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Specialty: Cardiology
Condition: Mitochondrial Disease

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Total 58 results found since Jan 2013.

Abstract P160: Role of Uncoupling Protein 2 in Stroke Susceptibility of Stroke-prone Spontaneously Hypertensive Rat Session Title: Cerebrovascular Disease and Stroke
Mitochondrial dysfunction causes severe cellular derangements potentially underlying tissue injury and consequent diseases. Evidence of a direct involvement of mitochondrial dysfunction in hypertensive target organ damage is still poor.The gene encoding Uncoupling Protein 2 (UCP2), a inner mitochondrial membrane protein, maps inside stroke QTL/STR1 in stroke prone spontaneously hypertensive rat (SHRSP). We explored the role of UCP2 in stroke pathogenesis of SHRSP. Male SHRSP, stroke resistant SHR (SHRSR) and reciprocal STR1/congenic rats were fed with stroke permissive Japanese style diet (JD). A group of SHRSP received JD...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Rubattu, S., Cotugno, M., Bianchi, F., Di Castro, S., Stanzione, R., Busceti, C., Marchitti, S., Nicoletti, F., Volpe, M. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease Stroke
Conclusions A significant reduction of Ndufc2 expression causes complex I dysfunction and contributes to stroke susceptibility in SHRSP. Moreover, our current evidence may suggest that Ndufc2 can contribute to an increased occurrence of early-onset ischemic stroke in humans.
Source: JAHA:Journal of the American Heart Association - February 17, 2016 Category: Cardiology Authors: Rubattu, S., Di Castro, S., Schulz, H., Geurts, A. M., Cotugno, M., Bianchi, F., Maatz, H., Hummel, O., Falak, S., Stanzione, R., Marchitti, S., Scarpino, S., Giusti, B., Kura, A., Gensini, G. F., Peyvandi, F., Mannucci, P. M., Rasura, M., Sciarretta, S., Tags: Basic Science Research, Gene Expression & Regulation, Cerebrovascular Disease/Stroke Source Type: research

The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses
CONCLUSIONS: Although the results from both multivariable-adjusted prospective and basis MR analyses did not show an association between low mtDNA and increased risk of ischemic stroke, in-depth MR sensitivity analyses may suggest evidence for a causal relationship.PMID:35793595 | DOI:10.1016/j.atherosclerosis.2022.06.1012
Source: Atherosclerosis - July 6, 2022 Category: Cardiology Authors: Leon G Martens Jiao Luo Marieke J H Wermer Ko Willems van Dijk Sara H ägg Felix Grassmann Raymond Noordam Diana van Heemst Source Type: research

Prioritizing Functional Capacity as a Principal End Point for Therapies Oriented to Older Adults With Cardiovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association.
ncil on Quality of Care and Outcomes Research; and Stroke Council Abstract Adults are living longer, and cardiovascular disease is endemic in the growing population of older adults who are surviving into old age. Functional capacity is a key metric in this population, both for the perspective it provides on aggregate health and as a vital goal of care. Whereas cardiorespiratory function has long been applied by cardiologists as a measure of function that depended primarily on cardiac physiology, multiple other factors also contribute, usually with increasing bearing as age advances. Comorbidity, inflammation, mito...
Source: Circulation - March 23, 2017 Category: Cardiology Authors: Forman DE, Arena R, Boxer R, Dolansky MA, Eng JJ, Fleg JL, Haykowsky M, Jahangir A, Kaminsky LA, Kitzman DW, Lewis EF, Myers J, Reeves GR, Shen WK, American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Co Tags: Circulation Source Type: research

The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyse
Mitochondrial dysfunction is associated with increased reactive oxygen species (ROS) that are thought to drive disease risk, including stroke. We investigated the association between mtDNA abundance, as a proxy measure of mitochondrial function, and incident stroke, using multivariable-adjusted survival and Mendelian Randomization (MR) analyses.
Source: Atherosclerosis - June 19, 2022 Category: Cardiology Authors: Leon G. Martens, Jiao Luo, Marieke J.H. Wermer, Ko Willems van Dijk, Sara H ägg, Felix Grassmann, Raymond Noordam, Diana van Heemst Source Type: research

Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection
Conclusion: The results suggest that the cardiorenal protective effects of fenofibrate in young male salt-loaded SHRSPs are explained by its capacity to preserve mitochondrial function.
Source: Journal of Hypertension - March 27, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Pathophysiological aspects Source Type: research

Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies Original Articles
Conclusions— We identified several novel LEA regions, in addition to previously identified genetic variations, associated with cCIMT and cardiovascular disease events among African Americans.
Source: Circulation: Cardiovascular Genetics - April 13, 2017 Category: Cardiology Authors: Shendre, A., Wiener, H., Irvin, M. R., Zhi, D., Limdi, N. A., Overton, E. T., Wassel, C. L., Divers, J., Rotter, J. I., Post, W. S., Shrestha, S. Tags: Cardiovascular Disease, Epidemiology, Genetic, Association Studies, Ultrasound, Atherosclerosis Original Articles Source Type: research

Mitochondrial Implications in Cardiovascular Aging and Diseases: The Specific Role of Mitochondrial Dynamics and Shifts
Int J Mol Sci. 2022 Mar 9;23(6):2951. doi: 10.3390/ijms23062951.ABSTRACTCardiovascular disease has been, and remains, one of the leading causes of death in the modern world. The elderly are a particularly vulnerable group. The aging of the body is inevitably accompanied by the aging of all its systems, and the cardiovascular system is no exception. The aging of the cardiovascular system is a significant risk factor for the development of various diseases and pathologies, from atherosclerosis to ischemic stroke. Mitochondria, being the main supplier of energy necessary for the normal functioning of cells, play an important ...
Source: Atherosclerosis - March 25, 2022 Category: Cardiology Authors: Anastasia V Poznyak Tatiana V Kirichenko Evgeny E Borisov Nikolay K Shakhpazyan Andrey G Kartuesov Alexander N Orekhov Source Type: research

Age-related vascular changes exemplified by the carotid artery
Gefasschirurgie. 2022 Jun 24;27(4):1-7. doi: 10.1007/s00772-022-00901-5. Online ahead of print.ABSTRACTOne of the main risk factors for the presence of carotid stenosis and carotid-related stroke is age. The aim of this review article is to present the current state of knowledge on age-related vascular changes using carotid stenosis as an example.Vascular aging (vascular senescence) is a decrease of structural and functional properties of the vessel wall that takes place on different levels. At the multicellular level an increase in vessel volume and diameter as well as intima media thickness occurs with age mainly due to ...
Source: Atherosclerosis - July 5, 2022 Category: Cardiology Authors: Benedikt Reutersberg Philip D üppers Anna-Leonie Menges Claudia Schrimpf Alexander Zimmermann Jaroslav Pelisek Source Type: research

Evaluation of epicardial and intra-myocardial fat in a patient with mitochondrial cardiomyopathy
Mitochondrial cardiomyopathy is one of the main manifestations in patients with primary mitochondrial respiratory chain disease characterized by mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) and carries a similar prognosis. The phenotype frequently includes hypertrophic cardiomyopathy; dilated cardiomyopathy and left ventricular (LV) non-compaction are rarely present . Cardiac magnetic resonance imaging (MRI) with gadolinium-based contrast agents has been widely used for evaluating the morphology and function of the left ventricle and injured myocardial tissue . Cine imaging with a stan...
Source: International Journal of Cardiology - April 15, 2013 Category: Cardiology Authors: Satoshi Okayama, Shiro Uemura, Yoshihiko Saito Tags: Online letters to the editor Source Type: research

Mitochondrial DNA Damage, Oxidative Stress and Atherosclerosis: Where There is Smoke There is not Always Fire.
Abstract Atherosclerosis is an insidious disease which can remain undetected for decades before manifesting, sometimes lethally, in the form of a stroke or myocardial infarction. With over 900,000 Americans experiencing a heart attack annually(1), there is a strong need to develop better treatments or preventative measures, but these will necessitate a better understanding of the underlying process. Most evidence suggests that atherosclerosis is initiated by chronic endothelial injury in response to the accumulation of low-density lipoprotein (LDL) and oxidized-LDL in the vessel wall, which stimulates an inflammat...
Source: Circulation - July 10, 2013 Category: Cardiology Authors: Davidson SM, Yellon DM Tags: Circulation Source Type: research

Hypoxia and ischemia-reperfusion: a BiK contribution?
Over the last decades, cardiovascular disease has become the primary cause of death in the Western world, and this trend is expanding throughout the world. In particular, atherosclerosis and the subsequent vessel obliterations are the primary cause of ischemic disease (stroke and coronary heart disease). Excess calcium influx into the cells is one of the major pathophysiological mechanisms important for ischemic injury in the brain and heart in humans. The large-conductance calcium-activated K+ channels (BK) are thus interesting candidates to protect against excess calcium influx and the events leading to ischemic injury. ...
Source: AJP: Heart and Circulatory Physiology - September 15, 2014 Category: Cardiology Authors: Tano, J.-Y., Gollasch, M. Tags: REVIEW Source Type: research

Abstract P636: Sex Differences in Cardioprotective AT2R Expression in Diabetic Rats and Its Correlation with Myocardial Damage Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome
Diabetes mellitus (DM) is an independent risk factor for cardiovascular disease (CVD). Healthy, young women are protected from CVD, while diabetic women are more susceptible to CVD compared to age-matched diabetic men and non-diabetic women. Underlying mechanisms for this sex difference in CVD are not fully elucidated. The angiotensin II type 2 receptor (AT2R) is a member of the protective, vasodilative arm of the renin angiotensin system. The Agtr2 gene that codes for AT2R is X-linked, and increased Agtr2 expression is reported in female vasculature of rodent models. We hypothesized that a sex difference might exist in DM...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Lum-Naihe, K., Mahmood, A., Bajwa, J., Emter, C. A., Pulakat, L. Tags: Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome Source Type: research

MELAS syndrome and cardiomyopathy: linking mitochondrial function to heart failure pathogenesis
Abstract Heart failure remains an important clinical burden, and mitochondrial dysfunction plays a key role in its pathogenesis. The heart has a high metabolic demand, and mitochondrial function is a key determinant of myocardial performance. In mitochondrial disorders, hypertrophic remodeling is the early pattern of cardiomyopathy with progression to dilated cardiomyopathy, conduction defects and ventricular pre-excitation occurring in a significant proportion of patients. Cardiac dysfunction occurs in approximately a third of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like e...
Source: Heart Failure Reviews - December 28, 2015 Category: Cardiology Source Type: research