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Condition: Autoimmune Disease
Therapy: Immunotherapy

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Total 63 results found since Jan 2013.

The Role of Innate Immune Cells in Allergen Immunotherapy
Abstract   Purpose of reviewAllergic diseases have become a major health challenge across the world in recent years. Allergen immunotherapy (AIT) is the only disease-modifying therapy that can alter the natural course of allergic diseases. In this review, we aim to introduce the current study on innate immunity in AIT and the association between innate immune cells and the clinical efficacy of AIT briefly.Recent findingsAIT can induce long-term immune tolerance through induction of regulatory T cells, regulatory B cells, and inhibitory cytokines such as IL-10 and TGF- β, promotion of immunoglobulin class switching, and ...
Source: Current Treatment Options in Allergy - May 30, 2023 Category: Allergy & Immunology Source Type: research

The Adaptation Model of Immunity: Signal IV Matters Most in Determining the Functional Outcomes of Immune Responses
J Immunol. 2023 Mar 1;210(5):521-530. doi: 10.4049/jimmunol.2200672.ABSTRACTCurrent research in immunology and immunotherapy is fully influenced by the self-nonself model of immunity. This theoretical model suggests that alloreactivity results in graft rejection, whereas tolerance toward self-antigens expressed by malignant cells facilitates cancer development. Similarly, breakage of immunological tolerance toward self-antigens results in autoimmune diseases. Accordingly, immune suppression is recommended for the management of autoimmune diseases, allergy, and organ transplantation, whereas immune inducers are used for the...
Source: Journal of Immunology - March 7, 2023 Category: Allergy & Immunology Authors: Masoud H Manjili Source Type: research

Toxocara canis extract fractions promote mainly the production of Th1 and regulatory cytokines by human leukocytes in vitro
Acta Trop. 2022 Jul 14:106579. doi: 10.1016/j.actatropica.2022.106579. Online ahead of print.ABSTRACTHelminths possibly down-modulate immune responses to airborne allergens through the induction of a regulatory network. The identification of helminths bioactive molecules is highly desirable, given their immunomodulatory potential which could be used in immunotherapies for allergy and autoimmune diseases. To investigate the immunoregulatory potential of the adult Toxocara canis crude extract and ten protein fractions of its extract, human peripheral blood mononuclear cells (PBMC) from 10 allergic and 9 non-allergic individu...
Source: Acta Tropica - July 17, 2022 Category: Infectious Diseases Authors: Ana L úcia Moreno Amor Leonardo Nascimento Santos Eduardo Santos Silva Marina Borges Rab êlo de Santana Em ília Maria Medeiros de Andrade Belitardo Fl ávia de Araújo Sena Lain Pontes de-Carvalho Camila A Figueiredo Neuza Maria Alc ântara-Neves Source Type: research

Effectiveness and safety of allergen immunotherapy in patients with allergic rhinitis complicated by rheumatic autoimmune diseases: a case series study
Allergen immunotherapy (AIT) is the only treatment that has modified the natural history of allergic diseases. However, since its overall effect on the immune system has not been elucidated, AIT is either abso...
Source: Allergy, Asthma and Clinical Immunology - July 11, 2022 Category: Allergy & Immunology Authors: Kazuki Fujioka, Akiko Kasahara, Takashi Kida, Wataru Fujii, Takahiro Seno, Makoto Wada, Masataka Kohno and Yutaka Kawahito Tags: Research Source Type: research

Emerging strategies for treating autoimmune disorders with genetically modified Treg cells
Gene editing of living cells is a cornerstone of present-day medical research that has enabled scientists to address fundamental biologic questions and identify novel strategies to treat diseases. The ability to manipulate adoptive cell therapy products has revolutionized cancer immunotherapy and promises similar results for the treatment of autoimmune diseases, inflammatory disorders, and transplant rejection. Clinical trials have recently deemed polyclonal regulatory T (Treg) cell therapy to be a safe therapeutic option, but questions remain regarding the efficacy of this approach.
Source: Journal of Allergy and Clinical Immunology - January 1, 2022 Category: Allergy & Immunology Authors: Dominic A. Boardman, Megan K. Levings Tags: Reviews and feature article Source Type: research

Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management
AbstractAlopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in hair loss, that affects up to 2% of the general population. The exact pathobiology of AA has still remained elusive, while the common theory is the collapse of the immune privilege of the hair follicle caused by immunological mechanism. Multiple genetic and environment factors contribute to the pathogenesis of AA. There are several clinical treatments for AA, varying from one or multiple well-defined patches to more diffuse or total hair loss of the scalp (alopecia totalis) or hair loss of the entire body (alopecia universalis...
Source: Clinical Reviews in Allergy and Immunology - August 17, 2021 Category: Allergy & Immunology Source Type: research

Allergy, Immunotherapy, and Alternative Treatments for Dizziness
Allergic reactions may result in central symptoms of dizziness, including nonspecific chronic imbalance, Meniere's disease, and autoimmune inner ear disease. Excepting first-generation antihistamines, and short-term use of steroids, most pharmacotherapies used to treat allergic rhinitis have limited benefit in treating allergically induced or related dizziness. Allergy immunotherapy and/or an elimination diet for diagnosed food allergies have been found to be effective treatments. Individuals diagnosed with autoimmune inner ear disease remain challenging to treat and may require high-dose, long-term steroid treatment, biol...
Source: Otolaryngologic clinics of North America - July 20, 2021 Category: ENT & OMF Authors: M. Jennifer Derebery, Laura Christopher Source Type: research

NIDCR's Spring 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Spring 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR & NIH Stand Against Structural Racism NIDCR Director Rena D’Souza, DDS, MS, PhD, said in a statement that there is no place for structural racism in biomedical research, echoing remarks from NIH Director Francis Collins, MD, PhD, in his announcement of a new NIH initiative—called UNIT...
Source: NIDCR Science News - April 7, 2021 Category: Dentistry Source Type: news

Our Current Understanding of Checkpoint Inhibitor Therapy in Cancer Immunotherapy
CONCLUSION: Mechanisms of PD-1 and CTLA4 blockade and normal biological functions of these molecules are highly complex and require additional studies that will be critical for developing new approaches to dissociate the benefits of checkpoint blockade from off-target effects of the immune reactivation that lead to immune-related adverse events.PMID:33716146 | DOI:10.1016/j.anai.2021.03.003
Source: Annals of Allergy, Asthma and Immunology - March 15, 2021 Category: Allergy & Immunology Authors: Elena Goleva Taras Lyubchenko Lukas Kraehenbuehl Mario E LaCouture Donald Y M Leung Jeffrey A Kern Source Type: research

Genetically Engineered T Cells Could Lead to Therapies for Autoimmune Diseases
Digital media& downloads Genetically Engineered T Cells Could Lead to Therapies for Autoimmune Diseases UArizona immunobiologists have created a five-module chimeric antigen receptor T cell that is showing early potential to fight Type 1 diabetes. Stacy Pigott Today University of Arizona Health SciencesNHG-111220-KUHNS-LAB_DSC9160-web.jpg Michael Kuhns, associate professor in the Department of Immunobiology, and Shio Kobayashi, a post-doctoral research fellow, study the basic science of T cell activation in the immune system, and they are using that knowledge to find potential therapies for autoimmune diseases. ...
Source: The University of Arizona: Health - December 4, 2020 Category: Universities & Medical Training Authors: mittank Source Type: research

Role of orally induced regulatory T cells in immunotherapy and tolerance.
Abstract Oral antigen administration to induce regulatory T cells (Treg) takes advantage of regulatory mechanisms that the gastrointestinal tract utilizes to promote unresponsiveness against food antigens or commensal microorganisms. Recently, antigen-based oral immunotherapies (OITs) have shown efficacy as treatment for food allergy and autoimmune diseases. Similarly, OITs appear to prevent anti-drug antibody responses in replacement therapy for genetic diseases. Intestinal epithelial cells and microbiota possibly condition dendritic cells (DC) toward a tolerogenic phenotype that induces Treg via expression of se...
Source: Cellular Immunology - November 14, 2020 Category: Allergy & Immunology Authors: Bertolini TB, Biswas M, Terhorst C, Daniell H, Herzog RW, Piñeros AR Tags: Cell Immunol Source Type: research

Childhood Alopecia Areata: An Overview of Treatment and Recent Patents.
CONCLUSIONS: None of the established therapeutic options are curative. However, newer treatment modalities including excimer laser, interleukin-31 antibodies and biologics are evolving so that there may be significant advances in treatment in the near future. AA can be psychosocially devastating. It is important to assess the quality of life, degree of anxiety, social phobia and mood of the patients and their families. Psychological support is imperative for those who are adversely affected psychosocially. PMID: 32723274 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 30, 2020 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Autoimmunity in 2019
AbstractBased on the PubMed data, we have been performing a yearly evaluation of the publications related to autoimmune diseases and immunology to ascertain the relative weight of the former in the scientific literature. It is particularly intriguing to observe that despite the numerous new avenues of immune-related mechanisms, such as cancer immunotherapy, the proportion of immunology manuscripts related to autoimmunity continues to increase and has been approaching 20% in 2019. As in the previous 13  years, we performed an arbitrary selection of the peer-reviewed articles published by the major dedicated Journals and di...
Source: Clinical Reviews in Allergy and Immunology - July 28, 2020 Category: Allergy & Immunology Source Type: research