How Much Cetirizine Can Be Used?
Discussion Antihistamine medications have been available for over 70 years. The original H1-antihistamines, while effective in treated allergic rhinitis, urticaria and other allergic problems, easily penetrated the blood-brain barrier and caused somnolence. The newer, second generation H1-antihistamines have much less somnolent side effects because of poor penetrance. Fexofenadine (Allegra®), desloratadine (Claritin®) and levocetirizine (Zyrtec®) are commonly used H1-antihistamines in the US today. Previously Astemazole (Hismanal®) and Terfanadine (Seldane®) were used but were withdrawn because of problems with cardiac arrhythmias with a propensity to prolong the QT interval. Fexofenadine in studies has the same somnolence producing effect as placebo. Desloratadine and cetirizine both can have some sedative effects. Cetirizine is extensively and rapidly absorbed by the gut allowing a rapid onset of action. It interacts with target receptors at effective concentrations, and organs where it would not be effective or toxic are avoided. There is no hepatic metabolism (thus avoiding many potential drug-drug interactions) and the drug is excreted unchanged by the kidney. The half-life is about 10.5 hours in adults. Cetirizine has higher binding affinity for receptors than other similar drugs thus it has “…a more potent, faster onset and longer duration of action…” when used for seasonal allergic rhinitis. “…[T]here is evi...
Authors: Finley JR, Wixted JT, Roediger HL Abstract Recent research in the eyewitness identification literature has investigated whether simultaneous or sequential lineups yield better discriminability. In standard eyewitness identification experiments, subjects view a mock-crime video and then are tested only once, requiring large samples for adequate power. However, there is no reason why theories of simultaneous versus sequential lineup performance cannot be tested using more traditional recognition memory tasks. In two experiments, subjects studied DRM (Deese-Roediger-McDermott) word lists (e.g., bed, rest, tir...
Contributors : Lucas C Pantaleao ; Susan E Ozanne ; Ania WilczynskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity during pregnancy is associated with fetal growth restriction in the offspring. We used RNA next generation sequencing analysis (HiSeq2000) to have a snapshot of the placenta transcriptome at embryonic day 19 to examine whether mice exposed to maternal obesity had significant changes in their transcriptome which may lead to growth restriction in the fetus.
I have seen that a few companies are offering paid leave if their workers test positive for COVID19. In theory this is great. In reality, this is bogus. Policies are worded very specifically. Most of the statements I have seen that list paid leave are for patients that TEST positive for COVID19. The problem is we do not have enough tests! At my practice (a large, tertiary, University-based clinic in Southern California), we are operating under the assumption that most people who contract COVID19 will have a mild form of the disease that will not require a hospital admission. However, they will need...
Eosinophils are associated with the onset of chronic respiratory diseases like asthma and COPD. In lung transplantation, patients with increased bronchoalveolar lavage eosinophils demonstrated a worse chronic lung allograft dysfunction (CLAD)-free survival and overall survival. We investigated the association between blood eosinophilia, graft survival and CLAD-free survival after lung transplantation.
Creatinine clearance (CrCl) is the accepted clinical standard for the assessment of renal function and dosing of renally-excreted medications such as valganciclovir (VGC) among heart transplant (HT) pts. Cystatin C (CysC) has recently shown superiority to serum creatinine (sCr) for the estimation of renal function in advanced diseases. We hypothesize that CysC-estimated glomerular filtration rate (Cys-eGFR) more accurately guides VGC dosing than CrCL, and thereby may prevents drug overdosing and leukopenia in HT pts.
Amiodarone is a commonly used anti-arrhythmic medication for atrial and ventricular arrhythmias in end-stage heart failure. Due to heavy iodine content, amiodarone is implicated in a variety of thyroid disorders, which could lead to adverse outcomes in cardiac transplant (CT) patients. Data on the development of post-CT lymphocytic thyroiditis (LT) in patients with pre-CT amiodarone use is limited. We aimed to study the development of amiodarone-induced LT in CT patients in a tertiary care transplant center in the United States.
In this study we sought to examine outcomes in recipients stratified by donor brain death related to underlying donor disease vs brain death that was independent of any underlying donor disease (including trauma, suicide, drug overdose, and others).
Obstructive sleep apnea (OSA) is associated with increased all-cause and cardiovascular mortality in the general population and may be associated with decreased exercise capacity on cardiopulmonary exercise testing (CPET). While comorbid OSA is often considered when evaluating patients for heart transplantation, post-transplant outcomes are poorly studied.
The purpose of this study was to describe 171 pregnancies in 100 heart transplant recipients.
In the field of lung transplantation, there is a high wait list mortality. Broader use of extended criteria donors would provide additional organs for transplantation. An increasing number of organ donors are dying from drug overdose. These donors are often considered “high risk” because of their exposure to infectious diseases such as HIV and Hepatitis B and C. However, these organ donors are often younger and healthier than those that die from stroke or cardiac arrest. Successful use of lung donors who have a history of drug abuse may serve to provide addit ional organs for those patients on the wait list.
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