hypertriglyceridemia (HTG) and noalcoholic fat liver disease (NAFLD), while the mechanism remains to be explored. Here we test the hypothesis that H2S reduces serum TG level and ameliorates NAFLD through stimulating liver autophagic flux by AMPK-mTOR pathway. The level of serum H2S in patients with HTG was lower than that of control subjects. Sodium hy...
Source: Am J Physiol Endocri... - October 6, 2015 Category: Endocrinology Authors: Sun L, Zhang S, Yu C, Pan Z, Liu Y, Zhao J, Wang X, Yun F, Zhao H, Yan S, Yuan Y, Wang D, Ding X, Li W, Liu G, Zhao X, Liu Z, Li Y Tags: Am J Physiol Endocrinol Metab Source Type: research
RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases.
Abstract
RNA interference has emerged as an innovative technology for gene silencing that degrades mRNAs complementary to the antisense strands of double-stranded, short interfering RNAs (siRNAs). Its therapeutic application has important advantages over small-molecule drugs since offers the possibility of targeting virtually all genes and allows selective silencing of one or several genes. So far, a relative small proportion of cellular proteins can bind and respond to chemical drugs. Based on that, RNA interference-mediated gene silencing is widely considered as a crucial breakthrough in molecular biology with a...
Source: Current Pharmaceutical Design - October 23, 2015 Category: Drugs & Pharmacology Authors: Gonzalez-Rodriguez A, Valverde AM Tags: Curr Pharm Des Source Type: research
Peroxisome Proliferator-Activated Receptor Gamma Negatively Regulates the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Toward Myofibroblasts in Liver Fibrogenesis
Conclusions: PPAR#x03B3; negatively regulates the differentiation of BMSCs toward myofibroblasts, which highlights a further mechanism implicated in the BMSC differentiation.Cell Physiol Biochem 2015;37:2085-2100
Source: Cellular Physiology and Biochemistry - November 24, 2015 Category: Cytology Source Type: research
Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway
Autophagy plays an important role in liver triglyceride (TG) metabolism. Inhibition of autophagy could reduce the clearance of TG in the liver. Hydrogen sulfide (H2S) is a potent stimulator of autophagic flux. Recent studies showed H2S is protective against hypertriglyceridemia (HTG) and noalcoholic fatty liver disease (NAFLD), while the mechanism remains to be explored. Here, we tested the hypothesis that H2S reduces serum TG level and ameliorates NAFLD by stimulating liver autophagic flux by the AMPK-mTOR pathway. The level of serum H2S in patients with HTG was lower than that of control subjects. Sodium hydrosulfide (Na...
Source: AJP: Endocrinology and Metabolism - December 1, 2015 Category: Endocrinology Authors: Sun, L., Zhang, S., Yu, C., Pan, Z., Liu, Y., Zhao, J., Wang, X., Yun, F., Zhao, H., Yan, S., Yuan, Y., Wang, D., Ding, X., Liu, G., Li, W., Zhao, X., Liu, Z., Li, Y. Tags: Articles Source Type: research
miR-212 downregulation contributes to the protective effect of exercise against non-alcoholic fatty liver via targeting FGF-21.
In this study, normal or high-fat diet (HF) mice were either subjected to a 16-week running program or kept sedentary. Exercise attenuated liver steatosis in HF mice. MicroRNA array and qRT-PCR demonstrated that miR-212 was overexpressed in HF liver, while reduced by exercise. Next, we investigated the role of miR-212 in lipogenesis using HepG2 cells with/without long-chain fatty acid treatment (±FFA). FFA increased miR-212 in HepG2 cells. Moreover, miR-212 promoted lipogenesis in HepG2 cells (±FFA). Fibroblast growth factor (FGF)-21, a key regulator for lipid metabolism, was negatively regulated by miR-212 at protein le...
Source: J Cell Mol Med - December 9, 2015 Category: Molecular Biology Authors: Xiao J, Bei Y, Liu J, Dimitrova-Shumkovska J, Kuang D, Zhou Q, Li J, Yang Y, Xiang Y, Wang F, Yang C, Yang W Tags: J Cell Mol Med Source Type: research
Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells.
Authors: Wang H, Liu S, Wang Y, Chang B, Wang B
Abstract
Nod-like receptor protein 3 (NLRP3) inflammasome has been implicated in alcoholic liver disease. Chronic alcohol consumption enhances gut permeability and causes microbial translocation. The present study explored the activation of the NLRP3 inflammasome by Escherichia coli RNA in hepatic stellate cells (HSCs), and the potential role of NLRP3 inflammasome in hepatic fibrosis. E. coli RNA transfection induced HSC-T6 cells to secrete and express mature interleukin-1 beta (IL-1β), which was abolished by NLRP3 siRNA pretreatment. In addition, E. coli RNA transfe...
Source: Bosnian Journal of Basic Medical Sciences - January 20, 2016 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research
HCV-activated NLRP3 Inflammasome Regulates Lipid Metabolism Molecular Bases of Disease
In this study, we elucidate the potential link between chronic hepatitis C-associated inflammation and alteration of lipid homeostasis in infected cells. Our results reveal that the HCV-activated NLRP3 inflammasome is required for the up-regulation of lipogenic genes such as 3-hydroxy-3-methylglutaryl-coenzyme A synthase, fatty acid synthase, and stearoyl-CoA desaturase. Using pharmacological inhibitors and siRNA against the inflammasome components (NLRP3, apoptosis-associated speck-like protein containing a CARD, and caspase-1), we further show that the activation of the NLRP3 inflammasome plays a critical role in lipid d...
Source: Journal of Biological Chemistry - February 12, 2016 Category: Chemistry Authors: McRae, S., Iqbal, J., Sarkar-Dutta, M., Lane, S., Nagaraj, A., Ali, N., Waris, G. Tags: Microbiology Source Type: research
Novel roles for AhR and ARNT in the regulation of alcohol dehydrogenases in human hepatic cells.
In conclusion, activation of the AhR/ARNT signaling pathway by AhR ligands represents a novel mechanism for regulating the expression of ADHs. These effects may be implicated in the toxicity of AhR ligands as well as in the alteration of ethanol or retinol metabolism and may be associated further with higher risk of liver diseases or/and alcohol abuse disorders.
PMID: 27055685 [PubMed - as supplied by publisher]
Source: Archives of Toxicology - April 7, 2016 Category: Toxicology Authors: Attignon EA, Leblanc AF, Le-Grand B, Duval C, Aggerbeck M, Rouach H, Blanc EB Tags: Arch Toxicol Source Type: research
The angiogenic related functions of bone marrow mesenchymal stem cells are promoted by CBDL rat serum via the Akt/Nrf2 pathway.
In conclusion, these findings indicated that the number of MSCs increased in the peripheral blood of CBDL rats, and the Akt/Nrf2 pathway plays a vital role in promoting the angiogenic related functions of BM-MSCs, which could be a potent contributor to pulmonary angiogenesis in HPS.
PMID: 27105936 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - April 18, 2016 Category: Cytology Authors: Shen CC, Chen B, Gu JT, Ning JL, Chen L, Zeng J, Yi B, Lu KZ Tags: Exp Cell Res Source Type: research
