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Condition: Thrombocytopenia

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Total 366 results found since Jan 2013.

Systemic treatments for the prevention of venous thrombo-embolic events in paediatric cancer patients with tunnelled central venous catheters.
CONCLUSIONS: We found no significant effects of systemic treatments compared with no intervention in preventing (a)symptomatic VTE in paediatric oncology patients with CVCs. However, this could be a result of the low number of included participants, which resulted in low power. In one CCT, which compared one systemic treatment with another systemic treatment, we identified a significant reduction in symptomatic VTE with the addition of LMWH to AT supplementation.All studies investigated the prevalence of major and/or minor bleeding episodes, and none found a significant difference between study groups. None of the studies ...
Source: Cochrane Database of Systematic Reviews - September 11, 2013 Category: Journals (General) Authors: Schoot RA, Kremer LC, van de Wetering MD, van Ommen CH Tags: Cochrane Database Syst Rev Source Type: research

Adderall® (Amphetamine-Dextroamphetamine) Toxicity
This article discusses our present understanding of Adderall® intoxication and examines 3 dogs presented to our practice after ingestion of large amounts of the drug.
Source: Topics in Companion Animal Medicine - February 1, 2013 Category: Veterinary Research Authors: Kevin T. Fitzgerald, Alvin C. Bronstein Source Type: research

Low-dose intravenous heparin infusion in patients with aneurysmal subarachnoid hemorrhage: a preliminary assessment.
Conclusions In patients with Fisher Grade 3 aSAH whose aneurysm is secured, postprocedure use of a low-dose intravenous heparin infusion may be safe and beneficial. PMID: 24032706 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - September 13, 2013 Category: Neurosurgery Authors: Simard JM, Aldrich EF, Schreibman D, James RF, Polifka A, Beaty N Tags: J Neurosurg Source Type: research

Safety and feasibility of transcatheter aortic valve implantation in patients with severe persistent thrombocytopenia
Untreated symptomatic high-grade aortic stenosis remains a lethal disease. Therefore, a comprehensive evaluation is necessary to obtain the best individual treatment for each patient. Recently, transcatheter aortic valve implantation (TAVI) was developed as an innovative therapy for high-risk and inoperable patients. Persistent thrombocytopenia is an established risk for conventional open heart surgery, but is not covered by traditional surgical risk scores. The aim of the study was the investigation of safety and feasibility of TAVI in patients with severe thrombocytopenia. Because of the complicated outcome of patients w...
Source: Blood Coagulation and Fibrinolysis - September 25, 2013 Category: Hematology Tags: Original Articles Source Type: research

Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies
Conclusions: Our findings strongly support the suggestion that patients with some immune-mediated diseases have an increased risk of SAH. Further studies of the mechanisms behind this association are warranted.
Source: BMC Neurology - November 14, 2013 Category: Neurology Authors: Sreeram RamagopalanJulia PakpoorOlena SeminogRaph GoldacreLee GrahamMichael Goldacre Source Type: research

Reoperative aortic valve replacement in the octogenarians—minimally invasive technique in the era of transcatheter valve replacement
Conclusions: Octogenarians who undergo re-AVR are thought to be high-risk surgical candidates. The present single-center series revealed acceptable in-hospital outcomes and operative mortality. Mre-AVR was associated with better survival compared with Fre-AVR and might benefit this population.
Source: The Journal of Thoracic and Cardiovascular Surgery - November 4, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Tsuyoshi Kaneko, Dan Loberman, Igor Gosev, Fadi Rassam, Siobhan McGurk, Marzia Leacche, Lawrence Cohn Tags: Acquired Cardiovascular Disease Source Type: research

Diagnosis and classification of the antiphospholipid syndrome.
Abstract The antiphospholipid syndrome (APS) is defined by the occurrence of venous and arterial thromboses, often multiple, and recurrent fetal losses, frequently accompanied by a moderate thrombocytopenia, in the presence of antiphospholipid antibodies (aPL). Some estimates indicate that the incidence of the APS is around 5 new cases per 100,000 persons per year and the prevalence around 40-50 cases per 100,000 persons. The aPL are positive in approximately 13% of patients with stroke, 11% with myocardial infarction, 9.5% of patients with deep vein thrombosis and 6% of patients with pregnancy morbidity. The orig...
Source: Journal of Autoimmunity - January 22, 2014 Category: Allergy & Immunology Authors: Gómez-Puerta JA, Cervera R Tags: J Autoimmun Source Type: research

Major thrombocytopenia after balloon‐expandable transcatheter aortic valve replacement: Prognostic implications and comparison to surgical aortic valve replacement
Conclusions: Post‐TAVR thrombocytopenia is a common phenomenon and its magnitude appears similar to that seen after SAVR. It is most often transient, not associated with adverse sequelae and, unless persistent, should be managed in an expectant fashion. © 2014 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - February 13, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Hasan Jilaihawi, Niraj Doctor, Tarun Chakravarty, Mohammad Kashif, James Mirocha, Wen Cheng, Michael Lill, Mamoo Nakamura, Mitch Gheorghiu, Raj Makkar Tags: Original Studie Source Type: research

Ten-year screening for thrombocytopenia after aortic valve replacement
CONCLUSIONS Thrombocytopenia and Elisa (+) are more common after AVR than after other procedures, and both were associated with increased adverse clinical outcomes. Age and lower preoperative platelet count were associated with postoperative thrombocytopenia and Elisa (+).
Source: Interactive CardioVascular and Thoracic Surgery - April 21, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Sun, X., Hill, P. C., Ellis, J., Corso, P. J., Taylor-Panek, S. L., Chen, F. Tags: Adult Cardiac Source Type: research

Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder
We describe 2 new cases presenting with thrombotic stroke/thrombocytopenia: one following shoulder hemi-arthroplasty (performed without heparin) and the other presenting to the emergency room without prior hospitalization, heparin exposure, or preceding infection. Both patients tested strongly positive for anti-platelet factor 4 (PF4)/heparin immunoglobulin (Ig)G in 2 different immunoassays and in the platelet serotonin-release assay. Crucially, both patients’ sera also caused strong (>80%) serotonin release in the absence of heparin, a serologic feature characteristic of delayed-onset HIT (ie, where heparin use p...
Source: Blood - June 5, 2014 Category: Hematology Authors: Warkentin, T. E., Basciano, P. A., Knopman, J., Bernstein, R. A. Tags: Free Research Articles, Platelets and Thrombopoiesis, Thrombosis and Hemostasis, Brief Reports Source Type: research

432p * patterns and efficacy of bevacizumab use across treatment lines in glioblastoma
Conclusions: Our results show bevacizumab treatment may be more efficient after a recurrence than when used in the beginning of treatment and are in line with reported registration trials data.Disclosure: All authors have declared no conflicts of interest.
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Azam, M. B., Rho, Y. S., Mamo, A., Sahebjam, S., Muanza, T., Guiot, M., Al-Shami, J., Sharma, R., Kavan, P. Tags: CNS tumours Source Type: research

Platelet 12-LOX is essential for Fc{gamma}RIIa-mediated platelet activation
In this study, we show for the first time that platelet 12(S)-lipoxygenase (12-LOX), a highly expressed oxylipin-producing enzyme in the human platelet, is an essential component of FcRIIa-mediated thrombosis. Pharmacologic inhibition of 12-LOX in human platelets resulted in significant attenuation of FcRIIa-mediated aggregation. Platelet 12-LOX was shown to be essential for FcRIIa-induced phospholipase C2 activity leading to activation of calcium mobilization, Rap1 and protein kinase C activation, and subsequent activation of the integrin αIIbβ3. Additionally, platelets from transgenic mice expressing human FcR...
Source: Blood - October 2, 2014 Category: Hematology Authors: Yeung, J., Tourdot, B. E., Fernandez-Perez, P., Vesci, J., Ren, J., Smyrniotis, C. J., Luci, D. K., Jadhav, A., Simeonov, A., Maloney, D. J., Holman, T. R., McKenzie, S. E., Holinstat, M. Tags: Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research

Platelet aggregation inhibition by Eptifibatide versus high dose Tirofiban during primary percutaneous interventions
Conclusions • Platelet aggregation inhibition during PCI was significantly correlated with STR and MBG. Platelet aggregation inhibition cut-off point as a predictor of STR >70% was 89.5%, and as a predictor of MBG 2–3 was 87.5%. • Eptifibatide achieves better platelet aggregation inhibition 60min after bolus and 6h after PCI than high dose Tirofiban. • Eptifibatide is associated with better myocardial perfusion as indicated by post procedural mean MBG and STR >70% than high dose Tirofiban. • There was no significant differences between Eptifibatide and high dose Tirofiban regarding thrombocytope...
Source: The Egyptian Heart Journal - November 6, 2014 Category: Cardiology Source Type: research

Phase II trial of hypofractionated intensity-modulated radiation therapy combined with temozolomide and bevacizumab for patients with newly diagnosed glioblastoma
This study demonstrated 90 % 6-month PFS and OS comparable to historic data in patients receiving standard treatment. Bevacizumab did not prevent radiation necrosis associated with this hypofractionated radiation regimen and large PTV volumes may have contributed to high rates of presumed radiation necrosis.
Source: Journal of Neuro-Oncology - December 19, 2014 Category: Cancer & Oncology Source Type: research

Bivalirudin Versus Heparin With or Without Glycoprotein IIb/IIIa Inhibitors in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention Pooled Patient-Level Analysis From the HORIZONS-AMI and EUROMAX Trials
BackgroundIn the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) trial, 3,602 patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) treated with bivalirudin had lower bleeding and mortality rates, but higher acute stent thrombosis rates compared with heparin + a glycoprotein IIb/IIIa inhibitor (GPI). Subsequent changes in primary PCI, including the use of potent P2Y12 inhibitors, frequent radial intervention, and pre-hospital medication administration, were incorporated into the EUROMAX (European Ambu...
Source: Journal of the American College of Cardiology - January 5, 2015 Category: Cardiology Source Type: research