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Rheumatoid meningitis: A rare cause of aseptic meningitis with frequently stroke-like episodes
Conclusions RM is a rare manifestation of RA and often presents with stroke-like episodes. It is currently not implemented in the workup of aseptic meningitis in national guidelines. Crucial clues for diagnosis included recurrent stroke-like episodes refractory to antiepileptic treatment, headache and constitutional symptoms, meningeal enhancement on MRI, CSF pleocytosis, and positive serology findings for ACPA and RF. Prognosis is favorable with early immunosuppressive treatment.
Source: Neurology Clinical Practice - October 15, 2018 Category: Neurology Authors: Schuster, S., Braass, H., Iking-Konert, C., Schnoor, U., Matschke, J., Gerloff, C., Thomalla, G., Magnus, T. Tags: Autoimmune diseases, Meningitis, All Clinical Neurology Review Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Severe Symptoms, but a Truly Treatable Disease
​BY NOURA MAHDI; DARRON LEWIS; JEREMY OSBORNE; & AHMED RAZIUDDIN, MDA 73-year-old man was brought to the emergency department from his nursing home for rectal bleeding and anemia. The patient mentioned he had had episodes of bright red rectal bleeding and constipation for a few months. A colonoscopy had been done prior to the visit, which revealed a large intestine tumor and biopsy confirming adenocarcinoma. He was awaiting an appointment with his surgeon.The patient reported bloody rectal leakage, and a CBC done at the nursing home showed a hemoglobin level of 7.2. He also complained of dyspnea but denied any other ...
Source: The Case Files - March 20, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

What Causes Facial Nerve Palsy?
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - June 3, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Rheumatoid meningitis presenting with stroke-like episodes
Neurologic symptoms in patients with rheumatoid arthritis (RA) are most often caused by osseous compression, affecting the cervical spine or peripheral neurologic structures. CNS involvement in RA is infrequent, consisting of CNS vasculitis or meningitis with or without meningeal nodules.1 When meningeal infiltration is seen, symptoms of presentation can include focal neurologic deficits, seizure, cranial nerve dysfunction, or altered consciousness.1 Here we describe a patient with an unusual presentation of rheumatoid meningitis.
Source: Neurology - April 28, 2014 Category: Neurology Authors: Bourgeois, P., Rivest, J., Bocti, C. Tags: Autoimmune diseases CLINICAL/SCIENTIFIC NOTES Source Type: research

Neuro-Behcet's Syndrome:Case Reports Emphasizing Challenges of Early Diagnosis (P2.075)
CONCLUSIONS: In both cases, NBS was ultimately diagnosed based on characteristic MRI findings, particularly fluctuating brain stem-diencephalic involvement, superimposed on supportive clinical and CSF profiles. Challenges to early diagnosis are highlighted by our cases and by the literature. The differential diagnosis is often broad at onset. Mucocutaenous symptoms can be a clue but may not be present. Awareness of NBS and its neuroimaging correlates is critical to enable timely diagnosis, particularly given that this condition can favorably respond to steroids and steroid-sparing agents.Disclosure: Dr. Feldman has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Feldman, E. Tags: Neurological Consequences of Autoimmune Disease Source Type: research

Pituitary aspergillus infection
We report a case of Aspergillus infection involving the pituitary gland and sellar region discovered in a 74-year-old man. The patient had a history of hypertension, chronic renal disease, autoimmune hemolytic anemia and presented with right eye pain, headaches and worsening hemiparesis. Imaging studies revealed a right internal carotid artery occlusion and an acute right pontine stroke along with smaller infarcts in the right middle cerebral artery distribution. Clinically, the patient was thought to have vasculitis. An infectious etiology was not identified. He developed respiratory distress and died. At autopsy, necroti...
Source: Journal of Clinical Neuroscience - May 29, 2016 Category: Neuroscience Source Type: research

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

Parvovirus B19 infection associated with hemolytic anemia and cranial polyneuropathy
AbstractParvovirus B19 (PB19) is a common, widespread, small, single-stranded DNA virus which has been linked with a broad spectrum of clinical illnesses, including a variety of neurological complications such as encephalitis, meningitis, myelitis, stroke, cerebellar ataxia, and neuropathy. The authors describe a case of PB19 infection associated with hemolytic anemia and cranial polyneuropathy involving the second and third cranial nerves in a 23-year-old immunocompetent woman. The diagnosis of acute PB19 infection was established with detection of positive DNA and anti-PB19 IgM antibodies in blood samples. Antigangliosid...
Source: Journal of NeuroVirology - August 22, 2017 Category: Neurology Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Central Nervous System Opportunistic Infections
Semin Neurol 2019; 39: 383-390 DOI: 10.1055/s-0039-1687842Opportunistic infections of the central nervous system are classically associated with immunosuppression arising from infection with human immunodeficiency virus and with various hematologic malignancies. However, over the past few years, they are increasingly associated with transplantation and various immunosuppressive treatments used to treat autoimmune diseases. They cause significant morbidity and mortality and remain a diagnostic challenge due to the absence of typical signs and symptoms of infection and mimicry by various noninfectious causes. The pathogens a...
Source: Seminars in Neurology - August 1, 2019 Category: Neurology Authors: Agnihotri, Shruti P. Tags: Review Article Source Type: research

Potentially Reversible and Recognizable Acute Encephalopathic Syndromes: Disease Categorization and MRI Appearances ADULT BRAIN
SUMMARY: "Encephalopathy" is a vague term that encompasses varying definitions, often with a nonspecific clinical presentation and numerous possible pathophysiologic causes. Hence, MR imaging plays a crucial role in the early diagnosis and treatment by identifying imaging patterns when there is limited clinical history in such patients with acute encephalopathy. The aim of this review was to aid in remembrance of etiologies of potentially reversible acute encephalopathic syndromes on MR imaging. The differential includes vascular (reversible cerebral vasoconstriction syndrome, transient global amnesia, disseminated intrava...
Source: American Journal of Neuroradiology - August 11, 2020 Category: Radiology Authors: Koksel, Y., McKinney, A. M. Tags: ADULT BRAIN Source Type: research

A one-year longitudinal evaluation of cerebrospinal fluid and blood neurochemical markers in a patient with cryptococcal meningitis complicated by ischemic stroke.
Cryptococcal meningitis (CCM) is caused by the encapsulated basidiomycetous yeast Cryptococcus neoformans and is one of the most common central nervous system (CNS) infections in immunocompromised subjects [1 –4]. In this regard, autoimmune diseases, sarcoidosis, glucocorticoid treatment, solid-organ transplantation, hematologic malignancies, diabetes mellitus, chronic renal failure are well-known predisposing factors for CCM in HIV-negative patients [1–4]. Sources of C. neoformans are excrement of b irds such as pigeons, contaminated soil, and the bark of several tree species [1].
Source: Journal of the Neurological Sciences - December 13, 2021 Category: Neurology Authors: Samir Abu-Rumeileh, Tamara Garibashvili, J ürgen Benjamin Hagemann, Veronika Still, Franziska Bachhuber, Markus Otto, Hayrettin Tumani, Makbule Senel Tags: Letter to the Editor Source Type: research

Bilateral ballism as limb-shaking transient ischemic attacks treated with unilateral carotid artery stent placement
A man in his 80s with no medical history and a heavy smoking habit experienced a sudden involuntary movement of the bilateral limbs, trunk, and tongue. He had mild dysarthria, and could not eat (Video 1). Symptoms lasted for several hours and days, with frequent onset during the day. No consciousness impairments, paralysis, or sensory disturbances were observed. Physical examination and laboratory data did not indicate meningitis, encephalitis, post-infectious causes, or autoimmune disorders.The electroencephalogram showed no abnormalities.
Source: Journal of Stroke and Cerebrovascular Diseases - September 23, 2022 Category: Neurology Authors: Toshihiko Shimizu, Keiko Haro, Masahiko Tagawa, Masaaki Hirata, Sachiko Iwano, Hiroshi Kosaka, Yuji Yamamoto Tags: Case Report Source Type: research

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