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Risk Factors for Recurrence of Nasal Polyps after Endoscopic Sinus Surgery in Patients with Allergic Chronic Rhino Sinusitis
AbstractRhino sinusitis, is a common inflammatory disease that affects the nasal cavity and paranasal sinuses in millions of individuals. Chronic sinusitis patients complain of a combination of nasal obstruction, rhinorrhea, post nasal drip and facial pain. To identify the risk factors of the recurrence of nasal polyps in chronic rhino sinusitis patients after endoscopic sinus surgery. After a review of 60 patients with chronic rhino sinusitis with failed medical treatment requiring FESS presenting in Kasr Alainy Hospital in Cairo University and October 6 University Hospital from May 2022 to March 2023. All patients were s...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - June 23, 2023 Category: ENT & OMF Source Type: research

Characteristics of chronic rhinosinusitis phenotypes in patients undergoing functional endoscopic sinus surgery: an observational cohort retrospective study
This study analyzed the characteristics of chronic rhinosinusitis patients with and without nasal polyps failing conservative treatment and undergoing functional endoscopic sinus surgery as part of their treatment for chronic inflammatory sinonasal disease. The aim of this retrospective single-institution cohort study conducted at a university hospital tertiary referral center was to evaluate the characteristics of patients with both disease phenotypes in whom conservative treatment was unsuccessful. Patients who were surgically treated with functional endoscopic sinus surgery performed by two rhinology surgeons during a o...
Source: Acta Clinica Croatica - February 23, 2023 Category: General Medicine Authors: Martina Radeti ć Jeffry Mattar Andro Ko šec Filip Bacan Tomislav Baudoin Source Type: research

Multidisciplinary checklist approach for the 'severe phenotype: Asthma with Nasal Polyps
Asthma with chronic rhinosinusitis with nasal polyps (CRSwNP) associates with higher burden and more difficult treatment.Aim: To propose an evidence-based data checklist for a coordinated management of these patients.A multidisciplinary team of ENT physicians, allergologists, pneumologists and hospital pharmacist aimed to develop a checklist for the assessment of patients, based on the diagnostic definition, and the control and severity criteria establish in guidelines such GINA, ARIA, EPOS, and international consensus on biologic therapies for CRSwNP and Asthma from EUFOREA and from EAACI, and a multidisciplinary consensu...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Castillo Vizuete, J. A., Armengot, M., Delgado, J., Gil, M., Colas, C., Plasencia, I., Cisneros, C. Tags: 05.03 - Allergy and immunology Source Type: research

Confirmation of endotypes based on levels of eosinophil, mast cell and basophil microparticles in nasal lavage fluids in chronic rhinosinusitis with nasal polyps using two Northwestern Memorial Hospital cohorts
Microparticles (MPs) are extracellular vesicles that are released by shedding from plasma membrane of activated cells and new biomarkers to evaluate status of cell activation. MP profilings of activated eosinophils, mast cells and basophils in nasal mucosa in chronic rhinosinusitis with nasal polyps (CRSwNP) remain unclear.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Toru Takahashi, Lydia Suh, Roderick Carter, Kris Erickson, Julia Huang, James Norton, Atsushi Kato, Sergejs Berdnikovs, Whitney Stevens, Anju Peters, Leslie Grammer, Stephanie Shintani Smith, Bruce Tan, David Conley, Kevin Welch, Robert Kern, Robert Schle Source Type: research

What Are Common Gastrointestinal Polyposes in Children?
Discussion Bloody stools or blood in the diaper is a relatively common complaint in general pediatrics. For most patients it is often a minor concern. Commonly it is a transient problem (e.g. rectal fissure caused by constipation or trauma) or often not blood (e.g. urate crystals in the diaper, food, menses, etc.). Real blood does occur with an identifiable cause such as long distance running or heavy exercise, or milk protein allergy/sensitivity that improves with a milk-restricted diet. Many more serious causes are associated with heavier or more recalcitrant bleeding, increased defecation, abdominal pain, poor eating an...
Source: PediatricEducation.org - January 24, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Are objective 'findings' the same as subjective 'severity'? A study of the relationship between computed tomography findings and subjective severity in preoperative CRSwNP patients.
Authors: Lu H, Liu Z, Hu L, Feng X, Hu L, Gu Y, Li H, Li H, Wang D Abstract In pre-surgical patients with chronic rhinosinusitis with nasal polyps (CRSwNPs), positive findings on computed tomography (CT) scans and an exacerbation of symptoms are two possible factors that indicate surgery. However, the relationship between these factors remains unclear. Confirmed CRSwNP patients ready for sinus surgery were consecutively enrolled. The Sino-Nasal Outcome Test 22 (SNOT-22) and visual analog scale (VAS) scoring were completed by these patients, and scores were subjected to factor analysis using a principal component an...
Source: Experimental and Therapeutic Medicine - August 30, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF- β
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcript...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

Nasal polyps in patients with asthma: prevalence, impact, and management challenges
Cristobal Langdon,1,2 Joaquim Mullol1–3 1Rhinology Unit and Smell Clinic, Otorhinolaryngology Department, Hospital Clínic, 2Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 3Centre for Biomedical Research in Respiratory Diseases (CIBERES), Barcelona, Catalonia, SpainAbstract: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have coexisting asthma under the concept of “United Airway Disease”, being the combination of both diseases, which is one of the most challenging phenotypes to treat. A...
Source: Journal of Asthma and Allergy - March 13, 2016 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

LPS may enhance expression and release of HMGB1 in human nasal epithelial cells in vitro.
The objective of the present study was to investigate the relocation of HMGB1 in LPS-induced human nasal epithelial cells in vitro. We obtained epithelial cells of nasal polyps from 10 patients requiring surgery for sinusitis at the ENT Department of the Chinese PLA General Hospital. The primary cultured human nasal epithelial (HNE) cells were stimulated with LPS. The expression and translocation of HMGB1 in intracellular and culture supernatants were determined using Western blot and immunofluorescence assay. HMGB1 protein was released in a time-dependent fashion in culture supernatants: in fact, expression of HMGB1 prote...
Source: Acta Otorhinolaryngologica Italica - December 2, 2014 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

SNOT-22 Validation in Greek Patients
Background: Chronic rhinosinusitis (CRS) with or without nasal polyps is a frequent and significant health problem. The 22-item Sinonasal Outcome Test (SNOT-22) is a valid, disease-specific health status instrument translated into several languages. The translation into Greek has been considered essential for the individual assessment of the patients' symptoms and a reliable tool for quality of life evaluation. Methods: Our study included 40 patients with CRS without nasal polyps and 40 healthy individuals as control group recruited from the ENT Allergy and Endoscopy Clinic of Chania General Hospital. Assessment included f...
Source: ORL - November 6, 2014 Category: ENT & OMF Source Type: research

How Much Cetirizine Can Be Used?
Discussion Antihistamine medications have been available for over 70 years. The original H1-antihistamines, while effective in treated allergic rhinitis, urticaria and other allergic problems, easily penetrated the blood-brain barrier and caused somnolence. The newer, second generation H1-antihistamines have much less somnolent side effects because of poor penetrance. Fexofenadine (Allegra®), desloratadine (Claritin®) and levocetirizine (Zyrtec®) are commonly used H1-antihistamines in the US today. Previously Astemazole (Hismanal®) and Terfanadine (Seldane®) were used but were withdrawn because of prob...
Source: PediatricEducation.org - July 7, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Abby Clinic Update
I have updated everyone on facebook but I haven't been on here in quite some time because I have been on my first Vacation since Abby was diagnosed. I actually got to take my full 2 weeks and didn't have to spend my entire vacation at the hospital!!! It was fantastic!!! It would have been better had we have not been broke but still loving life with Kalydeco!!! So Abby has been taking Kalydeco since June 28, 2012. We went to clinic a couple of weeks ago and discovered that we had a completely new CF team! Dr was gone...fellow leaving...and nurse had a baby and not coming back. Wow!! So here is the comparison: ................
Source: Cystic Fibrosis CFTR Modulation and Gene Therapy Forum - July 9, 2013 Category: Respiratory Medicine Authors: JENNYC Tags: CFTR Modulation and Gene Therapy Talk Source Type: forums