• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Study finds long-term survival of human neural stem cells transplanted into primate brain
(Cell Transplantation Center of Excellence for Aging and Brain Repair) Human neural stem cells (hNSCs) labeled with magnetic nanoparticles were followed by MRI after transplantation into the brains of primates. The study evaluated the long-term survival and differentiation of hNSCs. The hNSCs differentiated into neurons at 24 months and did not cause tumors. Researchers concluded that hNSCs could be of great value as a source for cell replacement and gene transfer for treating Parkinson's disease, Huntington's disease, Alzheimer's disease, ALS, spinal cord injury and stroke.
Source: EurekAlert! - Biology - April 23, 2014 Category: Biology Source Type: news

The potential therapeutic applications of olfactory ensheathing cells in regenerative medicine.
Abstract Olfactory ensheathing cells (OECs) are unique glia cells restricted to the primary olfactory system including the olfactory mucosa, olfactory nerve, and the outer nerve layer of the olfactory bulb. OECs guide growing olfactory axons from the neurons of the nasal cavity olfactory mucosa to the olfactory bulb to connect both the peripheral nervous system (PNS) and central nervous system (CNS). Based on these specialized abilities of OECs, transplantation of OECs to injury sites has been widely investigated for their potential therapeutic applications in neural repair in different injuries. In this article, ...
Source: Cell Transplantation - May 17, 2014 Category: Cytology Authors: Chou RH, Lu CY, Wei-Lee, Fan JR, Yu YL, Shyu WC Tags: Cell Transplant Source Type: research

Regenerative cellular Therapies for neurologic Diseases.
Abstract The promise of stem cell regeneration has been the hope of many neurologic patients with permanent damage to the central nervous system. There are hundreds of stem cell trials worldwide intending to test the regenerative capacity of stem cells in various neurological conditions from Parkinson's disease to multiple sclerosis. Although no stem cell therapy is clinically approved for use in any human disease indication, patients are seeking out trials and asking clinicians for guidance. This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which ...
Source: Brain Research - July 31, 2015 Category: Neurology Authors: Levy M, Boulis N, Rao M, Svendsen CN Tags: Brain Res Source Type: research

Bone Morphogenetic Proteins: Inhibitors of Myelination in Development and Disease.
Abstract Myelin, the lipid membrane that surrounds axons, is critical for the propagation of nervous impulses and axonal maintenance. The destruction of myelin or lack of myelin formation due to disease or injury causes severe motor and cognitive disability. Regeneration of myelin is theoretically possible but rarely happens. Myelin is synthesized as the plasma membrane of the oligodendrocyte in the central nervous system. During development, myelin and oligodendrocytes are generated from oligodendrocyte progenitors through a process modulated by extrinsic growth factors signaling to cell-intrinsic proteins. Among...
Source: Vitamins and Hormones - August 20, 2015 Category: Endocrinology Authors: Grinspan JB Tags: Vitam Horm Source Type: research

Bio-Distribution of Infused Human Umbilical Cord Blood Cells in Alzheimer's Disease-Like Murine Model.
In this report, we followed the bioavailability of HUCBCs in AD-like transgenic PSAPP mice and non-transgenic Sprague-Dawley rats. HUCBCs were injected in tail veins of mice or rats at a single dose of 1 x 10(6) or 2.2 x 10(6) cells, respectively, prior to harvesting of tissues at 24 hours, 7 days, and 30 days after injection. For determination of HUCBC distribution, tissues from both species were subjected to total DNA isolation and PCR amplification of the gene for human glycerol-3-phosphate dehydrogenase. Our results show a relatively similar bio-distribution and retention of HUCBCs in both mouse and rat organs. HUCBCs ...
Source: Cell Transplantation - September 25, 2015 Category: Cytology Tags: Cell Transplant Source Type: research

5-Aminoisoquinolin-1-one (5-AIQ), a Water-Soluble Inhibitor of the Poly¬(ADP Ribose)¬Polymerases (PARPs).
Abstract 5-Aminoisoquinolin-1-one (5-AIQ) is a water-soluble inhibitor of the poly(ADP-ribose)polymerases (PARPs), lacking isoform-selectivity. Although of only moderate potency in vitro against PARP-1, it is highly active in many assays in cells and in models in vivo, indicating excellent uptake. Optimisation of the several synthetic sequences to 5-AIQ has led to development of a short and efficient route from 1-chloroisoquinoline. It has been used widely as a biochemical and pharmacological tool to study the effects of inhibition of the PARPs. It ameliorates the damage to cells and tissues following reperfusion ...
Source: Current Medicinal Chemistry - October 2, 2015 Category: Chemistry Authors: Threadgill MD Tags: Curr Med Chem Source Type: research

The Man Who Grew Eyes
The train line from mainland Kobe is a marvel of urban transportation. Opened in 1981, Japan’s first driverless, fully automated train pulls out of Sannomiya station, guided smoothly along elevated tracks that stand precariously over the bustling city streets below, across the bay to the Port Island. The island, and much of the city, was razed to the ground in the Great Hanshin Earthquake of 1995 – which killed more than 5,000 people and destroyed more than 100,000 of Kobe’s buildings – and built anew in subsequent years. As the train proceeds, the landscape fills with skyscrapers. The Rokkō mounta...
Source: Healthy Living - The Huffington Post - October 11, 2015 Category: Consumer Health News Source Type: news

Disrupting Today's Healthcare System
This week in San Diego, Singularity University is holding its Exponential Medicine Conference, a look at how technologists are redesigning and rebuilding today's broken healthcare system. Healthcare today is reactive, retrospective, bureaucratic and expensive. It's sick care, not healthcare. This blog is about why the $3 trillion healthcare system is broken and how we are going to fix it. First, the Bad News: Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability. Americans spend, on average, $8,915 per person on healthcare – more than any other count...
Source: Healthy Living - The Huffington Post - November 9, 2015 Category: Consumer Health News Source Type: news

Serotonin 1A Receptors on Astrocytes as a Potential Target for Treatment of Parkinson's Disease.
We reported recently that stimulation of serotonin 1A (5-HT1A) receptors on astrocytes promoted astrocyte proliferation and upregulated antioxidative molecules to act as a neuroprotectant in parkinsonian mice. PD is a progressive neurodegenerative disease with motor symptoms such as tremor, bradykinesia, rigidity and postural instability, that are based on selective loss of nigrostriatal dopaminergic neurons, and with non-motor symptoms such as orthostatic hypotension and constipation based on peripheral neurodegeneration. Although dopaminergic therapy for managing the motor disability associated with PD is being assessed ...
Source: Current Medicinal Chemistry - January 21, 2016 Category: Chemistry Authors: Miyazaki I, Asanuma M Tags: Curr Med Chem Source Type: research

Ethical clinical translation of stem cell interventions for neurologic disease
The application of stem cell transplants in clinical practice has increased in frequency in recent years. Many of the stem cell transplants in neurologic diseases, including stroke, Parkinson disease, spinal cord injury, and demyelinating diseases, are unproven—they have not been tested in prospective, controlled clinical trials and have not become accepted therapies. Stem cell transplant procedures currently being carried out have therapeutic aims, but are frequently experimental and unregulated, and could potentially put patients at risk. In some cases, patients undergoing such operations are not included in a clin...
Source: Neurology - January 15, 2017 Category: Neurology Authors: Cote, D. J., Bredenoord, A. L., Smith, T. R., Ammirati, M., Brennum, J., Mendez, I., Ammar, A. S., Balak, N., Bolles, G., Esene, I. N., Mathiesen, T., Broekman, M. L. Tags: Parkinson's disease/Parkinsonism, All Ethics in Neurology/Legal issues, Malpractice, Error in medicine, Professional conduct and ethics CONTEMPORARY ISSUES Source Type: research

Defining recovery neurobiology of injured spinal cord by synthetic matrix-assisted hMSC implantation Neuroscience
Mesenchymal stromal stem cells (MSCs) isolated from adult tissues offer tangible potential for regenerative medicine, given their feasibility for autologous transplantation. MSC research shows encouraging results in experimental stroke, amyotrophic lateral sclerosis, and neurotrauma models. However, further translational progress has been hampered by poor MSC graft survival, jeopardizing cellular and...
Source: Proceedings of the National Academy of Sciences - January 30, 2017 Category: Science Authors: Alexander E. Ropper, Devang K. Thakor, InBo Han, Dou Yu, Xiang Zeng, Jamie E. Anderson, Zaid Aljuboori, Soo-Woo Kim, Hongjun Wang, Richard L. Sidman, Ross D. Zafonte, Yang D. Teng Tags: PNAS Plus Source Type: research

How to Boost Your Stem Cells
A California man named Kris Boesen was completely paralyzed after breaking his neck in a terrible car crash last March. But now he can brush his teeth and hug his family again… He's even started to regain sensation in his legs. And it's all because of a simple procedure he underwent about a month after his accident: stem cell therapy. During Kris' procedure, researchers at the University of Southern California injected 10 million stem cells into his spinal cord. Within two weeks, he could wiggle his fingers. Three months later, he was able to feed himself, write his name and operate his wheelchair. His re...
Source: Al Sears, MD Natural Remedies - March 23, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news

The Application of Nanomaterials in Stem Cell Therapy for some Neurological Diseases.
Abstract Stem cell therapy provides great promising therapeutic benefits for various neurological disorders. Cell transplantation has emerged as cell replacement application for nerve damage. Recently, nanomaterials obtain wide development in various industrial and medical fields, and nanoparticles have been applied to neuro-medical field for tracking and treating nervous system diseases. Combining stem cell with nanotechnology has raised more and more attentions; and it has demonstrated that it has huge effects on clinical diagnosis and therapeutics in multiple central nervous system diseases, meanwhile, improvin...
Source: Current Drug Targets - March 28, 2017 Category: Drugs & Pharmacology Authors: Zhang G, Khan AA, Wu H, Chen L, Gu Y, Gu N Tags: Curr Drug Targets Source Type: research

Assessment of stability of CD34+ cell products enriched by immunoselection from peripheral blood mononuclear cells during refrigerated storage
Haematopoietic stem cell transplantation is generally used for haematopoietic regeneration after myeloablative therapy [1]. Therapeutic effects of stem cells in other diseases like heart failure [2,3], bone healing [4], chronic spinal cord injuries [5], retinal disorders [6], stroke [7], refractory Crohn disease [8] and multiple sclerosis [9] are being investigated in various clinical studies. Haematopoietic stem cells are most often collected in a mononuclear cell fraction by leukapheresis from peripheral blood.
Source: Transfusion and Apheresis Science - July 21, 2017 Category: Hematology Authors: Metka Krasna, Elvira Malicev, Jasmina Ziva Rozman, Bojan Vrtovec Source Type: research

Pages: 1  2  3